Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.1493 | 0.2553 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.5791 | 0.4308 |
Plasmodium vivax | adenosine deaminase, putative | 0.009 | 0.2605 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.009 | 0.2605 | 0.259 |
Trypanosoma brucei | AMP deaminase, putative | 0.0029 | 0.0126 | 0.5 |
Brugia malayi | adenosine monophosphate deaminase | 0.0029 | 0.0126 | 0.0106 |
Loa Loa (eye worm) | glutaminase 2 | 0.0272 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0029 | 0.0126 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.5791 | 0.4308 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1387 | 0.2369 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1387 | 0.5088 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.5791 | 0.4308 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.5791 | 0.4308 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0126 | 0.0126 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0029 | 0.0126 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.009 | 0.2605 | 1 |
Echinococcus multilocularis | geminin | 0.0169 | 0.5791 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1387 | 0.137 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1493 | 0.1476 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0257 | 0.9388 | 0.9388 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.9388 | 0.9172 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.9388 | 0.9172 |
Schistosoma mansoni | glutaminase | 0.0272 | 1 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0257 | 0.9388 | 0.9387 |
Echinococcus granulosus | geminin | 0.0169 | 0.5791 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.009 | 0.2605 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0029 | 0.0126 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.9388 | 0.9172 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.1493 | 0.1493 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1407 | 0.1407 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1493 | 0.1476 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0029 | 0.0126 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0029 | 0.0126 | 0.0183 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0029 | 0.0126 | 0.5 |
Schistosoma mansoni | AMP deaminase | 0.0029 | 0.0126 | 0.0106 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.002 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.002 | 0.002 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.009 | 0.2605 | 0.4479 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.002 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1407 | 0.1407 |
Schistosoma mansoni | adenosine deaminase-related | 0.009 | 0.2605 | 0.259 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0169 | 0.5791 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0178 | 0.6161 | 0.4808 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1387 | 0.5088 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.1493 | 0.1493 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0029 | 0.0126 | 0.0183 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.5791 | 0.4308 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0029 | 0.0126 | 0.5 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0029 | 0.0126 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.1493 | 0.2553 |
Echinococcus multilocularis | adenosine deaminase | 0.009 | 0.2605 | 0.4479 |
Entamoeba histolytica | adenosine deaminase, putative | 0.009 | 0.2605 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1493 | 0.1476 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.5791 | 0.5783 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0029 | 0.0126 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.1493 | 0.1476 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.1493 | 0.1493 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.5791 | 0.4308 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.2605 | 0.2605 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.9388 | 0.9172 |
Plasmodium falciparum | adenosine deaminase | 0.009 | 0.2605 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0029 | 0.0126 | 0.5 |
Brugia malayi | RNA binding protein | 0.0063 | 0.1493 | 0.1476 |
Echinococcus granulosus | adenosine deaminase | 0.009 | 0.2605 | 0.4479 |
Loa Loa (eye worm) | glutaminase | 0.0272 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1493 | 0.1476 |
Entamoeba histolytica | adenosine deaminase, putative | 0.009 | 0.2605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1407 | 0.1407 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.009 | 0.2605 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1493 | 0.1476 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.1493 | 0.1476 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.009 | 0.2605 | 0.259 |
Trichomonas vaginalis | glutaminase, putative | 0.0272 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0029 | 0.0126 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1387 | 0.2369 |
Loa Loa (eye worm) | AMP deaminase | 0.0029 | 0.0126 | 0.0126 |
Mycobacterium ulcerans | adenosine deaminase | 0.009 | 0.2605 | 0.1414 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.009 | 0.2605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1407 | 0.1407 |
Treponema pallidum | adenosine deaminase | 0.009 | 0.2605 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.9388 | 0.9172 |
Leishmania major | adenine aminohydrolase | 0.009 | 0.2605 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0029 | 0.0126 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.0272 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0257 | 0.9388 | 0.9172 |
Onchocerca volvulus | 0.0029 | 0.0126 | 0.0183 | |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.5791 | 0.5783 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0178 | 0.6161 | 0.4808 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1387 | 0.137 |
Echinococcus granulosus | AMP deaminase 2 | 0.0029 | 0.0126 | 0.0183 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.5791 | 0.4308 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Intrinsic activity (binding) | = 0.7 | The compound was tested for intrinsic activity against 5-HT1D receptor | ChEMBL. | 7658443 |
Intrinsic activity (binding) | = 0.7 | The compound was tested for intrinsic activity against 5-HT1D receptor | ChEMBL. | 7658443 |
p[A50] (binding) | = 5.3 | The compound was tested for binding affinity against 5-HT2A receptor | ChEMBL. | 7658443 |
p[A50] (binding) | = 7.1 | The compound was tested for binding affinity against 5-HT1D receptor | ChEMBL. | 7658443 |
p[A50] (binding) | = 5.3 | The compound was tested for binding affinity against 5-HT2A receptor | ChEMBL. | 7658443 |
p[A50] (binding) | = 7.1 | The compound was tested for binding affinity against 5-HT1D receptor | ChEMBL. | 7658443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.