Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Cysteinyl leukotriene receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.4006 | 0.4637 | 0.5 |
Onchocerca volvulus | 0.2846 | 0.2609 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.1354 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4006 | 0.4637 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2846 | 0.2609 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4006 | 0.4637 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4006 | 0.4637 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.7074 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.2846 | 0.2609 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4006 | 0.4637 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.2846 | 0.2609 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.7074 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4006 | 0.4637 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2846 | 0.2609 | 1 |
Brugia malayi | thymidylate synthase | 0.2846 | 0.2609 | 0.2609 |
Echinococcus granulosus | thymidylate synthase | 0.2846 | 0.2609 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.2846 | 0.2609 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 30 mg kg-1 | Oral activity expressed as effective dose in leukotriene mediated anaphylaxis assay in guinea pig | ChEMBL. | 2157010 |
IC50 (functional) | = 12 nM | Inhibition of LTC4-induced contractions from guinea pig peripheral lung strips | ChEMBL. | 2157010 |
Inhibition (functional) | = 34 % | Oral activity expressed as percent inhibition in LTD4-induced wheal assay in guinea pig at 9 uM | ChEMBL. | 2157010 |
Ki (binding) | = 8.5 nM | Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM) | ChEMBL. | 2157010 |
Ki (binding) | = 8.5 nM | Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM) | ChEMBL. | 2157010 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.