Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0301 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0150677 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0301 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0301 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0150677 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0150677 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0150677 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0150677 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0301 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0150677 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0301 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0150677 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0301 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0301 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0301 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0150677 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0150677 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0150677 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0301 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0150677 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0150677 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0150677 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.31 milliequivalent | Inhibition of beta-hematin formation after 18 hrs by microtiter plate assay | ChEMBL. | 19364118 |
IC50 (functional) | = 1 uM | Antimicrobial activity against Trypanosoma brucei | ChEMBL. | 20185316 |
IC50 (functional) | = 1.3 uM | Antitrypanosomal activity against Trypanosoma brucei. | ChEMBL. | 12139461 |
IC50 (functional) | = 1.3 uM | Antitrypanosomal activity against Trypanosoma brucei. | ChEMBL. | 12139461 |
IC50 (functional) | = 5 uM | Antiplasmodial activity against Plasmodium falciparum chloroquine resistant W2 Strain | ChEMBL. | 12139461 |
IC50 (functional) | = 5 uM | Antiplasmodial activity against Plasmodium falciparum chloroquine resistant W2 Strain | ChEMBL. | 12139461 |
IC50 (functional) | = 12 uM | Antitrypanosomal activity against Trypanosoma cruzi | ChEMBL. | 12139461 |
IC50 (functional) | = 12 uM | Antitrypanosomal activity against Trypanosoma cruzi | ChEMBL. | 12139461 |
IC50 (functional) | = 12 uM | Antimicrobial activity against Trypanosoma cruzi | ChEMBL. | 20185316 |
IC50 (functional) | = 16.5 uM | Cytotoxicity against human diploid embryonic lung cell line MRC-5 using MTT assay | ChEMBL. | 12139461 |
IC50 (functional) | = 16.5 uM | Cytotoxicity against human diploid embryonic lung cell line MRC-5 using MTT assay | ChEMBL. | 12139461 |
IC50 (functional) | = 21 uM | Antiplasmodial activity against Plasmodium falciparum chloroquine sensitive Ghana Strain | ChEMBL. | 12139461 |
IC50 (functional) | = 21 uM | Antiplasmodial activity against Plasmodium falciparum chloroquine sensitive Ghana Strain | ChEMBL. | 12139461 |
IC50 (functional) | = 21 uM | Antimicrobial activity against Plasmodium falciparum | ChEMBL. | 20185316 |
IC50 (functional) | = 52 uM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum Ghana in human erythrocytes after 72 hrs by Malstat assay | ChEMBL. | 19364118 |
IC50 (binding) | > 500 uM | Inhibition of DNA interaction using DNA Methyl Green Assay. | ChEMBL. | 12139461 |
Inhibition (functional) | 0 | Inhibition of beta-hematin formation; Compound is active | ChEMBL. | 12139461 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 12139461 | |
Trypanosoma brucei gambiense | 12139461 | ||
Homo sapiens | ChEMBL23 | 12139461 | |
Trypanosoma cruzi | ChEMBL23 | 12139461 | |
Trypanosoma brucei | ChEMBL23 | 12139461 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.