Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine-1-phosphate receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | sphingosine-1-phosphate receptor 2 | Starlite/ChEMBL | References |
Homo sapiens | sphingosine-1-phosphate receptor 3 | Starlite/ChEMBL | References |
Homo sapiens | lysophosphatidic acid receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Adenosine deaminase homolog | 0.0477 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0477 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0477 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0477 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0477 | 1 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0477 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0477 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0477 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0477 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0477 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0477 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0477 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0477 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0477 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0477 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0477 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0477 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0477 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.7 nM | Binding affinity to human sphingosine 1-phosphate receptor 1 expressed in CHO cells was determined by using [33P]-S1P as radioligand | ChEMBL. | 15177461 |
IC50 (binding) | = 0.7 nM | Binding affinity to human sphingosine 1-phosphate receptor 1 expressed in CHO cells was determined by using [33P]-S1P as radioligand | ChEMBL. | 15177461 |
IC50 (binding) | = 1.2 nM | Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligand | ChEMBL. | 15177461 |
IC50 (binding) | = 1.2 nM | Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligand | ChEMBL. | 15177461 |
IC50 (binding) | = 2 nM | Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand | ChEMBL. | 15177461 |
IC50 (binding) | = 2 nM | Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand | ChEMBL. | 15177461 |
IC50 (binding) | = 59 nM | Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand | ChEMBL. | 15177461 |
IC50 (binding) | = 59 nM | Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand | ChEMBL. | 15177461 |
IC50 (binding) | = 4700 nM | Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligand | ChEMBL. | 15177461 |
IC50 (binding) | = 4700 nM | Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligand | ChEMBL. | 15177461 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.