Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | NADPH:adrenodoxin oxidoreductase FprA | 0.0041 | 0.0213 | 0.0681 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0155 | 0.1309 | 0.4301 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0334 | 0.3034 | 1 |
Leishmania major | pyruvate kinase | 0.0037 | 0.0173 | 0.0403 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0041 | 0.0213 | 0.0514 |
Schistosoma mansoni | sulfide quinone reductase | 0.0041 | 0.0213 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0301 | 0.0336 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.005 | 0.0301 | 0.0726 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0155 | 0.1309 | 0.3176 |
Loa Loa (eye worm) | pyruvate kinase | 0.0037 | 0.0173 | 0.019 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0334 | 0.3034 | 0.7314 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0007 | 0.0017 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0007 | 0.0008 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0155 | 0.1309 | 0.1911 |
Loa Loa (eye worm) | programmed cell death 8 | 0.0041 | 0.0213 | 0.0235 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0026 | 0.0066 | 0.0067 |
Schistosoma mansoni | glutamate synthase | 0.0041 | 0.0213 | 0.0221 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0037 | 0.0173 | 0.019 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0155 | 0.1309 | 0.3164 |
Mycobacterium leprae | PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) | 0.0041 | 0.0213 | 0.006 |
Mycobacterium ulcerans | monoxygenase | 0.0041 | 0.0213 | 0.0681 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0133 | 0.1101 | 0.267 |
Giardia lamblia | Glutamate synthase | 0.0041 | 0.0213 | 0.1629 |
Trichomonas vaginalis | glutamate synthase, putative | 0.0041 | 0.0213 | 0.0206 |
Schistosoma mansoni | sulfide quinone reductase | 0.0041 | 0.0213 | 0.0221 |
Trichomonas vaginalis | dihydrolipoamide dehydrogenase, putative | 0.0041 | 0.0213 | 0.0206 |
Mycobacterium ulcerans | NADH dehydrogenase Ndh1 | 0.0041 | 0.0213 | 0.0681 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0041 | 0.0213 | 0.0206 |
Echinococcus granulosus | pyridine nucleotide disulfide oxidoreductase | 0.0041 | 0.0213 | 0.0514 |
Toxoplasma gondii | thioredoxin reductase | 0.0448 | 0.4122 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0448 | 0.4122 | 1 |
Plasmodium falciparum | ferrodoxin reductase-like protein | 0.0041 | 0.0213 | 0.0517 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0155 | 0.1309 | 0.1303 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0155 | 0.1309 | 0.3176 |
Trypanosoma cruzi | 2,4-dienoyl-coa reductase fadh1, putative | 0.0041 | 0.0213 | 0.0501 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0155 | 0.1309 | 0.3164 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0155 | 0.1309 | 0.3164 |
Trypanosoma cruzi | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0041 | 0.0213 | 0.0501 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0037 | 0.0173 | 0.0166 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0155 | 0.1309 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0037 | 0.0173 | 0.0244 |
Leishmania major | 2,4-dienoyl-coa reductase fadh1, putative | 0.0041 | 0.0213 | 0.0501 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0041 | 0.0213 | 0.2197 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0213 | 0.0235 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0728 | 0.6822 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0728 | 0.6822 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0041 | 0.0213 | 0.0514 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0066 | 0.0067 |
Echinococcus granulosus | pyruvate kinase | 0.0037 | 0.0173 | 0.0418 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0128 | 0.1053 | 0.2539 |
Trypanosoma cruzi | NADH dehydrogenase, putative | 0.0041 | 0.0213 | 0.0501 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.0768 | 0.0795 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0284 | 0.0294 |
Brugia malayi | glutamate synthase | 0.0041 | 0.0213 | 0.0235 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0213 | 0.0501 |
Mycobacterium tuberculosis | Possible dehydrogenase/reductase | 0.0041 | 0.0213 | 0.0302 |
Mycobacterium ulcerans | thioredoxin reductase TrxB2 | 0.0041 | 0.0213 | 0.0681 |
Mycobacterium tuberculosis | Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) | 0.0041 | 0.0213 | 0.0302 |
Leishmania major | NADH dehydrogenase, putative | 0.0041 | 0.0213 | 0.0501 |
Echinococcus multilocularis | pyruvate kinase | 0.0037 | 0.0173 | 0.0418 |
Mycobacterium tuberculosis | Probable thioredoxin reductase TrxB2 (TRXR) (TR) | 0.0041 | 0.0213 | 0.0302 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0007 | 0.0018 |
Brugia malayi | CHE-14 protein | 0.005 | 0.0301 | 0.0336 |
Schistosoma mansoni | patched 1 | 0.005 | 0.0301 | 0.0312 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0037 | 0.0173 | 0.0403 |
Loa Loa (eye worm) | glutathione reductase | 0.0448 | 0.4122 | 0.4699 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0099 | 0.0768 | 0.0869 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0155 | 0.1309 | 0.3176 |
Mycobacterium ulcerans | NADPH:adrenodoxin oxidoreductase FprA | 0.0041 | 0.0213 | 0.0681 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0041 | 0.0213 | 0.2197 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0037 | 0.0173 | 0.0166 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0155 | 0.1309 | 0.3164 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0114 | 0.0913 | 0.1035 |
Echinococcus granulosus | apoptosis inducing factor 1 mitochondrial | 0.0041 | 0.0213 | 0.0514 |
Echinococcus multilocularis | NADPH:adrenodoxin oxidoreductase | 0.0041 | 0.0213 | 0.0514 |
Plasmodium falciparum | thioredoxin reductase | 0.0448 | 0.4122 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0037 | 0.0173 | 0.042 |
Wolbachia endosymbiont of Brugia malayi | thioredoxin reductase | 0.0041 | 0.0213 | 0.1583 |
Schistosoma mansoni | disulfide oxidoreductase | 0.0041 | 0.0213 | 0.0221 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0099 | 0.0768 | 0.1852 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0155 | 0.1309 | 0.3176 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0117 | 0.0945 | 1 |
Trypanosoma cruzi | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0041 | 0.0213 | 0.0501 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0007 | 0.0018 |
Mycobacterium tuberculosis | Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) | 0.0041 | 0.0213 | 0.0302 |
Plasmodium vivax | ferrodoxin reductase, putative | 0.0041 | 0.0213 | 0.0517 |
Plasmodium falciparum | glutathione reductase | 0.0448 | 0.4122 | 1 |
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0041 | 0.0213 | 0.1629 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0155 | 0.1309 | 0.4301 |
Plasmodium vivax | pyruvate kinase, putative | 0.0037 | 0.0173 | 0.042 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0041 | 0.0213 | 0.0206 |
Entamoeba histolytica | pyridine nucleotide-disulfide oxidoreductase family protein | 0.0041 | 0.0213 | 0.2197 |
Schistosoma mansoni | glutamate synthase | 0.0041 | 0.0213 | 0.0221 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0334 | 0.3034 | 0.736 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0213 | 0.0221 |
Trypanosoma brucei | 2,4-dienoyl-coa reductase-like protein | 0.0041 | 0.0213 | 0.0501 |
Echinococcus granulosus | NADPH:adrenodoxin oxidoreductase | 0.0041 | 0.0213 | 0.0514 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.045 | 0.4149 | 1 |
Mycobacterium leprae | Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate | 0.0041 | 0.0213 | 0.006 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0155 | 0.1309 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0041 | 0.0213 | 0.0235 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0133 | 0.1101 | 0.1139 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0041 | 0.0213 | 0.2197 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0.0301 | 0.0294 |
Entamoeba histolytica | disulphide oxidoreductase, putative | 0.0041 | 0.0213 | 0.2197 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0155 | 0.1309 | 0.3164 |
Treponema pallidum | NADH oxidase | 0.0155 | 0.1309 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0117 | 0.0945 | 0.2278 |
Plasmodium vivax | glutathione reductase, putative | 0.0448 | 0.4122 | 1 |
Trypanosoma brucei | NADPH:adrenodoxin oxidoreductase, mitochondrial, putative | 0.0041 | 0.0213 | 0.0501 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0041 | 0.0213 | 0.0517 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0117 | 0.0945 | 0.2278 |
Loa Loa (eye worm) | pyruvate kinase | 0.0037 | 0.0173 | 0.019 |
Trypanosoma brucei | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0041 | 0.0213 | 0.0501 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0155 | 0.1309 | 0.1303 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0099 | 0.0768 | 0.0869 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0133 | 0.1101 | 0.2653 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0334 | 0.3034 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0213 | 0.0501 |
Mycobacterium ulcerans | dehydrogenase | 0.0041 | 0.0213 | 0.0681 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.005 | 0.0301 | 0.0336 |
Plasmodium falciparum | type II NADH:ubiquinone oxidoreductase | 0.0041 | 0.0213 | 0.0517 |
Toxoplasma gondii | NADH dehydrogenase (NDH2-II) | 0.0041 | 0.0213 | 0.0517 |
Brugia malayi | NADPH:adrenodoxin oxidoreductase, mitochondrial precursor | 0.0041 | 0.0213 | 0.0235 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0041 | 0.0213 | 0.0206 |
Mycobacterium tuberculosis | NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) | 0.0041 | 0.0213 | 0.0302 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0041 | 0.0213 | 0.0517 |
Plasmodium vivax | NAD(P)H-dependent glutamate synthase, putative | 0.0041 | 0.0213 | 0.0517 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0119 | 0.0963 | 0.0996 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.041 | 0.046 |
Treponema pallidum | thioredoxin reductase (trxB) | 0.0041 | 0.0213 | 0.1583 |
Giardia lamblia | Thioredoxin reductase | 0.0041 | 0.0213 | 0.1629 |
Trypanosoma brucei | NADH dehydrogenase | 0.0041 | 0.0213 | 0.0501 |
Echinococcus multilocularis | expressed conserved protein | 0.011 | 0.0877 | 0.2114 |
Trichomonas vaginalis | set domain proteins, putative | 0.1059 | 1 | 1 |
Toxoplasma gondii | selenide, water dikinase | 0.0041 | 0.0213 | 0.0517 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0155 | 0.1309 | 0.3164 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0041 | 0.0213 | 0.0206 |
Echinococcus multilocularis | pyridine nucleotide disulfide oxidoreductase | 0.0041 | 0.0213 | 0.0514 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0334 | 0.3034 | 0.3141 |
Echinococcus granulosus | glutamate synthase | 0.0041 | 0.0213 | 0.0514 |
Plasmodium falciparum | glutathione reductase | 0.0155 | 0.1309 | 0.3176 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0041 | 0.0213 | 0.0206 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0155 | 0.1309 | 0.3164 |
Wolbachia endosymbiont of Brugia malayi | thioredoxin reductase | 0.0041 | 0.0213 | 0.1583 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0155 | 0.1309 | 0.3164 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0448 | 0.4122 | 0.6039 |
Brugia malayi | Pre-SET motif family protein | 0.0133 | 0.1101 | 0.1249 |
Brugia malayi | Pre-SET motif family protein | 0.093 | 0.8764 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0614 | 0.5726 | 0.8392 |
Plasmodium vivax | type II NADH:ubiquinone oxidoreductase, putative | 0.0041 | 0.0213 | 0.0517 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0133 | 0.1101 | 0.1139 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.045 | 0.4149 | 1 |
Echinococcus multilocularis | protein patched | 0.005 | 0.0301 | 0.0726 |
Plasmodium falciparum | thioredoxin reductase | 0.0155 | 0.1309 | 0.3176 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0614 | 0.5726 | 0.8392 |
Mycobacterium tuberculosis | Probable reductase | 0.0614 | 0.5726 | 0.8392 |
Schistosoma mansoni | glutamate synthase | 0.0041 | 0.0213 | 0.0221 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0728 | 0.6822 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0168 | 0.1429 | 0.3445 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0155 | 0.1309 | 0.3156 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.005 | 0.0301 | 0.0726 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0213 | 0.0501 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0041 | 0.0213 | 0.0206 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0155 | 0.1309 | 0.3176 |
Chlamydia trachomatis | thioredoxin reductase | 0.0041 | 0.0213 | 0.0353 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0155 | 0.1309 | 0.4301 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0614 | 0.5726 | 0.8392 |
Leishmania major | 2,4-dienoyl-coa reductase-like protein | 0.0041 | 0.0213 | 0.0501 |
Trypanosoma brucei | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0041 | 0.0213 | 0.0501 |
Leishmania major | pyruvate kinase | 0.0037 | 0.0173 | 0.0403 |
Trypanosoma cruzi | 2,4-dienoyl-coa reductase-like protein, putative | 0.0041 | 0.0213 | 0.0501 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0155 | 0.1309 | 0.3164 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0168 | 0.1429 | 0.3445 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0041 | 0.0213 | 0.2197 |
Echinococcus multilocularis | protein dispatched 1 | 0.0057 | 0.037 | 0.0891 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0448 | 0.4122 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0155 | 0.1309 | 0.3156 |
Plasmodium vivax | SET domain protein, putative | 0.0133 | 0.1101 | 0.267 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0155 | 0.1309 | 0.3164 |
Treponema pallidum | oxidoreductase | 0.0041 | 0.0213 | 0.1583 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0155 | 0.1309 | 0.3164 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0037 | 0.0173 | 0.0403 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0114 | 0.0913 | 0.1035 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0173 | 0.019 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0041 | 0.0213 | 0.0206 |
Trypanosoma cruzi | NADH dehydrogenase, putative | 0.0041 | 0.0213 | 0.0501 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0614 | 0.5726 | 0.8352 |
Mycobacterium ulcerans | pyruvate kinase | 0.0037 | 0.0173 | 0.0548 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0133 | 0.1101 | 0.2653 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0155 | 0.1309 | 0.3164 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0614 | 0.5726 | 0.8392 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0728 | 0.6822 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0037 | 0.0173 | 0.0418 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0213 | 0.0501 |
Mycobacterium leprae | Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) | 0.0041 | 0.0213 | 0.006 |
Toxoplasma gondii | non-proton pumping type-II NADH dehydrogenase I | 0.0041 | 0.0213 | 0.0517 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0155 | 0.1309 | 0.3164 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0099 | 0.0768 | 0.1852 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0448 | 0.4122 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0213 | 0.0501 |
Mycobacterium ulcerans | NADH dehydrogenase | 0.0041 | 0.0213 | 0.0681 |
Mycobacterium tuberculosis | Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate | 0.0041 | 0.0213 | 0.0302 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0155 | 0.1309 | 1 |
Mycobacterium ulcerans | glutamate synthase subunit beta | 0.0041 | 0.0213 | 0.0681 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0037 | 0.0173 | 0.019 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.0768 | 0.0795 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0155 | 0.1309 | 0.3164 |
Echinococcus granulosus | sulfide:quinone oxidoreductase | 0.0041 | 0.0213 | 0.0514 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0041 | 0.0213 | 0.0514 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0041 | 0.0213 | 0.0206 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0448 | 0.4122 | 0.4699 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0334 | 0.3034 | 0.7356 |
Echinococcus granulosus | pyruvate kinase | 0.0037 | 0.0173 | 0.0418 |
Leishmania major | trypanothione reductase | 0.0448 | 0.4122 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0334 | 0.3034 | 0.4442 |
Echinococcus multilocularis | pyruvate kinase | 0.0029 | 0.0098 | 0.0237 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0041 | 0.0213 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0945 | 0.1071 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0155 | 0.1309 | 0.3176 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0037 | 0.0173 | 0.0403 |
Loa Loa (eye worm) | pyridine nucleotide-disufhide oxidoreductase | 0.0041 | 0.0213 | 0.0235 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0155 | 0.1309 | 0.3164 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0155 | 0.1309 | 0.1355 |
Trypanosoma cruzi | NADPH:adrenodoxin oxidoreductase, mitochondrial, putative | 0.0041 | 0.0213 | 0.0501 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0213 | 0.0681 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0284 | 0.0294 |
Plasmodium falciparum | NAD(P)H-dependent glutamate synthase, putative | 0.0041 | 0.0213 | 0.0517 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0155 | 0.1309 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.093 | 0.8764 | 1 |
Wolbachia endosymbiont of Brugia malayi | NADPH-dependent glutamate synthase beta chain | 0.0041 | 0.0213 | 0.1583 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0155 | 0.1309 | 0.3164 |
Onchocerca volvulus | 0.0133 | 0.1101 | 0.0944 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0099 | 0.0768 | 0.1852 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0284 | 0.0294 |
Mycobacterium ulcerans | NADH dehydrogenase Ndh | 0.0041 | 0.0213 | 0.0681 |
Mycobacterium leprae | THIOREDOXIN TRXC (TRX) (MPT46) | 0.0041 | 0.0213 | 0.006 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0334 | 0.3034 | 1 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.0041 | 0.0213 | 0.2197 |
Loa Loa (eye worm) | pyruvate kinase | 0.0037 | 0.0173 | 0.019 |
Echinococcus multilocularis | sulfide:quinone oxidoreductase | 0.0041 | 0.0213 | 0.0514 |
Trichomonas vaginalis | glutamate synthase, putative | 0.0041 | 0.0213 | 0.0206 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0334 | 0.3034 | 0.3141 |
Echinococcus granulosus | Protein patched homolog 1 | 0.005 | 0.0301 | 0.0726 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0133 | 0.1101 | 0.1139 |
Echinococcus multilocularis | glutamate synthase | 0.0041 | 0.0213 | 0.0514 |
Plasmodium falciparum | pyruvate kinase | 0.0037 | 0.0173 | 0.042 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0041 | 0.0213 | 0.0514 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0155 | 0.1309 | 0.3164 |
Onchocerca volvulus | 0.0041 | 0.0213 | 0.0041 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.0768 | 0.0795 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0041 | 0.0213 | 0.0206 |
Echinococcus multilocularis | apoptosis inducing factor 1 mitochondrial | 0.0041 | 0.0213 | 0.0514 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0007 | 0.0008 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0037 | 0.0173 | 0.0403 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0614 | 0.5726 | 0.8392 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0284 | 0.0294 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0007 | 0.0017 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0155 | 0.1309 | 0.1487 |
Trichomonas vaginalis | apoptosis inducing factor, putative | 0.0041 | 0.0213 | 0.0206 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0007 | 0.0055 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0213 | 0.0501 |
Mycobacterium ulcerans | NADPH dependent 2,4-dienoyl-CoA reductase FadH | 0.0041 | 0.0213 | 0.0681 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0041 | 0.0213 | 0.0235 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0334 | 0.3034 | 0.7314 |
Echinococcus granulosus | expressed conserved protein | 0.011 | 0.0877 | 0.2114 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0117 | 0.0945 | 0.1071 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0099 | 0.0768 | 0.1852 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0133 | 0.1101 | 0.1139 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1101 | 0.1249 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0007 | 0.0018 |
Mycobacterium ulcerans | NADPH:adrenodoxin oxidoreductase FprB | 0.0041 | 0.0213 | 0.0681 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0133 | 0.1101 | 0.2653 |
Schistosoma mansoni | pyruvate kinase | 0.0037 | 0.0173 | 0.0179 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0026 | 0.0066 | 0.0621 |
Brugia malayi | Thioredoxin reductase | 0.0448 | 0.4122 | 0.4699 |
Giardia lamblia | Pyruvate kinase | 0.0037 | 0.0173 | 0.1323 |
Brugia malayi | glutathione reductase | 0.0448 | 0.4122 | 0.4699 |
Schistosoma mansoni | pyruvate kinase | 0.0037 | 0.0173 | 0.0179 |
Mycobacterium ulcerans | ferredoxin reductase | 0.0041 | 0.0213 | 0.0681 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 79 % | Inhibition of Leishmania mexicana GAPDH(glyceraldehyde-3-phosphate dehydrogenase) | ChEMBL. | 9934461 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.