Detailed information for compound 206270

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.464 | Formula: C20H21N3O3S
  • H donors: 1 H acceptors: 1 LogP: 4.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N/C(=N\N=C/c1ccc(cc1)OC(=O)c1ccc2c(c1)C(C)(C)CCO2)/S
  • InChi: 1S/C20H21N3O3S/c1-20(2)9-10-25-17-8-5-14(11-16(17)20)18(24)26-15-6-3-13(4-7-15)12-22-23-19(21)27/h3-8,11-12H,9-10H2,1-2H3,(H3,21,23,27)/b22-12-
  • InChiKey: SMLQDCCTDXVYIJ-UUYOSTAYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hexokinase, putative 0.0088 0.0737 0.2676
Plasmodium vivax glutathione reductase, putative 0.0215 0.2302 1
Echinococcus granulosus FTZ F1 alpha 0.007 0.0521 0.0783
Echinococcus multilocularis thyroid hormone receptor alpha 0.007 0.0521 0.0849
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0068
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0074 0.0574 0.5
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.018 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.018 0.0711
Echinococcus multilocularis geminin 0.0186 0.1954 0.3513
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0119
Schistosoma mansoni hypothetical protein 0.0186 0.1954 0.3238
Schistosoma mansoni thyroid hormone receptor 0.007 0.0521 0.0783
Echinococcus granulosus hexokinase 0.0088 0.0737 0.1151
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.018 0.0711
Echinococcus granulosus hexokinase 0.0088 0.0737 0.1151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0119
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0074 0.0574 0.1913
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.047 0.5443 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0074 0.0574 0.1913
Echinococcus multilocularis ecdysone induced protein 78C 0.007 0.0521 0.0849
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.018 0.0198
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.018 0.0073
Toxoplasma gondii thioredoxin reductase 0.0215 0.2302 1
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.0521 0.0546
Brugia malayi Steroid receptor seven-up type 2 0.007 0.0521 0.0546
Loa Loa (eye worm) hypothetical protein 0.007 0.0521 0.0546
Brugia malayi nuclear receptor NHR-67 0.0033 0.0065 0.0068
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0074 0.0574 0.1913
Loa Loa (eye worm) hypothetical protein 0.007 0.0521 0.0546
Brugia malayi Hexokinase family protein 0.0088 0.0737 0.0772
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.018 0.0073
Loa Loa (eye worm) hypothetical protein 0.007 0.0521 0.0546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.007 0.0521 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.018 0.0711
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0037 0.0113 0.0084
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0074 0.0574 0.1854
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.007 0.0521 0.0546
Brugia malayi hypothetical protein 0.0037 0.0113 0.0119
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.018 0.0711
Echinococcus multilocularis hexokinase type 2 0.0088 0.0737 0.1249
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0215 0.2302 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0507 0.59 1
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.018 0.0711
Trypanosoma cruzi hexokinase, putative 0.0088 0.0737 0.2676
Trypanosoma cruzi trypanothione reductase, putative 0.0215 0.2302 1
Brugia malayi nuclear hormone receptor 0.007 0.0521 0.0546
Onchocerca volvulus 0.0088 0.0737 0.0676
Onchocerca volvulus Protein ultraspiracle homolog 0.007 0.0521 0.046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0521 0.0546
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.007 0.0521 0.0849
Echinococcus granulosus ecdysone induced protein 78C 0.007 0.0521 0.0783
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.007 0.0521 0.0849
Toxoplasma gondii hexokinase 0.0088 0.0737 0.2676
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0574 0.1913
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0074 0.0574 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0574 0.1913
Trichomonas vaginalis mercuric reductase, putative 0.0074 0.0574 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.007 0.0521 0.0783
Brugia malayi Thioredoxin reductase 0.0215 0.2302 0.2413
Loa Loa (eye worm) hexokinase 0.0055 0.0334 0.035
Brugia malayi nuclear receptor NHR-88 0.007 0.0521 0.0546
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0055 0.033 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-49 0.007 0.0521 0.0546
Trypanosoma brucei hexokinase, putative 0.0088 0.0737 0.3147
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.018 0.0073
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0074 0.0574 0.0601
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0521 0.0849
Loa Loa (eye worm) hypothetical protein 0.0769 0.9135 0.9573
Onchocerca volvulus 0.0055 0.0334 0.0271
Schistosoma mansoni RAR-like nuclear receptor 0.007 0.0521 0.0783
Toxoplasma gondii NADPH-glutathione reductase 0.0074 0.0574 0.1913
Onchocerca volvulus Hexokinase homolog 0.0055 0.0334 0.0271
Loa Loa (eye worm) hypothetical protein 0.006 0.0393 0.0412
Loa Loa (eye worm) DR-78 0.0033 0.0065 0.0068
Leishmania major DNA polymerase eta, putative 0.007 0.0525 0.1688
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0521 0.0783
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0074 0.0574 0.5
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.018 0.0198
Entamoeba histolytica hexokinase 2 0.0088 0.0737 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.007 0.0521 0.0783
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0055 0.033 0.0346
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0574 0.1913
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0574 0.1913
Echinococcus multilocularis hexokinase 0.0088 0.0737 0.1249
Brugia malayi Hexokinase family protein 0.0055 0.0334 0.035
Loa Loa (eye worm) steroid hormone receptor 0.007 0.0521 0.0546
Trypanosoma brucei DNA polymerase eta, putative 0.007 0.0525 0.2222
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0333 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-3 0.007 0.0521 0.0546
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.018 0.0073
Brugia malayi nuclear hormone receptor family member odr-7 0.0033 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.007 0.0521 0.0546
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0074 0.0574 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0074 0.0574 0.2433
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0113 0.0119
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0074 0.0574 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.007 0.0521 0.0546
Brugia malayi steroid hormone receptor 0.007 0.0521 0.0546
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0521 0.0849
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0068
Trypanosoma brucei trypanothione reductase 0.0215 0.2302 1
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.018 0.0189
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.007 0.0521 0.0783
Echinococcus multilocularis hexokinase 0.0088 0.0737 0.1249
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0521 0.0546
Onchocerca volvulus 0.0088 0.0737 0.0676
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.018 0.0189
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.007 0.0521 0.0783
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.007 0.0521 0.0546
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0068
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0037 0.0113 0.0091
Loa Loa (eye worm) hypothetical protein 0.007 0.0521 0.0546
Brugia malayi nuclear hormone receptor family member nhr-6 0.0033 0.0065 0.0068
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0521 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-41 0.007 0.0521 0.0546
Echinococcus granulosus dna polymerase eta 0.007 0.0525 0.079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.007 0.0521 0.0546
Trypanosoma brucei hexokinase 0.0088 0.0737 0.3147
Leishmania major DNA polymerase kappa, putative 0.0042 0.018 0.0073
Loa Loa (eye worm) nuclear hormone receptor 0.0033 0.0065 0.0068
Loa Loa (eye worm) hexokinase 0.0088 0.0737 0.0772
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0033 0.0065 0.0068
Brugia malayi hypothetical protein 0.0033 0.0065 0.0068
Echinococcus multilocularis thioredoxin glutathione reductase 0.0215 0.2302 0.4161
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.007 0.0521 0.0546
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.007 0.0521 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.018 0.0711
Brugia malayi nuclear hormone receptor 0.0802 0.9543 1
Brugia malayi glutathione reductase 0.0215 0.2302 0.2413
Leishmania major trypanothione reductase 0.0215 0.2302 1
Leishmania major hexokinase, putative 0.0088 0.0737 0.2676
Brugia malayi Nuclear hormone receptor family member nhr-40 0.007 0.0521 0.0546
Plasmodium vivax hexokinase, putative 0.0088 0.0737 0.0943
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.018 0.0711
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0074 0.0574 0.1913
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.007 0.0521 0.0849
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.018 0.0711
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0802 0.9543 1
Schistosoma mansoni hypothetical protein 0.0037 0.0119 0.0093
Trichomonas vaginalis glutathione reductase, putative 0.0074 0.0574 1
Brugia malayi ecdysteroid receptor 0.007 0.0521 0.0546
Plasmodium falciparum glutathione reductase 0.0215 0.2302 1
Echinococcus multilocularis dna polymerase kappa 0.0042 0.018 0.0215
Schistosoma mansoni thyroid hormone receptor 0.007 0.0521 0.0783
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.018 0.0073
Brugia malayi tailless protein 0.0033 0.0065 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.018 0.0711
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0521 0.0546
Entamoeba histolytica hexokinase 1 0.0088 0.0737 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0521 0.0546
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0074 0.0574 0.0872
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0074 0.0574 0.2433
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0074 0.0574 0.1854
Plasmodium falciparum thioredoxin reductase 0.0215 0.2302 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0119 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0521 0.0546
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0068
Schistosoma mansoni hypothetical protein 0.0186 0.1954 0.3238
Brugia malayi hexokinase 0.0088 0.0737 0.0772
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.007 0.0521 0.0546
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.018 0.0711
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0113 0.0119
Onchocerca volvulus Bile acid receptor homolog 0.007 0.0521 0.046
Trypanosoma brucei hexokinase 0.0088 0.0737 0.3147
Brugia malayi hypothetical protein 0.0033 0.0065 0.0068
Schistosoma mansoni DNA polymerase eta 0.007 0.0525 0.079
Leishmania major hexokinase, putative 0.0088 0.0737 0.2676
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.0037 0.0119 0.0124
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.007 0.0521 0.0783
Echinococcus granulosus thioredoxin glutathione reductase 0.0215 0.2302 0.3835
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.018 0.0711
Brugia malayi Nuclear hormone receptor family member nhr-1 0.007 0.0521 0.0546
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.007 0.0521 0.0546
Brugia malayi nuclear receptor RXR 0.0033 0.0065 0.0068
Echinococcus granulosus geminin 0.0186 0.1954 0.3238
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.007 0.0521 0.0849
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0574 0.1913
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0074 0.0574 0.2433
Plasmodium vivax thioredoxin reductase, putative 0.0215 0.2302 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.018 0.0711
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0074 0.0574 0.5
Brugia malayi nuclear receptor RXR 0.0037 0.0113 0.0119
Treponema pallidum hexokinase (hxk) 0.0088 0.0737 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0074 0.0574 1
Brugia malayi orphan nuclear receptor NR2E1 0.0033 0.0065 0.0068
Loa Loa (eye worm) hexokinase type II 0.0088 0.0737 0.0772
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0074 0.0574 0.0872
Trypanosoma cruzi DNA polymerase eta, putative 0.007 0.0525 0.1688
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0065 0.0068
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0113 0.0084
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0074 0.0574 0.1913
Echinococcus granulosus hexokinase 0.0088 0.0737 0.1151
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.007 0.0521 0.0783
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0074 0.0574 0.1913
Trypanosoma cruzi trypanothione reductase, putative 0.0074 0.0574 0.1913
Loa Loa (eye worm) nuclear receptor NHR-67 0.0033 0.0065 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0574 0.1913
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0119
Loa Loa (eye worm) thioredoxin reductase 0.0215 0.2302 0.2413
Schistosoma mansoni retinoic acid receptor RXR 0.0507 0.59 1
Plasmodium falciparum hexokinase 0.0088 0.0737 0.0943
Loa Loa (eye worm) hexokinase 0.0088 0.0737 0.0772
Trypanosoma brucei unspecified product 0.0042 0.018 0.0711
Schistosoma mansoni steroid hormone receptor ad4bp 0.007 0.0521 0.0783
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.0521 0.0783
Onchocerca volvulus 0.007 0.0521 0.046
Schistosoma mansoni hexokinase 0.0088 0.0737 0.1151
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0521 0.0783
Loa Loa (eye worm) glutathione reductase 0.0215 0.2302 0.2413
Echinococcus multilocularis dna polymerase eta 0.007 0.0525 0.0857
Echinococcus granulosus dna polymerase kappa 0.0042 0.018 0.0198
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.018 0.0215
Mycobacterium tuberculosis Probable oxidoreductase 0.0074 0.0574 0.1854
Schistosoma mansoni coup transcription factor 0.007 0.0521 0.0783
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0037 0.0113 0.0119
Brugia malayi ImpB/MucB/SamB family protein 0.007 0.0525 0.055
Brugia malayi Nuclear hormone receptor family member nhr-14 0.007 0.0521 0.0546
Brugia malayi hypothetical protein 0.0037 0.0113 0.0119
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.007 0.0521 0.0783
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.007 0.0521 0.0783
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0333 0.0348
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0074 0.0574 0.1913
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0333 0.0348
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0074 0.0574 1
Brugia malayi ecdysone receptor 0.0033 0.0065 0.0068
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0065 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.007 0.0521 0.0546
Loa Loa (eye worm) hypothetical protein 0.007 0.0525 0.055
Echinococcus multilocularis hexokinase 0.0088 0.0737 0.1249
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0037 0.0113 0.0084
Schistosoma mansoni Tr4/Tr2 (homologue) 0.007 0.0521 0.0783
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0074 0.0574 0.1854
Onchocerca volvulus 0.0088 0.0737 0.0676
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.007 0.0521 0.0546
Brugia malayi photoreceptor-specific nuclear receptor 0.007 0.0521 0.0546
Brugia malayi conserved hypotetical protein 0.0033 0.0065 0.0068
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0074 0.0574 0.0946
Loa Loa (eye worm) hypothetical protein 0.0055 0.0333 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.018 0.0711
Echinococcus granulosus hexokinase type 2 0.0088 0.0737 0.1151
Brugia malayi nuclear receptor NHR-88 0.0033 0.0065 0.0068
Echinococcus multilocularis FTZ F1 alpha 0.007 0.0521 0.0849
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0074 0.0574 0.2433
Schistosoma mansoni nuclear hormone receptor 0.007 0.0521 0.0783

Activities

Activity type Activity value Assay description Source Reference
Relative activity (functional) = 33 Relative transcriptional activation activity of the compound relative to t-RA ChEMBL. 9357524

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.