Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Beta-glucuronidase precursor | 0.0192 | 0.5347 | 0.5347 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0283 | 0.0234 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0318 | 0.9184 | 0.9184 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0462 | 0.0462 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0462 | 0.0696 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.4115 | 1 |
Trichomonas vaginalis | glycoside hydrolase, putative | 0.0192 | 0.5347 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.002 | 0.0091 | 0.0091 |
Mycobacterium leprae | Possible regulatory protein | 0.0027 | 0.0283 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0462 | 0.0696 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0462 | 0.0696 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0027 | 0.0283 | 1 |
Echinococcus multilocularis | beta mannosidase | 0.0139 | 0.3717 | 0.8218 |
Loa Loa (eye worm) | manba-prov protein | 0.0139 | 0.3717 | 0.3717 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0027 | 0.0283 | 0.0234 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0161 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0027 | 0.0283 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0161 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0462 | 0.0462 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0164 | 0.4488 | 1 |
Onchocerca volvulus | 0.0076 | 0.179 | 1 | |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0462 | 0.0762 |
Schistosoma mansoni | lamin | 0.0033 | 0.0462 | 0.0696 |
Schistosoma mansoni | beta-mannosidase | 0.0139 | 0.3717 | 0.8218 |
Brugia malayi | bHLH-PAS transcription factor | 0.0076 | 0.179 | 0.179 |
Brugia malayi | manba-prov protein | 0.0331 | 0.9597 | 0.9597 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0027 | 0.0283 | 1 |
Trichomonas vaginalis | adenylate cyclase, type VII, putative | 0.0027 | 0.0283 | 0.0234 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0462 | 0.0462 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.002 | 0.0091 | 0.0091 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0462 | 0.0462 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0192 | 0.5347 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0103 | 0.2606 | 0.5651 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0283 | 0.0283 |
Schistosoma mansoni | single-minded | 0.0103 | 0.2606 | 0.5651 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0076 | 0.179 | 0.3765 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0027 | 0.0283 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0161 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0161 | 0.5 |
Trichomonas vaginalis | beta-mannosidase, putative | 0.0139 | 0.3717 | 0.6857 |
Brugia malayi | hypoxia-induced factor 1 | 0.0318 | 0.9184 | 0.9184 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0161 | 0.5 |
Echinococcus granulosus | Aryl hydrocarbon receptor nuclear | 0.0027 | 0.0283 | 0.0307 |
Trichomonas vaginalis | beta-galactosidase, putative | 0.0192 | 0.5347 | 1 |
Leishmania major | protein kinase, putative | 0.0027 | 0.0283 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0462 | 0.0696 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0161 | 0.0161 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0161 | 0.5 |
Brugia malayi | PAS domain containing protein | 0.0103 | 0.2606 | 0.2606 |
Echinococcus granulosus | lamin | 0.0033 | 0.0462 | 0.0762 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0027 | 0.0283 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.4488 | 1 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0027 | 0.0283 | 0.0234 |
Onchocerca volvulus | 0.0033 | 0.0462 | 0.1193 | |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0462 | 0.0762 |
Leishmania major | protein kinase, putative | 0.0027 | 0.0283 | 1 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0027 | 0.0283 | 0.0307 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0027 | 0.0283 | 0.0234 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0027 | 0.0283 | 0.0234 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0027 | 0.0283 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.4488 | 1 |
Echinococcus granulosus | beta mannosidase | 0.0139 | 0.3717 | 0.8993 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0444 | 0.0444 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0027 | 0.0283 | 0.0234 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0283 | 0.0234 |
Loa Loa (eye worm) | beta-glucuronidase | 0.0192 | 0.5347 | 0.5347 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0462 | 0.0462 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0161 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0283 | 0.0234 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0161 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0027 | 0.0283 | 0.0234 |
Echinococcus granulosus | single minded 2 | 0.0076 | 0.179 | 0.412 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0161 | 0.0161 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0027 | 0.0283 | 0.0283 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.4115 | 0.9138 |
Mycobacterium ulcerans | putative regulatory protein | 0.0076 | 0.179 | 1 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0027 | 0.0283 | 1 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0027 | 0.0283 | 0.0234 |
Echinococcus multilocularis | Aryl hydrocarbon receptor nuclear | 0.0027 | 0.0283 | 0.0281 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0027 | 0.0283 | 0.0281 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0161 | 0.5 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0027 | 0.0283 | 1 |
Onchocerca volvulus | 0.0033 | 0.0462 | 0.1193 | |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.4115 | 0.9138 |
Schistosoma mansoni | lamin | 0.0033 | 0.0462 | 0.0696 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.