Detailed information for compound 2063723

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 333.452 | Formula: C16H23N5OS
  • H donors: 1 H acceptors: 3 LogP: 2.79 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nccn1C1CCCN(C1)C(=O)c1c(NC)snc1C
  • InChi: 1S/C16H23N5OS/c1-4-13-18-7-9-21(13)12-6-5-8-20(10-12)16(22)14-11(2)19-23-15(14)17-3/h7,9,12,17H,4-6,8,10H2,1-3H3
  • InChiKey: AZNNGAWUVJSHBB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0566 0.1309
Loa Loa (eye worm) hypothetical protein 0.0032 0.0045 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0142 0.1489 0.3429
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0331 0.3985 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0045 0.0045
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.1168 0.236
Brugia malayi photoreceptor-specific nuclear receptor 0.0061 0.0427 0.0427
Brugia malayi nuclear hormone receptor 0.0061 0.0427 0.0427
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0331 0.3985 0.9186
Brugia malayi Synaptic glycoprotein SC2 0.005 0.028 0.028
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0566 0.103
Echinococcus granulosus muscleblind protein 0.0334 0.4029 0.4028
Schistosoma mansoni tar DNA-binding protein 0.0142 0.1489 0.3429
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0427 0.0427
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.006 0.0414 0.0414
Leishmania major cytochrome p450-like protein 0.0331 0.3985 0.9211
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Trypanosoma cruzi cytochrome P450, putative 0.035 0.4238 0.9795
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0141 0.1485 0.1483
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0331 0.3985 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.3987 0.9215
Echinococcus granulosus synaptic glycoprotein sc2 0.005 0.028 0.0278
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0427 0.0425
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0532 0.1157
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0331 0.3985 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0061 0.0427 0.0427
Schistosoma mansoni steroid hormone receptor ad4bp 0.0061 0.0427 0.0907
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0331 0.3985 0.9211
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0331 0.3985 0.9186
Loa Loa (eye worm) hypothetical protein 0.0032 0.0045 0.0045
Echinococcus multilocularis muscleblind protein 1 0.0334 0.4029 0.4028
Echinococcus multilocularis neuropeptide receptor A26 0.0532 0.6644 0.6643
Onchocerca volvulus 0.0061 0.0427 0.0464
Loa Loa (eye worm) hypothetical protein 0.0032 0.0045 0.0045
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0331 0.3985 1
Plasmodium falciparum glutathione reductase 0.0051 0.0297 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0427 0.0425
Entamoeba histolytica hypothetical protein 0.005 0.028 0.0347
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0052 0.005
Trypanosoma brucei cytochrome P450, putative 0.035 0.4238 0.9795
Mycobacterium ulcerans hypothetical protein 0.0174 0.1919 0.4257
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0061 0.0427 0.0425
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0331 0.3985 0.9186
Brugia malayi glutathione reductase 0.0051 0.0297 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0061 0.0427 0.0427
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.005 0.028 0.5885
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.1168 0.236
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0135 0.0133
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0351 0.4256 0.4256
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0061 0.0427 0.0425
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0331 0.3985 0.9186
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0186 0.2069 0.4807
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0331 0.3985 0.9186
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0061 0.0427 0.0427
Plasmodium vivax polyprenol reductase, putative 0.005 0.028 0.5885
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0476 0.1022
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0331 0.3985 1
Onchocerca volvulus Bile acid receptor homolog 0.0061 0.0427 0.0464
Onchocerca volvulus 0.005 0.028 0.023
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.1341 0.0614
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0331 0.3985 0.9186
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0476 0.0474
Loa Loa (eye worm) hypothetical protein 0.007 0.054 0.054
Trichomonas vaginalis set domain proteins, putative 0.0515 0.6426 1
Loa Loa (eye worm) cytochrome P450 0.0331 0.3985 0.3985
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0427 0.0907
Mycobacterium leprae putative cytochrome p450 0.0331 0.3985 1
Echinococcus multilocularis neuropeptide s receptor 0.0532 0.6644 0.6643
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0356 0.4326 1
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.005 0.028 0.0347
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0476 0.0474
Brugia malayi RNA recognition motif domain containing protein 0.0142 0.1489 0.1489
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0331 0.3985 0.9186
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0414 0.0414
Mycobacterium tuberculosis Probable reductase 0.0117 0.1168 0.236
Brugia malayi TAR-binding protein 0.0142 0.1489 0.1489
Brugia malayi nuclear receptor RXR 0.0032 0.0045 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0061 0.0427 0.0427
Brugia malayi hypothetical protein 0.0032 0.0045 0.0045
Brugia malayi Latrophilin receptor protein 2 0.007 0.054 0.054
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0356 0.4326 0.4326
Brugia malayi Cytochrome P450 family protein 0.0331 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.0151 0.161 0.161
Loa Loa (eye worm) hypothetical protein 0.0065 0.0476 0.0476
Brugia malayi RNA, U transporter 1 0.0094 0.0853 0.0853
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0427 0.0427
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0331 0.3985 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0331 0.3985 1
Echinococcus granulosus geminin 0.0186 0.2069 0.2068
Onchocerca volvulus 0.016 0.1735 0.2544
Leishmania major cytochrome p450-like protein 0.035 0.4238 0.9795
Echinococcus granulosus intermediate filament protein 0.006 0.0414 0.0412
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0532 0.0638
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0356 0.4326 0.6584
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0444 0.0442
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0061 0.0427 0.0425
Schistosoma mansoni synaptic glycoprotein sc2 related 0.005 0.028 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0061 0.0427 0.0427
Loa Loa (eye worm) latrophilin receptor protein 2 0.007 0.054 0.054
Leishmania major trypanothione reductase 0.0051 0.0297 0.0687
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0331 0.3985 0.9211
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1685 0.3896
Echinococcus granulosus lamin dm0 0.006 0.0414 0.0412
Schistosoma mansoni tar DNA-binding protein 0.0142 0.1489 0.3429
Schistosoma mansoni coup transcription factor 0.0061 0.0427 0.0907
Echinococcus multilocularis lamin dm0 0.006 0.0414 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0786 1 1
Echinococcus multilocularis geminin 0.0186 0.2069 0.2068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0476 0.1022
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.005 0.028 0.942
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.0045 0.0043
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0356 0.4326 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0297 0.0295
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0427 0.0907
Plasmodium falciparum thioredoxin reductase 0.0051 0.0297 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0061 0.0427 0.0907
Echinococcus multilocularis thyroid hormone receptor alpha 0.0061 0.0427 0.0425
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.007 0.054 0.054
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0061 0.0427 0.0907
Schistosoma mansoni hypothetical protein 0.007 0.054 0.1175
Echinococcus granulosus snurportin 1 0.0351 0.4256 0.4255
Loa Loa (eye worm) hypothetical protein 0.0221 0.2533 0.2533
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0566 0.0564
Loa Loa (eye worm) CYP4Cod1 0.035 0.4238 0.4238
Brugia malayi follicle stimulating hormone receptor 0.0271 0.3202 0.3202
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0061 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0059 0.0399 0.0399
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0566 0.1309
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.1685 0.3896
Brugia malayi hypothetical protein 0.0032 0.0045 0.0045
Brugia malayi Cytochrome P450 family protein 0.0331 0.3985 0.3985
Brugia malayi intermediate filament protein 0.006 0.0414 0.0414
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0331 0.3985 0.9186
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0174 0.1912 0.1911
Brugia malayi Cytochrome P450 family protein 0.035 0.4238 0.4238
Loa Loa (eye worm) cytochrome P450 family protein 0.035 0.4238 0.4238
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Brugia malayi hypothetical protein 0.0299 0.3567 0.3567
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0061 0.0427 0.0425
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0331 0.3985 1
Plasmodium falciparum polyprenol reductase, putative 0.005 0.028 0.942
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0232 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0427 0.0427
Loa Loa (eye worm) hypoxia-induced factor 1 0.0164 0.1781 0.1781
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0427 0.0425
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0331 0.3985 1
Brugia malayi steroid hormone receptor 0.0061 0.0427 0.0427
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0331 0.3985 0.9186
Leishmania major mitochondrial DNA polymerase beta 0.0331 0.3987 0.9215
Schistosoma mansoni hypothetical protein 0.0059 0.0397 0.0835
Schistosoma mansoni hypothetical protein 0.0351 0.4256 1
Schistosoma mansoni synaptic glycoprotein sc2 related 0.005 0.028 0.0557
Loa Loa (eye worm) hypothetical protein 0.0178 0.1963 0.1963
Schistosoma mansoni hypothetical protein 0.016 0.1735 0.4014
Echinococcus multilocularis GPCR, family 2 0.007 0.054 0.0538
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.1168 0.236
Schistosoma mansoni intermediate filament proteins 0.006 0.0414 0.0876
Schistosoma mansoni hypothetical protein 0.007 0.054 0.1175
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.007 0.054 0.0538
Loa Loa (eye worm) cytochrome P450 family protein 0.0331 0.3985 0.3985
Schistosoma mansoni importin beta-1 0.0033 0.0052 0.0016
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0566 0.0566
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0566 0.1309
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0331 0.3985 0.9186
Echinococcus granulosus survival motor neuron protein 1 0.0786 1 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0566 0.0564
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.016 0.1735 0.1735
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.005 0.028 0.0278
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0356 0.4326 0.6584
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0427 0.0425
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.1341 0.2829
Echinococcus granulosus cytochrome P450 2K1 0.0331 0.3985 0.3984
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0532 0.0948
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.1168 0.236
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0453 0.5599 0.5599
Echinococcus multilocularis snurportin 1 0.0351 0.4256 0.4255
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0297 0.0687
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0356 0.4326 1
Brugia malayi Thioredoxin reductase 0.0051 0.0297 0.0297
Echinococcus granulosus GPCR family 2 0.007 0.054 0.0538
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0532 0.1231
Echinococcus multilocularis tar DNA binding protein 0.0142 0.1489 0.1487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0061 0.0427 0.0427
Echinococcus granulosus neuropeptide s receptor 0.0532 0.6644 0.6643
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0331 0.3985 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0532 0.0531
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0331 0.3985 0.9186
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0331 0.3985 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0271 0.3202 0.3202
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0331 0.3985 0.9211
Plasmodium vivax glutathione reductase, putative 0.0051 0.0297 0.6247
Schistosoma mansoni lamin 0.006 0.0414 0.0876
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0427 0.0427
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.1168 0.236
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0142 0.1489 0.1489
Schistosoma mansoni retinoic acid receptor RXR 0.0174 0.1912 0.4435
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.3987 0.9215
Loa Loa (eye worm) hypothetical protein 0.0032 0.0045 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0476 0.1022
Schistosoma mansoni tar DNA-binding protein 0.0142 0.1489 0.3429
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0331 0.3985 1
Echinococcus multilocularis FTZ F1 alpha 0.0061 0.0427 0.0425
Giardia lamblia Synaptic glycoprotein SC2 0.005 0.028 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0221 0.2533 0.2533
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0061 0.0427 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0033 0.0052 0.0052
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0331 0.3985 1
Brugia malayi hypoxia-induced factor 1 0.0164 0.1781 0.1781
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0331 0.3985 1
Onchocerca volvulus 0.006 0.0414 0.0444
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0331 0.3985 0.9186
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0566 0.1237
Schistosoma mansoni hypothetical protein 0.0331 0.3985 0.9357
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0331 0.3985 1
Schistosoma mansoni cytochrome P450 0.0331 0.3985 0.9357
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0052 0.012
Echinococcus granulosus importin subunit beta 1 0.0033 0.0052 0.005
Brugia malayi Muscleblind-like protein 0.0334 0.4029 0.4029
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0061 0.0427 0.0464
Echinococcus multilocularis 0.0331 0.3985 0.3984
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0061 0.0427 0.0907
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0045 0.0045
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0061 0.0427 0.0425
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0427 0.0427
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0061 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0334 0.4029 0.4029
Brugia malayi Pre-SET motif family protein 0.0453 0.5599 0.5599
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0232 0.0536
Onchocerca volvulus 0.0515 0.6426 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0331 0.3985 1
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.005 0.028 0.0278
Brugia malayi MH2 domain containing protein 0.0136 0.1416 0.1416
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.1416 0.1416
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0476 0.0474
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0297 0.0295
Schistosoma mansoni hypothetical protein 0.007 0.054 0.1175
Toxoplasma gondii thioredoxin reductase 0.0051 0.0297 0.0687
Onchocerca volvulus 0.006 0.0414 0.0444
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.007 0.054 0.0538
Echinococcus granulosus ecdysone induced protein 78C 0.0061 0.0427 0.0425
Schistosoma mansoni tar DNA-binding protein 0.0142 0.1489 0.3429
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.0045 0.0043
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.005 0.028 0.0647
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Schistosoma mansoni hypothetical protein 0.0039 0.0135 0.0212
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0356 0.4326 1
Loa Loa (eye worm) hypothetical protein 0.005 0.028 0.028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0061 0.0427 0.0427
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0061 0.0427 0.0907
Echinococcus granulosus FTZ F1 alpha 0.0061 0.0427 0.0425
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.1416 0.1416
Plasmodium vivax SET domain protein, putative 0.0065 0.0476 1
Brugia malayi PAS domain containing protein 0.0053 0.0317 0.0317
Schistosoma mansoni lamin 0.006 0.0414 0.0876
Brugia malayi hypothetical protein 0.0178 0.1963 0.1963
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0356 0.4326 0.6584
Leishmania major cytochrome p450-like protein 0.0331 0.3985 0.9211
Schistosoma mansoni hypothetical protein 0.0151 0.161 0.3717
Echinococcus granulosus expressed protein 0.0426 0.5242 0.5241
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0532 0.1157
Brugia malayi Cytochrome P450 family protein 0.035 0.4238 0.4238
Echinococcus multilocularis synaptic glycoprotein sc2 0.005 0.028 0.0278
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0331 0.3985 0.9186
Echinococcus multilocularis lamin 0.006 0.0414 0.0412
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0414 0.0414
Brugia malayi Importin beta-1 subunit 0.0033 0.0052 0.0052
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0052 0.012
Onchocerca volvulus Protein ultraspiracle homolog 0.0061 0.0427 0.0464
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0331 0.3985 0.9186
Echinococcus multilocularis survival motor neuron protein 1 0.0786 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0476 0.1099
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0331 0.3985 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0331 0.3985 0.9186
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.0045 0.0045
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0331 0.3985 0.9186
Brugia malayi RNA binding protein 0.0142 0.1489 0.1489
Brugia malayi Pre-SET motif family protein 0.0065 0.0476 0.0476
Schistosoma mansoni hypothetical protein 0.007 0.054 0.1175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0061 0.0427 0.0427
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0052 0.012
Mycobacterium ulcerans hypothetical protein 0.0356 0.4326 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0317 0.0645
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0331 0.3985 0.9211
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0167 0.0165
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0297 0.0297
Loa Loa (eye worm) steroid hormone receptor 0.0061 0.0427 0.0427
Loa Loa (eye worm) cytochrome P450 family protein 0.035 0.4238 0.4238
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.007 0.054 0.0538
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.1341 0.2829
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0061 0.0427 0.0907
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0297 0.6247
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0331 0.3985 0.9186
Schistosoma mansoni hypothetical protein 0.0186 0.2069 0.4807
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.005 0.028 0.0647
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0221 0.2533 0.2533
Loa Loa (eye worm) hypothetical protein 0.0029 0.0002 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.1919 0.4398
Toxoplasma gondii hypothetical protein 0.0053 0.0322 0.0745
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0232 0.0536
Plasmodium falciparum importin beta, putative 0.0033 0.0052 0.1751
Echinococcus multilocularis ecdysone induced protein 78C 0.0061 0.0427 0.0425
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.035 0.4238 0.9789
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.005 0.028 0.0647
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0331 0.3985 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0331 0.3985 0.9211
Trypanosoma brucei trypanothione reductase 0.0051 0.0297 0.0687
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0061 0.0427 0.0425
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0331 0.3985 1
Loa Loa (eye worm) intermediate filament protein 0.006 0.0414 0.0414
Echinococcus granulosus lamin 0.006 0.0414 0.0412
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0135 0.0133
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.005 0.028 0.0347
Loa Loa (eye worm) glutathione reductase 0.0051 0.0297 0.0297
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0045 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0061 0.0427 0.0427
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0135 0.0133
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0532 0.0948
Echinococcus granulosus tar DNA binding protein 0.0142 0.1489 0.1487
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0221 0.2533 0.2533
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0044 0.0044
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1685 0.3896
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0061 0.0427 0.0427
Brugia malayi latrophilin 2 splice variant baaae 0.0151 0.161 0.161
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0476 0.1022
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0331 0.3985 0.9186
Echinococcus multilocularis muscleblind protein 0.0334 0.4029 0.4028
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0532 0.1231
Echinococcus multilocularis expressed protein 0.0426 0.5242 0.5241
Loa Loa (eye worm) hypothetical protein 0.0127 0.1289 0.1289
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0356 0.4326 1
Echinococcus granulosus neuropeptide receptor A26 0.0532 0.6644 0.6643
Onchocerca volvulus 0.0065 0.0476 0.0541
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0232 0.0536
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0366 0.0847
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.0427 0.0907
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0331 0.3985 0.9186
Loa Loa (eye worm) RNA binding protein 0.0142 0.1489 0.1489
Schistosoma mansoni survival motor neuron protein 0.016 0.1735 0.4014
Loa Loa (eye worm) hypothetical protein 0.0334 0.4029 0.4029
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0061 0.0427 0.0425
Brugia malayi ecdysteroid receptor 0.0061 0.0427 0.0427
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0356 0.4326 0.4326
Brugia malayi cytochrome P450 0.0331 0.3985 0.3985
Plasmodium vivax importin-beta 2, putative 0.0033 0.0052 0.1094
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0331 0.3987 0.9215
Brugia malayi Steroid receptor seven-up type 2 0.0061 0.0427 0.0427
Echinococcus multilocularis musashi 0.006 0.0414 0.0412
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.1341 0.2829
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0331 0.3985 0.9186
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0356 0.4326 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0532 0.0948
Loa Loa (eye worm) hypothetical protein 0.005 0.028 0.028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0061 0.0427 0.0427
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0331 0.3985 0.9211
Echinococcus granulosus single minded 2 0.0039 0.0135 0.0133
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0167 0.0165
Loa Loa (eye worm) TAR-binding protein 0.0142 0.1489 0.1489
Schistosoma mansoni single-minded 0.0053 0.0317 0.0645
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0331 0.3985 1
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0135 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0061 0.0427 0.0427
Mycobacterium leprae Conserved hypothetical protein 0.0331 0.3985 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0427 0.0427
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.005 0.028 0.0647
Brugia malayi nuclear receptor NHR-88 0.0061 0.0427 0.0427
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0566 0.1309
Schistosoma mansoni RAR-like nuclear receptor 0.0061 0.0427 0.0907
Schistosoma mansoni nuclear hormone receptor 0.0061 0.0427 0.0907
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0532 0.0531
Brugia malayi hypothetical protein 0.0039 0.0135 0.0135
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.007 0.054 0.0538
Trypanosoma cruzi cytochrome P450, putative 0.035 0.4238 0.9795

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.