Detailed information for compound 206449

Basic information

Technical information
  • TDR Targets ID: 206449
  • Name: 2-[[ethoxy(heptyl)phosphoryl]oxymethyl]isoind ole-1,3-dione
  • MW: 367.377 | Formula: C18H26NO5P
  • H donors: 0 H acceptors: 3 LogP: 3.49 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCP(=O)(OCN1C(=O)c2c(C1=O)cccc2)OCC
  • InChi: 1S/C18H26NO5P/c1-3-5-6-7-10-13-25(22,23-4-2)24-14-19-17(20)15-11-8-9-12-16(15)18(19)21/h8-9,11-12H,3-7,10,13-14H2,1-2H3
  • InChiKey: YKHVVESVXSDNIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[ethoxy(heptyl)phosphoryl]oxymethyl]isoindoline-1,3-dione
  • 2-[[ethoxy(heptyl)phosphoryl]oxymethyl]isoindoline-1,3-quinone
  • 2-[(ethoxy-heptylphosphoryl)oxymethyl]isoindole-1,3-dione
  • 2-[(ethoxy-heptyl-phosphoryl)oxymethyl]isoindoline-1,3-dione
  • 2-[(ethoxy-heptylphosphoryl)oxymethyl]isoindoline-1,3-dione
  • 2-[(ethoxy-heptyl-phosphoryl)oxymethyl]isoindoline-1,3-quinone
  • 2-[(ethoxy-heptyl-phosphoryl)oxymethyl]isoindole-1,3-dione
  • AIDS-212316
  • AIDS212316
  • Phosphonic acid, heptyl-, (1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl ethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) Get druggable targets OG5_237839 All targets in OG5_237839
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) Get druggable targets OG5_237839 All targets in OG5_237839
Mycobacterium ulcerans secreted antigen 85-C FbpC Get druggable targets OG5_237839 All targets in OG5_237839
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus glycine receptor subunit alpha 1 0.0261 0.0668 0.2622
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.0236 0.0215
Leishmania major DNA polymerase eta, putative 0.0166 0.0399 0.4833
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Giardia lamblia Histone acetyltransferase GCN5 0.0036 0.0037 0.0703
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0461 0.5866
Onchocerca volvulus 0.0055 0.0088 0.0928
Brugia malayi Cation transporter family protein 0.0261 0.0668 0.0647
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0102 0.0219 0.0676
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Brugia malayi polk-prov protein 0.0032 0.0023 0.0001
Onchocerca volvulus 0.0169 0.0408 0.5869
Mycobacterium ulcerans hypothetical protein 0.0043 0.0056 0.012
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.0088 0.027
Onchocerca volvulus Glucosylceramidase homolog 0.0178 0.0434 0.6282
Mycobacterium ulcerans hypothetical protein 0.0043 0.0056 0.012
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0155 0.0368 0.1183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0088 0.0227
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0048 0.1298
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0088 0.0227
Brugia malayi hypothetical protein 0.0107 0.0234 0.0213
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0261 0.0668 0.0647
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Echinococcus granulosus tar DNA binding protein 0.0267 0.0682 0.268
Schistosoma mansoni amine GPCR 0.0055 0.0088 0.0227
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Loa Loa (eye worm) ACC-1 protein 0.0261 0.0668 0.2267
Loa Loa (eye worm) hypothetical protein 0.005 0.0074 0.0252
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.0088 0.0227
Mycobacterium ulcerans DNA polymerase IV 0.0102 0.0219 0.0707
Schistosoma mansoni aldehyde dehydrogenase 0.031 0.0805 0.2677
Schistosoma mansoni opsin-like receptor 0.0055 0.0088 0.0227
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.0088 0.03
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0088 0.027
Trichomonas vaginalis rotamase, putative 0.0031 0.0022 0.0027
Brugia malayi ImpB/MucB/SamB family protein 0.0236 0.0596 0.0575
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0261 0.0668 0.2622
Brugia malayi Cation transporter family protein 0.0261 0.0668 0.0647
Schistosoma mansoni hypothetical protein 0.0048 0.007 0.0165
Schistosoma mansoni neuropeptide receptor 0.0055 0.0088 0.0227
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0088 0.0227
Echinococcus multilocularis pyruvate kinase 0.0033 0.0028 0.008
Leishmania major DNA polymerase kappa, putative 0.0032 0.0023 0.0039
Loa Loa (eye worm) hypothetical protein 0.0155 0.0368 0.1249
Schistosoma mansoni tar DNA-binding protein 0.0267 0.0682 0.2258
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Schistosoma mansoni hypothetical protein 0.0055 0.0088 0.0227
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.0696 0.899
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.0088 0.0227
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.0088 0.027
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0261 0.0668 0.2622
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0205 0.0742
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0023 0.0054
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0102 0.0219 0.2653
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.1877 0.7543
Schistosoma mansoni acetylcholine receptor subunit beta 0.0107 0.0234 0.0727
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.031 0.0805 1
Loa Loa (eye worm) matrixin family protein 0.0288 0.0741 0.2517
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0261 0.0668 0.2622
Brugia malayi Matrixin family protein 0.0119 0.0268 0.0247
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.004 0.0046 0.0334
Trichomonas vaginalis DNA polymerase eta, putative 0.0102 0.0219 0.2653
Mycobacterium leprae Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0043 0.0056 0.0101
Brugia malayi Melatonin receptor type 1A 0.0055 0.0088 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0205 0.0625
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0048 0.037
Echinococcus granulosus glycine receptor subunit alpha 1 0.0261 0.0668 0.2622
Echinococcus granulosus S formylglutathione hydrolase 0.0043 0.0056 0.014
Onchocerca volvulus 0.0055 0.0088 0.0928
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0107 0.0234 0.0213
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.0088 0.0928
Brugia malayi neuropeptide F receptor 0.0055 0.0088 0.0067
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.0088 0.027
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.0696 0.899
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0155 0.0368 0.0347
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.0088 0.0322
Trypanosoma cruzi DNA polymerase eta, putative 0.0166 0.0399 0.6587
Echinococcus multilocularis glycine receptor subunit beta 0.0261 0.0668 0.2662
Brugia malayi Matrixin family protein 0.0119 0.0268 0.0247
Loa Loa (eye worm) TAR-binding protein 0.0267 0.0682 0.2316
Brugia malayi putative neuropeptide receptor 0.0055 0.0088 0.0067
Brugia malayi Cation transporter family protein 0.0261 0.0668 0.0647
Onchocerca volvulus 0.0261 0.0668 0.9895
Schistosoma mansoni aldehyde dehydrogenase 0.031 0.0805 0.2677
Schistosoma mansoni biogenic amine receptor 0.0055 0.0088 0.0227
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0028 0.0006
Loa Loa (eye worm) glutaminase 0.0299 0.0772 0.2622
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0088 0.0227
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.0088 0.03
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.0088 0.027
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0088 0.0322
Giardia lamblia DINP protein human, muc B family 0.0102 0.0219 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.0088 0.0227
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0461 0.5866
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0088 0.0227
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0088 0.0322
Loa Loa (eye worm) hypothetical protein 0.0155 0.0368 0.1249
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0096
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0434 0.5509
Onchocerca volvulus 0.0055 0.0088 0.0928
Mycobacterium ulcerans glutaminase 0.0299 0.0772 0.2695
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0135 0.0314 0.1233
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0088 0.027
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0434 0.5509
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0048 0.1261
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0048 0.0158
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.0376 0.1276
Trypanosoma cruzi DNA polymerase eta, putative 0.0236 0.0596 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0088 0.0227
Mycobacterium ulcerans hypothetical protein 0.0043 0.0056 0.012
Schistosoma mansoni nAChR subunit 0.0261 0.0668 0.2209
Brugia malayi Serotonin receptor 0.0055 0.0088 0.0067
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0088 0.027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0088 0.0322
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0088 0.027
Loa Loa (eye worm) esterase D 0.0043 0.0056 0.0191
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.0088 0.0227
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0107 0.0234 0.0213
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0088 0.0227
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0088 0.0322
Onchocerca volvulus 0.0055 0.0088 0.0928
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0434 0.5509
Loa Loa (eye worm) hypothetical protein 0.1074 0.2945 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.0088 0.0067
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0088 0.0322
Schistosoma mansoni amine GPCR 0.0055 0.0088 0.0227
Schistosoma mansoni neurotransmitter gated ion channel 0.0107 0.0234 0.0727
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0261 0.0668 0.0647
Trypanosoma brucei unspecified product 0.007 0.0131 0.1931
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Mycobacterium tuberculosis Conserved protein 0.0043 0.0056 0.0101
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0107 0.0234 0.0862
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.0696 0.899
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0155 0.0368 0.1183
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Onchocerca volvulus 0.0055 0.0088 0.0928
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.0088 0.0322
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0088 0.0322
Echinococcus granulosus fmrfamide receptor 0.0055 0.0088 0.027
Brugia malayi larval opioid receptor 0.0055 0.0088 0.0067
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0088 0.027
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Loa Loa (eye worm) acetylcholine receptor protein 0.0107 0.0234 0.0796
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0088 0.0227
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0048 0.0355
Brugia malayi neuropeptide F receptor 0.0055 0.0088 0.0067
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0028 0.0096
Brugia malayi GnHR receptor homolog 0.0055 0.0088 0.0067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.0088 0.0067
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.0088 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0107 0.0234 0.0862
Mycobacterium ulcerans hydrolase 0.0145 0.0341 0.1144
Echinococcus multilocularis S formylglutathione hydrolase 0.0043 0.0056 0.0193
Mycobacterium tuberculosis Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind 0.0043 0.0056 0.0101
Echinococcus multilocularis GPCR, family 2 0.005 0.0074 0.0265
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0088 0.0227
Mycobacterium tuberculosis Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular 0.0043 0.0056 0.0101
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0074 0.0052
Schistosoma mansoni glutaminase 0.0299 0.0772 0.2566
Onchocerca volvulus Matrix metalloproteinase homolog 0.0264 0.0674 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0048 0.037
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Schistosoma mansoni hypothetical protein 0.0383 0.1009 0.3376
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0434 0.5509
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0048 0.0088
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0088 0.027
Mycobacterium tuberculosis Probable conserved exported protein 0.0043 0.0056 0.0101
Loa Loa (eye worm) ACC-1 protein 0.0261 0.0668 0.2267
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.0088 0.027
Brugia malayi follicle stimulating hormone receptor 0.0055 0.0088 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0267 0.0682 0.2258
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0023 0.0054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0074 0.0265
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0261 0.0668 0.2622
Giardia lamblia Pyruvate kinase 0.0033 0.0028 0.0277
Loa Loa (eye worm) hypothetical protein 0.091 0.2485 0.8437
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0043 0.0056 0.1532
Echinococcus granulosus g protein coupled receptor 0.0055 0.0088 0.027
Brugia malayi ImpB/MucB/SamB family protein 0.0102 0.0219 0.0198
Trypanosoma brucei unspecified product 0.007 0.0131 0.1931
Onchocerca volvulus 0.0119 0.0268 0.3711
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0088 0.0322
Brugia malayi RNA binding protein 0.0267 0.0682 0.0662
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0434 0.5509
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0088 0.03
Loa Loa (eye worm) hypothetical protein 0.0119 0.0268 0.091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0205 0.0792
Brugia malayi ORL1-like opioid receptor 0.0055 0.0088 0.0067
Loa Loa (eye worm) acetyltransferase 0.0135 0.0314 0.1066
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0028 0.0006
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0028 0.0148
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0261 0.0668 0.0647
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0028 0.0113
Echinococcus granulosus serotonin receptor 0.0055 0.0088 0.027
Echinococcus multilocularis nAChR subunit 0.0155 0.0368 0.1451
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0205 0.0625
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0048 0.0105
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0261 0.0668 0.2662
Loa Loa (eye worm) hypothetical protein 0.0108 0.0236 0.0802
Entamoeba histolytica acetyltransferase, GNAT family 0.0036 0.0037 0.1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0267 0.0682 0.2316
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0155 0.0368 0.0347
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0088 0.0322
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.1877 0.6344
Schistosoma mansoni neurotransmitter gated ion channel 0.0155 0.0368 0.1183
Leishmania major pyruvate kinase 0.0033 0.0028 0.0109
Loa Loa (eye worm) hypothetical protein 0.0155 0.0368 0.1249
Onchocerca volvulus 0.0055 0.0088 0.0928
Schistosoma mansoni neuropeptide receptor 0.0055 0.0088 0.0227
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0088 0.0322
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0088 0.027
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0028 0.0148
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0261 0.0668 0.2622
Schistosoma mansoni hypothetical protein 0.0383 0.1009 0.3376
Onchocerca volvulus 0.0107 0.0234 0.3188
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0205 0.0695
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.031 0.0805 0.2798
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0088 0.0227
Entamoeba histolytica hypothetical protein 0.0155 0.0368 1
Mycobacterium tuberculosis Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0043 0.0056 0.0101
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0088 0.03
Echinococcus multilocularis serotonin receptor 0.091 0.2485 1
Brugia malayi G-protein coupled receptor 0.0055 0.0088 0.0067
Loa Loa (eye worm) hypothetical protein 0.0155 0.0368 0.1249
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0074 0.0252
Schistosoma mansoni nAChR subunit 0.0261 0.0668 0.2209
Entamoeba histolytica deoxycytidyl transferase, putative 0.0102 0.0219 0.5967
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0088 0.0322
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0261 0.0668 0.2267
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.0088 0.027
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.0088 0.0322
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Mycobacterium tuberculosis Conserved hypothetical protein 0.0102 0.0219 0.0689
Brugia malayi G-protein coupled receptor 0.0055 0.0088 0.0067
Schistosoma mansoni nAChR subunit 0.0261 0.0668 0.2209
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0074 0.0212
Onchocerca volvulus 0.0055 0.0088 0.0928
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0088 0.03
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0023 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0205 0.0742
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0205 0.0183
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.0088 0.027
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0028 0.2351
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0088 0.0322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0088 0.0322
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.0088 0.03
Brugia malayi glutaminase DH11.1 0.0299 0.0772 0.0752
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.0088 0.0227
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0131 0.1931
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.0088 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0088 0.027
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.0088 0.0067
Toxoplasma gondii aldehyde dehydrogenase 0.031 0.0805 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0261 0.0668 0.0647
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.1023 0.2802 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0088 0.0227
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0088 0.027
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0107 0.0234 0.0796
Brugia malayi Esterase D 0.0043 0.0056 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0023 0.0054
Schistosoma mansoni biogenic amine (5HT) receptor 0.091 0.2485 0.8425
Echinococcus multilocularis geminin 0.0383 0.1009 0.4039
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0088 0.027
Onchocerca volvulus 0.0261 0.0668 0.9895
Brugia malayi hypothetical protein 0.0055 0.0088 0.0067
Echinococcus granulosus neuropeptide s receptor 0.0055 0.0088 0.027
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.0088 0.03
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0261 0.0668 0.2209
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Schistosoma mansoni pyruvate kinase 0.0033 0.0028 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0088 0.0322
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0102 0.0219 0.2544
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0088 0.027
Mycobacterium ulcerans secreted Mpt51/Mpb51 antigen protein FbpD 0.0043 0.0056 0.012
Loa Loa (eye worm) hypothetical protein 0.0236 0.0596 0.2022
Echinococcus granulosus neuropeptide receptor 0.0055 0.0088 0.027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Schistosoma mansoni DNA polymerase IV / kappa 0.0032 0.0023 0.0003
Echinococcus granulosus g protein coupled receptor 0.0055 0.0088 0.027
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.06 0.2388
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.086 0.2346 0.9439
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0261 0.0668 0.2662
Onchocerca volvulus 0.0055 0.0088 0.0928
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.0376 0.0355
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0074 0.0212
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.0088 0.0322
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0261 0.0668 0.2662
Onchocerca volvulus 0.0055 0.0088 0.0928
Schistosoma mansoni terminal deoxycytidyl transferase 0.0102 0.0219 0.0676
Echinococcus granulosus sex peptide receptor 0.0055 0.0088 0.027
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.0088 0.0227
Schistosoma mansoni biogenic amine receptor 0.0055 0.0088 0.0227
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0023 0.0039
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.0088 0.0322
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0088 0.0227
Loa Loa (eye worm) hypothetical protein 0.091 0.2485 0.8437
Plasmodium vivax histone acetyltransferase GCN5, putative 0.004 0.0046 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0155 0.0368 0.0347
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0261 0.0668 0.0647
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Echinococcus granulosus allatostatin A receptor 0.0055 0.0088 0.027
Loa Loa (eye worm) GABA receptor subunit 0.0155 0.0368 0.1249
Loa Loa (eye worm) hypothetical protein 0.0155 0.0368 0.1249
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Loa Loa (eye worm) hypothetical protein 0.0155 0.0368 0.1249
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.1023 0.2802 1
Schistosoma mansoni hypothetical protein 0.005 0.0074 0.0179
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0048 0.0484
Onchocerca volvulus 0.0055 0.0088 0.0928
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.007 0.0048
Schistosoma mansoni acetylcholine receptor-related 0.0107 0.0234 0.0727
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Onchocerca volvulus 0.0261 0.0668 0.9895
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Brugia malayi hypothetical protein 0.0055 0.0088 0.0067
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.0696 0.899
Schistosoma mansoni survival motor neuron protein 0.0048 0.007 0.0165
Mycobacterium ulcerans aldehyde dehydrogenase 0.031 0.0805 0.2812
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0088 0.0227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0088 0.0322
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.0088 0.0322
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.0162
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.0088 0.0227
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0048 0.0105
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0032 0.0023 0.0039
Brugia malayi hypothetical protein 0.0055 0.0088 0.0067
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0088 0.027
Brugia malayi RNA recognition motif domain containing protein 0.0267 0.0682 0.0662
Brugia malayi TAR-binding protein 0.0267 0.0682 0.0662
Schistosoma mansoni myosin xvIII 0.0055 0.0088 0.0227
Brugia malayi hypothetical protein 0.0107 0.0234 0.0213
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.003 0.002 0.0541
Schistosoma mansoni hypothetical protein 0.0055 0.0088 0.0227
Mycobacterium ulcerans aldehyde dehydrogenase 0.031 0.0805 0.2812
Echinococcus multilocularis nAChR subunit 0.0261 0.0668 0.2662
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0261 0.0668 0.0647
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.0088 0.027
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0088 0.027
Echinococcus multilocularis serotonin receptor 0.091 0.2485 1
Schistosoma mansoni hypothetical protein 0.0055 0.0088 0.0227
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.004 0.0046 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0023 0.0054
Trypanosoma brucei DNA polymerase eta, putative 0.0236 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0433 0.1148 0.457
Schistosoma mansoni hypothetical protein 0.005 0.0074 0.0179
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0088 0.03
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0028 0.0148
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0074 0.0265
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.0088 0.0322
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0107 0.0234 0.0796
Brugia malayi Matrixin family protein 0.0288 0.0741 0.0721
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0088 0.027
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0088 0.0227
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0261 0.0668 0.0647
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0048 0.0484
Leishmania major pyruvate kinase 0.0033 0.0028 0.0109
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0261 0.0668 0.2662
Schistosoma mansoni nAChR subunit 0.0107 0.0234 0.0727
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0107 0.0234 0.0912
Chlamydia trachomatis pyruvate kinase 0.0033 0.0028 0.5
Schistosoma mansoni pyruvate kinase 0.0033 0.0028 0.0022
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0088 0.0227
Echinococcus multilocularis tar DNA binding protein 0.0267 0.0682 0.272
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0145 0.0341 0.1126
Echinococcus multilocularis sex peptide receptor 0.0055 0.0088 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0048 0.037
Brugia malayi RE15519p 0.0055 0.0088 0.0067
Onchocerca volvulus Matrilysin homolog 0.0264 0.0674 1
Loa Loa (eye worm) hypothetical protein 0.0557 0.1496 0.508
Loa Loa (eye worm) hypothetical protein 0.0157 0.0376 0.1276
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.0088 0.0322
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0028 0.0113
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0088 0.027
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0261 0.0668 0.2622
Echinococcus multilocularis dna polymerase kappa 0.0102 0.0219 0.0852
Echinococcus multilocularis orexin receptor type 2 0.0055 0.0088 0.0322
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.0696 0.899
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Brugia malayi hypothetical protein 0.0055 0.0088 0.0067
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0088 0.027
Onchocerca volvulus 0.0055 0.0088 0.0928
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.0088 0.0227
Echinococcus granulosus GPCR family 2 0.005 0.0074 0.0212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0205 0.0625
Brugia malayi hypothetical protein 0.0107 0.0234 0.0213
Brugia malayi hypothetical protein 0.0055 0.0088 0.0067
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.0088 0.027
Brugia malayi hypothetical protein 0.0107 0.0234 0.0213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0088 0.0322
Trypanosoma brucei DNA damage repair protein, putative 0.0032 0.0023 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0088 0.027
Loa Loa (eye worm) hypothetical protein 0.0145 0.0341 0.1157
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0155 0.0368 0.0347
Echinococcus multilocularis expressed protein 0.0031 0.0022 0.0054
Leishmania major DNA polymerase eta, putative 0.0236 0.0596 0.7338
Onchocerca volvulus 0.0261 0.0668 0.9895
Echinococcus granulosus somatostatin receptor 0.0055 0.0088 0.027
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0261 0.0668 0.2209
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.0088 0.0928
Schistosoma mansoni nAChR subunit 0.0261 0.0668 0.2209
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0261 0.0668 0.2662
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0261 0.0668 0.2209
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0261 0.0668 0.0647
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0088 0.0322
Onchocerca volvulus 0.0055 0.0088 0.0928
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.0088 0.03
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Schistosoma mansoni nAChR subunit 0.0261 0.0668 0.2209
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0048 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0107 0.0234 0.0213
Brugia malayi hypothetical protein 0.0107 0.0234 0.0213
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0107 0.0234 0.0213
Mycobacterium ulcerans hypothetical protein 0.0043 0.0056 0.012
Mycobacterium ulcerans DNA polymerase IV 0.0102 0.0219 0.0707
Brugia malayi hypothetical protein 0.0055 0.0088 0.0067
Echinococcus multilocularis pyruvate kinase 0.0033 0.0028 0.008
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0088 0.0322
Onchocerca volvulus 0.0261 0.0668 0.9895
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0102 0.0219 0.0852
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0023 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0205 0.0792
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0043 0.0056 0.0101
Brugia malayi sulfakinin receptor protein 0.0055 0.0088 0.0067
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.0088 0.0322
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.06 0.2347
Echinococcus granulosus g-protein coupled receptor 0.0055 0.0088 0.027
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0028 0.0148
Schistosoma mansoni opsin-like receptor 0.0055 0.0088 0.0227
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0107 0.0234 0.0213
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0272 0.0696 0.0676
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0261 0.0668 0.2662
Echinococcus granulosus dna polymerase eta 0.0236 0.0596 0.2329
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Schistosoma mansoni opsin-like receptor 0.0055 0.0088 0.0227
Onchocerca volvulus 0.0155 0.0368 0.5254
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0048 0.0026
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Loa Loa (eye worm) LGC-31 protein 0.0261 0.0668 0.2267
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.0696 0.899
Schistosoma mansoni histamine h1 receptor 0.0055 0.0088 0.0227
Mycobacterium leprae SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR 0.0043 0.0056 0.0101
Onchocerca volvulus 0.0048 0.007 0.0648
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0048 0.0158
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Echinococcus multilocularis glycine receptor subunit beta 0.0261 0.0668 0.2662
Schistosoma mansoni amine GPCR 0.0055 0.0088 0.0227
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Onchocerca volvulus 0.0055 0.0088 0.0928
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0261 0.0668 0.0647
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0135 0.0314 0.0999
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0088 0.0322
Trypanosoma cruzi DNA damage repair protein, putative 0.0032 0.0023 0.0054
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0261 0.0668 0.0647
Schistosoma mansoni tar DNA-binding protein 0.0267 0.0682 0.2258
Loa Loa (eye worm) matrix metalloproteinase 0.0119 0.0268 0.091
Echinococcus granulosus glycine receptor subunit beta 0.0261 0.0668 0.2622
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1074 0.2945 0.293
Loa Loa (eye worm) hypothetical protein 0.0237 0.06 0.2037
Loa Loa (eye worm) hypothetical protein 0.1074 0.2945 1
Leishmania major DNA damage repair protein, putative 0.0032 0.0023 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0088 0.0227
Leishmania major DNA polymerase kappa, putative 0.0102 0.0219 0.2544
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0088 0.0322
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0028 0.0096
Onchocerca volvulus 0.0107 0.0234 0.3188
Loa Loa (eye worm) glutaminase 2 0.0299 0.0772 0.2622
Trichomonas vaginalis bromodomain-containing protein, putative 0.004 0.0046 0.0348
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0102 0.0219 0.0745
Echinococcus granulosus nAChR subunit 0.0261 0.0668 0.2622
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0261 0.0668 0.2209
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0261 0.0668 0.0647
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0031 0.0022 0.0075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0261 0.0668 0.2622
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.0088 0.0067
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0088 0.0322
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0055 0.0088 0.03
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0078
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.0219 0.3467
Schistosoma mansoni adenoreceptor 0.0055 0.0088 0.0227
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0088 0.0322
Echinococcus granulosus biogenic amine 5HT receptor 0.091 0.2485 1
Schistosoma mansoni nAChR subunit 0.0107 0.0234 0.0727
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.0088 0.0067
Brugia malayi Hemopexin family protein 0.0169 0.0408 0.0386
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0261 0.0668 0.2662
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0261 0.0668 0.0647
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0261 0.0668 0.0647
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0261 0.0668 0.2267
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0261 0.0668 0.0647
Brugia malayi hypothetical protein 0.0055 0.0088 0.0067
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0107 0.0234 0.0213
Trypanosoma brucei unspecified product 0.0102 0.0219 0.3467
Brugia malayi Dopamine receptor protein 2 0.0055 0.0088 0.0067
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0261 0.0668 0.2622
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Echinococcus granulosus microtubule associated protein 2 0.0693 0.1877 0.753
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.0088 0.027
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Mycobacterium leprae PROBABLE HYDROLASE 0.0145 0.0341 0.1126
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.1023 0.2802 1
Schistosoma mansoni hypothetical protein 0.0108 0.0236 0.0733
Schistosoma mansoni amine GPCR 0.0055 0.0088 0.0227
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0107 0.0234 0.0912
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0261 0.0668 0.2209
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0088 0.027
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.004 0.0046 0.0348
Echinococcus multilocularis dna polymerase eta 0.0236 0.0596 0.2371
Trypanosoma brucei DNA damage repair protein, putative 0.0032 0.0023 0.0054
Echinococcus granulosus histone acetyltransferase KAT2B 0.0131 0.0303 0.1142
Echinococcus multilocularis allatostatin A receptor 0.0055 0.0088 0.0322
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0434 0.5509
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0261 0.0668 0.2662
Schistosoma mansoni hypothetical protein 0.0055 0.0088 0.0227
Loa Loa (eye worm) hypothetical protein 0.0119 0.0268 0.091
Mycobacterium tuberculosis Possible conserved membrane protein 0.0043 0.0056 0.0101
Trichomonas vaginalis glutaminase, putative 0.0299 0.0772 1
Brugia malayi Latrophilin receptor protein 2 0.005 0.0074 0.0052
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.0376 0.0355
Brugia malayi excitatory GABA receptor EXP-1A 0.0261 0.0668 0.0647
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.0088 0.0322
Brugia malayi Dopamine receptor 0.0055 0.0088 0.0067
Onchocerca volvulus Matrilysin homolog 0.0119 0.0268 0.3711
Echinococcus granulosus geminin 0.0383 0.1009 0.4007
Echinococcus granulosus orexin receptor type 2 0.0055 0.0088 0.027
Plasmodium falciparum pyruvate kinase 0.0033 0.0028 0.3932
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.0088 0.0322
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0261 0.0668 0.2662
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0433 0.1148 0.4599
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0048 0.0105
Loa Loa (eye worm) hypothetical protein 0.0155 0.0368 0.1249
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.0088 0.027
Brugia malayi hypothetical protein 0.0055 0.0088 0.0067
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Onchocerca volvulus 0.0055 0.0088 0.0928
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0048 0.0088
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0088 0.0322
Schistosoma mansoni biogenic amine receptor 0.0055 0.0088 0.0227
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0028 0.002
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0261 0.0668 0.2267
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.0088 0.0227
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0261 0.0668 0.2662
Onchocerca volvulus 0.0055 0.0088 0.0928
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Schistosoma mansoni DNA polymerase eta 0.0236 0.0596 0.1962
Mycobacterium ulcerans secreted antigen 85-A FbpA 0.0043 0.0056 0.012
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0166 0.0399 0.4833
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Mycobacterium ulcerans secreted antigen 85-B FbpB 0.0043 0.0056 0.012
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Echinococcus granulosus g protein coupled receptor 0.0055 0.0088 0.027
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0261 0.0668 0.2267
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.0088 0.0322
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0261 0.0668 0.2267
Brugia malayi G protein-coupled receptor 0.0055 0.0088 0.0067
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0261 0.0668 0.0647
Schistosoma mansoni hypothetical protein 0.005 0.0074 0.0179
Brugia malayi acetyltransferase, GNAT family protein 0.0135 0.0314 0.0293
Echinococcus granulosus pyruvate kinase 0.0033 0.0028 0.0026
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Echinococcus granulosus nAChR subunit 0.0155 0.0368 0.1404
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0102 0.0219 0.0802
Schistosoma mansoni hypothetical protein 0.0169 0.0408 0.1319
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0022 0.0027
Echinococcus granulosus hypothetical protein 0.0055 0.0088 0.027
Schistosoma mansoni neurotransmitter gated ion channel 0.0107 0.0234 0.0727
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.0088 0.0322
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.0088 0.03
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0088 0.0322
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.0088 0.0067
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0102 0.0219 0.0689
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0131 0.1931
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0048 0.0484
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Loa Loa (eye worm) hypothetical protein 0.0155 0.0368 0.1249
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0145 0.0341 0.032
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.0088 0.0227
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.0088 0.0322
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.031 0.0805 0.3177
Echinococcus granulosus glycine receptor subunit beta 0.0261 0.0668 0.2622
Schistosoma mansoni tar DNA-binding protein 0.0267 0.0682 0.2258
Brugia malayi Matrixin family protein 0.0119 0.0268 0.0247
Onchocerca volvulus 0.0055 0.0088 0.0928
Brugia malayi hypothetical protein 0.0237 0.06 0.0579
Echinococcus granulosus glycine receptor subunit alpha 1 0.0261 0.0668 0.2622
Schistosoma mansoni hypothetical protein 0.005 0.0074 0.0179
Onchocerca volvulus Putative nachr subunit 0.0261 0.0668 0.9895
Schistosoma mansoni nAChR subunit 0.0261 0.0668 0.2209
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1074 0.2945 1
Brugia malayi AKH receptor 0.0055 0.0088 0.0067
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0261 0.0668 0.0647
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Onchocerca volvulus 0.0107 0.0234 0.3188
Schistosoma mansoni amine GPCR 0.0055 0.0088 0.0227
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0261 0.0668 0.2267
Echinococcus granulosus dna polymerase kappa 0.0102 0.0219 0.0802
Onchocerca volvulus 0.0261 0.0668 0.9895
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Echinococcus granulosus pyruvate kinase 0.0033 0.0028 0.0026
Loa Loa (eye worm) matrixin family protein 0.0264 0.0674 0.229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0088 0.0322
Loa Loa (eye worm) RNA binding protein 0.0267 0.0682 0.2316
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0131 0.1931
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0272 0.0696 0.2364
Schistosoma mansoni neuropeptide receptor 0.0055 0.0088 0.0227
Schistosoma mansoni nAChR subunit 0.0261 0.0668 0.2209
Schistosoma mansoni tar DNA-binding protein 0.0267 0.0682 0.2258
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Loa Loa (eye worm) hypothetical protein 0.0119 0.0268 0.091
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Brugia malayi hypothetical protein 0.0055 0.0088 0.0067
Echinococcus granulosus histone acetyltransferase KAT2B 0.004 0.0046 0.0098
Loa Loa (eye worm) hypothetical protein 0.0155 0.0368 0.1249
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.0219 0.3467
Loa Loa (eye worm) hypothetical protein 0.0261 0.0668 0.2267
Onchocerca volvulus 0.0055 0.0088 0.0928
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.0088 0.0322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0088 0.0322
Mycobacterium ulcerans aldehyde dehydrogenase 0.031 0.0805 0.2812
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0088 0.0227
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0028 0.0109
Loa Loa (eye worm) hypothetical protein 0.0107 0.0234 0.0796
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0107 0.0234 0.0912
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0028 0.0096
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Brugia malayi hypothetical protein 0.0055 0.0088 0.0067
Loa Loa (eye worm) hypothetical protein 0.0055 0.0088 0.03
Schistosoma mansoni neuropeptide receptor 0.0055 0.0088 0.0227
Plasmodium falciparum histone acetyltransferase GCN5 0.0036 0.0037 1
Trypanosoma brucei chrX additional, unordered contigs 0.0032 0.0023 0.0054
Echinococcus granulosus neuropeptide receptor 0.0055 0.0088 0.027
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0261 0.0668 0.2209
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0434 0.5509
Brugia malayi Matrixin family protein 0.0119 0.0268 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0219 0.3467
Trypanosoma cruzi DNA damage repair protein, putative 0.0032 0.0023 0.0054
Echinococcus multilocularis somatostatin receptor 0.0055 0.0088 0.0322
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.031 0.0805 0.3214
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0119 0.0268 0.0842
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.0219 0.3467
Onchocerca volvulus 0.0155 0.0368 0.5254
Brugia malayi Dopamine receptor protein 1 0.0055 0.0088 0.0067

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Growth inhibition of Mycobacterium avium 2447 ChEMBL. 17010479
IC50 (binding) = 1.3 uM Inhibition of Mycobacterium tuberculosis recombinant antigen 85C mycolyltransferase ChEMBL. 17010479
IC50 (binding) = 1.3 uM Inhibition of Mycobacterium tuberculosis recombinant antigen 85C mycolyltransferase ChEMBL. 17010479
IC50 (binding) = 1.31 uM In vitro concentration required to inhibit antigen 85C mycolyltransferase activity in Mycobaterium tuberculosis ChEMBL. 15177473
IC50 (binding) = 1.31 uM In vitro concentration required to inhibit antigen 85C mycolyltransferase activity in Mycobaterium tuberculosis ChEMBL. 15177473

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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