Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.0597 | 0.4911 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0936 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0597 | 0.4911 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0597 | 0.4911 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0597 | 0.4911 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0566 | 0.4445 | 0.9052 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0597 | 0.4911 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0597 | 0.4911 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0597 | 0.4911 | 1 |
Onchocerca volvulus | 0.0566 | 0.4445 | 0.5 | |
Brugia malayi | thymidylate synthase | 0.0566 | 0.4445 | 0.9052 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0936 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0597 | 0.4911 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0597 | 0.4911 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0936 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0597 | 0.4911 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0269 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0936 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0936 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.41 uM | Inhibitory of human Prostaglandin G/H synthase 2 expressed in CHO cells. | ChEMBL. | 12643942 |
IC50 (binding) | = 0.41 uM | Inhibitory of human Prostaglandin G/H synthase 2 expressed in CHO cells. | ChEMBL. | 12643942 |
IC50 (binding) | = 4.3 uM | Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 2 in human whole blood | ChEMBL. | 12643942 |
IC50 (binding) | = 4.3 uM | Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 2 in human whole blood | ChEMBL. | 12643942 |
IC50 (binding) | > 100 uM | Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 1 in human whole blood | ChEMBL. | 12643942 |
IC50 (binding) | > 100 uM | Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 1 in human whole blood | ChEMBL. | 12643942 |
IC50 (binding) | > 300 uM | Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 1 in the sensitive U937 microsome assay | ChEMBL. | 12643942 |
IC50 (binding) | > 300 uM | Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 1 in the sensitive U937 microsome assay | ChEMBL. | 12643942 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.