Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Long chain fatty acid CoA ligase 4 | 0.0027 | 0 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 0.2636 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0657 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0166 | 0.221 | 0.221 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0193 | 0.2636 | 0.2636 |
Onchocerca volvulus | 0.0193 | 0.2636 | 0.2636 | |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0193 | 0.2636 | 0.2636 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0657 | 1 | 1 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0193 | 0.2636 | 1 |
Mycobacterium ulcerans | acetyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0464 | 0.6939 | 0.6939 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 0.2636 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0491 | 0.7364 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0657 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0657 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0657 | 1 | 1 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0193 | 0.2636 | 0.2636 |
Onchocerca volvulus | 0.0193 | 0.2636 | 0.2636 | |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0193 | 0.2636 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0491 | 0.7364 | 0.7364 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0193 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.7364 | 0.7364 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0657 | 1 | 1 |
Mycobacterium leprae | POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0193 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.7364 | 0.7364 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0193 | 0.2636 | 1 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0193 | 0.2636 | 1 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0193 | 0.2636 | 0.2636 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0464 | 0.6939 | 0.6939 |
Mycobacterium ulcerans | O-succinylbenzoic acid--CoA ligase | 0.0193 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.7364 | 0.7364 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.7364 | 0.7364 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0193 | 0.2636 | 0.2636 |
Brugia malayi | AMP-binding enzyme family protein | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0491 | 0.7364 | 0.7364 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.7364 | 0.7364 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0193 | 0.2636 | 1 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0193 | 0.2636 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0193 | 0.2636 | 0.2636 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0193 | 0.2636 | 0.2636 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0657 | 1 | 1 |
Giardia lamblia | Long chain fatty acid CoA ligase, putative | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0657 | 1 | 1 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0464 | 0.6939 | 0.6939 |
Brugia malayi | AMP-binding enzyme family protein | 0.0193 | 0.2636 | 0.2636 |
Giardia lamblia | Long chain fatty acid CoA ligase 5 | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0657 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0657 | 1 | 1 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0193 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.2636 | 0.2636 |
Giardia lamblia | Hypothetical protein | 0.0027 | 0 | 0.5 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0193 | 0.2636 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0491 | 0.7364 | 1 |
Treponema pallidum | long-chain-fatty-acid--CoA ligase | 0.0027 | 0 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0657 | 1 | 1 |
Onchocerca volvulus | 0.0193 | 0.2636 | 0.2636 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0193 | 0.2636 | 0.2636 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 1 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 0.3579 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0193 | 0.2636 | 1 |
Mycobacterium leprae | POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) | 0.0193 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.0657 | 1 | 1 |
Giardia lamblia | Long chain fatty acid CoA ligase 5 | 0.0027 | 0 | 0.5 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0193 | 0.2636 | 0.2636 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0193 | 0.2636 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0657 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0657 | 1 | 1 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 0.3579 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0464 | 0.6939 | 0.6939 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Onchocerca volvulus | 0.0193 | 0.2636 | 0.2636 | |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0657 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0657 | 1 | 1 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0657 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0491 | 0.7364 | 1 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 1 |
Toxoplasma gondii | propionate-CoA ligase | 0.0193 | 0.2636 | 1 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0193 | 0.2636 | 0.2636 |
Giardia lamblia | Long chain fatty acid CoA ligase 5 | 0.0027 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0193 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | oxidoreductase | 0.0193 | 0.2636 | 0.2636 |
Giardia lamblia | Long chain fatty acid CoA ligase 5 | 0.0027 | 0 | 0.5 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0193 | 0.2636 | 0.2636 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0193 | 0.2636 | 1 |
Mycobacterium leprae | Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) | 0.0193 | 0.2636 | 0.2636 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.