TDR Targets

Basic information

Technical information

TDR Targets ID: 206819
Name: (E)-2-[[(1-amino-2-cyclohexylethyl)-hydroxyph osphoryl]methyl]-3-(3-iodophenyl)prop-2-enoic acid
MW: 477.274 | Formula: C18H25INO4P
H donors: 3 H acceptors: 4 LogP: 1.03 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Ic1cccc(c1)/C=C(\C(=O)O)/CP(=O)(C(CC1CCCCC1)N)O
InChi: 1S/C18H25INO4P/c19-16-8-4-7-14(10-16)9-15(18(21)22)12-25(23,24)17(20)11-13-5-2-1-3-6-13/h4,7-10,13,17H,1-3,5-6,11-12,20H2,(H,21,22)(H,23,24)/b15-9-
InChiKey: UTOXOZGVFPIENW-DHDCSXOGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(E)-2-[[(1-amino-2-cyclohexyl-ethyl)-hydroxy-phosphoryl]methyl]-3-(3-iodophenyl)prop-2-enoic acid
(E)-2-[[(1-amino-2-cyclohexylethyl)-hydroxyphosphoryl]methyl]-3-(3-iodophenyl)-2-propenoic acid
(E)-2-[[(1-azanyl-2-cyclohexyl-ethyl)-hydroxy-phosphoryl]methyl]-3-(3-iodophenyl)prop-2-enoic acid
(E)-2-[[(1-amino-2-cyclohexyl-ethyl)-hydroxy-phosphoryl]methyl]-3-(3-iodophenyl)acrylic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dipeptidase 1 (renal)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_128396	All targets in OG5_128396
Chlamydia trachomatis	dipeptidase	Get druggable targets OG5_128396	All targets in OG5_128396

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0227	0.0754	0.0754
Brugia malayi	Cell death protein 3 precursor	0.0685	0.2595	0.3736
Echinococcus granulosus	aldehyde reductase	0.1255	0.4889	0.4889
Echinococcus multilocularis	aldo keto reductase	0.1766	0.6947	0.6947
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0256	0.0871	0.0871
Mycobacterium tuberculosis	Probable oxidoreductase	0.1766	0.6947	1
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0512	0.1899	0.2642
Echinococcus multilocularis	transfer RNA-Lys	0.0174	0.0542	0.0542
Trichomonas vaginalis	conserved hypothetical protein	0.0512	0.1899	0.2642
Onchocerca volvulus		0.033	0.1169	0.1578
Schistosoma mansoni	hypothetical protein	0.0422	0.1539	0.1539
Mycobacterium tuberculosis	Conserved protein	0.0512	0.1899	0.2733
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0227	0.0754	0.0754
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0048	0.0034	0.0049
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0247	0.0836	0.1203
Trichomonas vaginalis	aldo-keto reductase, putative	0.1766	0.6947	1
Trichomonas vaginalis	conserved hypothetical protein	0.0355	0.1267	0.172
Echinococcus granulosus	lipoxygenase domain containing protein	0.0422	0.1539	0.1539
Brugia malayi	PAS domain containing protein	0.0236	0.0788	0.1134
Giardia lamblia	Aldose reductase	0.1766	0.6947	1
Brugia malayi	NADH-dependent xylose reductase	0.0512	0.1899	0.2733
Plasmodium falciparum	aldo-keto reductase, putative	0.0512	0.1899	1
Schistosoma mansoni	single-minded	0.0236	0.0788	0.0788
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.1766	0.6947	1
Echinococcus granulosus	voltage gated potassium channel subunit	0.0512	0.1899	0.1899
Echinococcus multilocularis	aldehyde reductase	0.1255	0.4889	0.4889
Echinococcus granulosus	aryl hydrocarbon receptor	0.0061	0.0087	0.0087
Echinococcus multilocularis	aldo keto reductase	0.1766	0.6947	0.6947
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0256	0.0871	0.0871
Echinococcus granulosus	RUN	0.0422	0.1539	0.1539
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0227	0.0754	0.0754
Echinococcus granulosus	caspase 3	0.0583	0.2186	0.2186
Loa Loa (eye worm)	oxidoreductase	0.1766	0.6947	1
Loa Loa (eye worm)	hypothetical protein	0.033	0.1169	0.1683
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1766	0.6947	0.6947
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0355	0.1267	0.172
Trypanosoma brucei	Metacaspase-4	0.0355	0.1267	0.1824
Loa Loa (eye worm)	hypothetical protein	0.0355	0.1267	0.1824
Brugia malayi	Cytochrome P450 family protein	0.0048	0.0034	0.0049
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0061	0.0087	0.0125
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0061	0.0087	0.0125
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0512	0.1899	0.2733
Echinococcus multilocularis	RUN	0.0422	0.1539	0.1539
Echinococcus multilocularis	aldo keto reductase	0.1766	0.6947	0.6947
Loa Loa (eye worm)	CYP4Cod1	0.0048	0.0034	0.0049
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0256	0.0871	0.1254
Schistosoma mansoni	rab6-interacting	0.0422	0.1539	0.1539
Brugia malayi	hypothetical protein	0.033	0.1169	0.1683
Echinococcus granulosus	hypothetical protein	0.1766	0.6947	0.6947
Echinococcus granulosus	aldo keto reductase	0.1766	0.6947	0.6947
Trichomonas vaginalis	aldo-keto reductase, putative	0.1766	0.6947	1
Loa Loa (eye worm)	oxidoreductase	0.1766	0.6947	1
Echinococcus multilocularis	ubiquitin specific protease 41	0.0256	0.0871	0.0871
Mycobacterium ulcerans	putative regulatory protein	0.0174	0.0542	0.078
Plasmodium falciparum	LCCL domain-containing protein	0.0422	0.1539	0.4302
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1766	0.6947	0.6947
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1766	0.6947	0.6947
Schistosoma mansoni	caspase-7 (C14 family)	0.0685	0.2595	0.2595
Echinococcus multilocularis	caspase 8	0.0355	0.1267	0.1267
Mycobacterium ulcerans	oxidoreductase	0.1766	0.6947	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1766	0.6947	0.6947
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1766	0.6947	0.6947
Trichomonas vaginalis	aldo/keto reductase, putative	0.1766	0.6947	1
Trypanosoma cruzi	cytochrome P450, putative	0.0048	0.0034	0.0049
Trypanosoma brucei	cytochrome P450, putative	0.0048	0.0034	0.0049
Brugia malayi	bHLH-PAS transcription factor	0.0174	0.0542	0.078
Schistosoma mansoni	aryl hydrocarbon receptor	0.0236	0.0788	0.0788
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1766	0.6947	0.6947
Brugia malayi	hypoxia-induced factor 1	0.0729	0.2773	0.3992
Trichomonas vaginalis	aldo-keto reductase, putative	0.1766	0.6947	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0247	0.0836	0.0836
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1766	0.6947	0.6947
Trichomonas vaginalis	conserved hypothetical protein	0.0355	0.1267	0.172
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0422	0.1539	0.1539
Echinococcus granulosus	caspase 8	0.0355	0.1267	0.1267
Trichomonas vaginalis	conserved hypothetical protein	0.0256	0.0871	0.1143
Trichomonas vaginalis	aldo-keto reductase, putative	0.1766	0.6947	1
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0937	0.3612	0.3612
Plasmodium vivax	multidomain scavenger receptor, putative	0.0422	0.1539	0.4302
Brugia malayi	hypothetical protein	0.0422	0.1539	0.2215
Mycobacterium leprae	Conserved hypothetical protein	0.1255	0.4889	0.7037
Trypanosoma brucei	aldo/keto reductase, putative	0.0512	0.1899	0.2733
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0061	0.0087	0.0125
Echinococcus multilocularis	Polycystic kidney disease protein	0.0422	0.1539	0.1539
Echinococcus multilocularis	caspase 2	0.0685	0.2595	0.2595
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0247	0.0836	0.1203
Toxoplasma gondii	aldo-keto reductase	0.0512	0.1899	0.2733
Onchocerca volvulus	Cell death protein 3 homolog	0.0685	0.2595	0.3657
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0256	0.0871	0.1143
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.1766	0.6947	1
Trypanosoma cruzi	metacaspase 5, putative	0.0355	0.1267	0.1824
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1766	0.6947	0.6947
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0512	0.1899	0.1899
Echinococcus multilocularis	aldo keto reductase	0.1766	0.6947	0.6947
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0937	0.3612	0.3612
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0256	0.0871	0.0871
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.2525	1	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0247	0.0836	0.1203
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1766	0.6947	0.6947
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.1766	0.6947	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0227	0.0754	0.1086
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.1766	0.6947	1
Onchocerca volvulus		0.1766	0.6947	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.1766	0.6947	1
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0871	0.1254
Loa Loa (eye worm)	hypothetical protein	0.0422	0.1539	0.2215
Trichomonas vaginalis	conserved hypothetical protein	0.0355	0.1267	0.172
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0256	0.0871	0.1254
Toxoplasma gondii	aldehyde dehydrogenase	0.0247	0.0836	0.1203
Leishmania major	cytochrome p450-like protein	0.0048	0.0034	0.0049
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0061	0.0087	0.0087
Schistosoma mansoni	polycystin 1-related	0.0422	0.1539	0.1539
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0227	0.0754	0.1086
Loa Loa (eye worm)	oxidoreductase	0.1766	0.6947	1
Entamoeba histolytica	aldose reductase, putative	0.1766	0.6947	1
Trypanosoma brucei	prostaglandin f synthase	0.1766	0.6947	1
Schistosoma mansoni	potassium channel beta	0.0512	0.1899	0.1899
Trichomonas vaginalis	aldo-keto reductase, putative	0.1766	0.6947	1
Schistosoma mansoni	hypothetical protein	0.033	0.1169	0.1169
Plasmodium vivax	aldehyde reductase, putative	0.0512	0.1899	1
Onchocerca volvulus		0.1766	0.6947	1
Echinococcus multilocularis	caspase 3	0.0583	0.2186	0.2186
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0355	0.1267	0.1824
Echinococcus granulosus	aldo keto reductase	0.1766	0.6947	0.6947
Onchocerca volvulus		0.0512	0.1899	0.2642
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0355	0.1267	0.172
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0061	0.0087	0.0125
Trichomonas vaginalis	aldo-keto reductase, putative	0.1766	0.6947	1
Trichomonas vaginalis	conserved hypothetical protein	0.0355	0.1267	0.172
Brugia malayi	Cytochrome P450 family protein	0.0048	0.0034	0.0049
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0247	0.0836	0.1203
Trypanosoma cruzi	aldo-keto reductase	0.1766	0.6947	1
Entamoeba histolytica	aldose reductase, putative	0.1766	0.6947	1
Plasmodium falciparum	aldehyde reductase, putative	0.0512	0.1899	1
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0355	0.1267	0.1824
Trichomonas vaginalis	aldo-keto reductase, putative	0.0512	0.1899	0.2642
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0061	0.0087	0.0087
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0256	0.0871	0.0871
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0227	0.0754	0.1086
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0355	0.1267	0.172
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.1766	0.6947	1
Chlamydia trachomatis	dipeptidase	0.0549	0.205	1
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0512	0.1899	0.2733
Trypanosoma cruzi	aldo/keto reductase, putative	0.0512	0.1899	0.2733
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1766	0.6947	0.6947
Loa Loa (eye worm)	oxidoreductase	0.1766	0.6947	1
Echinococcus granulosus	single minded 2	0.0174	0.0542	0.0542
Trichomonas vaginalis	aldo-keto reductase, putative	0.0512	0.1899	0.2642
Schistosoma mansoni	lipoxygenase	0.2525	1	1
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0061	0.0087	0.0125
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0256	0.0871	0.1143
Onchocerca volvulus		0.0174	0.0542	0.0663
Onchocerca volvulus		0.0422	0.1539	0.2117
Brugia malayi	Cytochrome P450 family protein	0.0079	0.0158	0.0227
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0355	0.1267	0.172
Mycobacterium ulcerans	hypothetical protein	0.0549	0.205	0.2951
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0512	0.1899	0.2733
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0422	0.1539	0.1539
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0355	0.1267	0.172
Trypanosoma cruzi	aldo/keto reductase, putative	0.1766	0.6947	1
Schistosoma mansoni	pol-related	0.1766	0.6947	0.6947
Schistosoma mansoni	aldehyde dehydrogenase	0.0247	0.0836	0.0836
Echinococcus multilocularis	apoptotic protease activating factor 1	0.033	0.1169	0.1169
Trichomonas vaginalis	aldo/keto reductase, putative	0.1766	0.6947	1
Toxoplasma gondii	aldose reductase, putative	0.1766	0.6947	1
Trichomonas vaginalis	conserved hypothetical protein	0.0355	0.1267	0.172
Trypanosoma brucei	metacaspase	0.0355	0.1267	0.1824
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1766	0.6947	0.6947
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0355	0.1267	0.172
Schistosoma mansoni	aldo-keto reductase	0.1766	0.6947	0.6947
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1766	0.6947	0.6947
Brugia malayi	Doublecortin family protein	0.0422	0.1539	0.2215
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.1766	0.6947	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0247	0.0836	0.0836
Mycobacterium leprae	Possible regulatory protein	0.0061	0.0087	0.0125
Echinococcus granulosus	lipoxygenase domain containing protein	0.0422	0.1539	0.1539
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0355	0.1267	0.172
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0512	0.1899	0.1692
Schistosoma mansoni	caspase-3 (C14 family)	0.0937	0.3612	0.3612
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0729	0.2773	0.3992
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1766	0.6947	0.6947
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0512	0.1899	1
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0512	0.1899	0.2733
Mycobacterium ulcerans	hypothetical protein	0.0512	0.1899	0.2733
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.1766	0.6947	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1766	0.6947	0.6947
Onchocerca volvulus		0.1766	0.6947	1
Trypanosoma cruzi	cytochrome P450, putative	0.0048	0.0034	0.0049
Trypanosoma brucei	aldo-keto reductase, putative	0.1766	0.6947	1
Mycobacterium leprae	Possible oxidoreductase	0.0512	0.1899	0.2733
Trichomonas vaginalis	aldo-keto reductase, putative	0.1766	0.6947	1
Echinococcus granulosus	aldo keto reductase	0.1766	0.6947	0.6947
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0227	0.0754	0.1086
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0512	0.1899	0.1692
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0247	0.0836	0.0836
Trypanosoma cruzi	metacaspase, putative	0.0355	0.1267	0.1824
Leishmania major	metacaspase, putative	0.0355	0.1267	0.1824
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1766	0.6947	0.6947
Schistosoma mansoni	aldo-keto reductase	0.1766	0.6947	0.6947
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0355	0.1267	0.1824
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0512	0.1899	0.1899
Echinococcus granulosus	caspase	0.0937	0.3612	0.3612
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0355	0.1267	0.172
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0355	0.1267	0.1267
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0355	0.1267	0.1824
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0355	0.1267	0.172
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.1766	0.6947	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0256	0.0871	0.1254
Schistosoma mansoni	caspase-7 (C14 family)	0.0937	0.3612	0.3612
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0227	0.0754	0.1086
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0061	0.0087	0.0125
Brugia malayi	hypothetical protein	0.079	0.3019	0.4346
Onchocerca volvulus		0.1766	0.6947	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.1766	0.6947	1
Onchocerca volvulus		0.1766	0.6947	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0087	0.0125
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0061	0.0087	0.0125
Trichomonas vaginalis	aldo-keto reductase, putative	0.1766	0.6947	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1766	0.6947	0.6947
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0512	0.1899	0.2733
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.1766	0.6947	1
Trypanosoma cruzi	metacaspase, putative	0.0355	0.1267	0.1824
Trypanosoma cruzi	metacaspase 5, putative	0.0355	0.1267	0.1824
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0061	0.0087	0.0125
Loa Loa (eye worm)	doublecortin family protein	0.0422	0.1539	0.2215
Leishmania major	aldo-keto reductase-like protein	0.1766	0.6947	1
Trypanosoma cruzi	metacaspase, putative	0.0355	0.1267	0.1824
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0061	0.0087	0.0087
Echinococcus granulosus	apoptotic protease activating factor 1	0.033	0.1169	0.1169
Schistosoma mansoni	rab6-interacting	0.0422	0.1539	0.1539
Echinococcus granulosus	caspase 2	0.0685	0.2595	0.2595
Schistosoma mansoni	lipoxygenase	0.1765	0.6943	0.6943
Loa Loa (eye worm)	hypothetical protein	0.079	0.3019	0.4346
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0247	0.0836	0.1203
Giardia lamblia	Aldose reductase	0.1766	0.6947	1
Onchocerca volvulus		0.0422	0.1539	0.2117
Leishmania major	protein kinase, putative	0.0061	0.0087	0.0125
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1766	0.6947	0.6947
Echinococcus granulosus	Polycystic kidney disease protein	0.0422	0.1539	0.1539
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1766	0.6947	0.6947
Trypanosoma brucei	metacaspase MCA2	0.0355	0.1267	0.1824
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0256	0.0871	0.1254
Trichomonas vaginalis	aldo/keto reductase, putative	0.1766	0.6947	1
Loa Loa (eye worm)	hypothetical protein	0.1766	0.6947	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.0034	0.0049
Onchocerca volvulus		0.1766	0.6947	1
Echinococcus multilocularis	caspase	0.0937	0.3612	0.3612
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0256	0.0871	0.0871
Trypanosoma cruzi	metacaspase, putative	0.0355	0.1267	0.1824
Loa Loa (eye worm)	hypothetical protein	0.0685	0.2595	0.3736
Trypanosoma brucei	metacaspase 5, putative	0.0355	0.1267	0.1824
Loa Loa (eye worm)	oxidoreductase	0.1766	0.6947	1
Loa Loa (eye worm)	hypothetical protein	0.0422	0.1539	0.2215
Schistosoma mansoni	loxhd1	0.0422	0.1539	0.1539
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0212	0.0693	0.0997
Trichomonas vaginalis	aldo-keto reductase, putative	0.1766	0.6947	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0512	0.1899	0.2642
Leishmania major	protein kinase, putative	0.0061	0.0087	0.0125
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0256	0.0871	0.0871
Echinococcus granulosus	ubiquitin specific protease 41	0.0256	0.0871	0.0871
Entamoeba histolytica	aldose reductase, putative	0.1766	0.6947	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.1766	0.6947	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.0034	0.0049
Trypanosoma brucei	metacaspase MCA3	0.0355	0.1267	0.1824
Trichomonas vaginalis	conserved hypothetical protein	0.0355	0.1267	0.172
Trichomonas vaginalis	aldo-keto reductase, putative	0.1766	0.6947	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1766	0.6947	0.6947
Leishmania major	prostaglandin f synthase, putative	0.1766	0.6947	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0256	0.0871	0.1254
Brugia malayi	hypothetical protein	0.0422	0.1539	0.2215
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1766	0.6947	0.6947
Loa Loa (eye worm)	cytochrome P450 family protein	0.0079	0.0158	0.0227

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 250 nM	Concentration required to inhibit renal dipeptidase (RDP) by 50% in crude lysates prepared from human colon cancer	ChEMBL.	15177467
IC50 (binding)	= 250 nM	Concentration required to inhibit renal dipeptidase (RDP) by 50% in crude lysates prepared from human colon cancer	ChEMBL.	15177467

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10027996

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 206819