TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 330.4 | Formula: C18H23FN4O
H donors: 1 H acceptors: 2 LogP: 2.92 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cccc(c1)n1ccc(n1)C(=O)NCCN1CCCCC1C
InChi: 1S/C18H23FN4O/c1-14-5-2-3-10-22(14)12-9-20-18(24)17-8-11-23(21-17)16-7-4-6-15(19)13-16/h4,6-8,11,13-14H,2-3,5,9-10,12H2,1H3,(H,20,24)
InChiKey: XYNOYKVZMGTLGD-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0038	0.0239	0.1435
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0033	0.0162	0.0235
Chlamydia trachomatis	sulfite reductase	0.0037	0.0223	0.5
Brugia malayi	Patched related family protein 12	0.0028	0.0076	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0033	0.0162	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Brugia malayi	hypothetical protein	0.0093	0.1105	0.1604
Echinococcus multilocularis	Niemann Pick C1 protein	0.046	0.6888	0.6867
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0038	0.0239	0.5
Loa Loa (eye worm)	carboxylesterase	0.0038	0.0239	0.0346
Brugia malayi	hypothetical protein	0.0027	0.0068	0.0098
Echinococcus multilocularis	expressed conserved protein	0.0433	0.6448	0.6424
Brugia malayi	CHE-14 protein	0.0198	0.2749	0.399
Loa Loa (eye worm)	patched family protein	0.0028	0.0076	0.0111
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Schistosoma mansoni	coup transcription factor	0.0033	0.0162	0.0168
Schistosoma mansoni	thyroid hormone receptor	0.0033	0.0162	0.0168
Loa Loa (eye worm)	MH2 domain-containing protein	0.0091	0.1067	0.1549
Entamoeba histolytica	rodhanase-like domain containing protein	0.01	0.1207	0.1752
Brugia malayi	nuclear hormone receptor	0.0033	0.0162	0.0235
Brugia malayi	Rhodanese-like domain containing protein	0.01	0.1207	0.1752
Echinococcus granulosus	sterol regulatory element binding protein	0.0198	0.2749	0.2699
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0132	0.1719	0.6255
Brugia malayi	Presenilin family protein	0.0132	0.1719	0.2496
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0038	0.0239	0.0278
Leishmania major	cytochrome P450 reductase, putative	0.0053	0.0479	0.2784
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.01	0.1207	0.4391
Brugia malayi	hypothetical protein	0.0028	0.0076	0.0111
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Brugia malayi	Rhodanese-like domain containing protein	0.01	0.1207	0.1752
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.006	0.0587	0.3412
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0162	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.0346
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0162	0.0235
Schistosoma mansoni	cytochrome P450 reductase	0.006	0.0587	0.0779
Giardia lamblia	Hypothetical protein	0.0053	0.0479	0.5
Onchocerca volvulus	Bile acid receptor homolog	0.0033	0.0162	0.0757
Brugia malayi	FAD binding domain containing protein	0.006	0.0587	0.0852
Brugia malayi	hypothetical protein	0.0028	0.0076	0.0111
Entamoeba histolytica	rodhanase-like domain containing protein	0.01	0.1207	0.1752
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0033	0.0162	0.0168
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0279	0.4026	0.5844
Schistosoma mansoni	hypothetical protein	0.019	0.2636	0.3726
Echinococcus multilocularis	geminin	0.0129	0.1667	0.161
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0162	0.0235
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0033	0.0162	0.0095
Onchocerca volvulus		0.0038	0.0239	0.1435
Onchocerca volvulus	Huntingtin homolog	0.0093	0.1105	0.9096
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0033	0.0162	0.0095
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0162	0.0235
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0617	0.9353	0.9349
Echinococcus granulosus	presenilin	0.0132	0.1719	0.1663
Loa Loa (eye worm)	patched family protein	0.0028	0.0076	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Echinococcus granulosus	Protein patched homolog 1	0.0198	0.2749	0.2699
Echinococcus granulosus	m phase inducer phosphatasecdc25	0.01	0.1207	0.1147
Loa Loa (eye worm)	patched family protein	0.0028	0.0076	0.0111
Echinococcus granulosus	neuropeptide receptor A26	0.0353	0.5201	0.5168
Brugia malayi	steroid hormone receptor	0.0033	0.0162	0.0235
Brugia malayi	hypothetical protein	0.0046	0.0366	0.0531
Echinococcus granulosus	acetylcholinesterase	0.0226	0.3199	0.3153
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.006	0.0587	0.3412
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.006	0.0587	1
Brugia malayi	ecdysteroid receptor	0.0033	0.0162	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0033	0.0162	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0162	0.0235
Entamoeba histolytica	hypothetical protein	0.0027	0.0068	0.0098
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0033	0.0162	0.0168
Echinococcus granulosus	acetylcholinesterase	0.0226	0.3199	0.3153
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0162	0.0235
Echinococcus multilocularis	presenilin	0.0132	0.1719	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.0346
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0033	0.0162	0.0235
Toxoplasma gondii	hypothetical protein	0.0046	0.0366	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.0162	0.0235
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.006	0.0587	0.3412
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Schistosoma mansoni	thyroid hormone receptor	0.0033	0.0162	0.0168
Loa Loa (eye worm)	patched family protein	0.0028	0.0076	0.0111
Treponema pallidum	flavodoxin	0.0023	0	0.5
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.006	0.0587	0.3412
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0033	0.0162	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Entamoeba histolytica	rodhanase-like domain containing protein	0.01	0.1207	0.1752
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Loa Loa (eye worm)	hypothetical protein	0.01	0.1207	0.1752
Schistosoma mansoni	retinoic acid receptor RXR	0.0033	0.0162	0.0168
Echinococcus multilocularis	X box binding protein 1	0.0219	0.3089	0.3042
Giardia lamblia	Nitric oxide synthase, inducible	0.0053	0.0479	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Schistosoma mansoni	transcription factor LCR-F1	0.0027	0.0068	0.0033
Trypanosoma cruzi	p450 reductase, putative	0.006	0.0587	0.3412
Schistosoma mansoni	hypothetical protein	0.019	0.2636	0.3726
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0033	0.0162	0.0168
Brugia malayi	flavodoxin family protein	0.006	0.0587	0.0852
Brugia malayi	hypothetical protein	0.0028	0.0076	0.0111
Loa Loa (eye worm)	patched family protein	0.0028	0.0076	0.0111
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0033	0.0162	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0234	0.034
Loa Loa (eye worm)	hypothetical protein	0.0198	0.2749	0.399
Brugia malayi	FAD binding domain containing protein	0.0037	0.0223	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3199	0.4644
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0033	0.0162	0.0235
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0033	0.0162	0.0235
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0038	0.0239	0.0278
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Brugia malayi	Patched protein homolog 1	0.0028	0.0076	0.0111
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0033	0.0162	0.0095
Onchocerca volvulus		0.01	0.1207	1
Echinococcus granulosus	FTZ F1 alpha	0.0033	0.0162	0.0095
Echinococcus multilocularis	ecdysone induced protein 78C	0.0033	0.0162	0.0095
Entamoeba histolytica	presenilin 1 peptidase, putative	0.0132	0.1719	0.2496
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.0346
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0162	0.0235
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.006	0.0587	0.3412
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0162	0.0235
Echinococcus multilocularis	acetylcholinesterase	0.0226	0.3199	0.3153
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0038	0.0234	0.034
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0162	0.0235
Onchocerca volvulus		0.01	0.1207	1
Leishmania major	p450 reductase, putative	0.006	0.0587	0.3412
Trypanosoma brucei	presenilin-like aspartic peptidase, putative	0.0132	0.1719	1
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0279	0.4026	0.5723
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0038	0.0239	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Schistosoma mansoni	patched 1	0.0198	0.2749	0.3887
Echinococcus multilocularis	neuroligin	0.0038	0.0239	0.0172
Brugia malayi	Presenilin spe-4	0.0046	0.0366	0.0531
Trypanosoma cruzi	presenilin-like aspartic peptidase, putative	0.0132	0.1719	1
Brugia malayi	Myosin head containing protein	0.0028	0.0076	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0033	0.0162	0.0235
Loa Loa (eye worm)	hypothetical protein	0.046	0.6888	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0279	0.4026	0.5844
Echinococcus multilocularis	sterol regulatory element binding protein	0.0198	0.2749	0.2699
Echinococcus granulosus	neuropeptide s receptor	0.0353	0.5201	0.5168
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0033	0.0162	0.0235
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0038	0.0239	0.0172
Echinococcus multilocularis	FTZ F1 alpha	0.0033	0.0162	0.0095
Toxoplasma gondii	flavodoxin domain-containing protein	0.003	0.0108	0.1093
Brugia malayi	protein C24B5.3	0.0028	0.0076	0.0111
Schistosoma mansoni	hypothetical protein	0.019	0.2636	0.3726
Plasmodium vivax	patched family protein, putative	0.0028	0.0076	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Plasmodium vivax	flavodoxin domain containing protein	0.0053	0.0479	0.8159
Echinococcus multilocularis	acetylcholinesterase	0.0226	0.3199	0.3153
Brugia malayi	photoreceptor-specific nuclear receptor	0.0033	0.0162	0.0235
Echinococcus granulosus	Niemann Pick C1 protein	0.046	0.6888	0.6867
Schistosoma mansoni	RAR-like nuclear receptor	0.0033	0.0162	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1105	0.1604
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Brugia malayi	MH2 domain containing protein	0.0091	0.1067	0.1549
Brugia malayi	Patched related family protein 4	0.0028	0.0076	0.0111
Trichomonas vaginalis	conserved hypothetical protein	0.0198	0.2749	1
Schistosoma mansoni	hypothetical protein	0.0129	0.1667	0.2332
Schistosoma mansoni	NADPH flavin oxidoreductase	0.003	0.0115	0.0101
Onchocerca volvulus		0.01	0.1207	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0033	0.0162	0.0095
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0033	0.0162	0.0235
Echinococcus multilocularis	para nitrobenzyl esterase	0.0038	0.0239	0.0172
Schistosoma mansoni	hypothetical protein	0.0027	0.0068	0.0033
Echinococcus multilocularis	m phase inducer phosphatase(cdc25)	0.01	0.1207	0.1147
Trichomonas vaginalis	sulfite reductase, putative	0.006	0.0587	0.2134
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1084	0.1574
Echinococcus granulosus	X box binding protein 1	0.0219	0.3089	0.3042
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0033	0.0162	0.0235
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0198	0.2749	0.399
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0033	0.0162	0.0095
Onchocerca volvulus		0.0038	0.0239	0.1435
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Schistosoma mansoni	hypothetical protein	0.0129	0.1667	0.2332
Brugia malayi	Carboxylesterase family protein	0.0038	0.0239	0.0346
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Brugia malayi	Carboxylesterase family protein	0.0038	0.0239	0.0346
Brugia malayi	Steroid receptor seven-up type 2	0.0033	0.0162	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.0346
Onchocerca volvulus		0.01	0.1207	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0038	0.0239	0.0278
Onchocerca volvulus	Huntingtin homolog	0.0093	0.1105	0.9096
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Brugia malayi	Carboxylesterase family protein	0.0038	0.0239	0.0346
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0033	0.0162	0.0757
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0279	0.4026	0.3985
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.006	0.0587	0.3412
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0037	0.0223	0.0256
Loa Loa (eye worm)	carboxylesterase	0.0038	0.0239	0.0346
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0038	0.0239	0.0868
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0033	0.0162	0.0168
Schistosoma mansoni	hypothetical protein	0.019	0.2636	0.3726
Onchocerca volvulus		0.0038	0.0239	0.1435
Schistosoma mansoni	acetylcholinesterase	0.0038	0.0239	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Entamoeba histolytica	hypothetical protein	0.0027	0.0068	0.0098
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0162	0.0235
Brugia malayi	Carboxylesterase family protein	0.0226	0.3199	0.4644
Brugia malayi	Niemann-Pick C1 protein precursor	0.046	0.6888	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Trypanosoma cruzi	presenilin-like aspartic peptidase, putative	0.0132	0.1719	1
Echinococcus granulosus	methionine synthase reductase	0.0037	0.0223	0.0157
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.01	0.1207	0.4391
Echinococcus granulosus	expressed conserved protein	0.0433	0.6448	0.6424
Schistosoma mansoni	subfamily A22A unassigned peptidase (A22 family)	0.0132	0.1719	0.2407
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0033	0.0162	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.0346
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.01	0.1207	0.4391
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0045	0.0065
Echinococcus granulosus	ecdysone induced protein 78C	0.0033	0.0162	0.0095
Toxoplasma gondii	flavodoxin domain-containing protein	0.003	0.0108	0.1093
Echinococcus multilocularis	protein patched	0.0198	0.2749	0.2699
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.006	0.0587	0.0522
Onchocerca volvulus		0.0033	0.0162	0.0757
Leishmania major	presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative	0.0132	0.1719	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0162	0.0095
Echinococcus multilocularis	protein dispatched 1	0.0226	0.3188	0.3142
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Schistosoma mansoni	BC026374 protein (S09 family)	0.0038	0.0239	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Echinococcus granulosus	geminin	0.0129	0.1667	0.161
Trichomonas vaginalis	cdc25b, putative	0.01	0.1207	0.4391
Brugia malayi	hypothetical protein	0.0046	0.0366	0.0531
Brugia malayi	hypothetical protein	0.0038	0.0239	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.006	0.0587	0.0522
Loa Loa (eye worm)	steroid hormone receptor	0.0033	0.0162	0.0235
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0226	0.3199	0.4535
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0038	0.0239	0.5
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.006	0.0587	0.3412
Echinococcus multilocularis	methionine synthase reductase	0.0037	0.0223	0.0157
Schistosoma mansoni	diflavin oxidoreductase	0.003	0.0108	0.0091
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0037	0.0223	0.0324
Echinococcus granulosus	carboxylesterase 5A	0.0226	0.3199	0.3153
Brugia malayi	hypothetical protein	0.0028	0.0076	0.0111
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0162	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0279	0.4026	0.3985
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0033	0.0162	0.0168
Entamoeba histolytica	hypothetical protein	0.0027	0.0068	0.0098
Schistosoma mansoni	nuclear hormone receptor	0.0033	0.0162	0.0168
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0033	0.0162	0.0095
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0033	0.0162	0.0095
Echinococcus multilocularis	Niemann Pick C1 protein	0.0658	1	1
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.006	0.0587	0.0522
Trichomonas vaginalis	spcc417.12 protein, putative	0.0038	0.0239	0.0868
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0033	0.0162	0.0095
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.006	0.0587	0.0522
Brugia malayi	Patched related family protein 10	0.0028	0.0076	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0162	0.0235
Brugia malayi	Presenilin spe-4	0.0046	0.0366	0.0531
Plasmodium falciparum	lipid/sterol:H+ symporter	0.0028	0.0076	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0033	0.0162	0.0168
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0033	0.0162	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0033	0.0162	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0242	0.3449	0.5007
Plasmodium falciparum	nitric oxide synthase, putative	0.006	0.0587	1
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.006	0.0587	0.3412
Loa Loa (eye worm)	presenilin spe-4	0.0046	0.0366	0.0531
Brugia malayi	Carboxylesterase family protein	0.0226	0.3199	0.4644
Onchocerca volvulus		0.0038	0.0239	0.1435
Echinococcus granulosus	BC026374 protein S09 family	0.0038	0.0239	0.0172
Brugia malayi	protein C24B5.3	0.0028	0.0076	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Loa Loa (eye worm)	transcription factor SMAD2	0.0091	0.1067	0.1549
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1105	0.1604
Loa Loa (eye worm)	FAD binding domain-containing protein	0.006	0.0587	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Brugia malayi	nuclear receptor NHR-88	0.0033	0.0162	0.0235
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.046	0.6888	1
Trichomonas vaginalis	cdc25b, putative	0.01	0.1207	0.4391
Echinococcus granulosus	para nitrobenzyl esterase	0.0038	0.0239	0.0172
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0033	0.0162	0.0235
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0132	0.1719	0.6255
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0162	0.0235
Echinococcus multilocularis	neuropeptide receptor A26	0.0353	0.5201	0.5168
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0033	0.0162	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0038	0.0234	0.034
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.01	0.1207	0.4391
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0162	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3199	0.4644
Echinococcus multilocularis	neuropeptide s receptor	0.0353	0.5201	0.5168
Echinococcus multilocularis	carboxylesterase 5A	0.0226	0.3199	0.3153
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0038	0.0239	0.0172
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0162	0.0095
Loa Loa (eye worm)	hypothetical protein	0.01	0.1207	0.1752
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0038	0.0239	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0038	0.0234	0.034
Entamoeba histolytica	hypothetical protein	0.0027	0.0068	0.0098
Brugia malayi	Presenilin spe-4	0.0046	0.0366	0.0531
Schistosoma mansoni	gliotactin	0.0038	0.0239	0.0278
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0468	0.7	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1084	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Brugia malayi	Carboxylesterase family protein	0.0038	0.0239	0.0346
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0038	0.0239	0.0278
Echinococcus granulosus	neuroligin	0.0038	0.0239	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0162	0.0235
Loa Loa (eye worm)	carboxylesterase	0.0226	0.3199	0.4644
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Brugia malayi	Presenilin-like protein At2g29900	0.0046	0.0366	0.0531
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.006	0.0587	1
Brugia malayi	hypothetical protein	0.0046	0.0366	0.0531
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.01	0.1207	0.4391
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0111
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0132	0.1719	0.6255
Trichomonas vaginalis	cdc25c, putative	0.01	0.1207	0.4391
Schistosoma mansoni	m-phase inducer phosphatase(cdc25)	0.01	0.1207	0.167
Brugia malayi	latrophilin 2 splice variant baaae	0.0026	0.0045	0.0065
Brugia malayi	Patched family protein	0.0028	0.0076	0.0111
Schistosoma mansoni	hypothetical protein	0.0219	0.3089	0.4376
Loa Loa (eye worm)	acetylcholinesterase 1	0.0226	0.3199	0.4644
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0053	0.0479	0.1741
Loa Loa (eye worm)	hypothetical protein	0.006	0.0587	0.0852
Onchocerca volvulus	Protein ultraspiracle homolog	0.0033	0.0162	0.0757
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0162	0.0235

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3492456

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 2068445