TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 317.426 | Formula: C18H27N3O2
H donors: 1 H acceptors: 1 LogP: 2.31 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NCCN1C1CCN(CC1)CCOc1cc(C)ccc1C
InChi: 1S/C18H27N3O2/c1-14-3-4-15(2)17(13-14)23-12-11-20-8-5-16(6-9-20)21-10-7-19-18(21)22/h3-4,13,16H,5-12H2,1-2H3,(H,19,22)
InChiKey: AFPMEPAERLBKTE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0013	0.0106	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0015	0.0291	1
Echinococcus granulosus	tubulin alpha chain	0.0015	0.0291	0.0187
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0132	1	1
Schistosoma mansoni	coup transcription factor	0.0132	1	1
Giardia lamblia	Alpha-tubulin	0.0015	0.0291	0.5
Leishmania major	alpha tubulin	0.0015	0.0291	0.2114
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0132	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4213	0.4213
Schistosoma mansoni	nuclear hormone receptor	0.0062	0.4213	0.4151
Trypanosoma brucei	alpha tubulin	0.0015	0.0291	0.2114
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0291	0.0291
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0062	0.4213	0.4151
Brugia malayi	conserved hypotetical protein	0.0062	0.4213	0.4151
Echinococcus multilocularis	tubulin alpha chain	0.0015	0.0291	0.0187
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0132	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0015	0.0291	0.0291
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0013	0.0106	0.5
Loa Loa (eye worm)	hypothetical protein	0.0132	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0015	0.0291	0.0187
Loa Loa (eye worm)	nuclear hormone receptor	0.0062	0.4213	0.4213
Mycobacterium leprae	Conserved hypothetical protein	0.0013	0.0106	0.5
Leishmania major	alpha tubulin	0.0015	0.0291	0.2114
Plasmodium vivax	tubulin alpha chain, putative	0.0015	0.0291	0.5
Echinococcus multilocularis	tubulin alpha chain	0.0015	0.0291	0.0187
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0013	0.0106	0.5
Echinococcus granulosus	Tubulin alpha 1 chain	0.0015	0.0291	0.0187
Loa Loa (eye worm)	hypothetical protein	0.007	0.4833	0.4833
Echinococcus granulosus	tubulin alpha 1C chain	0.0015	0.0291	0.0187
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0132	1	1
Brugia malayi	nuclear receptor NHR-88	0.0132	1	1
Brugia malayi	alpha-tubulin	0.0015	0.0291	0.0187
Entamoeba histolytica	tubulin alpha-1 chain	0.0015	0.0291	0.5
Brugia malayi	nuclear receptor RXR	0.0062	0.4213	0.4151
Loa Loa (eye worm)	tubulin alpha chain	0.0015	0.0291	0.0291
Schistosoma mansoni	nuclear hormone receptor	0.0132	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0062	0.4213	0.4151
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4213	0.4213
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0132	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0132	1	1
Brugia malayi	hypothetical protein	0.0062	0.4213	0.4151
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0132	1	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0062	0.4213	0.4151
Brugia malayi	nuclear hormone receptor	0.0062	0.4213	0.4151
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0132	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4213	0.4213
Leishmania major	alpha tubulin	0.0015	0.0291	0.2114
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4213	0.4213
Brugia malayi	tubulin alpha chain - mouse	0.0015	0.0291	0.0187
Echinococcus granulosus	tubulin alpha 1C chain	0.0015	0.0291	0.0187
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0062	0.4213	0.4213
Trypanosoma brucei	cytochrome P450, putative	0.0023	0.0981	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0015	0.0291	1
Echinococcus granulosus	tubulin alpha chain	0.0015	0.0291	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4213	0.4213
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0132	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4213	0.4213
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0062	0.4213	0.4151
Brugia malayi	steroid hormone receptor	0.0132	1	1
Plasmodium falciparum	alpha tubulin 2	0.0015	0.0291	0.5
Leishmania major	alpha tubulin	0.0015	0.0291	0.2114
Schistosoma mansoni	thyroid hormone receptor	0.0132	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0132	1	1
Leishmania major	cytochrome p450-like protein	0.0023	0.0981	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0015	0.0291	1
Loa Loa (eye worm)	tubulin alpha chain	0.0015	0.0291	0.0291
Giardia lamblia	Alpha-tubulin	0.0015	0.0291	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0132	1	1
Leishmania major	alpha tubulin	0.0015	0.0291	0.2114
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0132	1	1
Echinococcus multilocularis	tubulin subunit TubB	0.0015	0.0291	0.0187
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0132	1	1
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0981	1
Leishmania major	alpha tubulin	0.0015	0.0291	0.2114
Brugia malayi	Steroid receptor seven-up type 2	0.0132	1	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0062	0.4213	0.4151
Loa Loa (eye worm)	steroid hormone receptor	0.0132	1	1
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0981	0.0884
Schistosoma mansoni	retinoic acid receptor RXR	0.0132	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4213	0.4213
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.007	0.4833	0.4833
Echinococcus multilocularis	peroxisome assembly protein 26	0.0015	0.0291	0.0187
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0132	1	1
Trypanosoma brucei	alpha tubulin	0.0015	0.0291	0.2114
Echinococcus granulosus	tubulin alpha 3 chain	0.0015	0.0291	0.0187
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0015	0.0291	0.0187
Plasmodium vivax	tubulin alpha chain, putative	0.0015	0.0291	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0013	0.0106	0.5
Leishmania major	alpha tubulin	0.0015	0.0291	0.2114
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0981	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0132	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0132	1	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0062	0.4213	0.4151
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0132	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0132	1	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.007	0.4833	0.4777
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4213	0.4213
Brugia malayi	orphan nuclear receptor NR2E1	0.0062	0.4213	0.4151
Leishmania major	alpha tubulin	0.0015	0.0291	0.2114
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0013	0.0106	0.5
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0132	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0015	0.0291	0.0187
Trichomonas vaginalis	tubulin beta chain, putative	0.0015	0.0291	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0015	0.0291	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0062	0.4213	0.4151
Brugia malayi	Nuclear hormone receptor E75	0.0062	0.4213	0.4151
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0062	0.4213	0.4151
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4213	0.4213
Schistosoma mansoni	nuclear hormone receptor	0.0062	0.4213	0.4151
Echinococcus granulosus	peroxisome assembly protein 26	0.0015	0.0291	0.0187
Schistosoma mansoni	alpha tubulin	0.0015	0.0291	0.0187
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0013	0.0106	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0132	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0013	0.0106	0.5
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0015	0.0291	0.0291
Brugia malayi	Nuclear hormone receptor-like 1	0.007	0.4833	0.4777
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0062	0.4213	0.4151
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0132	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0132	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0132	1	1
Schistosoma mansoni	nuclear receptor	0.0062	0.4213	0.4151
Trypanosoma brucei	alpha tubulin	0.0015	0.0291	0.2114
Echinococcus multilocularis	tubulin alpha 3 chain	0.0015	0.0291	0.0187
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0981	0.0884
Brugia malayi	nuclear receptor NHR-67	0.0062	0.4213	0.4151
Loa Loa (eye worm)	hypothetical protein	0.0132	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0062	0.4213	0.4151
Brugia malayi	Nuclear hormone receptor-like 1	0.007	0.4833	0.4777
Loa Loa (eye worm)	cytochrome P450 family protein	0.0036	0.2011	0.2011
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0013	0.0106	0.5
Echinococcus granulosus	thyroid hormone receptor alpha	0.0062	0.4213	0.4151
Loa Loa (eye worm)	hypothetical protein	0.0132	1	1
Loa Loa (eye worm)	hypothetical protein	0.0132	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0132	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.0132	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.4833	0.4833
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.007	0.4833	0.4777
Loa Loa (eye worm)	DR-78	0.0062	0.4213	0.4213
Loa Loa (eye worm)	hypothetical protein	0.007	0.4833	0.4833
Toxoplasma gondii	alpha tubulin TUBA1	0.0015	0.0291	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0132	1	1
Leishmania major	alpha tubulin	0.0015	0.0291	0.2114
Toxoplasma gondii	alpha-tubulin I, putative	0.0015	0.0291	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0015	0.0291	0.0187
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0062	0.4213	0.4151
Brugia malayi	hypothetical protein	0.007	0.4833	0.4777
Echinococcus multilocularis	tubulin alpha 3 chain	0.0015	0.0291	0.0187
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0132	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0132	1	1
Loa Loa (eye worm)	hypothetical protein	0.0132	1	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0132	1	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0062	0.4213	0.4151
Echinococcus granulosus	tubulin alpha chain	0.0015	0.0291	0.0187
Brugia malayi	ecdysone receptor	0.0062	0.4213	0.4151
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0013	0.0106	0.5
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0013	0.0106	0.5
Echinococcus granulosus	tubulin alpha chain	0.0015	0.0291	0.0187
Leishmania major	alpha tubulin	0.0015	0.0291	0.2114
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4213	0.4213
Echinococcus granulosus	tubulin alpha chain	0.0015	0.0291	0.0187
Loa Loa (eye worm)	CYP4Cod1	0.0023	0.0981	0.0981
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0013	0.0106	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0132	1	1
Loa Loa (eye worm)	hypothetical protein	0.0132	1	1
Leishmania major	alpha tubulin	0.0015	0.0291	0.2114
Schistosoma mansoni	tubulin subunit alpha	0.0015	0.0291	0.0187
Echinococcus multilocularis	tubulin alpha 1C chain	0.0015	0.0291	0.0187
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0062	0.4213	0.4151
Echinococcus granulosus	Tubulin alpha 1 chain	0.0015	0.0291	0.0187
Brugia malayi	tailless protein	0.0062	0.4213	0.4151
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0132	1	1
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0013	0.0106	0.5
Brugia malayi	nuclear receptor NHR-88	0.0062	0.4213	0.4151
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0013	0.0106	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0132	1	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0132	1	1
Schistosoma mansoni	zinc finger protein	0.0062	0.4213	0.4151
Brugia malayi	Tubulin alpha chain	0.0015	0.0291	0.0187
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0015	0.0291	0.0187
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0013	0.0106	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0132	1	1
Leishmania major	alpha tubulin	0.0015	0.0291	0.2114
Loa Loa (eye worm)	cytochrome P450	0.0013	0.0106	0.0106
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0023	0.0981	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.007	0.4833	0.4777
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0015	0.0291	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0132	1	1
Trypanosoma cruzi	alpha tubulin, putative	0.0015	0.0291	0.2114
Schistosoma mansoni	tubulin subunit alpha	0.0015	0.0291	0.0187
Schistosoma mansoni	nuclear receptor	0.0062	0.4213	0.4151
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0132	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0015	0.0291	0.0187
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0132	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0015	0.0291	1
Echinococcus multilocularis	tubulin alpha chain	0.0015	0.0291	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0132	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0013	0.0106	0.5
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4213	0.4213
Echinococcus multilocularis	tubulin alpha chain	0.0015	0.0291	0.0187
Echinococcus granulosus	alpha tubulin	0.0015	0.0291	0.0187
Onchocerca volvulus	Bile acid receptor homolog	0.0132	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.4833	0.4833
Schistosoma mansoni	alpha tubulin	0.0015	0.0291	0.0187
Brugia malayi	Nuclear hormone receptor-like 1	0.0132	1	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.007	0.4833	0.4777
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0132	1	1
Brugia malayi	tubulin alpha-2 chain	0.0015	0.0291	0.0187
Loa Loa (eye worm)	hypothetical protein	0.007	0.4833	0.4833
Echinococcus multilocularis	hypothetical protein	0.0015	0.0291	0.0187
Trypanosoma brucei	alpha tubulin	0.0015	0.0291	0.2114
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0132	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0132	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0981	0.0981
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0062	0.4213	0.4151
Onchocerca volvulus		0.0132	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0015	0.0291	1
Schistosoma mansoni	alpha tubulin	0.0015	0.0291	0.0187
Echinococcus granulosus	nuclear receptor nhr 48	0.0062	0.4213	0.4151
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0132	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0015	0.0291	0.0187
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0062	0.4213	0.4151
Brugia malayi	hypothetical protein	0.0062	0.4213	0.4151
Echinococcus granulosus	tubulin subunit TubB	0.0015	0.0291	0.0187
Echinococcus granulosus	ecdysone induced protein 78C	0.0132	1	1
Brugia malayi	hypothetical protein	0.007	0.4833	0.4777
Loa Loa (eye worm)	alpha-tubulin	0.0015	0.0291	0.0291
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0132	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4213	0.4213
Brugia malayi	Nuclear hormone receptor E75	0.0062	0.4213	0.4151
Schistosoma mansoni	RAR-like nuclear receptor	0.0132	1	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0015	0.0291	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0132	1	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0062	0.4213	0.4213
Brugia malayi	Cytochrome P450 family protein	0.0036	0.2011	0.1926
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0013	0.0106	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0013	0.0106	0.5
Echinococcus multilocularis	tubulin alpha 1C chain	0.0015	0.0291	0.0187
Brugia malayi	nuclear hormone receptor	0.0132	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0015	0.0291	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0013	0.0106	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0981	0.0981
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0132	1	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0062	0.4213	0.4151
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0015	0.0291	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0132	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0013	0.0106	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0132	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4213	0.4213
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0132	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0132	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0013	0.0106	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0132	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0015	0.0291	0.0187
Mycobacterium leprae	putative cytochrome p450	0.0013	0.0106	0.5
Brugia malayi	nuclear receptor RXR	0.007	0.4833	0.4777
Plasmodium falciparum	alpha tubulin 1	0.0015	0.0291	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3494487

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2068575