Detailed information for compound 2068579

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 299.346 | Formula: C16H18FN5
  • H donors: 0 H acceptors: 2 LogP: 1.3 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(c(c1)F)N1CCN(CC1)Cc1nccn1C
  • InChi: 1S/C16H18FN5/c1-20-5-4-19-16(20)12-21-6-8-22(9-7-21)15-3-2-13(11-18)10-14(15)17/h2-5,10H,6-9,12H2,1H3
  • InChiKey: ISLWYWZBRUFJHI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0055 0.2699 0.2721
Entamoeba histolytica thioredoxin reductase, putative 0.0019 0.0807 0.1315
Leishmania major hypothetical protein, conserved 0.0019 0.0807 0.0673
Schistosoma mansoni disulfide oxidoreductase 0.0019 0.0807 0.0801
Leishmania major DNA polymerase eta, putative 0.0032 0.1498 0.1382
Leishmania major cytochrome p450-like protein 0.0009 0.0244 0.0096
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0009 0.0244 0.0613
Echinococcus granulosus dna polymerase eta 0.0032 0.1498 0.1492
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0015 0.0574 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.015 0.0145
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0019 0.0807 0.2773
Chlamydia trachomatis thioredoxin reductase 0.0019 0.0807 0.2972
Loa Loa (eye worm) hypothetical protein 0.0032 0.1498 0.1507
Trypanosoma cruzi DNA polymerase kappa, putative 0.0033 0.1522 0.1532
Plasmodium falciparum flap endonuclease 1 0.0011 0.0358 0.0355
Loa Loa (eye worm) hypothetical protein 0.0018 0.0753 0.0754
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0004 0.0012 0.0006
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0807 0.0809
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0807 0.0809
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0008 0.0199 0.0193
Toxoplasma gondii cytochrome p450 superfamily protein 0.0009 0.0244 0.0246
Schistosoma mansoni nuclear hormone receptor 0.0004 0.0012 0.0006
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0777 0.0771
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0358 0.0573
Schistosoma mansoni glutamate synthase 0.0019 0.0807 0.0801
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.015 0.0145
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0019 0.0807 0.2067
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0055 0.2699 0.6956
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0006
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0807 0.0809
Plasmodium falciparum protein kinase 5 0.0026 0.1165 0.1171
Trichomonas vaginalis glutathione reductase, putative 0.0055 0.2699 0.4392
Brugia malayi Importin beta-1 subunit 0.0012 0.0419 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.1522 0.1532
Echinococcus multilocularis caspase 0.0048 0.2331 0.2326
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0055 0.2699 0.2721
Loa Loa (eye worm) hypothetical protein 0.0008 0.0199 0.0195
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0807 0.0801
Treponema pallidum NADH oxidase 0.0055 0.2699 0.4392
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0011 0.0358 0.0355
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0055 0.2699 0.6956
Echinococcus granulosus snurportin 1 0.0127 0.6474 0.6471
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0945 0.0726
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0011 0.0358 0.0213
Brugia malayi Flap endonuclease-1 0.0011 0.0358 0.0355
Echinococcus granulosus sodium bile acid cotransporter 0.0075 0.3766 0.3761
Brugia malayi nuclear receptor NHR-88 0.0004 0.0012 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.1522 0.1532
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0807 0.0809
Schistosoma mansoni DNA helicase recq5 0.0008 0.0199 0.0193
Trypanosoma brucei metacaspase 5, putative 0.0018 0.0753 0.0754
Loa Loa (eye worm) flap endonuclease-1 0.0011 0.0358 0.0355
Giardia lamblia Sgs1 DNA helicase, putative 0.0008 0.0199 0.0314
Onchocerca volvulus Bile acid receptor homolog 0.0004 0.0012 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0004 0.0012 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0004 0.0012 0.0006
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0777 0.0779
Echinococcus granulosus sodium bile acid cotransporter 0.0075 0.3766 0.3761
Brugia malayi Cytochrome P450 family protein 0.0009 0.0244 0.024
Echinococcus granulosus cyclin dependent kinase 5 0.0026 0.1165 0.116
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0009 0.0294 0.0297
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0019 0.0807 0.2067
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0004 0.0012 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0033 0.1522 0.1532
Mycobacterium ulcerans hypothetical protein 0.0019 0.0807 0.2067
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0019 0.0807 0.0583
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0009 0.0244 0.0613
Echinococcus granulosus caspase 0.0048 0.2331 0.2326
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.015 0.0145
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.1088 0.0874
Trypanosoma cruzi trypanothione reductase, putative 0.0192 0.9901 1
Toxoplasma gondii selenide, water dikinase 0.0019 0.0807 0.0815
Echinococcus granulosus cyclin dependent kinase 1 0.0026 0.1165 0.116
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.1522 0.1532
Entamoeba histolytica cell division protein kinase 2, putative 0.0026 0.1165 0.1899
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.1522 0.1532
Plasmodium vivax protein kinase Crk2 0.0026 0.1165 0.1171
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0019 0.0807 0.1315
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0777 0.1257
Trichomonas vaginalis Importin beta-1 subunit, putative 0.001 0.03 0.0479
Trypanosoma brucei unspecified product 0.0015 0.0587 0.0587
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0019 0.0807 0.0809
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0055 0.2699 0.2721
Giardia lamblia NADH oxidase lateral transfer candidate 0.0055 0.2699 0.4392
Mycobacterium ulcerans glutamate synthase subunit beta 0.0019 0.0807 0.2067
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0009 0.0254 0.0247
Mycobacterium tuberculosis Probable reductase 0.0019 0.0807 0.0583
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0077 0.3877 0.3762
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0048 0.2331 0.2326
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0055 0.2699 0.2542
Echinococcus granulosus ecdysone induced protein 78C 0.0004 0.0012 0.0006
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0009 0.0244 0.0613
Entamoeba histolytica hypothetical protein 0.0015 0.0574 0.0935
Onchocerca volvulus 0.0004 0.0012 0.0015
Plasmodium vivax ferrodoxin reductase, putative 0.0019 0.0807 0.0809
Leishmania major cytochrome p450-like protein 0.0009 0.0244 0.0096
Entamoeba histolytica hypothetical protein 0.0015 0.0574 0.0935
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0004 0.0012 0.0006
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0015 0.0574 0.0568
Schistosoma mansoni retinoic acid receptor RXR 0.0004 0.0012 0.0006
Toxoplasma gondii NADPH-glutathione reductase 0.0055 0.2699 0.2726
Trypanosoma brucei DNA polymerase eta, putative 0.0032 0.1498 0.1507
Echinococcus granulosus cytochrome P450 2K1 0.0009 0.0244 0.0237
Onchocerca volvulus 0.0075 0.3766 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0004 0.0012 0.0006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.045 0.0455
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.1165 0.116
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0004 0.0012 0.0006
Echinococcus granulosus apoptotic protease activating factor 1 0.0017 0.0687 0.0681
Trypanosoma cruzi metacaspase, putative 0.0018 0.0753 0.0754
Echinococcus granulosus caspase 3 0.003 0.1371 0.1366
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0019 0.0807 0.0583
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0009 0.0244 0.0613
Loa Loa (eye worm) thioredoxin reductase 0.0192 0.9901 1
Plasmodium falciparum metacaspase 1 0.0018 0.0753 0.0754
Loa Loa (eye worm) hypothetical protein 0.0057 0.2785 0.2808
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0019 0.0807 0.0801
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0036 0.1685 0.1696
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0192 0.9901 1
Trichomonas vaginalis CMGC family protein kinase 0.0026 0.1165 0.189
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.1165 0.116
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0009 0.0254 0.0256
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0004 0.0012 0.0006
Leishmania major GTP-binding protein, putative 0.0009 0.0254 0.0106
Schistosoma mansoni caspase-7 (C14 family) 0.0048 0.2331 0.2326
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0019 0.0807 0.0583
Echinococcus granulosus sodium bile acid cotransporter 0.0075 0.3766 0.3761
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0009 0.0254 0.025
Plasmodium falciparum ferrodoxin reductase-like protein 0.0019 0.0807 0.0809
Schistosoma mansoni hypothetical protein 0.0019 0.0807 0.0801
Leishmania major hypothetical protein, conserved 0.0019 0.0807 0.0673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0004 0.0012 0.0006
Echinococcus multilocularis dna polymerase eta 0.0032 0.1498 0.1492
Trypanosoma brucei cdc2-related kinase 1 0.0026 0.1165 0.1171
Echinococcus multilocularis glutamate synthase 0.0019 0.0807 0.0801
Mycobacterium ulcerans DNA polymerase IV 0.0033 0.1522 0.3916
Trypanosoma brucei unspecified product 0.0015 0.0587 0.0587
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0008 0.0199 0.0193
Trypanosoma cruzi cdc2-related kinase 3 0.0026 0.1165 0.1171
Leishmania major DNA polymerase kappa, putative 0.0025 0.1088 0.0962
Echinococcus multilocularis caspase 2 0.0035 0.1647 0.1642
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0009 0.0254 0.025
Onchocerca volvulus Cell death protein 3 homolog 0.0035 0.1647 0.4364
Schistosoma mansoni sodium-bile acid cotransporter related 0.0031 0.1404 0.1398
Echinococcus granulosus importin subunit beta 1 0.0012 0.0419 0.0412
Mycobacterium ulcerans DNA polymerase IV 0.0033 0.1522 0.3916
Schistosoma mansoni RAR-like nuclear receptor 0.0004 0.0012 0.0006
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0019 0.0807 0.1305
Leishmania major NADH dehydrogenase, putative 0.0019 0.0807 0.0673
Brugia malayi hypothetical protein 0.0015 0.0574 0.0573
Giardia lamblia DINP protein human, muc B family 0.0025 0.1088 0.1764
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0019 0.0807 0.2067
Schistosoma mansoni glutamate synthase 0.0019 0.0807 0.0801
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.015 0.0145
Echinococcus granulosus dna polymerase kappa 0.0033 0.1522 0.1516
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0006
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0019 0.0807 0.0815
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.6136 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0753 0.1218
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.057 0.0564
Leishmania major importin beta-1 subunit, putative 0.001 0.03 0.0154
Plasmodium falciparum metacaspase-like protein 0.0018 0.0753 0.0754
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0319 0.0173
Schistosoma mansoni caspase-7 (C14 family) 0.0035 0.1647 0.1642
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0807 0.1305
Mycobacterium ulcerans monoxygenase 0.0019 0.0807 0.2067
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0055 0.2699 0.2721
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0419 0.0423
Plasmodium vivax importin-beta 2, putative 0.0012 0.0419 0.0417
Echinococcus granulosus bloom syndrome protein 0.0019 0.0777 0.0771
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0026 0.1165 0.1041
Leishmania major metacaspase, putative 0.0018 0.0753 0.0618
Trichomonas vaginalis apoptosis inducing factor, putative 0.0019 0.0807 0.1305
Trichomonas vaginalis mercuric reductase, putative 0.0055 0.2699 0.4392
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0018 0.0753 0.0747
Trichomonas vaginalis CMGC family protein kinase 0.0026 0.1165 0.189
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0004 0.0012 0.0006
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0945 0.0948
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0026 0.1165 0.1171
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0004 0.0012 0.0006
Schistosoma mansoni sodium-bile acid cotransporter related 0.0075 0.3766 0.3761
Trypanosoma brucei metacaspase MCA3 0.0018 0.0753 0.0754
Mycobacterium tuberculosis Probable dehydrogenase 0.0019 0.0807 0.0583
Echinococcus granulosus flap endonuclease 1 0.0011 0.0358 0.0352
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0004 0.0012 0.0006
Trypanosoma cruzi metacaspase, putative 0.0018 0.0753 0.0754
Treponema pallidum fructose-bisphosphate aldolase 0.012 0.6136 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.1522 0.1532
Trypanosoma brucei importin beta-1 subunit, putative 0.0012 0.0419 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.1522 0.1532
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0753 0.1218
Brugia malayi hypothetical protein 0.0017 0.0687 0.0688
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0019 0.0807 0.2067
Schistosoma mansoni glutamate synthase 0.0019 0.0807 0.0801
Loa Loa (eye worm) glutathione reductase 0.0192 0.9901 1
Schistosoma mansoni ran 0.0009 0.0254 0.0247
Echinococcus multilocularis snurportin 1 0.0127 0.6474 0.6471
Brugia malayi Cytochrome P450 family protein 0.0009 0.0244 0.024
Plasmodium falciparum glutathione reductase 0.0055 0.2699 0.2721
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0019 0.0807 0.2773
Brugia malayi Cytochrome P450 family protein 0.0032 0.1459 0.1468
Onchocerca volvulus Protein ultraspiracle homolog 0.0004 0.0012 0.0015
Loa Loa (eye worm) steroid hormone receptor 0.0004 0.0012 0.0006
Echinococcus granulosus glutamate synthase 0.0019 0.0807 0.0801
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.015 0.0145
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0004 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0006
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0013 0.0458 0.0457
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0019 0.0807 0.0583
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0026 0.1165 0.1171
Brugia malayi glutamate synthase 0.0019 0.0807 0.0809
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0055 0.2699 0.2721
Echinococcus multilocularis ecdysone induced protein 78C 0.0004 0.0012 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.6136 1
Loa Loa (eye worm) CYP4Cod1 0.0009 0.0244 0.024
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0019 0.0807 0.1305
Treponema pallidum oxidoreductase 0.0019 0.0807 0.1305
Giardia lamblia Glutamate synthase 0.0019 0.0807 0.1305
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0009 0.0244 0.0613
Trypanosoma cruzi metacaspase, putative 0.0018 0.0753 0.0754
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0055 0.2699 0.2542
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0059 0.2892 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.2699 0.2721
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0753 0.1218
Schistosoma mansoni hypothetical protein 0.007 0.3471 0.3466
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.1498 0.1507
Treponema pallidum thioredoxin reductase (trxB) 0.0019 0.0807 0.1305
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0009 0.0244 0.0613
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.015 0.0152
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0945 0.0939
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0019 0.0807 0.2972
Entamoeba histolytica Ran family GTPase 0.0009 0.0254 0.0413
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0009 0.0244 0.0613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.6136 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0753 0.1218
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0019 0.0807 0.0583
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0019 0.0807 0.2773
Trichomonas vaginalis DNA polymerase eta, putative 0.0033 0.1522 0.2472
Schistosoma mansoni flap endonuclease-1 0.001 0.0304 0.0297
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0009 0.0254 0.025
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0055 0.2699 0.2721
Schistosoma mansoni thyroid hormone receptor 0.0004 0.0012 0.0006
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0055 0.2699 0.2694
Plasmodium falciparum thioredoxin reductase 0.0192 0.9901 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.001 0.03 0.0297
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0055 0.2699 0.2613
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0807 0.1305
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0753 0.0754
Trypanosoma brucei unspecified product 0.003 0.1379 0.1387
Echinococcus granulosus caspase 2 0.0035 0.1647 0.1642
Loa Loa (eye worm) hypothetical protein 0.0035 0.1647 0.1658
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0807 0.0801
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0055 0.2699 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0019 0.0807 0.1315
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0004 0.0012 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.2699 0.2721
Entamoeba histolytica Flap nuclease, putative 0.0011 0.0358 0.0584
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0004 0.0012 0.0006
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0807 0.1305
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0009 0.0254 0.0403
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0019 0.0807 0.0583
Echinococcus multilocularis caspase 8 0.0018 0.0753 0.0747
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0.015 0.0145
Giardia lamblia Flap structure-specific endonuclease 0.0011 0.0358 0.0573
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0009 0.0244 0.024
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0019 0.0807 0.2067
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0004 0.0012 0.0006
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0753 0.1218
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0807 0.0801
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0019 0.0807 0.0583
Echinococcus granulosus caspase 8 0.0018 0.0753 0.0747
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0004 0.0007 0.0007
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0807 0.1305
Entamoeba histolytica hypothetical protein 0.001 0.03 0.049
Giardia lamblia Kinase, CMGC CDK 0.0026 0.1165 0.189
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0009 0.0244 0.0613
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.467 0.4667
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0055 0.2699 0.2613
Mycobacterium ulcerans ferredoxin reductase 0.0019 0.0807 0.2067
Mycobacterium tuberculosis Probable oxidoreductase 0.0055 0.2699 0.2542
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0807 0.0809
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0009 0.0244 0.0613
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0004 0.0012 0.0006
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0011 0.0358 0.0362
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0807 0.0809
Entamoeba histolytica hypothetical protein 0.0004 0.0007 0.0011
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0059 0.2892 0.7455
Trypanosoma brucei NADH dehydrogenase 0.0019 0.0807 0.0809
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0009 0.0254 0.025
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0048 0.2331 0.2326
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0945 0.154
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0008 0.0199 0.0193
Entamoeba histolytica cell division protein kinase 2, putative 0.0026 0.1165 0.1899
Plasmodium falciparum thioredoxin reductase 0.0055 0.2699 0.2721
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0092 0.467 0.4714
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0807 0.0801
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.2699 0.2721
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0019 0.0807 0.1305
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.015 0.0145
Echinococcus multilocularis dna polymerase kappa 0.0033 0.1522 0.1516
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0199 0.0201
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0055 0.2699 0.2542
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0807 0.0809
Echinococcus multilocularis geminin 0.007 0.3471 0.3466
Trypanosoma brucei importin beta-1 subunit, putative 0.0012 0.0419 0.0417
Brugia malayi polk-prov protein 0.0018 0.0728 0.0729
Brugia malayi Sodium Bile acid symporter family protein 0.0075 0.3766 0.3799
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0055 0.2699 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0019 0.0807 0.0801
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0807 0.0815
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0127 0.6474 0.6536
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0807 0.0809
Mycobacterium ulcerans epoxide hydrolase EphA 0.0077 0.3877 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0807 0.0801
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0019 0.0807 0.2067
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.1459 0.1468
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0319 0.0315
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0807 0.0673
Trypanosoma cruzi DNA polymerase kappa, putative 0.0033 0.1522 0.1532
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0055 0.2699 0.2721
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0703 0.071
Echinococcus multilocularis apoptotic protease activating factor 1 0.0017 0.0687 0.0681
Plasmodium falciparum importin beta, putative 0.0012 0.0419 0.0417
Echinococcus granulosus cyclin dependent kinase 0.0026 0.1165 0.116
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0807 0.1315
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0019 0.0807 0.2972
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0004 0.0012 0.0006
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.012 0.6136 1
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0753 0.0754
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0033 0.1522 0.2472
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.1522 0.1532
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0004 0.0012 0.0006
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0753 0.0761
Echinococcus multilocularis cyclin dependent kinase 1 0.0026 0.1165 0.116
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0019 0.0807 0.0801
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.1522 0.1532
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0006
Trypanosoma cruzi cdc2-related kinase 3 0.0026 0.1165 0.1171
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0199 0.0195
Entamoeba histolytica hypothetical protein 0.0015 0.0574 0.0935
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.073 0.0732
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0807 0.1305
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0753 0.0754
Echinococcus multilocularis FTZ F1 alpha 0.0004 0.0012 0.0006
Onchocerca volvulus 0.0019 0.0807 0.2128
Loa Loa (eye worm) hypothetical protein 0.0025 0.1137 0.1143
Brugia malayi nuclear hormone receptor 0.0004 0.0012 0.0006
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0055 0.2699 0.2694
Echinococcus multilocularis cyclin dependent kinase 0.0026 0.1165 0.116
Loa Loa (eye worm) hypothetical protein 0.0012 0.0419 0.0417
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0807 0.0815
Loa Loa (eye worm) hypothetical protein 0.0017 0.0687 0.0688
Echinococcus multilocularis caspase 3 0.003 0.1371 0.1366
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0019 0.0807 0.0801
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.1088 0.0962
Brugia malayi Nuclear hormone receptor-like 1 0.0004 0.0012 0.0006
Schistosoma mansoni hypothetical protein 0.0017 0.0687 0.0681
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.1088 0.1093
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.015 0.0144
Schistosoma mansoni coup transcription factor 0.0004 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0006
Brugia malayi RNA, U transporter 1 0.0034 0.1573 0.1583
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0019 0.0807 0.0815
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0753 0.1218
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0807 0.1305
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.1522 0.1532
Schistosoma mansoni DNA helicase recq1 0.0008 0.0199 0.0193
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0807 0.1305
Loa Loa (eye worm) cytochrome P450 family protein 0.0009 0.0244 0.024
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0008 0.0199 0.0195
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0807 0.0809
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0807 0.1315
Schistosoma mansoni steroid hormone receptor ad4bp 0.0004 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0006
Echinococcus multilocularis thioredoxin glutathione reductase 0.0193 1 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0009 0.0244 0.0613
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0011 0.0358 0.0355
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0019 0.0807 0.2773
Trypanosoma brucei cdc2-related kinase 3 0.0026 0.1165 0.1171
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0319 0.0315
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0009 0.0244 0.0613
Schistosoma mansoni hypothetical protein 0.007 0.3471 0.3466
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0019 0.0807 0.0801
Loa Loa (eye worm) hypothetical protein 0.0019 0.0807 0.0809
Schistosoma mansoni importin beta-1 0.0012 0.0419 0.0412
Trichomonas vaginalis CMGC family protein kinase 0.0026 0.1165 0.189
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0753 0.1218
Echinococcus multilocularis thyroid hormone receptor alpha 0.0004 0.0012 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0004 0.0012 0.0006
Giardia lamblia Thioredoxin reductase 0.0019 0.0807 0.1305
Schistosoma mansoni thyroid hormone receptor 0.0004 0.0012 0.0006
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0009 0.0254 0.025
Plasmodium vivax flap endonuclease 1, putative 0.0011 0.0358 0.0355
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0019 0.0807 0.2067
Echinococcus granulosus FTZ F1 alpha 0.0004 0.0012 0.0006
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0807 0.0809
Echinococcus multilocularis cyclin dependent kinase 1 0.0026 0.1165 0.116
Loa Loa (eye worm) hypothetical protein 0.0075 0.3766 0.3799
Trichomonas vaginalis Importin beta-1 subunit, putative 0.001 0.03 0.0479
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0945 0.0939
Brugia malayi cell division control protein 2 homolog 0.0026 0.1165 0.1171
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0807 0.0809
Schistosoma mansoni caspase-3 (C14 family) 0.0048 0.2331 0.2326
Trichomonas vaginalis ran, putative 0.0009 0.0254 0.0403
Giardia lamblia Kinase, CMGC CDK 0.0026 0.1165 0.189
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0055 0.2699 0.2613
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0244 0.024
Echinococcus multilocularis flap endonuclease 1 0.0011 0.0358 0.0352
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0004 0.0012 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0004 0.0012 0.0006
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0753 0.0761
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.073 0.0732
Schistosoma mansoni cytochrome P450 0.0009 0.0244 0.0237
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0019 0.0807 0.1315
Mycobacterium ulcerans hypothetical protein 0.0007 0.015 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0728 0.0729
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0753 0.1218
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0009 0.0254 0.025
Echinococcus multilocularis sodium bile acid cotransporter 0.0075 0.3766 0.3761
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0199 0.0201
Loa Loa (eye worm) cytochrome P450 family protein 0.0009 0.0244 0.024
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0019 0.0807 0.0809
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0004 0.0012 0.0006
Trypanosoma cruzi cdc2-related kinase 1 0.0026 0.1165 0.1171
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0807 0.1305
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0009 0.0244 0.0613
Brugia malayi cytochrome P450 0.0009 0.0244 0.024
Plasmodium vivax metacaspase 1, putative 0.0018 0.0753 0.0754
Trypanosoma brucei trypanothione reductase 0.0192 0.9901 1
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0807 0.0809
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0004 0.0012 0.0006
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0753 0.0761
Mycobacterium ulcerans NADH dehydrogenase 0.0019 0.0807 0.2067
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0016 0.0658 0.0658
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0019 0.0807 0.2972
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0009 0.0254 0.025
Brugia malayi Steroid receptor seven-up type 2 0.0004 0.0012 0.0006
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.2699 0.2721
Brugia malayi Cell death protein 3 precursor 0.0035 0.1647 0.1658
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0004 0.0007 0.0011
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0009 0.0244 0.0613
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0728 0.0729
Trichomonas vaginalis DNA helicase recq, putative 0.001 0.0319 0.0509
Trypanosoma cruzi metacaspase, putative 0.0018 0.0753 0.0754
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0004 0.0012 0.0006
Schistosoma mansoni ran 0.0009 0.0254 0.0247
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0807 0.1305
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0055 0.2699 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0753 0.1218
Brugia malayi ImpB/MucB/SamB family protein 0.0032 0.1498 0.1507
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0019 0.0807 0.0801
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0019 0.0807 0.0583
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0807 0.1305
Leishmania major cytochrome p450-like protein 0.0009 0.0244 0.0096
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0055 0.2699 0.2726
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0009 0.0244 0.0613
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0009 0.0244 0.0613
Mycobacterium leprae putative cytochrome p450 0.0009 0.0244 0.0822
Schistosoma mansoni hypothetical protein 0.0127 0.6474 0.6471
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0019 0.0807 0.0673
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0019 0.0807 0.0809
Entamoeba histolytica recQ family helicase, putative 0.001 0.0319 0.0519
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0019 0.0807 0.2773
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0753 0.1218
Giardia lamblia Fructose-bisphosphate aldolase 0.012 0.6136 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0055 0.2699 0.6956
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.6136 1
Mycobacterium leprae Conserved hypothetical protein 0.0009 0.0244 0.0822
Leishmania major hypothetical protein, conserved 0.0019 0.0807 0.0673
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0026 0.1165 0.1171
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0055 0.2699 0.2694
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0753 0.1218
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0019 0.0807 0.0809
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0244 0.024
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0019 0.0807 0.0583
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0019 0.0807 0.0801
Onchocerca volvulus 0.0017 0.0687 0.181
Mycobacterium ulcerans dehydrogenase 0.0019 0.0807 0.2067
Schistosoma mansoni hypothetical protein 0.0009 0.0244 0.0237
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0009 0.0244 0.0613
Entamoeba histolytica disulphide oxidoreductase, putative 0.0019 0.0807 0.1315
Loa Loa (eye worm) programmed cell death 8 0.0019 0.0807 0.0809
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.2699 0.2721
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0807 0.0809
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.6136 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0026 0.1165 0.116
Schistosoma mansoni hypothetical protein 0.0015 0.0574 0.0568
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0004 0.0012 0.0006
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0055 0.2699 0.2721
Echinococcus multilocularis sodium bile acid cotransporter 0.0075 0.3766 0.3761
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.1522 0.1532
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0004 0.0012 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0004 0.0012 0.0006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0004 0.0012 0.0006
Toxoplasma gondii ATPase, AAA family protein 0.0004 0.0007 0.0007
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0055 0.2699 0.2721
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0055 0.2699 0.2721
Brugia malayi glutathione reductase 0.0192 0.9901 1
Loa Loa (eye worm) cytochrome P450 0.0009 0.0244 0.024
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0059 0.2892 0.2742
Loa Loa (eye worm) hypothetical protein 0.0018 0.0728 0.0729
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0055 0.2699 0.9331
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0018 0.0753 0.0754
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0753 0.1218
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0055 0.2699 0.2613
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0026 0.1165 0.1177
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0199 0.0195
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0807 0.0809
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.012 0.6136 1
Brugia malayi Thioredoxin reductase 0.0192 0.9901 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0009 0.0244 0.0613
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.015 0.0145
Brugia malayi photoreceptor-specific nuclear receptor 0.0004 0.0012 0.0006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0004 0.0012 0.0006
Schistosoma mansoni transcription factor LCR-F1 0.0015 0.0574 0.0568
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.6136 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0004 0.0012 0.0006
Trypanosoma cruzi cdc2-related kinase 1 0.0026 0.1165 0.1171
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0009 0.0244 0.0613
Schistosoma mansoni sodium-bile acid cotransporter 0.0045 0.2155 0.2149
Trypanosoma cruzi DNA polymerase kappa, putative 0.0033 0.1522 0.1532
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0004 0.0012 0.0006
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0945 0.0939
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0026 0.1165 0.116
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0777 0.1257
Plasmodium falciparum glutathione reductase 0.0192 0.9901 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0004 0.0012 0.0006
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0009 0.0244 0.024
Brugia malayi steroid hormone receptor 0.0004 0.0012 0.0006
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0945 0.0948
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0019 0.0807 0.0809
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0019 0.0807 0.0801
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0004 0.0012 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.6136 1
Echinococcus granulosus geminin 0.007 0.3471 0.3466
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0807 0.0801
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0703 0.0704
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.2699 0.2721
Leishmania major DNA polymerase eta, putative 0.0017 0.0703 0.0567
Brugia malayi Cytochrome P450 family protein 0.0009 0.0244 0.024
Echinococcus multilocularis 0.0009 0.0244 0.0237
Giardia lamblia DNA damage repair protein 0.0007 0.015 0.0235
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0753 0.1218
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.073 0.0732
Entamoeba histolytica hypothetical protein 0.0015 0.0574 0.0935
Trypanosoma brucei metacaspase MCA2 0.0018 0.0753 0.0754
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0004 0.0012 0.0006
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.015 0.0145
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.2699 0.2721
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0807 0.0809
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0008 0.0199 0.0193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0004 0.0012 0.0006
Loa Loa (eye worm) RecQ helicase 0.0019 0.0777 0.0779
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0026 0.1165 0.1041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0004 0.0012 0.0006
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0945 0.0939
Leishmania major trypanothione reductase 0.0192 0.9901 1
Echinococcus multilocularis importin subunit beta 1 0.0012 0.0419 0.0412
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0004 0.0012 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.1522 0.1532
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0009 0.0244 0.0096
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0036 0.1685 0.1696
Brugia malayi Protein kinase domain containing protein 0.0026 0.1165 0.1171
Toxoplasma gondii thioredoxin reductase 0.0192 0.9901 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0009 0.0244 0.0613
Trypanosoma brucei cytochrome P450, putative 0.0009 0.0244 0.024
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0019 0.0807 0.0583
Trichomonas vaginalis importin beta-1, putative 0.001 0.03 0.0479
Schistosoma mansoni DNA polymerase eta 0.0032 0.1498 0.1492
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0807 0.0815
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.015 0.0145
Trypanosoma brucei Metacaspase-4 0.0018 0.0753 0.0754
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0004 0.0012 0.0015
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0009 0.0244 0.024
Echinococcus granulosus GTP binding nuclear protein Ran 0.0009 0.0254 0.0247
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0019 0.0807 0.0809
Trypanosoma brucei metacaspase 0.0018 0.0753 0.0754
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0753 0.1218
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0.015 0.0145
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0008 0.0199 0.0195
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0009 0.0244 0.0613
Echinococcus multilocularis sodium bile acid cotransporter 0.0075 0.3766 0.3761
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0009 0.0244 0.024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0004 0.0012 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0807 0.0809
Brugia malayi Protein kinase domain containing protein 0.0092 0.467 0.4714
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0753 0.1218
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.1379 0.1387
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0009 0.0244 0.0613
Plasmodium vivax thioredoxin reductase, putative 0.0192 0.9901 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0055 0.2699 0.2721
Plasmodium vivax glutathione reductase, putative 0.0192 0.9901 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.012 0.6136 1
Brugia malayi ecdysteroid receptor 0.0004 0.0012 0.0006

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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