Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0193 | 0.2636 | 0.2636 | |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium leprae | Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium leprae | POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0657 | 1 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0193 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.7364 | 0.7364 |
Toxoplasma gondii | propionate-CoA ligase | 0.0193 | 0.2636 | 1 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0193 | 0.2636 | 0.2636 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0657 | 1 | 1 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0193 | 0.2636 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.7364 | 0.7364 |
Brugia malayi | AMP-binding enzyme family protein | 0.0657 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0464 | 0.6939 | 0.6939 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0193 | 0.2636 | 0.2636 |
Giardia lamblia | Hypothetical protein | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0193 | 0.2636 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0193 | 0.2636 | 0.2636 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0491 | 0.7364 | 1 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0193 | 0.2636 | 0.2636 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0657 | 1 | 1 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0464 | 0.6939 | 0.6939 |
Giardia lamblia | Long chain fatty acid CoA ligase, putative | 0.0027 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0657 | 1 | 1 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0657 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0657 | 1 | 1 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0193 | 0.2636 | 0.2636 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0193 | 0.2636 | 0.2636 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0193 | 0.2636 | 1 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 1 |
Onchocerca volvulus | 0.0193 | 0.2636 | 0.2636 | |
Loa Loa (eye worm) | hypothetical protein | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0657 | 1 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0193 | 0.2636 | 0.2636 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0193 | 0.2636 | 0.2636 |
Onchocerca volvulus | 0.0193 | 0.2636 | 0.2636 | |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0193 | 0.2636 | 0.2636 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 0.3579 |
Mycobacterium leprae | POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0491 | 0.7364 | 0.7364 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0464 | 0.6939 | 0.6939 |
Loa Loa (eye worm) | oxidoreductase | 0.0193 | 0.2636 | 0.2636 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0193 | 0.2636 | 1 |
Giardia lamblia | Long chain fatty acid CoA ligase 5 | 0.0027 | 0 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0657 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0491 | 0.7364 | 0.7364 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.7364 | 0.7364 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.7364 | 0.7364 |
Treponema pallidum | long-chain-fatty-acid--CoA ligase | 0.0027 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0657 | 1 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0193 | 0.2636 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 0.3579 |
Mycobacterium tuberculosis | PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0166 | 0.221 | 0.221 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0491 | 0.7364 | 0.5 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0193 | 0.2636 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0657 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | hypothetical protein | 0.0657 | 1 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0193 | 0.2636 | 0.2636 |
Brugia malayi | AMP-binding enzyme family protein | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0193 | 0.2636 | 0.2636 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0491 | 0.7364 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0193 | 0.2636 | 0.2636 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0193 | 0.2636 | 1 |
Giardia lamblia | Long chain fatty acid CoA ligase 4 | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.7364 | 0.7364 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0193 | 0.2636 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0657 | 1 | 1 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0193 | 0.2636 | 1 |
Mycobacterium ulcerans | acetyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0657 | 1 | 1 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0193 | 0.2636 | 1 |
Onchocerca volvulus | 0.0657 | 1 | 1 | |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0193 | 0.2636 | 0.2636 |
Giardia lamblia | Long chain fatty acid CoA ligase 5 | 0.0027 | 0 | 0.5 |
Mycobacterium ulcerans | O-succinylbenzoic acid--CoA ligase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Onchocerca volvulus | 0.0193 | 0.2636 | 0.2636 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0193 | 0.2636 | 0.2636 |
Giardia lamblia | Long chain fatty acid CoA ligase 5 | 0.0027 | 0 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0657 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0657 | 1 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0193 | 0.2636 | 1 |
Giardia lamblia | Long chain fatty acid CoA ligase 5 | 0.0027 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0193 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0464 | 0.6939 | 0.6939 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0193 | 0.2636 | 0.2636 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.