Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | heat shock protein 90 | 0.0008 | 0.011 | 0.0156 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0014 | 0.0326 | 0.074 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0008 | 0.011 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.0273 | 0.0165 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0008 | 0.011 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0026 | 0.0773 | 0.1549 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0026 | 0.0773 | 0.1945 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0026 | 0.0773 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0326 | 0.0219 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0012 | 0.0273 | 0.0165 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0026 | 0.0773 | 0.0671 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0012 | 0.0273 | 0.0474 |
Trypanosoma brucei | heat shock protein, putative | 0.0008 | 0.011 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0012 | 0.0273 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Brugia malayi | ecdysteroid receptor | 0.0026 | 0.0773 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0273 | 0.0596 |
Trichomonas vaginalis | heat shock protein, putative | 0.0006 | 0.0052 | 0.4732 |
Brugia malayi | steroid hormone receptor | 0.0026 | 0.0773 | 0.0671 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0108 | 0.376 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.376 | 0.7939 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.4707 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0026 | 0.0773 | 0.1443 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.0273 | 0.0165 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0026 | 0.0773 | 0.1443 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0026 | 0.0773 | 0.1945 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0008 | 0.011 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0012 | 0.0273 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0326 | 0.0219 |
Plasmodium vivax | heat shock protein 86, putative | 0.0008 | 0.011 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Brugia malayi | nuclear hormone receptor | 0.0026 | 0.0773 | 0.0671 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0012 | 0.0273 | 0.0165 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0026 | 0.0773 | 0.0671 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0012 | 0.0273 | 0.0354 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0026 | 0.0773 | 0.1945 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0773 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Schistosoma mansoni | nuclear receptor | 0.0012 | 0.0273 | 0.0354 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0026 | 0.0773 | 0.1945 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0026 | 0.0773 | 0.1945 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0026 | 0.0773 | 0.0671 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.0273 | 0.0354 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0026 | 0.0773 | 0.0671 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0026 | 0.0773 | 0.0671 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0026 | 0.0773 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0326 | 0.0219 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0014 | 0.0326 | 0.0589 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0026 | 0.0773 | 0.1443 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0134 | 0.4707 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0026 | 0.0773 | 0.0671 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0026 | 0.0773 | 0.0671 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0026 | 0.0773 | 0.1549 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0012 | 0.0273 | 0.0165 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0108 | 0.376 | 0.7965 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0773 | 0.0671 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0026 | 0.0773 | 0.1549 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0026 | 0.0773 | 0.0671 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0026 | 0.0773 | 0.1945 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0026 | 0.0773 | 0.0671 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0012 | 0.0273 | 0.0354 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0026 | 0.0773 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0773 | 0.0671 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0006 | 0.0052 | 0.4732 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0026 | 0.0773 | 0.0671 |
Trypanosoma brucei | heat shock protein, putative | 0.0008 | 0.011 | 0.5 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0326 | 0.0219 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0026 | 0.0773 | 0.1549 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0026 | 0.0773 | 0.0671 |
Onchocerca volvulus | 0.0026 | 0.0773 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0326 | 0.0219 |
Trypanosoma brucei | heat shock protein, putative | 0.0008 | 0.011 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0773 | 0.0671 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0012 | 0.0273 | 0.0596 |
Schistosoma mansoni | nuclear hormone receptor | 0.0026 | 0.0773 | 0.1443 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0026 | 0.0773 | 0.0671 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0026 | 0.0773 | 0.1443 |
Trichomonas vaginalis | heat shock protein, putative | 0.0008 | 0.011 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0008 | 0.011 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0026 | 0.0773 | 0.0671 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0006 | 0.0052 | 0.5 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0014 | 0.0326 | 0.0471 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0012 | 0.0273 | 0.0474 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0026 | 0.0773 | 0.1443 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0008 | 0.011 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0012 | 0.0273 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0026 | 0.0773 | 0.1549 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0026 | 0.0773 | 0.0671 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0014 | 0.0326 | 0.0471 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0012 | 0.0273 | 0.0596 |
Trypanosoma brucei | heat shock protein, putative | 0.0008 | 0.011 | 0.5 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0006 | 0.0052 | 0.5 |
Trypanosoma brucei | heat shock protein, putative | 0.0008 | 0.011 | 0.5 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0008 | 0.011 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0026 | 0.0773 | 0.1443 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0008 | 0.011 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0026 | 0.0773 | 0.1549 |
Plasmodium falciparum | heat shock protein 90 | 0.0008 | 0.011 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0012 | 0.0273 | 0.0165 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0026 | 0.0773 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Echinococcus multilocularis | heat shock protein | 0.0008 | 0.011 | 0.0124 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0012 | 0.0273 | 0.0474 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0008 | 0.011 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0014 | 0.0326 | 0.0219 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0012 | 0.0273 | 0.0165 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0273 | 0.0474 |
Brugia malayi | conserved hypotetical protein | 0.0012 | 0.0273 | 0.0165 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0012 | 0.0273 | 0.0474 |
Loa Loa (eye worm) | DR-78 | 0.0012 | 0.0273 | 0.0165 |
Echinococcus granulosus | heat shock protein | 0.0008 | 0.011 | 0.0156 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0012 | 0.0273 | 0.0596 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0026 | 0.0773 | 0.0671 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0008 | 0.011 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0026 | 0.0773 | 0.0671 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0026 | 0.0773 | 0.1945 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0026 | 0.0773 | 0.1945 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0008 | 0.011 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0026 | 0.0773 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0773 | 0.0671 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0012 | 0.0273 | 0.0596 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0773 | 0.0671 |
Brugia malayi | tailless protein | 0.0012 | 0.0273 | 0.0165 |
Trichomonas vaginalis | heat shock protein, putative | 0.0006 | 0.0052 | 0.4732 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0014 | 0.0326 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0326 | 0.0219 |
Brugia malayi | nuclear receptor RXR | 0.0012 | 0.0273 | 0.0165 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0026 | 0.0773 | 0.1443 |
Trypanosoma brucei | heat shock protein, putative | 0.0008 | 0.011 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0014 | 0.0326 | 0.0219 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0026 | 0.0773 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0026 | 0.0773 | 0.1549 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0012 | 0.0273 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Trypanosoma brucei | heat shock protein, putative | 0.0008 | 0.011 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0026 | 0.0773 | 0.0671 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0014 | 0.0326 | 0.0219 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.0273 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0026 | 0.0773 | 0.0671 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0026 | 0.0773 | 0.0671 |
Plasmodium vivax | endoplasmin, putative | 0.0008 | 0.011 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.4707 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0012 | 0.0273 | 0.0596 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0008 | 0.011 | 0.5 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0008 | 0.011 | 0.5 |
Trypanosoma brucei | heat shock protein, putative | 0.0008 | 0.011 | 0.5 |
Echinococcus multilocularis | heat shock protein 90 | 0.0008 | 0.011 | 0.0124 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0026 | 0.0773 | 0.1443 |
Treponema pallidum | heat shock protein 90 | 0.0006 | 0.0052 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0026 | 0.0773 | 0.1443 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0026 | 0.0773 | 0.1549 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0026 | 0.0773 | 0.0671 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0008 | 0.011 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0012 | 0.0273 | 0.0354 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0026 | 0.0773 | 0.1443 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0012 | 0.0273 | 0.0165 |
Schistosoma mansoni | zinc finger protein | 0.0012 | 0.0273 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0773 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0773 | 0.0671 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0026 | 0.0773 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0026 | 0.0773 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0012 | 0.0273 | 0.0165 |
Brugia malayi | ecdysone receptor | 0.0012 | 0.0273 | 0.0165 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0006 | 0.0052 | 0.5 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0326 | 0.0219 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0273 | 0.0165 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0012 | 0.0273 | 0.0165 |
Leishmania major | heat shock protein 83-1 | 0.0008 | 0.011 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0026 | 0.0773 | 0.1945 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0006 | 0.0052 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.