Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | 0.0179 | 0.1488 | 0.4056 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0705 | 0.7301 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0376 | 0.3669 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0376 | 0.3669 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0376 | 0.3669 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0376 | 0.3669 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0705 | 0.7301 | 1 |
Leishmania major | thymidine kinase, putative | 0.0705 | 0.7301 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0421 | 0.416 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0376 | 0.3669 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0044 | 0 | 0.5 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0705 | 0.7301 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0376 | 0.3669 | 1 |
Brugia malayi | hypothetical protein | 0.0179 | 0.1488 | 0.4056 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.416 | 0.4597 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0039 | 0.0107 |
Brugia malayi | thymidylate synthase | 0.0376 | 0.3669 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.416 | 0.5 |
Onchocerca volvulus | 0.0376 | 0.3669 | 0.5 | |
Trichomonas vaginalis | thymidine kinase, putative | 0.0705 | 0.7301 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0376 | 0.3669 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0705 | 0.7301 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0705 | 0.7301 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.416 | 0.5 |
Entamoeba histolytica | thymidine kinase, putative | 0.0705 | 0.7301 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.