Detailed information for compound 206919

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 429.465 | Formula: C26H23NO5
  • H donors: 0 H acceptors: 1 LogP: 4.9 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(OCc2ccccc2)c(OC)cc2c1c1cc(OC)cc3c1c(c2)n(c3=O)C
  • InChi: 1S/C26H23NO5/c1-27-20-10-16-11-21(30-3)24(32-14-15-8-6-5-7-9-15)25(31-4)22(16)18-12-17(29-2)13-19(23(18)20)26(27)28/h5-13H,14H2,1-4H3
  • InChiKey: ZIUAXOYUOGMUFT-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2754 1
Onchocerca volvulus 0.0019 0.0416 0.0621
Echinococcus multilocularis dna polymerase eta 0.0088 0.2713 0.75
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0828 0.2267
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0391 0.1382
Brugia malayi Serotonin receptor 0.0014 0.0247 0.0235
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.0247 0.0235
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0014 0.0247 0.0361
Brugia malayi polk-prov protein 0.0048 0.1385 0.1375
Schistosoma mansoni neuropeptide receptor 0.0014 0.0247 0.0247
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0125 0.0113
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0828 0.2267
Loa Loa (eye worm) hypothetical protein 0.001 0.0125 0.0113
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.0247 0.0247
Brugia malayi MH2 domain containing protein 0.0009 0.0079 0.0067
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0828 0.2267
Brugia malayi follicle stimulating hormone receptor 0.0014 0.0247 0.0235
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.0247 0.0235
Trypanosoma cruzi aldo/keto reductase, putative 0.0009 0.008 0.0249
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.0828 0.2976
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0247 0.0247
Trypanosoma brucei aldo-keto reductase, putative 0.0031 0.0828 0.2797
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.001 0.0125 0.0113
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0107 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0391 0.1382
Echinococcus granulosus smad 0.0009 0.0079 0.0187
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0318 0.0851
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0096
Schistosoma mansoni hypothetical protein 0.0014 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.0068 0.2066 0.2066
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0079 0.0067
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.0247 0.0653
Echinococcus multilocularis dna polymerase kappa 0.0089 0.2754 0.7616
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Echinococcus granulosus FTZ F1 alpha 0.001 0.0125 0.0314
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0107 0.0096
Schistosoma mansoni myosin xvIII 0.0014 0.0247 0.0247
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0145 0.0449
Mycobacterium ulcerans glutaminase 0.0305 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Brugia malayi hypothetical protein 0.001 0.0107 0.0096
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.008 0.039
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.0247 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0125 0.0113
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0009 0.008 0.0189
Brugia malayi hypothetical protein 0.0019 0.0416 0.0405
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0125 0.0314
Loa Loa (eye worm) hypothetical protein 0.0135 0.4295 0.4288
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.1812 0.1812
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.0016 0.0318 0.0307
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0125 0.0314
Brugia malayi G-protein coupled receptor 0.0014 0.0247 0.0235
Echinococcus granulosus neuropeptide receptor A26 0.0014 0.0247 0.0653
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0031 0.0828 0.2842
Brugia malayi Cytochrome P450 family protein 0.0013 0.0201 0.0189
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.0247 0.0653
Schistosoma mansoni dishevelled 0.001 0.0107 0.0107
Loa Loa (eye worm) DnaJ domain-containing protein 0.0068 0.2066 0.2057
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0247 0.0653
Schistosoma mansoni smad1 5 8 and 0.0009 0.0079 0.0079
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0145 0.0134
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0828 0.2267
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0012 0.0012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0125 0.0314
Schistosoma mansoni regulator of G protein signaling 0.001 0.0107 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0125 0.0113
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0125 0.0314
Echinococcus granulosus aldo keto reductase 0.0031 0.0828 0.2267
Schistosoma mansoni polycystin 1-related 0.0019 0.0416 0.0416
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.0247 0.0235
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0254 0.0885
Echinococcus granulosus neuropeptide receptor 0.0014 0.0247 0.0653
Echinococcus granulosus neuropeptide s receptor 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Leishmania major prostaglandin f synthase, putative 0.0031 0.0828 0.2842
Trichomonas vaginalis DNA polymerase eta, putative 0.0089 0.2754 0.2746
Brugia malayi Dopamine receptor protein 1 0.0014 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Echinococcus granulosus somatostatin receptor 0.0014 0.0247 0.0653
Brugia malayi hypothetical protein 0.0014 0.0247 0.0235
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0067 0.2007 0.7318
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Schistosoma mansoni biogenic amine receptor 0.0014 0.0247 0.0247
Brugia malayi Dopamine receptor 0.0014 0.0247 0.0235
Onchocerca volvulus 0.0014 0.0247 0.0361
Schistosoma mansoni amine GPCR 0.0014 0.0247 0.0247
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0247 0.0247
Leishmania major DNA polymerase eta, putative 0.0047 0.1344 0.48
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0031 0.0828 1
Echinococcus granulosus g-protein coupled receptor 0.0014 0.0247 0.0653
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2754 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0125 0.0125
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0125 0.0314
Brugia malayi Doublecortin family protein 0.0019 0.0416 0.0405
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Echinococcus multilocularis allatostatin A receptor 0.0014 0.0247 0.0653
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.0247 0.0247
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0145 0.0134
Schistosoma mansoni hypothetical protein 0.0014 0.0247 0.0247
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0125 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0125 0.0113
Brugia malayi Flap endonuclease-1 0.0029 0.0749 0.0738
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0089 0.2754 0.2746
Echinococcus multilocularis smad 0.0009 0.0079 0.0187
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.001 0.0125 0.0113
Schistosoma mansoni amine GPCR 0.0014 0.0247 0.0247
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0247 0.0653
Trypanosoma brucei prostaglandin f synthase 0.0031 0.0828 0.2797
Brugia malayi jmjC domain containing protein 0.0016 0.0318 0.0307
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0079 0.0187
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0718 0.4368
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0247 0.0247
Brugia malayi ORL1-like opioid receptor 0.0014 0.0247 0.0235
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0828 0.0817
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0318 0.0318
Schistosoma mansoni smad 0.0009 0.0079 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0247 0.0247
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0382 0.4515
Loa Loa (eye worm) hypothetical protein 0.0016 0.0318 0.0307
Brugia malayi jmjC domain containing protein 0.0061 0.1812 0.1803
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0125 0.0314
Brugia malayi GnHR receptor homolog 0.0014 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.001 0.0125 0.0113
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.0247 0.0235
Brugia malayi hypothetical protein 0.0014 0.0247 0.0235
Entamoeba histolytica aldose reductase, putative 0.0031 0.0828 0.467
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0247 0.0247
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.0247 0.0653
Echinococcus granulosus aldo keto reductase 0.0031 0.0828 0.2267
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0828 0.0817
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0828 0.2267
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.1812 0.4999
Echinococcus multilocularis aldo keto reductase 0.0031 0.0828 0.2267
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.008 0.0068
Echinococcus multilocularis somatostatin receptor 0.0014 0.0247 0.0653
Schistosoma mansoni aldo-keto reductase 0.0031 0.0828 0.0828
Brugia malayi RE15519p 0.0014 0.0247 0.0235
Schistosoma mansoni dishevelled 0.001 0.0107 0.0107
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0247 0.0247
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.154 0.153
Onchocerca volvulus 0.0014 0.0247 0.0361
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0318 0.1632
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0247 0.0653
Trypanosoma brucei DNA polymerase IV, putative 0.0089 0.2754 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2754 1
Entamoeba histolytica aldose reductase, putative 0.0031 0.0828 0.467
Trypanosoma brucei unspecified product 0.0041 0.1144 0.3978
Schistosoma mansoni hypothetical protein 0.0019 0.0416 0.0416
Echinococcus multilocularis neuropeptide receptor A26 0.0014 0.0247 0.0653
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0318 0.0318
Trypanosoma brucei DNA polymerase IV, putative 0.0089 0.2754 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0828 0.2267
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0107 0.0265
Schistosoma mansoni hypothetical protein 0.0013 0.0198 0.0198
Schistosoma mansoni pol-related 0.0031 0.0828 0.0828
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0318 0.1632
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0247 0.0653
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0125 0.0113
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0318 0.3561
Schistosoma mansoni amine GPCR 0.0014 0.0247 0.0247
Brugia malayi MAP kinase sur-1 0.0053 0.154 0.153
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0828 0.0817
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0828 0.0817
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0391 0.1382
Schistosoma mansoni Smad4 0.0009 0.0079 0.0079
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0749 0.2688
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2754 1
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0125 0.0113
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0145 0.0134
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0523 0.5922
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Echinococcus multilocularis Smad4 0.0009 0.0079 0.0187
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0564 0.7232
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0828 0.2267
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0012 0.0012
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0749 0.0738
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.0011 0.0145 0.0134
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Echinococcus multilocularis neuropeptide s receptor 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.001 0.0125 0.0113
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.0247 0.0653
Leishmania major DNA polymerase kappa, putative 0.0067 0.2007 0.7318
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.0247 0.0653
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.0247 0.0653
Brugia malayi Serotonin receptor 0.0014 0.0247 0.0235
Brugia malayi hypothetical protein 0.0014 0.0247 0.0235
Echinococcus multilocularis aldo keto reductase 0.0031 0.0828 0.2267
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0107 0.0265
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.0048 0.1385 0.1375
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0145 0.0449
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Echinococcus multilocularis RUN 0.0019 0.0416 0.1124
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Schistosoma mansoni biogenic amine receptor 0.0014 0.0247 0.0247
Onchocerca volvulus Neuropeptide F receptor homolog 0.0014 0.0247 0.0361
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.0247 0.0247
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.154 0.5459
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0125 0.0113
Onchocerca volvulus 0.0014 0.0247 0.0361
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0247 0.0653
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0201 0.6527 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0828 0.0817
Onchocerca volvulus 0.0031 0.0828 0.1253
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0247 0.0653
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0828 0.0817
Onchocerca volvulus 0.0014 0.0247 0.0361
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0828 0.2267
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Brugia malayi hypothetical protein 0.0019 0.0416 0.0405
Loa Loa (eye worm) hypothetical protein 0.0019 0.0416 0.0405
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.1385 0.4882
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.176 0.175
Echinococcus granulosus aldehyde reductase 0.0022 0.0523 0.142
Brugia malayi ImpB/MucB/SamB family protein 0.0088 0.2713 0.2704
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0247 0.0653
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0107 0.0265
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.2508 0.9077
Leishmania major DNA polymerase kappa, putative 0.0018 0.0391 0.1181
Plasmodium vivax JmjC domain containing protein 0.0016 0.0318 0.3561
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.3613 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0828 0.2267
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0247 0.0653
Schistosoma mansoni dep domain containing protein 0.001 0.0107 0.0107
Schistosoma mansoni neuropeptide receptor 0.0014 0.0247 0.0247
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0247 0.0247
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.0247 0.0653
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0318 0.0891
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0125 0.0113
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.1344 0.8656
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0145 0.0371
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0012 0.0012
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0318 0.0318
Brugia malayi hypothetical protein 0.0014 0.0247 0.0235
Schistosoma mansoni DNA polymerase eta 0.0088 0.2713 0.2713
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0125 0.0113
Schistosoma mansoni coup transcription factor 0.001 0.0125 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0416 0.1124
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.2754 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.0247 0.0247
Onchocerca volvulus 0.0014 0.0247 0.0361
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0718 0.2384
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0828 0.0817
Brugia malayi hypothetical protein 0.0018 0.0383 0.0372
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0391 0.4649
Onchocerca volvulus 0.0014 0.0247 0.0361
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0828 0.0817
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0254 0.0653
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0125 0.0125
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0828 0.2267
Brugia malayi AKH receptor 0.0014 0.0247 0.0235
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0749 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0318 0.1117
Loa Loa (eye worm) hypothetical protein 0.0019 0.0416 0.0405
Brugia malayi sulfakinin receptor protein 0.0014 0.0247 0.0235
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0247 0.0235
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0201 0.0189
Giardia lamblia DINP protein human, muc B family 0.0067 0.2007 1
Loa Loa (eye worm) RecQ helicase 0.0027 0.0673 0.0662
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Giardia lamblia Aldose reductase 0.0031 0.0828 0.3668
Brugia malayi DnaJ domain containing protein 0.0068 0.2066 0.2057
Schistosoma mansoni loxhd1 0.0019 0.0416 0.0416
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0107 0.0146
Echinococcus granulosus RUN 0.0019 0.0416 0.1124
Loa Loa (eye worm) oxidoreductase 0.0031 0.0828 0.0817
Echinococcus multilocularis voltage gated potassium channel subunit 0.0009 0.008 0.0189
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0198 0.0516
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0201 0.0189
Onchocerca volvulus 0.0014 0.0247 0.0361
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0125 0.0174
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0828 0.0817
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0079 0.0187
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0125 0.0125
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Leishmania major DNA damage repair protein, putative 0.0018 0.0391 0.1181
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0125 0.0125
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0247 0.0653
Brugia malayi Cytochrome P450 family protein 0.0013 0.0201 0.0189
Echinococcus multilocularis serotonin receptor 0.0014 0.0247 0.0653
Schistosoma mansoni rab6-interacting 0.0019 0.0416 0.0416
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0247 0.0653
Echinococcus multilocularis aldo keto reductase 0.0031 0.0828 0.2267
Brugia malayi larval opioid receptor 0.0014 0.0247 0.0235
Giardia lamblia Aldose reductase 0.0031 0.0828 0.3668
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0125 0.0314
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.139 0.49
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0416 0.1124
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.008 0.0068
Echinococcus granulosus phd:f box containing protein 0.0016 0.0318 0.0851
Onchocerca volvulus 0.001 0.0125 0.0174
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.0247 0.0653
Onchocerca volvulus 0.0014 0.0247 0.0361
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0201 0.069
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0318 0.0851
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0247 0.0653
Echinococcus granulosus g protein coupled receptor 0.0014 0.0247 0.0653
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0125 0.0113
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0318 0.0851
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.0247 0.0653
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0125 0.0314
Leishmania major hypothetical protein, conserved 0.0016 0.0318 0.0905
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0107 0.0265
Loa Loa (eye worm) Smad1 0.0009 0.0079 0.0067
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0125 0.0125
Onchocerca volvulus 0.0009 0.008 0.0105
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.2007 0.7204
Brugia malayi jmjC domain containing protein 0.0016 0.0318 0.0307
Brugia malayi putative neuropeptide receptor 0.0014 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0673 0.0662
Loa Loa (eye worm) glutaminase 2 0.0305 1 1
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0749 0.3242
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0828 0.0817
Trypanosoma brucei DNA polymerase eta, putative 0.0088 0.2713 0.9844
Brugia malayi nuclear hormone receptor 0.001 0.0125 0.0113
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.0247 0.0247
Schistosoma mansoni opsin-like receptor 0.0014 0.0247 0.0247
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0145 0.098
Loa Loa (eye worm) oxidoreductase 0.0031 0.0828 0.0817
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.1812 0.4999
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0391 0.1163
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0079 0.0187
Brugia malayi hypothetical protein 0.0014 0.0247 0.0235
Onchocerca volvulus 0.0031 0.0828 0.1253
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0391 0.1163
Echinococcus multilocularis sex peptide receptor 0.0014 0.0247 0.0653
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0125 0.0314
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2754 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0828 0.0817
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0125 0.0174
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0828 0.2267
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.1344 0.4856
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Echinococcus granulosus orexin receptor type 2 0.0014 0.0247 0.0653
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0749 0.2047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.2754 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0247 0.0247
Echinococcus multilocularis G protein coupled receptor 139 0.0014 0.0247 0.0653
Brugia malayi neuropeptide F receptor 0.0014 0.0247 0.0235
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0673 0.1835
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.0247 0.0653
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0067 0.2007 1
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0107 0.0265
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0828 0.0817
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0125 0.0113
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.154 0.5572
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0318 0.0307
Brugia malayi hypothetical protein 0.0014 0.0247 0.0235
Schistosoma mansoni hypothetical protein 0.0014 0.0247 0.0247
Schistosoma mansoni flap endonuclease-1 0.0026 0.0655 0.0655
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0012 0.0012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0125 0.0314
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0749 0.2541
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0828 0.0817
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.154 0.153
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0247 0.0653
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.001 0.0125 0.0113
Trypanosoma brucei protein kinase, putative 0.0053 0.154 0.5459
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.0247 0.0235
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.1812 0.1803
Schistosoma mansoni neuropeptide receptor 0.0014 0.0247 0.0247
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0318 0.0851
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.0247 0.0235
Onchocerca volvulus 0.0014 0.0247 0.0361
Onchocerca volvulus 0.0014 0.0247 0.0361
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Loa Loa (eye worm) oxidoreductase 0.0031 0.0828 0.0817
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0125 0.0113
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0125 0.0113
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0247 0.0247
Leishmania major cytochrome p450-like protein 0.0013 0.0201 0.046
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0391 0.4649
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.154 0.4243
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0391 0.1163
Echinococcus granulosus dna polymerase eta 0.0088 0.2713 0.75
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.1812 0.1812
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0375 0.2019
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0012 0.0012
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.154 0.5546
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0125 0.0125
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0718 0.9533
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0416 0.1124
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0125 0.0113
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.154 0.5572
Onchocerca volvulus 0.0014 0.0247 0.0361
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Echinococcus granulosus neuropeptide receptor 0.0014 0.0247 0.0653
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0828 0.2267
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0107 0.0265
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.154 0.5546
Onchocerca volvulus 0.0014 0.0247 0.0361
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0031 0.0828 0.2842
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0254 0.0663
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.0247 0.0235
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.176 0.4854
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.0247 0.0235
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0145 0.0371
Leishmania major hypothetical protein, conserved 0.0028 0.0718 0.2422
Mycobacterium ulcerans DNA polymerase IV 0.0089 0.2754 0.2696
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0125 0.0125
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0125 0.0314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0107 0.0265
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0391 0.0391
Trypanosoma brucei unspecified product 0.0081 0.2508 0.9077
Echinococcus multilocularis aldo keto reductase 0.0031 0.0828 0.2267
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0718 0.2574
Schistosoma mansoni amine GPCR 0.0014 0.0247 0.0247
Echinococcus granulosus bloom syndrome protein 0.0027 0.0673 0.1835
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0201 0.0122
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.0247 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.139 0.49
Schistosoma mansoni lipoxygenase 0.0114 0.3613 0.3613
Brugia malayi ecdysteroid receptor 0.001 0.0125 0.0113
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0125 0.0113
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0828 0.0817
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0247 0.0235
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.154 0.154
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0318 0.0851
Schistosoma mansoni opsin-like receptor 0.0014 0.0247 0.0247
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0718 0.9533
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0201 0.6527 0.6523
Mycobacterium ulcerans hypothetical protein 0.0018 0.0391 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0125 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0125 0.0113
Echinococcus granulosus dnaJ subfamily C 6 0.0068 0.2066 0.5704
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0828 0.0817
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0828 0.0817
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0318 0.0851
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0718 0.2574
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0107 0.0265
Echinococcus granulosus hypothetical protein 0.0031 0.0828 0.2267
Brugia malayi jmjC domain containing protein 0.0016 0.0318 0.0307
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0416 0.5031
Echinococcus granulosus Smad4 0.0009 0.0079 0.0187
Echinococcus multilocularis serotonin receptor 0.0014 0.0247 0.0653
Trypanosoma cruzi aldo-keto reductase 0.0031 0.0828 0.2976
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0079 0.0067
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0009 0.008 0.0068
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0318 0.0307
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0201 0.069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Schistosoma mansoni rab6-interacting 0.0019 0.0416 0.0416
Onchocerca volvulus 0.0019 0.0416 0.0621
Echinococcus granulosus fmrfamide receptor 0.0014 0.0247 0.0653
Onchocerca volvulus 0.0014 0.0247 0.0361
Schistosoma mansoni glutaminase 0.0305 1 1
Plasmodium falciparum flap endonuclease 1 0.0029 0.0749 1
Mycobacterium ulcerans oxidoreductase 0.0031 0.0828 0.0754
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0318 0.0318
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0125 0.0174
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0828 0.2267
Onchocerca volvulus 0.001 0.0107 0.0146
Trypanosoma brucei unspecified product 0.0041 0.1144 0.3978
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2754 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0247 0.0247
Brugia malayi Dopamine receptor protein 2 0.0014 0.0247 0.0235
Onchocerca volvulus 0.0014 0.0247 0.0361
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0125 0.0314
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0416 0.1124
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.0247 0.0247
Loa Loa (eye worm) oxidoreductase 0.0031 0.0828 0.0817
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0145 0.0371
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0247 0.0653
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.176 1
Onchocerca volvulus 0.0031 0.0828 0.1253
Loa Loa (eye worm) hypothetical protein 0.001 0.0125 0.0113
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0828 0.0817
Brugia malayi G protein-coupled receptor 0.0014 0.0247 0.0235
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.0247 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2754 1
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0391 0.1163
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0026 0.0638 0.382
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0391 0.213
Mycobacterium ulcerans DNA polymerase IV 0.0089 0.2754 0.2696
Schistosoma mansoni histamine h1 receptor 0.0014 0.0247 0.0247
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0828 0.0817
Schistosoma mansoni aldo-keto reductase 0.0031 0.0828 0.0828
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0107 0.0107
Brugia malayi hypothetical protein 0.0014 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.0009 0.0078 0.0067
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0828 0.2267
Loa Loa (eye worm) hypothetical protein 0.0016 0.0318 0.0307
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.0247 0.0235
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0828 0.0817
Brugia malayi Melatonin receptor type 1A 0.0014 0.0247 0.0235
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0254 0.0243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0247 0.0247
Leishmania major aldo-keto reductase-like protein 0.0031 0.0828 0.2842
Trichomonas vaginalis glutaminase, putative 0.0305 1 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0125 0.0113
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.0247 0.0653
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.154 0.153
Schistosoma mansoni DNA helicase recq5 0.0011 0.0145 0.0145
Brugia malayi G-protein coupled receptor 0.0014 0.0247 0.0235
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0673 0.0662
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0247 0.0235
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0125 0.0314
Toxoplasma gondii aldose reductase, putative 0.0031 0.0828 0.5125
Giardia lamblia DNA damage repair protein 0.0018 0.0391 0.1319
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.1812 0.4999
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.154 0.5572
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.154 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.0247 0.0653
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.008 0.039
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.154 0.153
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0125 0.0113
Schistosoma mansoni smad1 5 8 and 0.0009 0.0079 0.0079
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0828 0.0817
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0247 0.0247
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0107 0.0096
Brugia malayi MH1 domain containing protein 0.0009 0.0079 0.0067
Onchocerca volvulus 0.0031 0.0828 0.1253
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.176 0.4854
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.424 0.4234
Schistosoma mansoni neuropeptide receptor 0.0014 0.0247 0.0247
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0125 0.0125
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.2754 1
Onchocerca volvulus 0.0031 0.0828 0.1253
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0247 0.0247
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.0247 0.0247
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.176 0.175
Brugia malayi N-terminal motif family protein 0.0201 0.6527 0.6523
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0749 0.4217
Echinococcus multilocularis dnaJ subfamily C 6 0.0068 0.2066 0.5704
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.3613 1
Brugia malayi MH2 domain containing protein 0.0009 0.0079 0.0067
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0828 0.2267
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0828 0.2267
Echinococcus granulosus hypothetical protein 0.0014 0.0247 0.0653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0247 0.0247
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0318 0.0851
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.154 0.153
Brugia malayi neuropeptide F receptor 0.0014 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0096
Trichomonas vaginalis protein kinase inhibitor, putative 0.0068 0.2066 0.2057
Entamoeba histolytica aldose reductase, putative 0.0031 0.0828 0.467
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0201 0.0189
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0673 0.0662
Loa Loa (eye worm) hypothetical protein 0.0031 0.0828 0.0817
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0107 0.0096
Brugia malayi hypothetical protein 0.0028 0.0718 0.0707
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.139 0.49
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0125 0.0113
Brugia malayi jmjC domain containing protein 0.0016 0.0318 0.0307
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.154 0.4243
Brugia malayi MH1 domain containing protein 0.0009 0.0079 0.0067
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0828 0.2267
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0096
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0749 0.4582
Schistosoma mansoni opsin-like receptor 0.0014 0.0247 0.0247
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0107 0.0265
Brugia malayi NADH-dependent xylose reductase 0.0009 0.008 0.0068
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0318 0.0851
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0828 0.2267
Loa Loa (eye worm) hypothetical protein 0.001 0.0125 0.0113
Brugia malayi Smad1 0.0009 0.0079 0.0067
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.0247 0.0247
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0318 0.1117
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.0247 0.0235
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.1812 0.4999
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Brugia malayi MH2 domain containing protein 0.0133 0.424 0.4234
Echinococcus granulosus g protein coupled receptor 0.0014 0.0247 0.0653
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0247 0.0653
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0749 0.0738
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0107 0.0265
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.2754 1
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0107 0.0107
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0828 0.2267
Echinococcus granulosus serotonin receptor 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0318 0.0307
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.176 0.176
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0009 0.008 0.0068
Onchocerca volvulus 0.0014 0.0247 0.0361
Echinococcus granulosus g protein coupled receptor 0.0014 0.0247 0.0653
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0009 0.008 0.0068
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.0247 0.0653
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0247 0.0653
Brugia malayi hypothetical protein 0.0014 0.0247 0.0235
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0145 0.0371
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0484 0.0484
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Mycobacterium tuberculosis Conserved protein 0.0009 0.008 0.0294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0125 0.0113
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.0247 0.0653
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0198 0.0516
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0125 0.0314
Schistosoma mansoni lipoxygenase 0.008 0.2458 0.2458
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Schistosoma mansoni jumonji domain containing protein 0.0061 0.1812 0.1812
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.0247 0.0653
Schistosoma mansoni thyroid hormone receptor 0.001 0.0125 0.0125
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.154 0.4243
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2754 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0247 0.0653
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.008 0.0068
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0247 0.0653
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0247 0.0653
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0125 0.0113
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0247 0.0653
Loa Loa (eye worm) hypothetical protein 0.0028 0.0718 0.0707
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.154 0.7492
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0247 0.0247
Loa Loa (eye worm) glutaminase 0.0305 1 1
Onchocerca volvulus 0.0014 0.0247 0.0361
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Echinococcus granulosus voltage gated potassium channel subunit 0.0009 0.008 0.0189
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0254 0.1389
Onchocerca volvulus 0.0031 0.0828 0.1253
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0247 0.0653
Schistosoma mansoni hypothetical protein 0.0014 0.0247 0.0247
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0247 0.0653
Trypanosoma cruzi DNA polymerase eta, putative 0.0088 0.2713 0.9848
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Echinococcus multilocularis aldehyde reductase 0.0022 0.0523 0.142
Schistosoma mansoni DNA helicase recq1 0.0011 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0088 0.2713 0.2704
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0828 0.2267
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0247 0.0247
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0125 0.0113
Schistosoma mansoni biogenic amine receptor 0.0014 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Echinococcus granulosus flap endonuclease 1 0.0029 0.0749 0.2047
Loa Loa (eye worm) oxidoreductase 0.0031 0.0828 0.0817
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0079 0.0187
Echinococcus granulosus aldo keto reductase 0.0031 0.0828 0.2267
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0247 0.0653
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0201 0.0452
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0718 0.9533
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0125 0.0314
Brugia malayi jmjC domain containing protein 0.0061 0.1812 0.1803
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0247 0.0653
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0416 0.1124
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0014 0.0247 0.0235
Echinococcus granulosus sex peptide receptor 0.0014 0.0247 0.0653
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.0247 0.0247
Onchocerca volvulus 0.0014 0.0247 0.0361
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.0247 0.0653
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.176 0.176
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.154 0.5572
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0318 0.0851
Schistosoma mansoni thyroid hormone receptor 0.001 0.0125 0.0125
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0125 0.0113
Echinococcus granulosus dna polymerase kappa 0.0089 0.2754 0.7616
Schistosoma mansoni potassium channel beta 0.0009 0.008 0.008
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0828 0.0817
Brugia malayi hypothetical protein 0.0014 0.0247 0.0235
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Leishmania major DNA polymerase eta, putative 0.0088 0.2713 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0828 0.4063
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0416 0.1124
Brugia malayi DIX domain containing protein 0.001 0.0107 0.0096
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.176 0.8757
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.0247 0.0235
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0107 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.1385 0.4882
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0125 0.0113
Echinococcus multilocularis orexin receptor type 2 0.0014 0.0247 0.0653
Schistosoma mansoni adenoreceptor 0.0014 0.0247 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2754 1
Echinococcus granulosus allatostatin A receptor 0.0014 0.0247 0.0653
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.424 0.4234
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0749 0.2501
Schistosoma mansoni amine GPCR 0.0014 0.0247 0.0247
Brugia malayi hypothetical protein 0.001 0.0107 0.0096
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0828 0.0817
Schistosoma mansoni smad1 5 8 and 0.0009 0.0079 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0391 0.1163
Brugia malayi hypothetical protein 0.0014 0.0247 0.0235
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0391 0.1382
Toxoplasma gondii hypothetical protein 0.001 0.0107 0.0187
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.0247 0.0653
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.0247 0.0653
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0247 0.0653
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0416 0.0405
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0125 0.0314
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0416 0.5031
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0235
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0125 0.0125
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.154 0.4243
Brugia malayi steroid hormone receptor 0.001 0.0125 0.0113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0247 0.0653
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0125 0.0125
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0079 0.0079
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0318 0.0318
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.008 0.0068

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 10 uM In vitro cytotoxic activity against L1210 murine leukemia cells ChEMBL. 12443775
IC50 (functional) > 10 uM In vitro cytotoxic activity against L1210 murine leukemia cells ChEMBL. 12443775

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 12443775

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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