TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.397 | Formula: C16H18FN3OS
H donors: 0 H acceptors: 2 LogP: 2.37 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCN(CC1)c1ccccc1F)CCc1nccs1
InChi: 1S/C16H18FN3OS/c17-13-3-1-2-4-14(13)19-8-10-20(11-9-19)16(21)6-5-15-18-7-12-22-15/h1-4,7,12H,5-6,8-11H2
InChiKey: SQTRCPFBCCXWNJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	enteropeptidase	0.0028	0.0031	0.0032
Echinococcus granulosus	microtubule associated protein 2	0.0637	0.2741	0.3882
Echinococcus multilocularis	beta LACTamase domain containing family member	0.007	0.0221	0.0301
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0042	0.0096	0.4105
Brugia malayi	TAR-binding protein	0.0034	0.006	0.0073
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0278	0.1142	0.161
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.007	0.0221	0.1117
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0337	0.1404	0.7351
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0031	0.0022
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0042	0.0096	0.0624
Echinococcus multilocularis	lamin dm0	0.0033	0.0053	0.0062
Loa Loa (eye worm)	hypothetical protein	0.007	0.0221	0.0301
Brugia malayi	hypothetical protein	0.0025	0.0017	0.0012
Echinococcus granulosus	beta LACTamase domain containing family member	0.007	0.0221	0.0301
Onchocerca volvulus		0.0278	0.1142	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0053	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1142	0.161
Leishmania major	hypothetical protein, conserved	0.007	0.0221	1
Schistosoma mansoni	hypothetical protein	0.0127	0.0471	0.0462
Loa Loa (eye worm)	carboxylesterase	0.0278	0.1142	0.161
Echinococcus multilocularis	neuroligin	0.0278	0.1142	0.161
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0031	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0123	0.0162
Brugia malayi	RNA binding protein	0.0034	0.006	0.0073
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.0221	0.1871
Loa Loa (eye worm)	hypothetical protein	0.1605	0.7045	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0278	0.1142	0.161
Schistosoma mansoni	aldehyde dehydrogenase	0.0045	0.011	0.0101
Loa Loa (eye worm)	beta-lactamase	0.007	0.0221	0.0301
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0278	0.1142	1
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0031	0.016
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0009	0.5
Entamoeba histolytica	hypothetical protein	0.0025	0.0017	1
Schistosoma mansoni	tar DNA-binding protein	0.0034	0.006	0.0051
Brugia malayi	beta-lactamase	0.007	0.0221	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0031	0.0032
Loa Loa (eye worm)	acetylcholinesterase 1	0.1605	0.7045	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0028	0.0031	0.0022
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0042	0.0096	0.4105
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0031	0.0032
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0053	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1142	0.161
Onchocerca volvulus		0.0048	0.0123	0.1079
Entamoeba histolytica	hypothetical protein	0.0025	0.0017	1
Brugia malayi	hypothetical protein	0.0278	0.1142	0.161
Echinococcus granulosus	tar DNA binding protein	0.0034	0.006	0.0073
Mycobacterium tuberculosis	Probable lipase LipD	0.007	0.0221	0.1117
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0028	0.0031	0.0032
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0028	0.0031	0.0032
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0028	0.0031	0.0032
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0042	0.0096	0.5
Mycobacterium tuberculosis	Probable hydrolase	0.007	0.0221	0.1117
Onchocerca volvulus		0.0278	0.1142	1
Mycobacterium ulcerans	lipase LipD	0.007	0.0221	0.1519
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0045	0.011	0.0722
Mycobacterium ulcerans	esterase/lipase LipP	0.007	0.0221	0.1519
Mycobacterium tuberculosis	Conserved protein	0.007	0.0221	0.1117
Echinococcus granulosus	BC026374 protein S09 family	0.0278	0.1142	0.161
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0053	0.0062
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.007	0.0221	0.1117
Trichomonas vaginalis	spcc417.12 protein, putative	0.0278	0.1142	1
Echinococcus granulosus	lamin	0.0033	0.0053	0.0062
Echinococcus granulosus	protein tyrosine kinase	0.0153	0.059	0.0826
Onchocerca volvulus		0.0278	0.1142	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0221	0.0301
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0048	0.0123	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0031	0.0032
Brugia malayi	Carboxylesterase family protein	0.0278	0.1142	0.161
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0045	0.011	0.0722
Onchocerca volvulus		0.007	0.0221	0.1934
Trichomonas vaginalis	esterase, putative	0.007	0.0221	0.1871
Schistosoma mansoni	hypothetical protein	0.0127	0.0471	0.0462
Schistosoma mansoni	gabp alpha	0.0039	0.0082	0.0073
Schistosoma mansoni	acetylcholinesterase	0.0278	0.1142	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0123	0.0162
Trypanosoma brucei	hypothetical protein, conserved	0.007	0.0221	1
Schistosoma mansoni	microtubule-associated protein tau	0.0637	0.2741	0.2734
Entamoeba histolytica	hypothetical protein	0.0025	0.0017	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0278	0.1142	0.5968
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.0221	0.0212
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0042	0.0096	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0096	0.0124
Onchocerca volvulus		0.0028	0.0031	0.0273
Echinococcus granulosus	glycoprotein Antigen 5	0.0028	0.0031	0.0032
Schistosoma mansoni	BC026374 protein (S09 family)	0.0278	0.1142	0.1134
Echinococcus granulosus	lamin dm0	0.0033	0.0053	0.0062
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.0221	0.0212
Schistosoma mansoni	gliotactin	0.0278	0.1142	0.1134
Echinococcus multilocularis	lamin	0.0033	0.0053	0.0062
Plasmodium vivax	hypothetical protein, conserved	0.007	0.0221	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0045	0.011	0.4755
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1142	0.161
Echinococcus multilocularis	acetylcholinesterase	0.1605	0.7045	1
Loa Loa (eye worm)	TAR-binding protein	0.0034	0.006	0.0073
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.0221	0.1871
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.0221	0.1871
Onchocerca volvulus		0.0033	0.0053	0.0462
Brugia malayi	Carboxylesterase family protein	0.1605	0.7045	1
Echinococcus multilocularis	Mastin	0.0028	0.0031	0.0032
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0031	0.0022
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0028	0.0031	0.0022
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0039	0.0082	0.0104
Brugia malayi	Ets-domain containing protein	0.0039	0.0082	0.0104
Brugia malayi	Carboxylesterase family protein	0.0278	0.1142	0.161
Brugia malayi	Fli-1 protein	0.0119	0.0436	0.0608
Schistosoma mansoni	tar DNA-binding protein	0.0034	0.006	0.0051
Brugia malayi	Trypsin family protein	0.0028	0.0031	0.0032
Entamoeba histolytica	hypothetical protein	0.0025	0.0017	1
Onchocerca volvulus		0.0278	0.1142	1
Schistosoma mansoni	tar DNA-binding protein	0.0034	0.006	0.0051
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.007	0.0221	0.1117
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0045	0.011	0.0722
Brugia malayi	Trypsin family protein	0.0028	0.0031	0.0032
Schistosoma mansoni	peptidase Clp (S14 family)	0.0042	0.0096	0.0087
Brugia malayi	Carboxylesterase family protein	0.1605	0.7045	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0278	0.1142	0.1134
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0042	0.0096	0.3414
Echinococcus granulosus	neuroligin	0.0278	0.1142	0.161
Echinococcus granulosus	geminin	0.0127	0.0471	0.0657
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0031	0.0022
Mycobacterium leprae	conserved hypothetical protein	0.007	0.0221	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1605	0.7045	0.7042
Brugia malayi	hypothetical protein	0.0028	0.0031	0.0032
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0028	0.0031	0.0117
Schistosoma mansoni	lamin	0.0033	0.0053	0.0044
Brugia malayi	Carboxylesterase family protein	0.0278	0.1142	0.161
Brugia malayi	Probable ClpP-like protease	0.0042	0.0096	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1142	0.161
Echinococcus multilocularis	para nitrobenzyl esterase	0.0278	0.1142	0.161
Echinococcus granulosus	Mastin	0.0028	0.0031	0.0032
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0278	0.1142	0.5968
Schistosoma mansoni	tar DNA-binding protein	0.0034	0.006	0.0051
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0042	0.0096	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0028	0.0031	0.0022
Onchocerca volvulus		0.0028	0.0031	0.0273
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0028	0.0031	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0031	0.0032
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0031	0.0022
Mycobacterium tuberculosis	Conserved protein	0.007	0.0221	0.1117
Schistosoma mansoni	hypothetical protein	0.0028	0.0031	0.0022
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0042	0.0096	0.0124
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0278	0.1142	0.161
Echinococcus granulosus	transmembrane protease serine 3	0.0028	0.0031	0.0032
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0042	0.0096	0.0124
Loa Loa (eye worm)	RNA binding protein	0.0034	0.006	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0031	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0057	0.0068
Mycobacterium tuberculosis	Probable lipase LipE	0.007	0.0221	0.1117
Schistosoma mansoni	hypothetical protein	0.0025	0.0017	0.0008
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0028	0.0031	0.0032
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.0221	1
Mycobacterium tuberculosis	Conserved protein	0.007	0.0221	0.1117
Schistosoma mansoni	tyrosine kinase	0.0153	0.059	0.0582
Echinococcus multilocularis	acetylcholinesterase	0.1605	0.7045	1
Echinococcus multilocularis	musashi	0.0033	0.0053	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1142	0.161
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0042	0.0096	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0221	0.0301
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0042	0.0096	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0031	0.0022
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0045	0.011	0.0143
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.007	0.0221	0.0301
Onchocerca volvulus		0.0028	0.0031	0.0273
Loa Loa (eye worm)	carboxylesterase	0.0278	0.1142	0.161
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0048	0.0123	0.0114
Echinococcus multilocularis	carboxylesterase 5A	0.1605	0.7045	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0031	0.0022
Toxoplasma gondii	ABC1 family protein	0.007	0.0221	1
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.0221	1
Schistosoma mansoni	lamin	0.0033	0.0053	0.0044
Echinococcus granulosus	acetylcholinesterase	0.1605	0.7045	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0042	0.0096	0.4105
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0025	0.0017	0.0012
Onchocerca volvulus		0.0278	0.1142	1
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0028	0.0031	0.0032
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0045	0.011	0.4755
Onchocerca volvulus		0.0028	0.0031	0.0273
Mycobacterium ulcerans	carboxylesterase, LipT	0.0337	0.1404	1
Mycobacterium leprae	Probable lipase LipE	0.007	0.0221	1
Echinococcus multilocularis	microtubule associated protein 2	0.0637	0.2741	0.3882
Loa Loa (eye worm)	carboxylesterase	0.1605	0.7045	1
Brugia malayi	beta-lactamase family protein	0.007	0.0221	0.0301
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0278	0.1142	0.1134
Mycobacterium tuberculosis	Probable esterase LipL	0.007	0.0221	0.1117
Schistosoma mansoni	tar DNA-binding protein	0.0034	0.006	0.0051
Echinococcus multilocularis	protein tyrosine kinase	0.0153	0.059	0.0826
Onchocerca volvulus		0.0028	0.0031	0.0273
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0031	0.0022
Schistosoma mansoni	aldehyde dehydrogenase	0.0045	0.011	0.0101
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0031	0.0022
Brugia malayi	Carboxylesterase family protein	0.0278	0.1142	0.161
Loa Loa (eye worm)	hypothetical protein	0.007	0.0221	0.0301
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0028	0.0031	0.0022
Echinococcus granulosus	acetylcholinesterase	0.1605	0.7045	1
Onchocerca volvulus		0.007	0.0221	0.1934
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1142	0.161
Echinococcus granulosus	peptidase Clp S14 family	0.0028	0.0031	0.0032
Brugia malayi	Trypsin family protein	0.0048	0.0123	0.0162
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0031	0.0022
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0053	0.0062
Echinococcus granulosus	carboxylesterase 5A	0.1605	0.7045	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0053	0.0062
Echinococcus multilocularis	transmembrane protease serine 3	0.0028	0.0031	0.0032
Mycobacterium ulcerans	beta-lactamase	0.007	0.0221	0.1519
Echinococcus multilocularis	glycoprotein Antigen 5	0.0028	0.0031	0.0032
Echinococcus granulosus	GA binding protein alpha chain	0.0039	0.0082	0.0104
Onchocerca volvulus		0.007	0.0221	0.1934
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0278	0.1142	0.1134
Onchocerca volvulus		0.0033	0.0053	0.0462
Brugia malayi	Trypsin-like protease protein 5	0.0028	0.0031	0.0032
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0031	0.0022
Schistosoma mansoni	transcription factor LCR-F1	0.0025	0.0017	0.0008
Echinococcus multilocularis	GA binding protein alpha chain	0.0039	0.0082	0.0104
Brugia malayi	intermediate filament protein	0.0033	0.0053	0.0062
Loa Loa (eye worm)	trypsin family protein	0.0028	0.0031	0.0032
Brugia malayi	Protein kinase domain containing protein	0.0155	0.0598	0.0837
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0278	0.1142	0.161
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.0221	0.1871
Brugia malayi	RNA recognition motif domain containing protein	0.0034	0.006	0.0073
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0042	0.0096	0.0624
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.0221	0.1871
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.007	0.0221	0.0301
Mycobacterium ulcerans	hypothetical protein	0.007	0.0221	0.1519
Loa Loa (eye worm)	hypothetical protein	0.007	0.0221	0.0301
Echinococcus granulosus	intermediate filament protein	0.0033	0.0053	0.0062
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0034	0.006	0.0073
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0413	0.1743	0.1735
Loa Loa (eye worm)	hypothetical protein	0.007	0.0221	0.0301
Loa Loa (eye worm)	TK/FAK protein kinase	0.0155	0.0598	0.0837
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0045	0.011	0.0531
Brugia malayi	Ets-domain containing protein	0.0039	0.0082	0.0104
Brugia malayi	Trypsin family protein	0.0028	0.0031	0.0032
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0028	0.0031	0.0022
Loa Loa (eye worm)	hypothetical protein	0.1605	0.7045	1
Echinococcus granulosus	enteropeptidase	0.0028	0.0031	0.0032
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0025	0.0017	0.0012
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0028	0.0031	0.0022
Schistosoma mansoni	hypothetical protein	0.0028	0.0031	0.0022
Schistosoma mansoni	ets-related	0.0119	0.0436	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0032	0.005	0.0059
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.045	0.1907	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0278	0.1142	0.1134
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.007	0.0221	0.1519
Loa Loa (eye worm)	fli-1 protein	0.0119	0.0436	0.0608
Brugia malayi	beta-lactamase family protein	0.007	0.0221	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1142	0.161
Echinococcus multilocularis	geminin	0.0127	0.0471	0.0657
Echinococcus multilocularis	tar DNA binding protein	0.0034	0.006	0.0073
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0045	0.011	0.0143
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0028	0.0031	0.0032

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3495804

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2069230