Detailed information for compound 2069232

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 341.408 | Formula: C18H23N5O2
  • H donors: 1 H acceptors: 3 LogP: 1.61 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)NC(=O)N1CCN(CC1)Cc1noc(n1)C1CC1
  • InChi: 1S/C18H23N5O2/c1-13-2-6-15(7-3-13)19-18(24)23-10-8-22(9-11-23)12-16-20-17(25-21-16)14-4-5-14/h2-3,6-7,14H,4-5,8-12H2,1H3,(H,19,24)
  • InChiKey: YJAZQDMOLAFCDL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0025 0.0067 0.0095
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0025 0.0067 0.0095
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1605 0.706 0.706
Schistosoma mansoni acetylcholinesterase 0.0278 0.1186 0.1186
Mycobacterium tuberculosis Conserved protein 0.007 0.027 0.1369
Schistosoma mansoni hypothetical protein 0.0127 0.0518 0.0518
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0278 0.1186 0.168
Loa Loa (eye worm) TK/FAK protein kinase 0.0155 0.0645 0.0914
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0081 0.0081
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0035 0.005
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0037 0.0053
Echinococcus granulosus Mastin 0.0028 0.0081 0.0115
Brugia malayi hypothetical protein 0.0028 0.0081 0.0115
Schistosoma mansoni apoferritin-2 0.001 0.0004 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0034 0.011 0.011
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0037 0.0296
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0059 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0045 0.0159 0.1077
Echinococcus multilocularis tar DNA binding protein 0.0034 0.011 0.0155
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0059 0.0452
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.027 0.1369
Echinococcus multilocularis acetylcholinesterase 0.1605 0.706 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0037 0.0053
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0042 0.0145 0.4965
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0042 0.0145 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0037 0.0053
Schistosoma mansoni lamin 0.0033 0.0102 0.0102
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0037 0.0053
Loa Loa (eye worm) hypothetical protein 0.007 0.027 0.0382
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0081 0.0081
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0059 0.3892
Mycobacterium tuberculosis Conserved protein 0.007 0.027 0.1369
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.007 0.027 0.0382
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0115
Onchocerca volvulus 0.0011 0.0006 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.027 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0045 0.0159 0.1077
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0037 0.0053
Brugia malayi Trypsin family protein 0.0028 0.0081 0.0115
Trypanosoma brucei hypothetical protein, conserved 0.007 0.027 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1186 0.168
Brugia malayi Carboxylesterase family protein 0.0278 0.1186 0.168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.007 0.027 0.0382
Loa Loa (eye worm) fli-1 protein 0.0119 0.0484 0.0686
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0059 0.1459
Onchocerca volvulus 0.0278 0.1186 0.9693
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0028 0.0081 0.0115
Loa Loa (eye worm) carboxylesterase 0.1605 0.706 1
Trichomonas vaginalis esterase, putative 0.007 0.027 0.2181
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0102 0.0145
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0028 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0039
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0081 0.0115
Mycobacterium tuberculosis Possible penicillin-binding protein 0.045 0.1948 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0028 0.0039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0037 0.0053
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0037 0.0053
Brugia malayi Fli-1 protein 0.0119 0.0484 0.0686
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0278 0.1186 0.9692
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0011
Brugia malayi Protein kinase domain containing protein 0.0155 0.0645 0.0914
Schistosoma mansoni tar DNA-binding protein 0.0034 0.011 0.011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0045 0.0159 0.1077
Onchocerca volvulus 0.0033 0.0102 0.0828
Entamoeba histolytica hypothetical protein 0.0025 0.0067 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0028 0.0081 0.0081
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0042 0.0145 0.5
Echinococcus multilocularis peptidase Clp (S14 family) 0.0028 0.0081 0.0115
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0037 0.0053
Loa Loa (eye worm) hypothetical protein 0.0032 0.01 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0037 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0037 0.0053
Echinococcus multilocularis expressed protein 0.001 0.0004 0.0005
Brugia malayi steroid hormone receptor 0.0018 0.0037 0.0053
Brugia malayi Trypsin-like protease protein 5 0.0028 0.0081 0.0115
Echinococcus multilocularis BC026374 protein (S09 family) 0.0278 0.1186 0.168
Echinococcus granulosus expressed protein 0.001 0.0004 0.0005
Onchocerca volvulus 0.0278 0.1186 0.9693
Schistosoma mansoni tyrosine kinase 0.0153 0.0637 0.0637
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0037 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0037 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0037 0.0053
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1224 1
Toxoplasma gondii exonuclease III APE 0.0023 0.0059 0.1459
Toxoplasma gondii ABC1 family protein 0.007 0.027 1
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.027 0.2181
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0102 0.0145
Echinococcus granulosus acetylcholinesterase 0.1605 0.706 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0172 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0037 0.0053
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0037 0.0053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0053
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0037 0.0053
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0631 0.0893
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.027 0.027
Onchocerca volvulus 0.007 0.027 0.2196
Onchocerca volvulus 0.0028 0.0081 0.0652
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0059 0.0083
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0045 0.0159 0.4755
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0011 0.0007 0.0009
Brugia malayi Trypsin family protein 0.0048 0.0172 0.0244
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0115
Echinococcus multilocularis lamin dm0 0.0033 0.0102 0.0145
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.107 0.1516
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0053
Brugia malayi Trypsin family protein 0.0028 0.0081 0.0115
Brugia malayi C1-like domain containing protein 0.0011 0.0007 0.0009
Echinococcus granulosus intermediate filament protein 0.0033 0.0102 0.0145
Brugia malayi beta-lactamase family protein 0.007 0.027 0.0382
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0042 0.0145 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0037 0.0053
Entamoeba histolytica hypothetical protein 0.0025 0.0067 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0081 0.0081
Brugia malayi nuclear hormone receptor 0.0018 0.0037 0.0053
Schistosoma mansoni peptidase Clp (S14 family) 0.0042 0.0145 0.0145
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0112 0.0158
Schistosoma mansoni BC026374 protein (S09 family) 0.0278 0.1186 0.1186
Loa Loa (eye worm) beta-lactamase 0.007 0.027 0.0382
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0037 0.0053
Echinococcus multilocularis transmembrane protease serine 3 0.0028 0.0081 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0037 0.0053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0053
Echinococcus granulosus para nitrobenzyl esterase 0.0278 0.1186 0.168
Onchocerca volvulus 0.0278 0.1186 0.9693
Loa Loa (eye worm) trypsin family protein 0.0028 0.0081 0.0115
Mycobacterium ulcerans hypothetical protein 0.007 0.027 0.1843
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0053
Schistosoma mansoni ferritin 0.001 0.0004 0.0004
Plasmodium vivax hypothetical protein, conserved 0.007 0.027 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0042 0.0145 0.0206
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0037 0.0053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0037 0.0037
Brugia malayi beta-lactamase 0.007 0.027 0.0382
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0037 0.0053
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0081 0.0081
Onchocerca volvulus 0.0028 0.0081 0.0652
Loa Loa (eye worm) carboxylesterase 0.0278 0.1186 0.168
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0278 0.1186 0.1186
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0145
Echinococcus multilocularis Mastin 0.0028 0.0081 0.0115
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.027 0.2181
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0037 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0037 0.0053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0053
Brugia malayi RNA binding protein 0.0034 0.011 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0034 0.011 0.011
Loa Loa (eye worm) carboxylesterase 0.0278 0.1186 0.168
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0081 0.0081
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0037 0.0053
Brugia malayi Ets-domain containing protein 0.0039 0.0131 0.0186
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0081 0.0081
Echinococcus granulosus peptidase Clp S14 family 0.0028 0.0081 0.0115
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0028 0.0081 0.0398
Onchocerca volvulus 0.0278 0.1186 0.9693
Loa Loa (eye worm) hypothetical protein 0.007 0.027 0.0382
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0045 0.0159 0.0225
Loa Loa (eye worm) acetylcholinesterase 1 0.1605 0.706 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0413 0.1784 0.1784
Brugia malayi Carboxylesterase family protein 0.1605 0.706 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0102 0.0145
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0042 0.0145 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0278 0.1186 0.6083
Echinococcus granulosus lamin 0.0033 0.0102 0.0145
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0037 0.0296
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0037 0.0037
Schistosoma mansoni ferritin light chain 0.001 0.0004 0.0004
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0081 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.027 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0037 0.0053
Trichomonas vaginalis spcc417.12 protein, putative 0.0278 0.1186 0.9692
Brugia malayi Probable ClpP-like protease 0.0042 0.0145 0.0206
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0115
Echinococcus multilocularis protein tyrosine kinase 0.0153 0.0637 0.0902
Echinococcus granulosus neuroligin 0.0278 0.1186 0.168
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0059 0.0382
Schistosoma mansoni microtubule-associated protein tau 0.0637 0.2777 0.2777
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0059 0.0452
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0118 0.0167
Schistosoma mansoni hypothetical protein 0.0028 0.0081 0.0081
Brugia malayi Carboxylesterase family protein 0.1605 0.706 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0028 0.0081 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0037 0.0053
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.027 0.1369
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0081 0.0081
Onchocerca volvulus 0.007 0.027 0.2196
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.027 0.1369
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0081 0.0081
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0278 0.1186 0.6083
Onchocerca volvulus 0.0011 0.0008 0.0055
Schistosoma mansoni thyroid hormone receptor 0.017 0.071 0.071
Schistosoma mansoni hypothetical protein 0.0028 0.0081 0.0081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0037 0.0053
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0035 0.005
Mycobacterium ulcerans lipase LipD 0.007 0.027 0.1843
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0002
Brugia malayi hypothetical protein 0.0278 0.1186 0.168
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0059 0.0284
Schistosoma mansoni neuroligin 3 (S09 family) 0.0278 0.1186 0.1186
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0037 0.0053
Schistosoma mansoni apoferritin-2 0.001 0.0004 0.0004
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0059 0.3892
Schistosoma mansoni gabp alpha 0.0039 0.0131 0.0131
Echinococcus granulosus glycoprotein Antigen 5 0.0028 0.0081 0.0115
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0037 0.0037
Schistosoma mansoni thyroid hormone receptor 0.017 0.071 0.071
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0167
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0118 0.0118
Schistosoma mansoni aldehyde dehydrogenase 0.0045 0.0159 0.0159
Schistosoma mansoni ferritin 0.001 0.0004 0.0004
Echinococcus multilocularis geminin 0.0127 0.0518 0.0734
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0042 0.0145 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0037 0.0053
Leishmania major hypothetical protein, conserved 0.007 0.027 1
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.027 0.2181
Schistosoma mansoni lamin 0.0033 0.0102 0.0102
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0081 0.0081
Echinococcus granulosus transmembrane protease serine 3 0.0028 0.0081 0.0115
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0045 0.0159 0.0225
Echinococcus granulosus BC026374 protein S09 family 0.0278 0.1186 0.168
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0036
Mycobacterium tuberculosis Conserved protein 0.007 0.027 0.1369
Brugia malayi nuclear receptor NHR-88 0.0018 0.0037 0.0053
Echinococcus multilocularis para nitrobenzyl esterase 0.0278 0.1186 0.168
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0115
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0037 0.0037
Echinococcus multilocularis musashi 0.0033 0.0102 0.0145
Echinococcus multilocularis neuroligin 0.0278 0.1186 0.168
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0042 0.0145 0.0982
Echinococcus multilocularis GA binding protein alpha chain 0.0039 0.0131 0.0186
Schistosoma mansoni ap endonuclease 0.0023 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0025 0.0067 0.0067
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0278 0.1186 0.1186
Onchocerca volvulus 0.0286 0.1224 1
Echinococcus multilocularis carboxylesterase 5A 0.1605 0.706 1
Schistosoma mansoni ferritin 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0002
Echinococcus granulosus GA binding protein alpha chain 0.0039 0.0131 0.0186
Brugia malayi intermediate filament protein 0.0033 0.0102 0.0145
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.027 0.2181
Schistosoma mansoni transcription factor LCR-F1 0.0025 0.0067 0.0067
Schistosoma mansoni protein kinase C mu 0.0011 0.0007 0.0007
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0042 0.0145 0.0982
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0011 0.0007 0.0009
Mycobacterium ulcerans hypothetical protein 0.0028 0.0081 0.0536
Brugia malayi TAR-binding protein 0.0034 0.011 0.0155
Echinococcus multilocularis microtubule associated protein 2 0.0637 0.2777 0.3933
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.027 0.027
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0045 0.0159 0.08
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0028 0.0081 0.0398
Loa Loa (eye worm) hypothetical protein 0.0278 0.1186 0.168
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0037 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0037 0.0053
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.007 0.027 0.0382
Loa Loa (eye worm) hypothetical protein 0.0278 0.1186 0.168
Echinococcus multilocularis lamin 0.0033 0.0102 0.0145
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0037 0.0053
Brugia malayi Ets-domain containing protein 0.0039 0.0131 0.0186
Brugia malayi Carboxylesterase family protein 0.0278 0.1186 0.168
Entamoeba histolytica hypothetical protein 0.0025 0.0067 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0037 0.0053
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0278 0.1186 0.1186
Schistosoma mansoni ferritin 0.001 0.0004 0.0004
Echinococcus granulosus lamin dm0 0.0033 0.0102 0.0145
Echinococcus granulosus tar DNA binding protein 0.0034 0.011 0.0155
Schistosoma mansoni hypothetical protein 0.0127 0.0518 0.0518
Echinococcus granulosus carboxylesterase 5A 0.1605 0.706 1
Brugia malayi beta-lactamase family protein 0.007 0.027 0.0382
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0037 0.0037
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0028 0.0081 0.0115
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0042 0.0145 0.4965
Mycobacterium leprae Probable lipase LipE 0.007 0.027 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1186 0.168
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0118 0.0167
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0037 0.0053
Onchocerca volvulus 0.0028 0.0081 0.0652
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0028 0.0081 0.0115
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0118 0.0167
Loa Loa (eye worm) hypothetical protein 0.0278 0.1186 0.168
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0081 0.0081
Brugia malayi RNA recognition motif domain containing protein 0.0034 0.011 0.0155
Echinococcus granulosus ferritin 0.001 0.0004 0.0005
Onchocerca volvulus 0.0048 0.0172 0.1402
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0037 0.0053
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0015 0.0023 0.1351
Echinococcus multilocularis thyroid hormone receptor alpha 0.017 0.071 0.1005
Echinococcus multilocularis ferritin 0.001 0.0004 0.0005
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0631 0.0893
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.027 0.0382
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0081 0.0081
Plasmodium vivax SET domain protein, putative 0.0036 0.0118 0.3848
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0037 0.0053
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0115
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0028 0.0081 0.2906
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0059 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0037 0.0053
Loa Loa (eye worm) hypothetical protein 0.007 0.027 0.0382
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.027 0.0382
Loa Loa (eye worm) hypothetical protein 0.0278 0.1186 0.168
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0048 0.0172 0.0172
Schistosoma mansoni ferritin light chain 0.001 0.0004 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0037 0.0053
Mycobacterium tuberculosis Carboxylesterase LipT 0.0337 0.1447 0.7426
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0034 0.011 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0037 0.0053
Echinococcus multilocularis glycoprotein Antigen 5 0.0028 0.0081 0.0115
Mycobacterium leprae conserved hypothetical protein 0.007 0.027 1
Echinococcus granulosus acetylcholinesterase 0.1605 0.706 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0151
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0036
Mycobacterium ulcerans carboxylesterase, LipT 0.0337 0.1447 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0081 0.0081
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0037 0.0053
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.027 0.1369
Schistosoma mansoni coup transcription factor 0.0018 0.0037 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0034 0.011 0.011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0059 0.0083
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0048 0.0172 0.0172
Toxoplasma gondii aldehyde dehydrogenase 0.0045 0.0159 0.552
Onchocerca volvulus 0.0021 0.005 0.0399
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0081 0.0081
Brugia malayi ecdysteroid receptor 0.0018 0.0037 0.0053
Echinococcus granulosus microtubule associated protein 2 0.0637 0.2777 0.3933
Loa Loa (eye worm) TAR-binding protein 0.0034 0.011 0.0155
Loa Loa (eye worm) CAMK/PKD protein kinase 0.001 0.0001 0.0002
Onchocerca volvulus 0.0018 0.0037 0.0296
Schistosoma mansoni hypothetical protein 0.0152 0.0631 0.0631
Echinococcus multilocularis acetylcholinesterase 0.1605 0.706 1
Brugia malayi Trypsin family protein 0.0028 0.0081 0.0115
Schistosoma mansoni aldehyde dehydrogenase 0.0045 0.0159 0.0159
Schistosoma mansoni tar DNA-binding protein 0.0034 0.011 0.011
Schistosoma mansoni gliotactin 0.0278 0.1186 0.1186
Schistosoma mansoni intermediate filament proteins 0.0033 0.0102 0.0102
Onchocerca volvulus 0.0028 0.0081 0.0652
Onchocerca volvulus 0.0278 0.1186 0.9693
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0042 0.0145 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0042 0.0145 0.5328
Onchocerca volvulus 0.0033 0.0102 0.0828
Echinococcus granulosus geminin 0.0127 0.0518 0.0734
Loa Loa (eye worm) hypothetical protein 0.0278 0.1186 0.168
Loa Loa (eye worm) hypothetical protein 0.1605 0.706 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0042 0.0145 0.4965
Loa Loa (eye worm) hypothetical protein 0.0042 0.0145 0.0206
Echinococcus granulosus enteropeptidase 0.0028 0.0081 0.0115
Onchocerca volvulus 0.007 0.027 0.2196
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.027 0.1369
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.027 0.0382
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0037 0.0053
Schistosoma mansoni ap endonuclease 0.0023 0.0059 0.0059
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.027 0.1843
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0059 0.2938
Brugia malayi Pre-SET motif family protein 0.0251 0.107 0.1516
Entamoeba histolytica hypothetical protein 0.0025 0.0067 1
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.027 0.2181
Mycobacterium tuberculosis Probable hydrolase 0.007 0.027 0.1369
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0053
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0278 0.1186 0.168
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0037 0.0053
Schistosoma mansoni hypothetical protein 0.0062 0.0235 0.0235
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.027 0.1369
Brugia malayi Carboxylesterase family protein 0.0278 0.1186 0.168
Mycobacterium ulcerans beta-lactamase 0.007 0.027 0.1843
Brugia malayi Carboxylesterase family protein 0.0278 0.1186 0.168
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.027 0.1843
Onchocerca volvulus 0.0028 0.0081 0.0652
Echinococcus multilocularis enteropeptidase 0.0028 0.0081 0.0115
Schistosoma mansoni ets-related 0.0119 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0053
Brugia malayi hypothetical protein 0.0025 0.0067 0.0095
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0037 0.0037
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.027 0.0382
Onchocerca volvulus 0.0036 0.0118 0.0954
Echinococcus granulosus protein tyrosine kinase 0.0153 0.0637 0.0902
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0015 0.0023 0.072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0053
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0118 0.3848
Loa Loa (eye worm) hypothetical protein 0.1605 0.706 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0172 0.0244
Loa Loa (eye worm) RNA binding protein 0.0034 0.011 0.0155
Brugia malayi Pre-SET motif family protein 0.0036 0.0118 0.0167
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0059 0.0083
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0039 0.0131 0.0186
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0118 0.0118

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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