Detailed information for compound 2069235

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 311.385 | Formula: C16H21N7
  • H donors: 1 H acceptors: 4 LogP: 2.38 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nn(c(n1)C)CC1CCCN(C1)c1ncnc2c1cc[nH]2
  • InChi: 1S/C16H21N7/c1-11-20-12(2)23(21-11)9-13-4-3-7-22(8-13)16-14-5-6-17-15(14)18-10-19-16/h5-6,10,13H,3-4,7-9H2,1-2H3,(H,17,18,19)
  • InChiKey: MFFQGZFMLTYYNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.0314 0.0314
Trichomonas vaginalis cdc25b, putative 0.0068 0.0317 0.0945
Loa Loa (eye worm) hypothetical protein 0.0239 0.1417 0.4827
Echinococcus multilocularis Regulator of G protein signaling 20 0.0065 0.0295 0.0295
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0105 0.0554 0.1874
Loa Loa (eye worm) hypothetical protein 0.0452 0.2793 0.9536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0373 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0118 0.3072
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0006 0.0018
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0213 0.1252 0.1252
Schistosoma mansoni zinc finger protein 0.0213 0.1252 0.1252
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0213 0.1252 0.1252
Brugia malayi hypothetical protein 0.0274 0.1644 0.5604
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0068 0.0314 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Brugia malayi Pre-SET motif family protein 0.0068 0.0314 0.1052
Brugia malayi Doublecortin family protein 0.0024 0.0029 0.0079
Echinococcus granulosus regulator of G protein signaling 3 0.0065 0.0295 0.0295
Brugia malayi Regulator of G protein signaling domain containing protein 0.0065 0.0295 0.0988
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0452 0.2793 0.2793
Schistosoma mansoni retinoic acid receptor RXR 0.0452 0.2793 0.2793
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0452 0.2793 0.9536
Loa Loa (eye worm) hypothetical protein 0.0213 0.1252 0.4263
Loa Loa (eye worm) norepinephrine transporter 0.0105 0.0554 0.1874
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0452 0.2793 0.9536
Onchocerca volvulus 0.0213 0.1252 0.3725
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0452 0.2793 0.9536
Loa Loa (eye worm) solute carrier family 6 member 4 0.0105 0.0554 0.1874
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Echinococcus granulosus regulator of G protein signaling 7 0.0065 0.0295 0.0295
Brugia malayi nuclear receptor NHR-88 0.0213 0.1252 0.4263
Loa Loa (eye worm) hypothetical protein 0.0213 0.1252 0.4263
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0329 0.8824
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0019 0 0.5
Brugia malayi nuclear receptor NHR-88 0.0452 0.2793 0.9536
Schistosoma mansoni nuclear receptor nhr-48 0.0213 0.1252 0.1252
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0452 0.2793 0.9536
Brugia malayi hypothetical protein 0.0239 0.1417 0.4827
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0068 0.0317 0.0945
Onchocerca volvulus 0.0105 0.0554 0.1638
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0295 0.0295
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0452 0.2793 0.9536
Echinococcus multilocularis cysteine protease 0.002 0.0006 0.0006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0452 0.2793 0.2793
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0196 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0079
Onchocerca volvulus Protein ultraspiracle homolog 0.0452 0.2793 0.8333
Brugia malayi nuclear hormone receptor family member odr-7 0.0213 0.1252 0.4263
Leishmania major DNA polymerase kappa, putative 0.0025 0.004 0.092
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0452 0.2793 0.2793
Schistosoma mansoni steroid hormone receptor ad4bp 0.0452 0.2793 0.2793
Loa Loa (eye worm) hypothetical protein 0.0213 0.1252 0.4263
Loa Loa (eye worm) hypothetical protein 0.0068 0.0317 0.1063
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0213 0.1252 0.3725
Loa Loa (eye worm) hypothetical protein 0.0063 0.0282 0.0945
Loa Loa (eye worm) hypothetical protein 0.0213 0.1252 0.4263
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0196 0.5186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0452 0.2793 0.9536
Loa Loa (eye worm) RGS-3 protein 0.0065 0.0295 0.0988
Brugia malayi nuclear receptor NHR-67 0.0213 0.1252 0.4263
Leishmania major cathepsin L-like protease 0.0077 0.0373 1
Leishmania major cathepsin L-like protease 0.0077 0.0373 1
Brugia malayi nuclear hormone receptor 0.0452 0.2793 0.9536
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0213 0.1252 0.1252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Echinococcus granulosus expressed protein 0.1265 0.8036 0.8036
Schistosoma mansoni regulator of G protein signaling 0.0065 0.0295 0.0295
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0065 0.0295 0.0988
Onchocerca volvulus 0.0024 0.0029 0.0069
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0006 0.0006
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0065 0.0295 0.0988
Schistosoma mansoni loxhd1 0.0024 0.0029 0.0029
Brugia malayi nuclear hormone receptor family member nhr-6 0.0213 0.1252 0.4263
Onchocerca volvulus 0.0068 0.0317 0.0928
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0019 0 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0295 0.0295
Schistosoma mansoni axis inhibition protein axin 0.0065 0.0295 0.0295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0006 0.0018
Schistosoma mansoni thyroid hormone receptor 0.0452 0.2793 0.2793
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0196 0.5186
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0452 0.2793 0.9536
Loa Loa (eye worm) nuclear receptor NHR-67 0.0213 0.1252 0.4263
Onchocerca volvulus 0.0213 0.1252 0.3725
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0196 0.5169
Echinococcus granulosus Nuclear hormone receptor HR96 0.0213 0.1252 0.1252
Schistosoma mansoni hypothetical protein 0.0393 0.241 0.241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0452 0.2793 0.9536
Loa Loa (eye worm) hypothetical protein 0.0452 0.2793 0.9536
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0213 0.1252 0.1252
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0029 0.0029
Schistosoma mansoni survival motor neuron protein 0.0056 0.0236 0.0236
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0452 0.2793 0.2793
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0213 0.1252 0.1252
Schistosoma mansoni rab6-interacting 0.0024 0.0029 0.0029
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0452 0.2793 0.2793
Loa Loa (eye worm) hypothetical protein 0.0239 0.1417 0.4827
Schistosoma mansoni RAR-like nuclear receptor 0.0452 0.2793 0.2793
Schistosoma mansoni nuclear hormone receptor 0.0452 0.2793 0.2793
Giardia lamblia DINP protein human, muc B family 0.0025 0.004 0.5
Echinococcus granulosus axis inhibition protein axin 0.0065 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0213 0.1252 0.4263
Echinococcus multilocularis expressed protein 0.1265 0.8036 0.8036
Brugia malayi Rhodanese-like domain containing protein 0.0068 0.0317 0.1063
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0239 0.1417 0.1417
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0213 0.1252 0.3725
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0006 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0373 1
Brugia malayi nuclear receptor RXR 0.0239 0.1417 0.4827
Brugia malayi hypothetical protein 0.0239 0.1417 0.4827
Loa Loa (eye worm) hypothetical protein 0.0068 0.0317 0.1063
Echinococcus granulosus nuclear receptor nhr 48 0.0213 0.1252 0.1252
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0068 0.0317 0.0317
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0213 0.1252 0.1252
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0068 0.0314 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0452 0.2793 0.2793
Echinococcus granulosus Regulator of G protein signaling 20 0.0065 0.0295 0.0295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0373 1
Schistosoma mansoni microtubule-associated protein tau 0.1569 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0239 0.1417 0.1417
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0213 0.1252 0.1252
Schistosoma mansoni hypothetical protein 0.0024 0.0029 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0452 0.2793 0.9536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0068 0.0314 0.0314
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0452 0.2793 0.2793
Brugia malayi Rhodanese-like domain containing protein 0.0068 0.0317 0.1063
Trichomonas vaginalis cdc25c, putative 0.0068 0.0317 0.0945
Entamoeba histolytica rodhanase-like domain containing protein 0.0068 0.0317 1
Brugia malayi orphan nuclear receptor NR2E1 0.0213 0.1252 0.4263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0006 0.0018
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0029 1
Schistosoma mansoni thyroid hormone receptor 0.0452 0.2793 0.2793
Onchocerca volvulus 0.0068 0.0314 0.0919
Brugia malayi ecdysteroid receptor 0.0452 0.2793 0.9536
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0373 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Onchocerca volvulus 0.0068 0.0317 0.0928
Brugia malayi hypothetical protein 0.0065 0.0295 0.0988
Onchocerca volvulus 0.0068 0.0317 0.0928
Echinococcus multilocularis ecdysone induced protein 78C 0.0452 0.2793 0.2793
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0196 0.5186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0006 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0373 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0213 0.1252 0.1252
Brugia malayi conserved hypotetical protein 0.0213 0.1252 0.4263
Loa Loa (eye worm) hypothetical protein 0.0213 0.1252 0.4263
Schistosoma mansoni nuclear hormone receptor 0.0213 0.1252 0.1252
Echinococcus multilocularis RUN 0.0024 0.0029 0.0029
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0213 0.1252 0.1252
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0065 0.0295 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0118 0.3072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0006 0.0018
Brugia malayi tailless protein 0.0213 0.1252 0.4263
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0196 0.5186
Schistosoma mansoni regulator of G protein signaling 0.0065 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0452 0.2793 0.9536
Loa Loa (eye worm) serotonin transporter b 0.0105 0.0554 0.1874
Loa Loa (eye worm) hypothetical protein 0.0065 0.0295 0.0988
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.0314 0.0314
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0006 0.0006
Brugia malayi PXA domain containing protein 0.0065 0.0295 0.0988
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0452 0.2793 0.2793
Brugia malayi ecdysone receptor 0.0213 0.1252 0.4263
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0239 0.1417 0.4827
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0079
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0006 0.0006
Echinococcus multilocularis axis inhibition protein axin 0.0065 0.0295 0.0295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0373 1
Entamoeba histolytica hypothetical protein 0.0065 0.0295 0.9294
Brugia malayi Nuclear hormone receptor E75 0.0213 0.1252 0.4263
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0196 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0065 0.0295 0.0295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0452 0.2793 0.9536
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0196 0.5186
Loa Loa (eye worm) hypothetical protein 0.0065 0.0295 0.0988
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.1644 0.1644
Trypanosoma brucei unspecified product 0.0042 0.0144 0.3789
Loa Loa (eye worm) hypothetical protein 0.0065 0.0295 0.0988
Loa Loa (eye worm) hypothetical protein 0.0038 0.0118 0.0382
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0213 0.1252 0.4263
Loa Loa (eye worm) hypothetical protein 0.0105 0.0554 0.1874
Onchocerca volvulus 0.0539 0.3351 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0373 1
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0068 0.0317 0.0945
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0452 0.2793 0.9536
Echinococcus multilocularis dna polymerase kappa 0.005 0.0196 0.0196
Loa Loa (eye worm) nuclear hormone receptor 0.0213 0.1252 0.4263
Loa Loa (eye worm) hypothetical protein 0.0452 0.2793 0.9536
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0295 0.088
Echinococcus multilocularis nuclear receptor nhr 48 0.0213 0.1252 0.1252
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0239 0.1417 0.1417
Brugia malayi hypothetical protein 0.0213 0.1252 0.4263
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0029 0.0079
Loa Loa (eye worm) hypothetical protein 0.0065 0.0295 0.0988
Schistosoma mansoni regulator of G protein signaling 0.0065 0.0295 0.0295
Brugia malayi A-kinase anchor protein 10, precursor 0.0065 0.0295 0.0988
Entamoeba histolytica hypothetical protein 0.0065 0.0295 0.9294
Schistosoma mansoni z-protein (S1r protein) 0.0065 0.0295 0.0295
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0068 0.0314 0.1052
Brugia malayi nuclear hormone receptor 0.0213 0.1252 0.4263
Echinococcus granulosus beta-adrenergic receptor kinase 0.0065 0.0295 0.0295
Trichomonas vaginalis set domain proteins, putative 0.0539 0.3351 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0452 0.2793 0.9536
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0213 0.1252 0.4263
Echinococcus multilocularis beta adrenergic receptor kinase 0.0065 0.0295 0.0295
Brugia malayi Pre-SET motif family protein 0.0473 0.2929 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.1417 0.4827
Trichomonas vaginalis cdc25b, putative 0.0068 0.0317 0.0945
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0452 0.2793 0.9536
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0196 0.5169
Loa Loa (eye worm) hypothetical protein 0.0452 0.2793 0.9536
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0452 0.2793 0.2793
Schistosoma mansoni axis inhibition protein axin 0.0065 0.0295 0.0295
Schistosoma mansoni lipoxygenase 0.0024 0.0029 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0373 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0452 0.2793 0.9536
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0065 0.0295 0.0988
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0236 0.0788
Brugia malayi Regulator of G protein signaling domain containing protein 0.0065 0.0295 0.0988
Brugia malayi polk-prov protein 0.0038 0.0118 0.0382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0006 0.0018
Treponema pallidum sodium- and chloride- dependent transporter 0.0105 0.0554 1
Echinococcus multilocularis geminin 0.0393 0.241 0.241
Echinococcus multilocularis axis inhibition protein axin 0.0065 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0452 0.2793 0.9536
Brugia malayi regulator of G-protein signaling rgs-7 0.0065 0.0295 0.0988
Echinococcus multilocularis regulator of G protein signaling 3 0.0065 0.0295 0.0295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0006 0.0018
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0196 0.5186
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0068 0.0317 0.0945
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0452 0.2793 0.2793
Brugia malayi regulator of G-protein signaling egl-10 0.0065 0.0295 0.0988
Loa Loa (eye worm) hypothetical protein 0.0239 0.1417 0.4827
Schistosoma mansoni sodium/chloride dependent transporter 0.0105 0.0554 0.0554
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0452 0.2793 0.9536
Onchocerca volvulus Bile acid receptor homolog 0.0452 0.2793 0.8333
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0105 0.0554 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0452 0.2793 0.9536
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0452 0.2793 0.2793
Echinococcus granulosus RUN 0.0024 0.0029 0.0029
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0373 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0196 0.5169
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0213 0.1252 0.1252
Leishmania major cathepsin L-like protease 0.0077 0.0373 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0473 0.2929 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0144 0.3789
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0452 0.2793 0.2793
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0452 0.2793 0.2793
Entamoeba histolytica hypothetical protein 0.0065 0.0295 0.9294
Onchocerca volvulus 0.0068 0.0317 0.0928
Trichomonas vaginalis DNA polymerase eta, putative 0.005 0.0196 0.0584
Schistosoma mansoni nuclear hormone receptor 0.0213 0.1252 0.1252
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0295 0.088
Echinococcus multilocularis cysteine protease 0.002 0.0006 0.0006
Loa Loa (eye worm) DR-78 0.0213 0.1252 0.4263
Echinococcus granulosus ecdysone induced protein 78C 0.0452 0.2793 0.2793
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0452 0.2793 0.9536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0373 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0239 0.1417 0.1417
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0373 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0065 0.0295 0.0295
Echinococcus granulosus regulator of G protein signaling 3 0.0065 0.0295 0.0295
Brugia malayi Nuclear hormone receptor-like 1 0.0239 0.1417 0.4827
Brugia malayi steroid hormone receptor 0.0452 0.2793 0.9536
Brugia malayi PXA domain containing protein 0.0065 0.0295 0.0988
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0452 0.2793 0.8333
Schistosoma mansoni hypothetical protein 0.0393 0.241 0.241
Schistosoma mansoni nuclear receptor 0.0213 0.1252 0.1252
Brugia malayi Nuclear hormone receptor-like 1 0.0239 0.1417 0.4827
Schistosoma mansoni regulator of G protein signaling 0.0065 0.0295 0.0295
Echinococcus granulosus Nuclear hormone receptor HR96 0.0213 0.1252 0.1252
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0068 0.0317 0.0317
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0006 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.004 1
Brugia malayi Steroid receptor seven-up type 2 0.0452 0.2793 0.9536
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0029 0.0029
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0068 0.0317 0.0945
Loa Loa (eye worm) hypothetical protein 0.0213 0.1252 0.4263
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0196 0.5186
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0314 0.0314
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0065 0.0295 0.0988
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0065 0.0295 0.088
Brugia malayi hypothetical protein 0.0213 0.1252 0.4263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0068 0.0317 0.0317
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0105 0.0554 0.1874
Loa Loa (eye worm) hypothetical protein 0.0274 0.1644 0.5604
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0452 0.2793 0.2793
Echinococcus granulosus axis inhibition protein axin 0.0065 0.0295 0.0295
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0295 0.0295
Brugia malayi hypothetical protein 0.0024 0.0029 0.0079
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0452 0.2793 0.2793
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0196 0.5186
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0306 0.0306
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.004 0.092
Brugia malayi nuclear receptor RXR 0.0213 0.1252 0.4263
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0266 0.7098
Schistosoma mansoni regulator of G protein signaling 0.0065 0.0295 0.0295
Echinococcus multilocularis microtubule associated protein 2 0.1569 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0196 0.5186
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0065 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0213 0.1252 0.4263
Echinococcus multilocularis regulator of G protein signaling 0.0065 0.0295 0.0295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0373 1
Echinococcus granulosus serotonin transporter 0.0105 0.0554 0.0554
Echinococcus multilocularis regulator of G protein signaling 3 0.0065 0.0295 0.0295
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0452 0.2793 0.9536
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.005 0.0196 0.0584
Schistosoma mansoni hypothetical protein 0.0235 0.1393 0.1393
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.1644 0.1644
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0213 0.1252 0.4263
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0065 0.0295 0.0295
Echinococcus granulosus FTZ F1 alpha 0.0452 0.2793 0.2793
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0314 0.0314
Loa Loa (eye worm) PXA domain-containing protein 0.0065 0.0295 0.0988
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.004 0.0951
Brugia malayi Nuclear hormone receptor-like 1 0.0452 0.2793 0.9536
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0295 0.088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0006 0.0018
Brugia malayi Nuclear hormone receptor E75 0.0213 0.1252 0.4263
Loa Loa (eye worm) steroid hormone receptor 0.0452 0.2793 0.9536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0373 1
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0068 0.0317 0.0945
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0196 0.5186
Loa Loa (eye worm) hypothetical protein 0.0213 0.1252 0.4263
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0196 0.5186
Schistosoma mansoni lipoxygenase 0.0067 0.0306 0.0306
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0029 0.0029
Schistosoma mansoni coup transcription factor 0.0452 0.2793 0.2793
Loa Loa (eye worm) hypothetical protein 0.0105 0.0554 0.1874
Plasmodium vivax SET domain protein, putative 0.0068 0.0314 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0282 0.0945
Echinococcus granulosus regulator of G protein signaling 7 0.0065 0.0295 0.0295
Echinococcus multilocularis regulator of G protein signaling 7 0.0065 0.0295 0.0295
Echinococcus granulosus dna polymerase kappa 0.005 0.0196 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0452 0.2793 0.9536
Loa Loa (eye worm) hypothetical protein 0.0452 0.2793 0.9536
Schistosoma mansoni polycystin 1-related 0.0024 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0239 0.1417 0.4827
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0452 0.2793 0.9536
Loa Loa (eye worm) hypothetical protein 0.0452 0.2793 0.9536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Echinococcus granulosus geminin 0.0393 0.241 0.241
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0029 0.0029
Brugia malayi photoreceptor-specific nuclear receptor 0.0452 0.2793 0.9536
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0065 0.0297 0.0297
Entamoeba histolytica rodhanase-like domain containing protein 0.0068 0.0317 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0295 0.088
Onchocerca volvulus 0.0024 0.0029 0.0069
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0213 0.1252 0.4263
Onchocerca volvulus 0.0452 0.2793 0.8333
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0373 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0452 0.2793 0.2793
Loa Loa (eye worm) hypothetical protein 0.0065 0.0295 0.0988
Echinococcus granulosus cathepsin l1 0.002 0.0006 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0196 0.5169
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0373 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0295 0.088
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0006 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Schistosoma mansoni nuclear receptor 0.0213 0.1252 0.1252
Echinococcus multilocularis FTZ F1 alpha 0.0452 0.2793 0.2793
Echinococcus multilocularis serotonin transporter 0.0105 0.0554 0.0554
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0452 0.2793 0.2793
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0295 0.088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0452 0.2793 0.2793
Onchocerca volvulus 0.0056 0.0236 0.0689
Schistosoma mansoni rab6-interacting 0.0024 0.0029 0.0029
Entamoeba histolytica rodhanase-like domain containing protein 0.0068 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0213 0.1252 0.4263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0213 0.1252 0.4263
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0452 0.2793 0.2793
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0452 0.2793 0.2793
Brugia malayi hypothetical protein 0.0024 0.0029 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0018
Brugia malayi hypothetical protein 0.0065 0.0295 0.0988
Loa Loa (eye worm) hypothetical protein 0.0065 0.0295 0.0988
Schistosoma mansoni hypothetical protein 0.0056 0.0236 0.0236
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0029 0.0753
Echinococcus multilocularis regulator of G protein signaling 7 0.0065 0.0295 0.0295

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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