Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0689 | 0.1388 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2503 | 0.5043 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0689 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4963 | 0.4963 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2503 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0.0689 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2503 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4963 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4727 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4963 | 0.4963 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4963 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2503 | 0.5043 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.4727 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0689 | 0.1388 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2503 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2503 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0689 | 0.0689 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4963 | 0.4963 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0689 | 0.1388 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.4727 | 0.9524 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.4727 | 0.9524 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0.0689 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.4727 | 0.9524 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2503 | 0.5043 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.4727 | 0.9524 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0689 | 0.1388 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0689 | 0.1388 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4963 | 0.4963 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0.0689 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4727 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0.0689 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0689 | 0.1388 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0689 | 0.0689 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0689 | 0.0689 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4963 | 0.4963 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4963 | 0.4963 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4727 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2503 | 0.5043 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.4727 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.4727 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2503 | 0.2503 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0689 | 0.1388 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0689 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.