Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.4531 | 0.4172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5458 | 0.516 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0056 | 0.7778 | 0.7632 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.4531 | 0.4172 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.4531 | 0.4172 |
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0.1817 | 0.128 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.5458 | 0.516 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.4531 | 0.4172 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.0999 | 0.0408 |
Echinococcus granulosus | dna polymerase kappa | 0.0043 | 0.5458 | 0.516 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0056 | 0.7778 | 0.7632 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5458 | 0.516 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4531 | 0.453 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0022 | 0.1817 | 0.128 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5458 | 0.516 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.5458 | 0.516 |
Toxoplasma gondii | CAAX amino terminal protease family protein | 0.0012 | 0.0002 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5458 | 0.516 |
Toxoplasma gondii | hypothetical protein | 0.0012 | 0.0002 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.7398 | 0.7227 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.7778 | 0.7632 |
Brugia malayi | polk-prov protein | 0.0032 | 0.364 | 0.3223 |
Plasmodium vivax | protease, putative | 0.0012 | 0.0002 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0012 | 0.0002 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 1 | 1 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0056 | 0.7778 | 0.7632 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4531 | 0.453 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0015 | 0.0616 | 0.0614 |
Chlamydia trachomatis | hypothetical protein | 0.0012 | 0.0002 | 0.5 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0056 | 0.7778 | 0.7632 |
Brugia malayi | hypothetical protein | 0.0037 | 0.4531 | 0.4172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5458 | 0.516 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0056 | 0.7778 | 0.7632 |
Plasmodium falciparum | protease, putative | 0.0012 | 0.0002 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.5458 | 0.516 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4531 | 0.453 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0015 | 0.0616 | 0.3382 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.0999 | 0.0408 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.364 | 0.3223 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0056 | 0.7778 | 0.7632 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.5458 | 0.516 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0056 | 0.7778 | 0.7632 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.5458 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.5458 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5458 | 0.516 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.364 | 0.3223 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0056 | 0.7778 | 1 |
Trypanosoma brucei | unspecified product | 0.0036 | 0.4257 | 0.3879 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.5458 | 1 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0056 | 0.7778 | 0.7632 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.0999 | 0.0408 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5458 | 0.516 |
Echinococcus multilocularis | dna polymerase kappa | 0.0043 | 0.5458 | 0.516 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.1817 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0012 | 0.0002 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5458 | 0.516 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 1 | 1 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0056 | 0.7778 | 0.7777 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4531 | 0.453 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0036 | 0.4257 | 0.3879 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0068 | 1 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0068 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0068 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.364 | 0.3223 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.4938 | 0.4606 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5458 | 0.516 |
Giardia lamblia | Hypothetical protein | 0.0056 | 0.7778 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 1 | 1 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0056 | 0.7778 | 0.7632 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.4938 | 0.4606 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.5458 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1817 | 0.128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.