Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0106 | 0.211 | 0.5712 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0102 | 0.0078 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0079 | 0.1486 | 0.6892 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0056 | 0.0948 | 0.1035 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0102 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0292 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1317 | 0.1317 |
Echinococcus multilocularis | geminin | 0.0171 | 0.3618 | 1 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0399 | 0.8869 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.3618 | 1 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0399 | 0.8869 | 1 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0399 | 0.8869 | 1 |
Onchocerca volvulus | Putative GMP reductase | 0.0044 | 0.068 | 0.0399 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0502 | 0.114 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0106 | 0.211 | 0.235 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0292 | 0.0542 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0102 | 0.5 |
Echinococcus multilocularis | N terminal of biotin protein ligase | 0.0072 | 0.1317 | 0.3457 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0072 | 0.1317 | 0.8779 |
Chlamydia trachomatis | biotin synthetase | 0.0079 | 0.1486 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.3618 | 1 |
Loa Loa (eye worm) | runx1 | 0.0056 | 0.096 | 0.096 |
Loa Loa (eye worm) | GMP reductase | 0.0044 | 0.068 | 0.068 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0502 | 0.0502 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0292 | 0.0292 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0106 | 0.211 | 1 |
Mycobacterium leprae | POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS | 0.0072 | 0.1317 | 0.1453 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0056 | 0.0948 | 0.1035 |
Trypanosoma cruzi | GMP reductase | 0.0106 | 0.211 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0106 | 0.211 | 0.2291 |
Echinococcus granulosus | N terminal of biotin protein ligase | 0.0072 | 0.1317 | 0.3457 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.0079 | 0.1486 | 0.1486 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0106 | 0.211 | 0.5712 |
Echinococcus multilocularis | biotin protein ligase | 0.0079 | 0.1486 | 0.3937 |
Plasmodium falciparum | biotin protein ligase, putative | 0.0079 | 0.1486 | 0.743 |
Loa Loa (eye worm) | hypothetical protein | 0.0448 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.087 | 0.2185 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0502 | 0.114 |
Trypanosoma cruzi | GMP reductase | 0.0106 | 0.211 | 1 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0106 | 0.211 | 1 |
Schistosoma mansoni | biotin-protein ligase | 0.0072 | 0.1317 | 0.3457 |
Echinococcus granulosus | lamin | 0.0027 | 0.0292 | 0.0542 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0502 | 0.114 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0292 | 0.0292 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0102 | 0.0102 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0044 | 0.068 | 0.068 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0292 | 0.0542 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0292 | 0.0292 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0079 | 0.1486 | 0.6892 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1317 | 0.1317 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0502 | 0.114 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0399 | 0.8869 | 1 |
Echinococcus granulosus | 5'partial|biotin protein ligase | 0.0072 | 0.1317 | 0.3457 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0292 | 0.0542 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0072 | 0.1317 | 0.8779 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0072 | 0.1317 | 0.8779 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.0079 | 0.1486 | 0.743 |
Loa Loa (eye worm) | hypothetical protein | 0.0448 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0292 | 0.0542 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0072 | 0.1317 | 0.8779 |
Entamoeba histolytica | biotin--acetyl-CoA-carboxylase ligase, putative | 0.0079 | 0.1486 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.005 | 0.0825 | 0.0825 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0106 | 0.211 | 0.235 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0106 | 0.211 | 1 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.0169 | 0.3554 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0106 | 0.211 | 0.211 |
Mycobacterium tuberculosis | Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas | 0.0072 | 0.1317 | 0.1453 |
Brugia malayi | GMP reductase | 0.0044 | 0.068 | 0.068 |
Giardia lamblia | Hypothetical protein | 0.0079 | 0.1486 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0072 | 0.1317 | 0.8779 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0292 | 0.0292 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.01 | 0.1965 | 0.2125 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0502 | 0.2895 |
Echinococcus multilocularis | biotin protein ligase | 0.0079 | 0.1486 | 0.3937 |
Trypanosoma brucei | GMP reductase | 0.0106 | 0.211 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0502 | 0.2895 |
Onchocerca volvulus | 0.0448 | 1 | 1 | |
Echinococcus granulosus | geminin | 0.0171 | 0.3618 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0292 | 0.0542 |
Echinococcus multilocularis | Protein lozenge | 0.0056 | 0.096 | 0.244 |
Leishmania major | guanosine monophosphate reductase | 0.0106 | 0.211 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0292 | 0.0542 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0502 | 0.2895 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0079 | 0.1486 | 0.6892 |
Schistosoma mansoni | lozenge | 0.0056 | 0.096 | 0.244 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.01 | 0.1965 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0072 | 0.1317 | 0.8779 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0106 | 0.211 | 0.5712 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0044 | 0.068 | 0.068 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.0079 | 0.1486 | 0.6892 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0106 | 0.211 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0072 | 0.1317 | 0.8779 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0072 | 0.1317 | 0.8779 |
Schistosoma mansoni | biotin-protein ligase | 0.0079 | 0.1486 | 0.3937 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0106 | 0.211 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0502 | 0.2895 |
Toxoplasma gondii | IMP dehydrogenas | 0.0106 | 0.211 | 0.2291 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0072 | 0.1317 | 0.8779 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.0161 | 0.3385 | 0.3744 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.01 | 0.1965 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0106 | 0.211 | 0.211 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.0079 | 0.1486 | 0.743 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0292 | 0.0542 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.0079 | 0.1486 | 0.6892 |
Mycobacterium leprae | PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) | 0.005 | 0.0825 | 0.0896 |
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.0079 | 0.1486 | 0.1486 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0106 | 0.211 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.