Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6742 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.1025 | 0.1025 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3094 | 0.459 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1025 | 0.1025 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1313 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3094 | 0.459 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3408 | 0.5054 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1025 | 0.1025 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.3408 | 0.5054 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1313 | 0.1313 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3094 | 0.459 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1313 | 0.1313 |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.1025 | 0.1025 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3094 | 0.3094 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1313 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1313 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5461 | 0.81 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.1025 | 0.1025 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3094 | 0.3094 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1313 | 0.1313 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3094 | 0.459 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3094 | 0.3094 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3094 | 0.3094 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1313 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6742 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3094 | 0.3094 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6742 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.012 | 0.5461 | 0.81 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.1025 | 0.152 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3094 | 0.459 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1313 | 0.1313 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.3408 | 0.3408 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.1025 | 0.1025 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.1025 | 0.1025 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1025 | 0.152 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1313 | 0.1948 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3094 | 0.459 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 0.5461 | 0.81 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1025 | 0.1025 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.1025 | 0.152 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1025 | 0.1025 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.1025 | 0.152 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 0.5461 | 0.81 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3094 | 0.3094 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.1025 | 0.1025 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3094 | 0.3094 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.