Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0044 | 0.3553 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0028 | 0.1381 | 0.0992 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0044 | 0.3553 | 0.4239 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.3553 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0044 | 0.3553 | 0.5462 |
Loa Loa (eye worm) | cysteine protease | 0.0044 | 0.3553 | 0.4239 |
Onchocerca volvulus | Cathepsin L homolog | 0.0044 | 0.3553 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0041 | 0.3091 | 0.87 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0066 | 0.6504 | 0.6053 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.3553 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0044 | 0.3553 | 0.5462 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0024 | 0.0825 | 0.1269 |
Echinococcus granulosus | cathepsin b | 0.0066 | 0.6504 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0028 | 0.1381 | 0.5 |
Echinococcus granulosus | cathepsin L | 0.0026 | 0.1142 | 0.1756 |
Leishmania major | cysteine peptidase A (CPA) | 0.0044 | 0.3553 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0044 | 0.3553 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0028 | 0.1381 | 0.3888 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0029 | 0.1498 | 0.0402 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0029 | 0.1565 | 0.0358 |
Onchocerca volvulus | 0.0044 | 0.3553 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0028 | 0.1381 | 0.0992 |
Onchocerca volvulus | 0.0044 | 0.3553 | 1 | |
Onchocerca volvulus | 0.0044 | 0.3553 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0044 | 0.3553 | 0.5462 |
Entamoeba histolytica | cysteine protease, putative | 0.0044 | 0.3553 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0044 | 0.3553 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0041 | 0.3091 | 0.4752 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0066 | 0.6504 | 0.6053 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0044 | 0.3553 | 0.5462 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.3553 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.3553 | 0.4496 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0029 | 0.1498 | 0.0664 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0074 | 0.7482 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0066 | 0.6501 | 0.8342 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0041 | 0.3091 | 0.3635 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0041 | 0.3091 | 0.3635 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0066 | 0.6504 | 0.6053 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.6504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1498 | 0.0228 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0066 | 0.6501 | 0.8342 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0041 | 0.3091 | 0.8084 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0066 | 0.6504 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0041 | 0.3091 | 0.3635 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0044 | 0.3553 | 0.5462 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0041 | 0.3091 | 0.4752 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.3553 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0029 | 0.1565 | 0.2406 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0029 | 0.1498 | 0.0664 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0029 | 0.1498 | 0.0664 |
Toxoplasma gondii | cathepsin CPL | 0.0044 | 0.3553 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.3553 | 0.4496 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Echinococcus granulosus | cysteine protease | 0.0026 | 0.1142 | 0.1756 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1498 | 0.0228 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0024 | 0.0825 | 0.1269 |
Echinococcus granulosus | cathepsin b | 0.0066 | 0.6504 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0066 | 0.6504 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0066 | 0.6504 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0074 | 0.7482 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.3553 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0066 | 0.6501 | 0.8342 |
Plasmodium falciparum | thioredoxin reductase | 0.0029 | 0.1565 | 0.1753 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.1975 | 0.1159 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3553 | 0.4239 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0044 | 0.3553 | 0.4496 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0044 | 0.3553 | 0.4496 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0029 | 0.1565 | 0.0788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0066 | 0.6504 | 0.6053 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.3553 | 0.4496 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0044 | 0.3553 | 0.4239 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0044 | 0.3553 | 0.4496 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.3553 | 0.4496 |
Giardia lamblia | Cathepsin B precursor | 0.0028 | 0.1381 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.3553 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0044 | 0.3553 | 1 |
Brugia malayi | glutathione reductase | 0.0029 | 0.1565 | 0.0788 |
Plasmodium falciparum | glutathione reductase | 0.0029 | 0.1565 | 0.1753 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.3553 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0028 | 0.1381 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0041 | 0.3091 | 0.22 |
Loa Loa (eye worm) | glutathione reductase | 0.0029 | 0.1565 | 0.0358 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0066 | 0.6501 | 0.8342 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0041 | 0.3091 | 0.8084 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0044 | 0.3553 | 0.4496 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0044 | 0.3553 | 0.5462 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0044 | 0.3553 | 0.2721 |
Onchocerca volvulus | 0.0044 | 0.3553 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0029 | 0.1498 | 0.1477 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.1975 | 0.1553 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0028 | 0.1381 | 0.0446 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0029 | 0.1498 | 0.1477 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0044 | 0.3553 | 0.2721 |
Brugia malayi | Thioredoxin reductase | 0.0029 | 0.1565 | 0.0788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0044 | 0.3553 | 0.5462 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.3553 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0029 | 0.1565 | 0.2406 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0044 | 0.3553 | 0.4239 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0074 | 0.7482 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0044 | 0.3553 | 0.4496 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.3553 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0044 | 0.3553 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Plasmodium vivax | vivapain-2 | 0.0044 | 0.3553 | 1 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.3553 | 1 |
Leishmania major | trypanothione reductase | 0.0029 | 0.1565 | 0.4404 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.3553 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0029 | 0.1498 | 0.0664 |
Echinococcus granulosus | cathepsin l1 | 0.0044 | 0.3553 | 0.5462 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1498 | 0.0228 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0074 | 0.7482 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0029 | 0.1498 | 0.0664 |
Loa Loa (eye worm) | fibroinase | 0.0044 | 0.3553 | 0.4239 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.3553 | 0.4496 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0066 | 0.6501 | 0.8342 |
Echinococcus multilocularis | cathepsin L | 0.0026 | 0.1142 | 0.1756 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0066 | 0.6501 | 0.8342 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.3553 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0044 | 0.3553 | 0.4496 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0044 | 0.3553 | 1 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.3553 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.3553 | 0.4496 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.3553 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.3553 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0029 | 0.1565 | 0.0845 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.3553 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0028 | 0.1381 | 0.027 |
Onchocerca volvulus | 0.0044 | 0.3553 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0066 | 0.6504 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0041 | 0.3091 | 0.3337 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0026 | 0.1142 | 0.1756 |
Trypanosoma brucei | trypanothione reductase | 0.0029 | 0.1565 | 0.1753 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0029 | 0.1498 | 0.1477 |
Onchocerca volvulus | 0.0044 | 0.3553 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0029 | 0.1498 | 0.2303 |
Onchocerca volvulus | 0.0044 | 0.3553 | 1 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0044 | 0.3553 | 0.5462 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.3553 | 1 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.3553 | 1 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.3553 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0029 | 0.1565 | 0.1753 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0044 | 0.3553 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.3553 | 1 |
Plasmodium vivax | vivapain-2 | 0.0044 | 0.3553 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0029 | 0.1565 | 0.1753 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.