TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 324.38 | Formula: C17H20N6O
H donors: 0 H acceptors: 4 LogP: 2.13 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: c1ccc(cc1)c1onc(n1)CN1CCCC(C1)Cn1cncn1
InChi: 1S/C17H20N6O/c1-2-6-15(7-3-1)17-20-16(21-24-17)11-22-8-4-5-14(9-22)10-23-13-18-12-19-23/h1-3,6-7,12-14H,4-5,8-11H2
InChiKey: UBZMBBFDDKWJNU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0185	0.2547	0.2528
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0087	0.087	0.1182
Loa Loa (eye worm)	nuclear hormone receptor	0.0087	0.087	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0425	0.6685	1
Echinococcus multilocularis	GA binding protein alpha chain	0.0076	0.0683	0.066
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0185	0.2547	0.2506
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.009	0.0921	0.5951
Brugia malayi	hypothetical protein	0.0087	0.087	0.127
Brugia malayi	Intermediate filament tail domain containing protein	0.0053	0.0276	0.0378
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0185	0.2547	0.3787
Toxoplasma gondii	hypothetical protein	0.0072	0.0615	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0185	0.2547	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0087	0.087	0.1182
Echinococcus granulosus	GA binding protein alpha chain	0.0076	0.0683	0.066
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0072	0.0615	0.0563
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0087	0.087	0.127
Loa Loa (eye worm)	hypothetical protein	0.0087	0.087	0.1182
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0185	0.2547	0.2528
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0425	0.6685	0.6667
Brugia malayi	nuclear receptor RXR	0.0098	0.105	0.1539
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0201	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2547	0.3724
Trypanosoma cruzi	cytochrome P450, putative	0.0042	0.0091	0.5
Toxoplasma gondii	hypothetical protein	0.0072	0.0615	0.5
Onchocerca volvulus		0.0087	0.087	0.127
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0053	0.0276	0.0281
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0201	0.0147
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0519	0.0467
Echinococcus multilocularis	lamin	0.0053	0.0276	0.0252
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (medium chain)	0.0064	0.0481	0.5229
Brugia malayi	hypothetical protein	0.0172	0.2325	0.3453
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0098	0.105	0.1028
Brugia malayi	hypothetical protein	0.0098	0.105	0.1539
Schistosoma mansoni	thyroid hormone receptor	0.0185	0.2547	0.2506
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0185	0.2547	0.2528
Echinococcus multilocularis	FTZ F1 alpha	0.0185	0.2547	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2547	0.3724
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0191	0.2655	0.5
Onchocerca volvulus		0.0142	0.1815	0.2688
Loa Loa (eye worm)	DR-78	0.0087	0.087	0.1182
Brugia malayi	hypothetical protein	0.0142	0.1815	0.2688
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0072	0.0615	0.0886
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0072	0.0615	0.0592
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0185	0.2547	0.3787
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0185	0.2547	0.3724
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0072	0.0615	0.0592
Brugia malayi	conserved hypotetical protein	0.0087	0.087	0.127
Schistosoma mansoni	nuclear receptor	0.0087	0.087	0.082
Plasmodium vivax	amine transporter, putative	0.0072	0.0615	0.5
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0072	0.0615	0.0886
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0185	0.2547	0.3787
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0185	0.2547	0.2506
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (large chain)	0.009	0.0921	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0185	0.2547	0.2528
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0185	0.2547	0.2506
Brugia malayi	photoreceptor-specific nuclear receptor	0.0185	0.2547	0.3787
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0087	0.087	0.127
Loa Loa (eye worm)	hypothetical protein	0.0098	0.105	0.1454
Brugia malayi	RNA binding protein	0.0067	0.0519	0.0742
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0191	0.2655	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0519	0.0467
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0185	0.2547	0.3787
Echinococcus granulosus	thyroid hormone receptor alpha	0.0087	0.087	0.0848
Echinococcus multilocularis	geminin	0.0241	0.3515	0.3499
Brugia malayi	bZIP transcription factor family protein	0.0181	0.2482	0.369
Echinococcus granulosus	tar DNA binding protein	0.0067	0.0519	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0087	0.087	0.1182
Brugia malayi	nuclear receptor NHR-67	0.0087	0.087	0.127
Loa Loa (eye worm)	hypothetical protein	0.0098	0.105	0.1454
Brugia malayi	Ets-domain containing protein	0.0076	0.0683	0.0989
Loa Loa (eye worm)	hypothetical protein	0.0087	0.087	0.1182
Brugia malayi	Nuclear hormone receptor-like 1	0.0098	0.105	0.1539
Brugia malayi	Cytochrome P450 family protein	0.0085	0.0834	0.1216
Mycobacterium ulcerans	carbon monoxide dehydrogenase	0.0126	0.1547	1
Schistosoma mansoni	hypothetical protein	0.0241	0.3515	0.3479
Echinococcus multilocularis	ecdysone induced protein 78C	0.0185	0.2547	0.2528
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0072	0.0615	0.5
Schistosoma mansoni	zinc finger protein	0.0087	0.087	0.082
Plasmodium falciparum	transporter, putative	0.0072	0.0615	0.5
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0072	0.0615	0.0592
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0519	0.0467
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0425	0.6685	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0072	0.0615	0.0592
Schistosoma mansoni	lamin	0.0053	0.0276	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0087	0.087	0.1182
Onchocerca volvulus		0.0087	0.087	0.127
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2547	0.3724
Loa Loa (eye worm)	hypothetical protein	0.0098	0.105	0.1454
Schistosoma mansoni	hypothetical protein	0.0147	0.19	0.1855
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0072	0.0615	0.0563
Brugia malayi	tailless protein	0.0087	0.087	0.127
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0061	0.0419	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0087	0.087	0.1182
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.0519	0.0649
Brugia malayi	PAS domain containing protein	0.0051	0.0253	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0615	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0087	0.087	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2547	0.3724
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0185	0.2547	0.2528
Onchocerca volvulus		0.0072	0.0615	0.0886
Brugia malayi	Nuclear hormone receptor E75	0.0087	0.087	0.127
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0098	0.105	0.1028
Brugia malayi	nuclear hormone receptor family member odr-7	0.0087	0.087	0.127
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0425	0.6685	1
Onchocerca volvulus		0.0053	0.0276	0.0378
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0185	0.2547	0.2528
Brugia malayi	steroid hormone receptor	0.0185	0.2547	0.3787
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0615	0.0794
Trypanosoma cruzi	cytochrome P450, putative	0.0042	0.0091	0.5
Schistosoma mansoni	sodium/chloride dependent transporter	0.0072	0.0615	0.0563
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxL_2	0.009	0.0921	0.5951
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2547	0.3724
Onchocerca volvulus	Bile acid receptor homolog	0.0185	0.2547	0.3787
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0061	0.0419	0.0395
Onchocerca volvulus		0.0425	0.6685	1
Echinococcus multilocularis	serotonin transporter	0.0425	0.6685	0.6677
Schistosoma mansoni	jun-related protein	0.0147	0.19	0.1855
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0185	0.2547	0.2528
Brugia malayi	Cytochrome P450 family protein	0.0042	0.0091	0.01
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0087	0.087	0.082
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0185	0.2547	0.3787
Loa Loa (eye worm)	hypothetical protein	0.0425	0.6685	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0098	0.105	0.1001
Brugia malayi	ecdysteroid receptor	0.0185	0.2547	0.3787
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0072	0.0615	0.5
Brugia malayi	hypothetical protein	0.0098	0.105	0.1539
Brugia malayi	nuclear receptor NHR-88	0.0087	0.087	0.127
Echinococcus granulosus	lamin	0.0053	0.0276	0.0252
Brugia malayi	Fli-1 protein	0.0231	0.3349	0.4991
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0185	0.2547	0.3787
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0158	0.2096	0.3041
Schistosoma mansoni	microtubule-associated protein tau	0.0618	1	1
Echinococcus multilocularis	jun protein	0.0181	0.2482	0.2464
Onchocerca volvulus		0.0072	0.0615	0.0886
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0087	0.087	0.127
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0087	0.087	0.0848
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0072	0.0615	0.0794
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0072	0.0615	0.0592
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.0615	0.5
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0072	0.0615	0.0592
Plasmodium falciparum	amino acid transporter, putative	0.0072	0.0615	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0087	0.087	0.0848
Trichomonas vaginalis	aldehyde oxidase, putative	0.0191	0.2655	0.5
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0072	0.0615	0.5
Echinococcus granulosus	serotonin transporter	0.0425	0.6685	0.6677
Loa Loa (eye worm)	steroid hormone receptor	0.0185	0.2547	0.3724
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0072	0.0615	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0052	0.026	0.0256
Brugia malayi	ecdysone receptor	0.0087	0.087	0.127
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0181	0.2482	0.2464
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0615	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2547	0.3724
Schistosoma mansoni	lamin	0.0053	0.0276	0.0223
Leishmania major	cytochrome p450-like protein	0.0042	0.0091	0.5
Loa Loa (eye worm)	hypothetical protein	0.0087	0.087	0.1182
Schistosoma mansoni	sodium/chloride dependent transporter	0.0425	0.6685	0.6667
Loa Loa (eye worm)	cytochrome P450 family protein	0.0085	0.0834	0.1127
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0185	0.2547	0.2528
Loa Loa (eye worm)	fli-1 protein	0.0231	0.3349	0.4941
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0087	0.087	0.082
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0185	0.2547	0.3724
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0185	0.2547	0.3787
Schistosoma mansoni	nuclear receptor	0.0087	0.087	0.082
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0185	0.2547	0.2528
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0072	0.0615	0.0886
Brugia malayi	intermediate filament protein	0.0053	0.0276	0.0378
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0055	0.003
Loa Loa (eye worm)	hypothetical protein	0.0087	0.087	0.1182
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0185	0.2547	0.2528
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxM_2	0.0064	0.0481	0.3111
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1208	0.1694
Loa Loa (eye worm)	hypothetical protein	0.0425	0.6685	1
Schistosoma mansoni	lipoxygenase	0.0061	0.0419	0.0366
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0185	0.2547	0.3787
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0185	0.2547	0.3787
Echinococcus multilocularis	nuclear receptor nhr 48	0.0087	0.087	0.0848
Brugia malayi	Steroid receptor seven-up type 2	0.0185	0.2547	0.3787
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0185	0.2547	0.3787
Schistosoma mansoni	single-minded	0.0051	0.0253	0.0199
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0087	0.087	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0615	0.0794
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0185	0.2547	0.2506
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0181	0.2482	0.2464
Schistosoma mansoni	nuclear receptor nhr-48	0.0087	0.087	0.082
Schistosoma mansoni	intermediate filament proteins	0.0053	0.0276	0.0223
Brugia malayi	Nuclear hormone receptor E75	0.0087	0.087	0.127
Mycobacterium ulcerans	carbon monoxyde dehydrogenase medium chain CoxM	0.0064	0.0481	0.3111
Echinococcus granulosus	jun protein	0.0181	0.2482	0.2464
Schistosoma mansoni	coup transcription factor	0.0185	0.2547	0.2506
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0201	0.0177
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0087	0.087	0.0848
Onchocerca volvulus		0.0185	0.2547	0.3787
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0072	0.0615	0.0563
Brugia malayi	hypothetical protein	0.004	0.0055	0.0045
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0098	0.105	0.1454
Schistosoma mansoni	nuclear hormone receptor	0.0185	0.2547	0.2506
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0493	0.061
Loa Loa (eye worm)	hypothetical protein	0.0087	0.087	0.1182
Brugia malayi	TAR-binding protein	0.0067	0.0519	0.0742
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0072	0.0615	0.0886
Loa Loa (eye worm)	norepinephrine transporter	0.0425	0.6685	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0087	0.087	0.0848
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0072	0.0615	0.0563
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0201	0.0166
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0057	0.0346	0.2238
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0519	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0615	0.0794
Onchocerca volvulus	Protein ultraspiracle homolog	0.0185	0.2547	0.3787
Loa Loa (eye worm)	serotonin transporter b	0.0425	0.6685	1
Brugia malayi	hypothetical protein	0.0072	0.0615	0.0886
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2547	0.3724
Loa Loa (eye worm)	hypothetical protein	0.0172	0.2325	0.3387
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0185	0.2547	0.2528
Trypanosoma brucei	cytochrome P450, putative	0.0042	0.0091	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.0519	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0276	0.0281
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0087	0.087	0.0848
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0185	0.2547	0.3724
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0185	0.2547	0.3787
Brugia malayi	nuclear receptor RXR	0.0087	0.087	0.127
Onchocerca volvulus		0.0053	0.0276	0.0378
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0072	0.0615	0.0592
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0185	0.2547	0.3724
Brugia malayi	hypothetical protein	0.0252	0.3707	0.5528
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0185	0.2547	0.3724
Brugia malayi	nuclear receptor NHR-88	0.0185	0.2547	0.3787
Brugia malayi	nuclear hormone receptor	0.0185	0.2547	0.3787
Brugia malayi	Nuclear hormone receptor-like 1	0.0185	0.2547	0.3787
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0185	0.2547	0.2506
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0043	0.012	1
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.0519	0.0496
Echinococcus granulosus	lamin dm0	0.0053	0.0276	0.0252
Brugia malayi	Ets-domain containing protein	0.0076	0.0683	0.0989
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0201	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0087	0.087	0.1182
Schistosoma mansoni	hypothetical protein	0.0241	0.3515	0.3479
Brugia malayi	hypothetical protein	0.0087	0.087	0.127
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0185	0.2547	0.2528
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0185	0.2547	0.2528
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0185	0.2547	0.2528
Echinococcus multilocularis	musashi	0.0053	0.0276	0.0252
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0185	0.2547	0.3787
Brugia malayi	orphan nuclear receptor NR2E1	0.0087	0.087	0.127
Loa Loa (eye worm)	hypothetical protein	0.0087	0.087	0.1182
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0185	0.2547	0.2506
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2547	0.3724
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0201	0.0177
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0043	0.012	1
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0072	0.0615	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0201	0.0177
Schistosoma mansoni	nuclear hormone receptor	0.0087	0.087	0.082
Loa Loa (eye worm)	RNA binding protein	0.0067	0.0519	0.0649
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0072	0.0615	0.0592
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0042	0.0091	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0615	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0098	0.105	0.1454
Loa Loa (eye worm)	hypothetical protein	0.0098	0.105	0.1454
Echinococcus granulosus	sodium and chloride dependent glycine	0.0072	0.0615	0.0592
Schistosoma mansoni	thyroid hormone receptor	0.0185	0.2547	0.2506
Treponema pallidum	sodium- and chloride- dependent transporter	0.0425	0.6685	0.5
Schistosoma mansoni	gabp alpha	0.0076	0.0683	0.0632
Schistosoma mansoni	sodium/chloride dependent transporter	0.0072	0.0615	0.0563
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0185	0.2547	0.3787
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0087	0.087	0.0848
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0185	0.2547	0.3787
Echinococcus multilocularis	lamin dm0	0.0053	0.0276	0.0252
Schistosoma mansoni	aryl hydrocarbon receptor	0.0051	0.0253	0.0199
Echinococcus granulosus	geminin	0.0241	0.3515	0.3499
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0072	0.0615	0.0563
Brugia malayi	Nuclear hormone receptor-like 1	0.0098	0.105	0.1539
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0072	0.0615	0.0563
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0201	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0615	0.0794
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0087	0.087	0.127
Echinococcus multilocularis	microtubule associated protein 2	0.0618	1	1
Echinococcus granulosus	intermediate filament protein	0.0053	0.0276	0.0252
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0519	0.0467
Brugia malayi	Cytochrome P450 family protein	0.0042	0.0091	0.01
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0072	0.0615	0.0563
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0098	0.105	0.1001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0185	0.2547	0.3724
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0055	0.003
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0072	0.0615	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0043	0.012	0.0045
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0087	0.087	0.0848
Loa Loa (eye worm)	intermediate filament protein	0.0053	0.0276	0.0281
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0185	0.2547	0.2528
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0087	0.087	0.0848
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0076	0.0683	0.0898
Schistosoma mansoni	retinoic acid receptor RXR	0.0185	0.2547	0.2506
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.0519	0.0742
Echinococcus granulosus	nuclear receptor nhr 48	0.0087	0.087	0.0848
Schistosoma mansoni	nuclear hormone receptor	0.0087	0.087	0.082
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0072	0.0615	0.0794
Schistosoma mansoni	ets-related	0.0231	0.3349	0.3312
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2397	0.3497
Echinococcus granulosus	sodium and chloride dependent glycine	0.0072	0.0615	0.0592
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0072	0.0615	0.0592
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0185	0.2547	0.3724
Brugia malayi	nuclear hormone receptor	0.0087	0.087	0.127
Schistosoma mansoni	RAR-like nuclear receptor	0.0185	0.2547	0.2506
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0201	0.0147
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0087	0.087	0.0848
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0185	0.2547	0.2506
Loa Loa (eye worm)	hypothetical protein	0.0087	0.087	0.1182
Mycobacterium ulcerans	putative regulatory protein	0.0038	0.0025	0.0159
Brugia malayi	hypoxia-induced factor 1	0.0158	0.2096	0.311
Onchocerca volvulus		0.0072	0.0615	0.0886

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3496379

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2069835