Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0134 | 0.0421 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1253 | 0.3944 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1253 | 0.3944 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 0.3177 | 0.3177 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1253 | 0.1364 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1253 | 0.1253 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1253 | 0.3944 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 0.3177 | 0.3177 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0014 | 0 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.3177 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.1253 | 0.1364 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0094 | 0.0296 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0249 | 0.0783 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1214 | 0.3819 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1253 | 0.1253 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0014 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.3177 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.9189 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0249 | 0.0783 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1253 | 0.1364 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0014 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3177 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.1253 | 0.1253 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0.3177 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 0.3177 | 0.3458 |
Schistosoma mansoni | lamin | 0.0033 | 0.1253 | 0.1253 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0014 | 0 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.3177 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.9189 | 0.9189 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.3177 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.9189 | 0.9189 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1253 | 0.3944 |
Schistosoma mansoni | lamin | 0.0033 | 0.1253 | 0.1253 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1253 | 0.3944 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3177 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 0.3177 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 0.3177 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0014 | 0 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0134 | 0.0134 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1253 | 0.1253 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0134 | 0.0146 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.3177 | 0.3177 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.3177 | 1 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.1253 | 0.5 | |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.3177 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3177 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 0.3177 | 0.3458 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0014 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.3177 | 1 |
Onchocerca volvulus | 0.0033 | 0.1253 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3177 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 0.3177 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0014 | 0 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.3177 | 1 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0094 | 0.0296 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0014 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.