Detailed information for compound 2070283

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 315.41 | Formula: C18H25N3O2
  • H donors: 0 H acceptors: 3 LogP: 1.69 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)C(=O)CC1CCCC1)Cc1ccccn1
  • InChi: 1S/C18H25N3O2/c22-17(13-15-5-1-2-6-15)20-9-11-21(12-10-20)18(23)14-16-7-3-4-8-19-16/h3-4,7-8,15H,1-2,5-6,9-14H2
  • InChiKey: XXZKATXHEKAXMM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.1838 0.5285 0.5284
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0037 0.0051 0.0092
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0057 0.0107 0.0922
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.006 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0008
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.001 0.0024
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.006 0.0071
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0057 0.0107 0.0302
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.1253 0.3585 0.868
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0128 0.0314 0.0568
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0069 0.0067
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1253 0.3585 0.5128
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0069 0.0085
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0057 0.0107 0.0922
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0131 0.0323 0.1091
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0069 0.0216
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0045 0.0075 0.018
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Schistosoma mansoni acetylcholine receptor-related 0.0584 0.1639 0.3969
Loa Loa (eye worm) hypothetical protein 0.0669 0.1888 0.1887
Loa Loa (eye worm) hypothetical protein 0.0043 0.0069 0.0067
Onchocerca volvulus 0.0056 0.0105 0.019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0083 0.0184 0.0333
Brugia malayi beta-lactamase 0.0043 0.0069 0.0085
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0966 0.2752 1
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0102 0.0207
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0324 0.0785
Brugia malayi beta-lactamase family protein 0.0043 0.0069 0.0085
Schistosoma mansoni cpg binding protein 0.0134 0.0333 0.0805
Loa Loa (eye worm) hypothetical protein 0.0669 0.1888 0.1887
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1253 0.3585 0.5128
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0057 0.0107 0.0922
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.1253 0.3585 0.5128
Schistosoma mansoni bromodomain containing protein 0.0081 0.0178 0.043
Onchocerca volvulus 0.1253 0.3585 1
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0069 0.0493
Schistosoma mansoni lamin 0.0033 0.0037 0.009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.006 0.0389
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0069 0.0216
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.1253 0.3585 0.3583
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0069 0.0167
Echinococcus granulosus cytochrome P450 2K1 0.0057 0.0107 0.026
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0046 0.0131
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0031 0.0077
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0057 0.0107 0.0302
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0584 0.1639 0.3969
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0046 0.0131
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.006 0.0052
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0653 0.1841 0.6631
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.014 0.035 0.0348
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0057 0.0107 0.0922
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0584 0.1639 0.2337
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0008
Echinococcus granulosus axis inhibition protein axin 0.0023 0.001 0.0024
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.1253 0.3585 0.868
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0057 0.0108 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0031 0.0077
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0165 0.0163
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.006 0.0127
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.006 0.0127
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Brugia malayi 6-phosphofructokinase 0.0131 0.0324 0.0451
Echinococcus granulosus tar DNA binding protein 0.0076 0.0165 0.04
Echinococcus multilocularis nAChR subunit 0.1253 0.3585 0.6498
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0105 0.0136
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.1253 0.3585 0.3583
Loa Loa (eye worm) CXXC zinc finger family protein 0.0134 0.0333 0.0331
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0057 0.0107 0.0302
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0069 0.0167
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0287 0.0695
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0069 0.0493
Loa Loa (eye worm) histone methyltransferase 0.0045 0.0075 0.0072
Brugia malayi hypothetical protein 0.0584 0.1639 0.2337
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0063 0.0115
Brugia malayi PHD-finger family protein 0.0036 0.0049 0.0056
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0126 0.031 0.3196
Echinococcus multilocularis glycine receptor subunit alpha 1 0.1253 0.3585 0.6498
Brugia malayi 6-phosphofructokinase 0.0131 0.0324 0.0451
Brugia malayi F/Y-rich N-terminus family protein 0.0047 0.0079 0.01
Plasmodium falciparum ataxin-2 like protein, putative 0.0047 0.0078 0.012
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.006 0.0052
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.0305 0.3142
Loa Loa (eye worm) hypothetical protein 0.0274 0.0738 0.0736
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.0324 0.0588
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0034 0.0041 0.0074
Onchocerca volvulus 0.0043 0.0069 0.0089
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0083
Loa Loa (eye worm) hypothetical protein 0.0669 0.1888 0.1887
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.0077 0.0096
Echinococcus multilocularis 0.0057 0.0107 0.0194
Brugia malayi cytochrome P450 0.0057 0.0107 0.014
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0069 0.0161
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.001 0.0008
Echinococcus granulosus neuropeptide s receptor 0.0569 0.1596 0.3864
Brugia malayi Cation transporter family protein 0.1253 0.3585 0.5128
Loa Loa (eye worm) cytochrome P450 family protein 0.0131 0.0323 0.0321
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0034 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0057 0.0107 0.0922
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.001 0.0024
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0966 0.2752 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0069 0.0493
Echinococcus multilocularis nAChR subunit 0.0669 0.1888 0.3423
Loa Loa (eye worm) hypothetical protein 0.0043 0.0069 0.0067
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0045 0.0075 0.0135
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0012 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0108 0.0256 0.062
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0057 0.0107 0.0302
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0287 0.0695
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0209 0.0551 0.0549
Loa Loa (eye worm) hypothetical protein 0.0669 0.1888 0.1887
Echinococcus multilocularis expressed protein 0.0451 0.1253 0.2271
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0209 0.0551 0.0776
Plasmodium falciparum thioredoxin reductase 0.0055 0.0102 0.0207
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0057 0.0107 0.0302
Echinococcus granulosus neuropeptide receptor A26 0.0569 0.1596 0.3864
Brugia malayi excitatory GABA receptor EXP-1A 0.1253 0.3585 0.5128
Schistosoma mansoni regulator of G protein signaling 0.0023 0.001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Brugia malayi Cytochrome P450 family protein 0.0131 0.0323 0.0448
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0966 0.2752 1
Schistosoma mansoni nAChR subunit 0.1253 0.3585 0.868
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0101 0.0236 0.0572
Brugia malayi Bromodomain containing protein 0.0044 0.0071 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.001 0.0024
Plasmodium vivax glutathione reductase, putative 0.0055 0.0102 0.0207
Echinococcus granulosus histone lysine methyltransferase setb 0.0128 0.0314 0.0759
Trypanosoma cruzi cytochrome P450, putative 0.0131 0.0323 0.1091
Loa Loa (eye worm) RNA binding protein 0.0076 0.0165 0.0163
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.1253 0.3585 0.6498
Mycobacterium tuberculosis Probable reductase 0.0125 0.0305 0.3142
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0669 0.1888 0.4573
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0031 0.0077
Schistosoma mansoni microtubule-associated protein tau 0.0793 0.2249 0.5447
Brugia malayi Cation transporter family protein 0.1253 0.3585 0.5128
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0669 0.1888 0.2695
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0966 0.2752 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0142 0.0357 0.0355
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.1253 0.3585 0.868
Loa Loa (eye worm) hypothetical protein 0.0079 0.0172 0.017
Trypanosoma cruzi cytochrome P450, putative 0.0131 0.0323 0.1091
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0165 0.04
Loa Loa (eye worm) hypothetical protein 0.0044 0.0072 0.007
Trypanosoma brucei PAB1-binding protein , putative 0.0047 0.0078 0.0068
Onchocerca volvulus 0.1253 0.3585 1
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Brugia malayi Cytochrome P450 family protein 0.0057 0.0107 0.014
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0669 0.1888 0.2695
Brugia malayi hypothetical protein 0.0584 0.1639 0.2337
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0324 0.1673
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0324 0.0322
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.1253 0.3585 0.3583
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Onchocerca volvulus Putative nachr subunit 0.1253 0.3585 1
Brugia malayi Cation transporter family protein 0.1253 0.3585 0.5128
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0209 0.0551 0.0999
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0057 0.0107 0.0922
Brugia malayi CXXC zinc finger family protein 0.0134 0.0333 0.0463
Onchocerca volvulus 0.0182 0.0473 0.1229
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0584 0.1639 0.2337
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0287 0.0695
Schistosoma mansoni survival motor neuron protein 0.0056 0.0105 0.0254
Entamoeba histolytica hypothetical protein 0.0669 0.1888 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.1253 0.3585 0.6498
Brugia malayi RNA binding protein 0.0076 0.0165 0.0222
Echinococcus granulosus glycine receptor subunit alpha 1 0.1253 0.3585 0.868
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0046 0.0131
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0083 0.0184 0.0445
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.006 0.0127
Plasmodium vivax SET domain protein, putative 0.0108 0.0256 0.0777
Mycobacterium ulcerans lipase LipD 0.0043 0.0069 0.0161
Brugia malayi Cytochrome P450 family protein 0.0131 0.0323 0.0448
Trypanosoma brucei trypanothione reductase 0.0055 0.0102 0.0156
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0057 0.0107 0.0922
Schistosoma mansoni regulator of G protein signaling 0.0023 0.001 0.0024
Echinococcus multilocularis zinc finger protein 0.003 0.0031 0.0056
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0057 0.0107 0.0302
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0008
Onchocerca volvulus 0.0669 0.1888 0.5218
Brugia malayi Bromodomain containing protein 0.0094 0.0217 0.0297
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0966 0.2752 0.2751
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0046 0.0131
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.006 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0069 0.0216
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1253 0.3585 0.5128
Loa Loa (eye worm) glutathione reductase 0.0055 0.0102 0.01
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0102 0.0859
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0209 0.0551 0.1334
Echinococcus multilocularis glycine receptor subunit beta 0.1253 0.3585 0.6498
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0031 0.0077
Mycobacterium tuberculosis Conserved protein 0.0043 0.0069 0.0493
Schistosoma mansoni hypothetical protein 0.0057 0.0107 0.026
Brugia malayi Receptor family ligand binding region containing protein 0.014 0.035 0.0488
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.0305 0.3142
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0057 0.0107 0.0302
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0584 0.1639 0.2337
Echinococcus multilocularis musashi 0.0033 0.0037 0.0068
Loa Loa (eye worm) hypothetical protein 0.0669 0.1888 0.1887
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0335 0.0917 1
Onchocerca volvulus 0.0043 0.0069 0.0089
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0324 0.1097
Schistosoma mansoni neurotransmitter gated ion channel 0.0584 0.1639 0.3969
Trypanosoma brucei cytochrome P450, putative 0.0131 0.0323 0.0976
Entamoeba histolytica hypothetical protein 0.0083 0.0184 0.0926
Brugia malayi hypothetical protein 0.0274 0.0738 0.1044
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0172 0.0417
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0057 0.0107 0.0302
Echinococcus multilocularis cpg binding protein 0.0144 0.0361 0.0655
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Toxoplasma gondii ABC1 family protein 0.0043 0.0069 0.0086
Loa Loa (eye worm) ACC-1 protein 0.1253 0.3585 0.3583
Leishmania major hypothetical protein, conserved 0.0043 0.0069 0.0161
Entamoeba histolytica hypothetical protein 0.0083 0.0184 0.0926
Echinococcus multilocularis citrate lyase subunit beta protein 0.0028 0.0025 0.0045
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.0305 0.3142
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0069 0.0216
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.0077 0.0075
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0126 0.031 0.0562
Loa Loa (eye worm) RGS-3 protein 0.0023 0.001 0.0008
Schistosoma mansoni zinc finger protein 0.003 0.0031 0.0074
Brugia malayi glucose-6-phosphate dehydrogenase 0.0966 0.2752 0.3934
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Loa Loa (eye worm) GABA receptor subunit 0.0669 0.1888 0.1887
Schistosoma mansoni hypothetical protein 0.0056 0.0105 0.0254
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0079 0.0172 0.0592
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0118 0.0287 0.052
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0966 0.2752 1
Echinococcus granulosus cpg binding protein 0.0144 0.0361 0.0875
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.031 0.0751
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0008
Schistosoma mansoni neurotransmitter gated ion channel 0.0669 0.1888 0.4573
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0669 0.1888 0.2695
Trypanosoma cruzi PAB1-binding protein , putative 0.0047 0.0078 0.0195
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.001 0.0018
Onchocerca volvulus 0.0108 0.0256 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0031 0.0077
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0057 0.0107 0.0922
Loa Loa (eye worm) cytochrome P450 0.0057 0.0107 0.0105
Schistosoma mansoni cpg binding protein 0.0144 0.0361 0.0875
Brugia malayi phosphofructokinase 0.0131 0.0324 0.0451
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0046 0.0131
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0108 0.0256 0.0464
Onchocerca volvulus 0.0584 0.1639 0.4515
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.001 0.0008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0031 0.0077
Trichomonas vaginalis helicase, putative 0.003 0.0031 0.0077
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0734 0.2077 0.2076
Loa Loa (eye worm) hypothetical protein 0.0182 0.0473 0.0471
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Brugia malayi hypothetical protein 0.0182 0.0473 0.0664
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.001 0.0018
Leishmania major cytochrome p450-like protein 0.0057 0.0107 0.0302
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0966 0.2752 1
Onchocerca volvulus 0.0584 0.1639 0.4515
Loa Loa (eye worm) hypothetical protein 0.0074 0.0158 0.0156
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0037 0.0035
Leishmania major hypothetical protein, conserved 0.0246 0.0658 0.2321
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0046 0.0131
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.1253 0.3585 0.868
Echinococcus granulosus glycine receptor subunit beta 0.1253 0.3585 0.868
Schistosoma mansoni hypothetical protein 0.0568 0.1593 0.3856
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0102 0.0281
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0966 0.2752 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0165 0.04
Echinococcus multilocularis lamin 0.0033 0.0037 0.0068
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0584 0.1639 0.2337
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.001 0.0018
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0584 0.1639 0.2337
Schistosoma mansoni regulator of G protein signaling 0.0023 0.001 0.0024
Echinococcus granulosus glycine receptor subunit alpha 1 0.1253 0.3585 0.868
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0165 0.0163
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0069 0.0035
Loa Loa (eye worm) cytochrome P450 family protein 0.0131 0.0323 0.0321
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.0324 0.3354
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.1253 0.3585 0.6498
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0028 0.0025 0.0055
Loa Loa (eye worm) hypothetical protein 0.0043 0.0069 0.0067
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0669 0.1888 0.4573
Echinococcus multilocularis dnaJ subfamily B 0.144 0.413 0.7486
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0584 0.1639 0.2971
Echinococcus granulosus geminin 0.0568 0.1593 0.3856
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.1253 0.3585 0.5128
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.001 0.0018
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.006 0.0265
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.0305 0.8538
Brugia malayi intermediate filament protein 0.0033 0.0037 0.0039
Toxoplasma gondii cytochrome p450 superfamily protein 0.0057 0.0107 0.0227
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.0658 0.2321
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.1253 0.3585 0.868
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0057 0.0107 0.0922
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.031 0.1046
Brugia malayi hypothetical protein 0.003 0.003 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0031 0.0077
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0324 0.1146
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0046 0.0131
Schistosoma mansoni intermediate filament proteins 0.0033 0.0037 0.009
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.0324 0.9219
Schistosoma mansoni regulator of G protein signaling 0.0023 0.001 0.0024
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0102 0.0184
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0057 0.0107 0.0302
Toxoplasma gondii histone lysine methyltransferase SET1 0.0261 0.0701 0.242
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.001 0.0024
Schistosoma mansoni cpg binding protein 0.0144 0.0361 0.0875
Toxoplasma gondii melibiase subfamily protein 0.0118 0.0287 0.0892
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0324 0.1146
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.1253 0.3585 0.868
Schistosoma mansoni nAChR subunit 0.1253 0.3585 0.868
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.0324 0.0785
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0057 0.0107 0.0922
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1253 0.3585 0.5128
Schistosoma mansoni nAChR subunit 0.1253 0.3585 0.868
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.006 0.0145
Loa Loa (eye worm) hypothetical protein 0.0047 0.008 0.0078
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0031 0.0077
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0324 0.1146
Schistosoma mansoni cytochrome P450 0.0057 0.0107 0.026
Schistosoma mansoni transcription factor LCR-F1 0.0083 0.0184 0.0445
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.001 0.0024
Schistosoma mansoni axis inhibition protein axin 0.0023 0.001 0.0024
Brugia malayi Pre-SET motif family protein 0.0734 0.2077 0.2966
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0057 0.0107 0.0302
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0108 0.0256 0.0777
Loa Loa (eye worm) CYP4Cod1 0.0131 0.0323 0.0321
Entamoeba histolytica hypothetical protein 0.0083 0.0184 0.0926
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.1253 0.3585 0.868
Loa Loa (eye worm) hypothetical protein 0.0043 0.0069 0.0067
Echinococcus multilocularis lamin dm0 0.0033 0.0037 0.0068
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0057 0.0107 0.0922
Schistosoma mansoni nAChR subunit 0.1253 0.3585 0.868
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.1253 0.3585 0.5128
Echinococcus multilocularis geminin 0.0568 0.1593 0.2887
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.001 0.0018
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.1253 0.3585 0.6498
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.031 0.1046
Onchocerca volvulus 0.0043 0.0069 0.0089
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0063 0.0154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0209 0.0551 0.1334
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0057 0.0107 0.0302
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0288 0.0781 0.1891
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0631 0.1778 0.6399
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0314 0.0759
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0324 0.0982
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.001 0.0018
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.001 0.0024
Toxoplasma gondii thioredoxin reductase 0.0055 0.0102 0.0207
Echinococcus granulosus dnaJ subfamily B 0.144 0.413 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0278 0.075 0.0748
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0057 0.0107 0.0302
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.1253 0.3585 0.868
Brugia malayi hypothetical protein 0.0047 0.0078 0.0098
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.0324 0.1029
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0057 0.0107 0.0922
Mycobacterium tuberculosis Conserved protein 0.0043 0.0069 0.0493
Echinococcus multilocularis glycine receptor subunit beta 0.1253 0.3585 0.6498
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0069 0.0493
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.001 0.0024
Schistosoma mansoni axis inhibition protein axin 0.0023 0.001 0.0024
Onchocerca volvulus 0.0669 0.1888 0.5218
Echinococcus granulosus zinc finger protein 0.003 0.0031 0.0074
Trypanosoma brucei hypothetical protein, conserved 0.0246 0.0658 0.2222
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.0324 0.1097
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.1253 0.3585 0.5128
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0966 0.2752 1
Brugia malayi follicle stimulating hormone receptor 0.0278 0.075 0.1061
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0069 0.0493
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0077 0.0166 0.03
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Echinococcus granulosus axis inhibition protein axin 0.0023 0.001 0.0024
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0057 0.0107 0.0302
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.0738 0.1787
Brugia malayi hypothetical protein 0.0584 0.1639 0.2337
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0037 0.0035
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.1253 0.3585 0.868
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0051 0.0123
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.1253 0.3585 0.868
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.001 0.0024
Brugia malayi Melibiase family protein 0.0079 0.0172 0.0233
Loa Loa (eye worm) hypothetical protein 0.0032 0.0036 0.0034
Onchocerca volvulus 0.0584 0.1639 0.4515
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0966 0.2752 0.4989
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0034 0.0041 0.0099
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.1253 0.3585 0.5128
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0069 0.0493
Schistosoma mansoni neurotransmitter gated ion channel 0.0584 0.1639 0.3969
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0209 0.0551 0.0999
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0324 0.0322
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0069 0.0167
Loa Loa (eye worm) hypothetical protein 0.0043 0.0069 0.0067
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.0324 0.1097
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0057 0.0107 0.0922
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Loa Loa (eye worm) hypothetical protein 0.0669 0.1888 0.1887
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0057 0.0107 0.0922
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0057 0.0107 0.0302
Onchocerca volvulus 0.1253 0.3585 1
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0966 0.2752 0.6664
Echinococcus granulosus citrate lyase subunit beta protein 0.0028 0.0025 0.0061
Trypanosoma cruzi PAB1-binding protein , putative 0.0047 0.0078 0.0195
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.001 0.0018
Brugia malayi hypothetical protein 0.014 0.035 0.0487
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0077 0.0166 0.0401
Trichomonas vaginalis set domain proteins, putative 0.0835 0.2371 0.8611
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.001 0.0024
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0966 0.2752 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.1253 0.3585 0.5128
Brugia malayi glutathione reductase 0.0055 0.0102 0.0132
Mycobacterium tuberculosis Conserved protein 0.0043 0.0069 0.0493
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.031 0.1046
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.001 0.0018
Brugia malayi hypothetical protein 0.0083 0.0184 0.025
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.0346 1
Echinococcus granulosus lamin 0.0033 0.0037 0.009
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0966 0.2752 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.2421 0.6981 1
Echinococcus granulosus expressed protein 0.0451 0.1253 0.3034
Mycobacterium leprae putative cytochrome p450 0.0057 0.0107 0.1381
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0031 0.0077
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.0346 0.3596
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0108 0.0256 0.062
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0287 0.0695
Brugia malayi hypothetical protein 0.0584 0.1639 0.2337
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0126 0.031 0.1046
Loa Loa (eye worm) hypothetical protein 0.0669 0.1888 0.1887
Toxoplasma gondii aldehyde dehydrogenase 0.0126 0.031 0.0977
Onchocerca volvulus 0.0134 0.0333 0.0832
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.1253 0.3585 0.3583
Brugia malayi hypothetical protein 0.0584 0.1639 0.2337
Schistosoma mansoni hypothetical protein 0.144 0.413 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.1253 0.3585 0.868
Echinococcus multilocularis neuropeptide receptor A26 0.0569 0.1596 0.2893
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1253 0.3585 0.5128
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0069 0.0161
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.1253 0.3585 0.868
Schistosoma mansoni acetylcholine receptor subunit beta 0.0584 0.1639 0.3969
Mycobacterium ulcerans hypothetical protein 0.0043 0.0069 0.0161
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0584 0.1639 0.2971
Schistosoma mansoni nAChR subunit 0.1253 0.3585 0.868
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.0077 0.0096
Loa Loa (eye worm) ACC-1 protein 0.1253 0.3585 0.3583
Schistosoma mansoni nAChR subunit 0.0584 0.1639 0.3969
Plasmodium falciparum ataxin-2 like protein, putative 0.0047 0.0078 0.012
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0021 0.0003 0.0008
Schistosoma mansoni nAChR subunit 0.1253 0.3585 0.868
Schistosoma mansoni regulator of G protein signaling 0.0023 0.001 0.0024
Brugia malayi Thioredoxin reductase 0.0055 0.0102 0.0132
Echinococcus granulosus nAChR subunit 0.0669 0.1888 0.4573
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Leishmania major cytochrome p450-like protein 0.0131 0.0323 0.1091
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.1253 0.3585 0.6498
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1253 0.3585 0.5128
Echinococcus granulosus intermediate filament protein 0.0033 0.0037 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0209 0.0551 0.1334
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0057 0.0107 0.0302
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0008
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.001 0.0024
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0057 0.0107 0.0302
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.1253 0.3585 0.6498
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0069 0.0086
Loa Loa (eye worm) acetylcholine receptor protein 0.0584 0.1639 0.1637
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0069 0.0161
Loa Loa (eye worm) hypothetical protein 0.0043 0.0069 0.0067
Schistosoma mansoni hypothetical protein 0.0083 0.0184 0.0445
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1917 0.5517 1
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0584 0.1639 0.2971
Loa Loa (eye worm) hypothetical protein 0.0128 0.0314 0.0312
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0584 0.1639 0.1637
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.0051 0.0123
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0057 0.0107 0.0302
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0057 0.0107 0.0302
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0035
Echinococcus granulosus glycine receptor subunit alpha 1 0.1253 0.3585 0.868
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0031 0.0077
Onchocerca volvulus 0.1253 0.3585 1
Mycobacterium leprae Conserved hypothetical protein 0.0057 0.0107 0.1381
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0057 0.0107 0.0922
Leishmania major hypothetical protein, conserved 0.0047 0.0078 0.0195
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.031 0.0751
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0584 0.1639 0.2337
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0324 0.1673
Loa Loa (eye worm) hypothetical protein 0.0365 0.1003 0.1001
Loa Loa (eye worm) hypothetical protein 0.0046 0.0077 0.0075
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0966 0.2752 1
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0324 0.0785
Plasmodium falciparum glutathione reductase 0.0055 0.0102 0.0207
Schistosoma mansoni nAChR subunit 0.1253 0.3585 0.868
Echinococcus granulosus microtubule associated protein 2 0.0793 0.2249 0.5447
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.001 0.0024
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.0738 0.1338
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0966 0.2752 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0031 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0031 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.0658 0.2321
Loa Loa (eye worm) LGC-31 protein 0.1253 0.3585 0.3583
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0584 0.1639 0.1637
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0669 0.1888 0.2695
Schistosoma mansoni ap endonuclease 0.004 0.006 0.0145
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.006 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0314 0.0759
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.1253 0.3585 0.6498
Loa Loa (eye worm) hypothetical protein 0.0047 0.0078 0.0076
Loa Loa (eye worm) hypothetical protein 0.2421 0.6981 0.698
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0311 0.0847 0.3013
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.1253 0.3585 0.3583
Brugia malayi beta-lactamase family protein 0.0043 0.0069 0.0085
Mycobacterium ulcerans beta-lactamase 0.0043 0.0069 0.0161
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0057 0.0107 0.0922
Trichomonas vaginalis ap endonuclease, putative 0.004 0.006 0.0182
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.001 0.0008
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0057 0.0107 0.0302
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0051 0.0092
Leishmania major trypanothione reductase 0.0055 0.0102 0.0281
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0102 0.0246
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.1253 0.3585 0.868
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0057 0.0107 0.0922
Brugia malayi TAR-binding protein 0.0076 0.0165 0.0222
Echinococcus multilocularis glycine receptor subunit alpha 1 0.1253 0.3585 0.6498
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.1253 0.3585 0.5128
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0057 0.0107 0.0177
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.1253 0.3585 0.6498
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0031 0.0077
Leishmania major cytochrome p450-like protein 0.0057 0.0107 0.0302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0209 0.0551 0.1334
Echinococcus granulosus mixed lineage leukemia protein mll 0.0037 0.0051 0.0123
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0057 0.0107 0.0302
Schistosoma mansoni hypothetical protein 0.0024 0.0012 0.0029
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0118 0.0287 0.052
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0037 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0165 0.04
Loa Loa (eye worm) hypothetical protein 0.0032 0.0034 0.0032
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0057 0.0107 0.0302
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.006 0.0127
Echinococcus granulosus glycine receptor subunit beta 0.1253 0.3585 0.868
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0057 0.0107 0.0302
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0126 0.031 0.0751
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.1253 0.3585 0.868
Echinococcus multilocularis microtubule associated protein 2 0.0793 0.2249 0.4078
Toxoplasma gondii exonuclease III APE 0.004 0.006 0.0052
Schistosoma mansoni hypothetical protein 0.0568 0.1593 0.3856
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.0305 0.3142
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0165 0.0299
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0069 0.0161
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0172 0.0417
Onchocerca volvulus 0.1253 0.3585 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.006 0.0108
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.006 0.0052
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.0346 0.3596
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0057 0.0107 0.0922
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0069 0.0493
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.075 0.8128
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0031 0.0077
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.1253 0.3585 0.5128
Echinococcus granulosus fetal alzheimer antigen falz 0.0034 0.0041 0.0099
Trichomonas vaginalis ap endonuclease, putative 0.004 0.006 0.0182
Echinococcus multilocularis neuropeptide s receptor 0.0569 0.1596 0.2893
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0966 0.2752 0.6664
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0631 0.1778 0.6426
Brugia malayi Pre-SET motif family protein 0.0108 0.0256 0.0353
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.001 0.0024
Loa Loa (eye worm) beta-lactamase 0.0043 0.0069 0.0067
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0069 0.0216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0209 0.0551 0.1334
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0031 0.0077
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0584 0.1639 0.3969
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0118 0.0287 0.0695
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0057 0.0107 0.0922
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0165 0.04
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0069 0.0125
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.1253 0.3585 0.3583
Echinococcus granulosus lamin dm0 0.0033 0.0037 0.009
Onchocerca volvulus 0.0835 0.2371 0.6579
Loa Loa (eye worm) hypothetical protein 0.0082 0.018 0.0178
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0057 0.0107 0.0922
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0165 0.04
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.0305 0.3142
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0057 0.0107 0.0302
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.1253 0.3585 0.5128
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0324 0.1673
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.001 0.0024
Brugia malayi Cytochrome P450 family protein 0.0142 0.0357 0.0498
Entamoeba histolytica hypothetical protein 0.0083 0.0184 0.0926
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0031 0.0077
Schistosoma mansoni hypothetical protein 0.006 0.0117 0.0282
Schistosoma mansoni ap endonuclease 0.004 0.006 0.0145
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0324 0.1146
Loa Loa (eye worm) phosphofructokinase 0.0131 0.0324 0.0322
Schistosoma mansoni lamin 0.0033 0.0037 0.009
Toxoplasma gondii LsmAD domain-containing protein 0.0047 0.0078 0.012
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0021 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0669 0.1888 0.1887
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0046 0.0191
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.032 0.0874 0.3112
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0165 0.0222
Plasmodium vivax ataxin-2 like protein, putative 0.0047 0.0078 0.012
Trichomonas vaginalis esterase, putative 0.0043 0.0069 0.0216
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0966 0.2752 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.001 0.0008
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0102 0.01
Schistosoma mansoni nAChR subunit 0.0584 0.1639 0.3969
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.001 0.0024
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.0346 0.3596
Onchocerca volvulus 0.1253 0.3585 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0031 0.0077
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0057 0.0107 0.0302
Echinococcus granulosus nAChR subunit 0.1253 0.3585 0.868
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.1253 0.3585 0.3583
Loa Loa (eye worm) hypothetical protein 0.0584 0.1639 0.1637

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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