Detailed information for compound 2070306

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 321.398 | Formula: C14H19N5O2S
  • H donors: 1 H acceptors: 3 LogP: 1.71 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(N1CCN(CC1)c1nccs1)C)Nc1onc(c1)C
  • InChi: 1S/C14H19N5O2S/c1-10-9-12(21-17-10)16-13(20)11(2)18-4-6-19(7-5-18)14-15-3-8-22-14/h3,8-9,11H,4-7H2,1-2H3,(H,16,20)
  • InChiKey: PRRYZQUYCAIYSN-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0013 0.0046 0.0046
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.003 0.0168 0.0398
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0064 0.0064
Echinococcus multilocularis nervana 2 0.0364 0.258 0.258
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0046 0.1916
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0092 0.0614 0.1711
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0107 0.4692
Echinococcus multilocularis cation transporting atpase worm 0.0012 0.0036 0.0036
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0046 0.0547
Schistosoma mansoni ran 0.0018 0.0079 0.0188
Brugia malayi MH2 domain containing protein 0.0101 0.0677 0.4783
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0038 0.0223 1
Trypanosoma brucei P-type H+-ATPase, putative 0.0024 0.0124 0.5065
Brugia malayi hypothetical protein 0.0062 0.0396 0.2799
Brugia malayi calcium ATPase 0.0014 0.0049 0.0348
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0018 0.0079 0.2864
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0052
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.003 0.0168 0.0168
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0084 0.056 0.1324
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0015 0.0656
Echinococcus multilocularis importin subunit beta 1 0.0024 0.0126 0.0126
Schistosoma mansoni cpg binding protein 0.0026 0.0135 0.0319
Loa Loa (eye worm) hypothetical protein 0.0066 0.0428 0.1012
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0592 0.4229 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Loa Loa (eye worm) hypothetical protein 0.0085 0.0568 0.1343
Echinococcus granulosus nervana 2 0.0364 0.258 0.6101
Echinococcus granulosus nervana 2 0.0592 0.4229 1
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.0004 0.0026
Echinococcus granulosus copper transporting ATPase 1 0.0012 0.0036 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Schistosoma mansoni cpg binding protein 0.0024 0.0125 0.0296
Loa Loa (eye worm) hypothetical protein 0.0092 0.0614 0.1453
Brugia malayi Membrane calcium atpase protein 3 0.003 0.0168 0.1189
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.003 0.0168 0.0398
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0064 0.0152
Schistosoma mansoni cation-transporting ATPase 0.0012 0.0036 0.0086
Plasmodium falciparum calcium-transporting ATPase 0.003 0.0168 0.7082
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0012 0.0036 0.0404
Entamoeba histolytica hypothetical protein 0.002 0.0093 0.1458
Loa Loa (eye worm) hypothetical protein 0.0592 0.4229 1
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0038 0.0223 0.0526
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0146 0.103
Loa Loa (eye worm) hypothetical protein 0.0036 0.0207 0.049
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0012 0.0036 0.1141
Trypanosoma brucei P-type H+-ATPase, putative 0.0024 0.0124 0.5065
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.003 0.0168 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0015 0.0656
Echinococcus multilocularis protein dispatched 1 0.0041 0.0244 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0146 0.0146
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.003 0.0168 0.252
Echinococcus multilocularis copper transporting ATPase 1 0.0012 0.0036 0.0036
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0062 0.0396 0.0937
Leishmania major P-type ATPase, putative 0.003 0.0168 0.7082
Echinococcus multilocularis cation transporting ATPase 13A1 0.0012 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Loa Loa (eye worm) hypothetical protein 0.0083 0.0549 0.1299
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0146 0.0146
Echinococcus multilocularis geminin 0.0143 0.0982 0.0982
Schistosoma mansoni hypothetical protein 0.0034 0.0198 0.0469
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0018 0.0079 0.0079
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0012 0.0036 0.0256
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0016 0.0064 0.1508
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0038 0.0223 0.0551
Brugia malayi Pax transcription factor protein 2 0.0203 0.1415 1
Toxoplasma gondii FATC domain-containing protein 0.0022 0.0107 0.3696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0015 0.0656
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0009 0.0015 0.0015
Trypanosoma brucei calcium motive p-type ATPase, putative 0.003 0.0168 0.729
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0016 0.0064 0.0152
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0038 0.0223 1
Brugia malayi latrophilin 2 splice variant baaae 0.0058 0.0373 0.2633
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0005 0.0005
Loa Loa (eye worm) CXXC zinc finger family protein 0.0024 0.0125 0.0296
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0079 0.3431
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0018 0.0079 0.2702
Schistosoma mansoni hypothetical protein 0.0058 0.0373 0.0881
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0038 0.0223 0.0223
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0018 0.0081 0.3497
Echinococcus granulosus Niemann Pick C1 protein 0.0118 0.0807 0.1907
Brugia malayi E1-E2 ATPase family protein 0.0012 0.0036 0.0256
Echinococcus granulosus Niemann Pick C1 protein 0.0083 0.0549 0.1299
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0015 0.0656
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0109 0.4798
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0592 0.4229 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0093 0.4158
Toxoplasma gondii histone lysine methyltransferase SET1 0.0046 0.0281 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0016 0.0064 0.2112
Schistosoma mansoni type V p-type atpase isoform 0.0012 0.0036 0.0086
Echinococcus granulosus cation transporting ATPase 13A1 0.0012 0.0036 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0038 0.0223 0.3889
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0086
Echinococcus granulosus snurportin 1 0.0259 0.1824 0.4312
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0016 0.0069 0.0164
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0022 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Brugia malayi Na,K-ATPase alpha subunit 0.0092 0.0614 0.4342
Entamoeba histolytica Ran family GTPase 0.0018 0.0079 0.1212
Brugia malayi follicle stimulating hormone receptor 0.0195 0.136 0.961
Onchocerca volvulus 0.0203 0.1415 0.3143
Trichomonas vaginalis cation-transporting ATPase, putative 0.0038 0.0223 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0107 0.0756
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0038 0.0223 1
Leishmania major importin beta-1 subunit, putative 0.002 0.0093 0.3023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0015 0.0656
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0014 0.0049 0.2049
Schistosoma mansoni hypothetical protein 0.0062 0.0396 0.0937
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0064 0.1508
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0046 0.0046
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0038 0.0223 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0062 0.0396 0.0396
Echinococcus multilocularis Niemann Pick C1 protein 0.0083 0.0549 0.0549
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0064 0.0455
Schistosoma mansoni transcription factor LCR-F1 0.0062 0.0396 0.0937
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0046 0.122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0259 0.1824 0.4312
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0038 0.0223 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0038 0.0223 1
Schistosoma mansoni cpg binding protein 0.0026 0.0135 0.0319
Echinococcus multilocularis calcium transporting atpase 0.003 0.0168 0.0168
Schistosoma mansoni hypothetical protein 0.0027 0.0146 0.0345
Toxoplasma gondii target of rapamycin (TOR), putative 0.0016 0.0064 0.2156
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0012 0.0036 0.0086
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0146 0.103
Toxoplasma gondii non-specific serine/threonine protein kinase 0.001 0.0022 0.0625
Leishmania major calcium-translocating P-type ATPase 0.0038 0.0223 1
Schistosoma mansoni hypothetical protein 0.0027 0.0146 0.0345
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.008 0.0527 0.1246
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0012 0.0036 0.1627
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0146 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Echinococcus granulosus nervana 2 0.0592 0.4229 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0027 0.0146 0.0345
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0038 0.0223 0.3889
Onchocerca volvulus 0.0364 0.258 0.5982
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.003 0.0168 0.0398
Echinococcus granulosus serine protein kinase ATM 0.0022 0.0107 0.0253
Brugia malayi hypothetical protein 0.0008 0.0005 0.0033
Treponema pallidum cation-transporting ATPase, P-type 0.0012 0.0036 1
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.003 0.0168 0.5911
Entamoeba histolytica hypothetical protein 0.0062 0.0396 0.7133
Echinococcus granulosus importin subunit beta 1 0.0024 0.0126 0.0297
Echinococcus multilocularis nervana 2 0.0364 0.258 0.258
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0592 0.4229 0.4229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Onchocerca volvulus 0.0592 0.4229 1
Leishmania major P-type H -ATPase, putative 0.0024 0.0124 0.4686
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0012 0.0036 0.1449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Loa Loa (eye worm) hypothetical protein 0.0022 0.0109 0.0258
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0592 0.4229 0.4229
Loa Loa (eye worm) hypothetical protein 0.0068 0.0441 0.1043
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0126 0.5173
Schistosoma mansoni hypothetical protein 0.0034 0.0198 0.0469
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0092 0.0614 0.1453
Brugia malayi E1-E2 ATPase family protein 0.0024 0.0124 0.0873
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0038 0.0223 0.7876
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0038 0.0223 0.7876
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0038 0.0223 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0064 0.0152
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0004 0.0004
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0064 0.2738
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0004 0.001
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.003 0.0168 0.0398
Leishmania major calcium-transporting ATPase, putative 0.003 0.0168 0.7082
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0018 0.0079 0.2318
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0038 0.0223 1
Schistosoma mansoni ATPase 0.0038 0.0223 0.0526
Echinococcus multilocularis sterol regulatory element binding protein 0.0036 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.0259 0.1824 0.4312
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0009 0.0015 0.0456
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0089
Leishmania major phosphatidylinositol kinase related protein, putative 0.0016 0.0065 0.152
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0364 0.258 0.258
Trypanosoma cruzi P-type H+-ATPase, putative 0.0024 0.0124 0.5456
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0093 0.4158
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0109 0.4798
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0016 0.0065 0.2748
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0046 0.0046
Trichomonas vaginalis cation-transporting ATPase, putative 0.0038 0.0223 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Echinococcus granulosus cpg binding protein 0.0026 0.0135 0.0319
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0016 0.0064 0.0152
Echinococcus granulosus Protein patched homolog 1 0.0036 0.0207 0.049
Schistosoma mansoni patched 1 0.0036 0.0207 0.049
Trypanosoma cruzi P-type H+-ATPase, putative 0.0016 0.0069 0.2961
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0079 0.3431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0201
Brugia malayi Importin beta-1 subunit 0.0024 0.0126 0.0889
Schistosoma mansoni transmemberane protein 0.0592 0.4229 1
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0038 0.0223 1
Trypanosoma brucei calcium-transporting ATPase, putative 0.0018 0.0081 0.2937
Schistosoma mansoni cation-transporting atpase worm 0.0012 0.0036 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0022 0.0986
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.048 0.3416 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0018 0.0079 0.0825
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0064 0.2112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Leishmania major hypothetical protein, conserved 0.0022 0.0109 0.3917
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0064 0.0455
Schistosoma mansoni hypothetical protein 0.0027 0.0146 0.0345
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0018 0.0079 0.0188
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0364 0.258 0.6101
Trypanosoma cruzi cation-transporting ATPase, putative 0.0012 0.0036 0.1449
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0026 0.0135 0.0293
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0038 0.0223 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0203 0.1415 0.3346
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.0345
Schistosoma mansoni ATPase 0.0038 0.0223 0.0526
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0018 0.0081 0.0191
Echinococcus granulosus GPCR family 2 0.0027 0.0146 0.0345
Brugia malayi calcium ATPase 0.0016 0.0069 0.0489
Brugia malayi CHE-14 protein 0.0036 0.0207 0.1466
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0064 0.2738
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0012 0.0036 0.0712
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0083 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0089
Brugia malayi RNA, U transporter 1 0.0069 0.0449 0.3175
Loa Loa (eye worm) isocitrate dehydrogenase 0.0013 0.0046 0.011
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0012 0.0036 0.0086
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.0046 0.1509
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0021 0.0104 0.1666
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0364 0.258 0.6101
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0012 0.0036 0.1449
Trypanosoma brucei calcium-translocating P-type ATPase 0.003 0.0168 0.729
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0016 0.0064 0.1508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0015 0.0656
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0018 0.0079 0.0561
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0016 0.0064 0.2112
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0109 0.3917
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0022 0.0022
Brugia malayi hypothetical protein 0.0022 0.0109 0.0772
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0016 0.0064 0.2112
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0364 0.258 0.6101
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0038 0.0223 0.3889
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0016 0.0064 0.093
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0038 0.0223 1
Echinococcus multilocularis nervana 2 0.0592 0.4229 0.4229
Toxoplasma gondii P-type ATPase PMA1 0.0024 0.0124 0.4297
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0009 0.0015 0.0035
Echinococcus multilocularis protein patched 0.0036 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.0143 0.0982 0.2321
Echinococcus granulosus expressed conserved protein 0.0078 0.0513 0.1213
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0016 0.0064 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0015 0.0656
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0064 0.0152
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0016 0.0064 0.2738
Trichomonas vaginalis cation-transporting ATPase, putative 0.0012 0.0036 0.1627
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0012 0.0036 0.1141
Schistosoma mansoni cation-transporting atpase worm 0.0012 0.0036 0.0086
Schistosoma mansoni atpase class VI type 11c 0.0008 0.0005 0.0011
Schistosoma mansoni phosphoserine phosphatase 0.0008 0.0005 0.0011
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0109 0.3779
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0592 0.4229 1
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0084 0.056 0.056
Schistosoma mansoni importin beta-1 0.0024 0.0126 0.0297
Loa Loa (eye worm) hypothetical protein 0.0044 0.0265 0.0627
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0092 0.0614 0.1453
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0009 0.0015 0.0103
Brugia malayi Niemann-Pick C1 protein precursor 0.0083 0.0549 0.3883
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0012 0.0036 0.0256
Echinococcus multilocularis cpg binding protein 0.0026 0.0135 0.0135
Brugia malayi CXXC zinc finger family protein 0.0024 0.0125 0.0884
Schistosoma mansoni hypothetical protein 0.0034 0.0198 0.0469
Trypanosoma cruzi importin beta-1 subunit, putative 0.002 0.0093 0.4033
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0012 0.0036 0.0404
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.048 0.3416 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0062 0.0396 0.7133
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0038 0.0223 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0109 0.3917
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0038 0.0223 1
Trypanosoma brucei cation-transporting ATPase, putative 0.0012 0.0036 0.0712
Echinococcus granulosus sterol regulatory element binding protein 0.0036 0.0207 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Plasmodium vivax P-type ATPase4, putative 0.0038 0.0223 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0022 0.0107 0.4235
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0038 0.0223 0.0526
Trichomonas vaginalis ran, putative 0.0018 0.0079 0.3568
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0005 0.0005
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Loa Loa (eye worm) hypothetical protein 0.0054 0.0342 0.0809
Schistosoma mansoni copper ABC transporter ATPase 0.0012 0.0036 0.0086
Echinococcus granulosus phospholipid transporting ATPase VA 0.0008 0.0005 0.0011
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0038 0.0223 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0069 0.0164
Entamoeba histolytica hypothetical protein 0.0062 0.0396 0.7133
Brugia malayi Calcitonin receptor-like protein seb-1 0.0085 0.0568 0.4015
Echinococcus granulosus Na:K ATPase alpha subunit 0.0084 0.056 0.1324
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0146 0.0345
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0005 0.0005
Toxoplasma gondii P-type ATPase4, putative 0.0038 0.0223 0.7876
Entamoeba histolytica hypothetical protein 0.0062 0.0396 0.7133
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.008 0.0527 0.3725
Echinococcus multilocularis serine protein kinase ATM 0.0022 0.0107 0.0107
Loa Loa (eye worm) transcription factor SMAD2 0.0101 0.0677 0.16
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0012 0.0036 0.0404
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0012 0.0036 0.1627
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0018 0.0079 0.2318
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0022 0.0107 0.0253
Echinococcus multilocularis cation transporting ATPase 13A3 0.0012 0.0036 0.0036
Schistosoma mansoni fkbp-rapamycin associated protein 0.0009 0.0015 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0592 0.4229 0.4229
Loa Loa (eye worm) MH2 domain-containing protein 0.0101 0.0677 0.16
Plasmodium vivax calcium-transporting ATPase, putative 0.0038 0.0223 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0013 0.0046 0.0046
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0592 0.4229 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.003 0.0168 0.7557
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.003 0.0168 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Plasmodium vivax importin-beta 2, putative 0.0024 0.0126 0.4803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0026 0.0135 0.0293
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0005 0.0005
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0016 0.0069 0.2961
Schistosoma mansoni hypothetical protein 0.0034 0.0198 0.0469
Trypanosoma cruzi target of rapamycin kinase 3 0.0016 0.0064 0.2738
Leishmania major P-type H -ATPase, putative 0.0024 0.0124 0.4686
Echinococcus multilocularis nervana 2 0.0592 0.4229 0.4229
Mycobacterium ulcerans proteasome PrcA 0.048 0.3416 1
Loa Loa (eye worm) hypothetical protein 0.0592 0.4229 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0118 0.0807 0.0807
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.003 0.0168 0.0398
Loa Loa (eye worm) hypothetical protein 0.0024 0.0126 0.0297
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0126 0.5173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0013 0.0046 0.0547
Echinococcus granulosus cation transporting atpase worm 0.0012 0.0036 0.0086
Entamoeba histolytica hypothetical protein 0.0022 0.0107 0.1726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0084 0.056 1
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.003 0.0168 0.7505
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0038 0.0223 0.3889
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0022 0.0986
Echinococcus granulosus geminin 0.0143 0.0982 0.2321
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0016 0.0064 0.1508
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0592 0.4229 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Echinococcus multilocularis GPCR, family 2 0.0027 0.0146 0.0146
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0038 0.0223 1
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0008 0.0005 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0085 0.0568 0.1343
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0012 0.0036 0.0036
Echinococcus granulosus calcium transporting atpase 0.003 0.0168 0.0398
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0016 0.0064 0.2738
Leishmania major GTP-binding protein, putative 0.0018 0.0079 0.2318
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.008 0.0527 0.1452
Trypanosoma cruzi P-type H+-ATPase, putative 0.0024 0.0124 0.5456
Echinococcus granulosus nervana 2 0.0364 0.258 0.6101
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0004 0.001
Trichomonas vaginalis importin beta-1, putative 0.002 0.0093 0.4158
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0038 0.0223 0.0223
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0016 0.0069 0.1021
Brugia malayi Isocitrate dehydrogenase 0.0013 0.0046 0.0328
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.003 0.0168 0.7505
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0013 0.0046 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0018 0.0081 0.0572
Schistosoma mansoni hypothetical protein 0.001 0.0022 0.0051
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0013 0.0046 0.011
Loa Loa (eye worm) hypothetical protein 0.0058 0.0373 0.0881
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0107 0.4803
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0085 0.0568 0.4015
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0013 0.0046 0.003
Schistosoma mansoni ran 0.0018 0.0079 0.0188
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.003 0.0168 0.0398
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0064 0.1508
Echinococcus granulosus GTP binding nuclear protein Ran 0.0018 0.0079 0.0188
Toxoplasma gondii HEAT repeat-containing protein 0.0024 0.0126 0.4376
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.0046 0.1509
Plasmodium falciparum importin beta, putative 0.0024 0.0126 0.4803
Echinococcus multilocularis snurportin 1 0.0259 0.1824 0.1824
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0109 0.435
Giardia lamblia GTOR 0.0016 0.0064 0.0536
Leishmania major calcium motive p-type ATPase, putative 0.003 0.0168 0.7082
Schistosoma mansoni hypothetical protein 0.0027 0.0146 0.0345
Schistosoma mansoni hypothetical protein 0.0143 0.0982 0.2321
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0016 0.0064 0.093
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0016 0.0069 0.0489
Onchocerca volvulus 0.0092 0.0614 0.1192
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.0109 0.3917
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0038 0.0223 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0035
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0038 0.0223 0.0526
Echinococcus granulosus cation transporting ATPase 13A3 0.0012 0.0036 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0064 0.289
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0021 0.0104 0.1666
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0013 0.0046 0.122
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0012 0.0036 0.0404
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0195 0.136 0.3216
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0013 0.0046 0.0547
Echinococcus multilocularis expressed conserved protein 0.0078 0.0513 0.0513
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0064 0.2112
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0051 0.0321 0.0759
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0038 0.0223 0.0223
Loa Loa (eye worm) calcium ATPase 0.0021 0.0104 0.0245
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0016 0.0069 0.2332
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0016 0.0069 0.2961
Brugia malayi hypothetical protein 0.0014 0.0053 0.0374
Brugia malayi isocitrate dehydrogenase 0.0013 0.0046 0.0328
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0064 0.0152
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0013 0.0046 0.1916
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0012 0.0036 0.1627
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0021 0.0104 0.0733
Loa Loa (eye worm) E1-E2 ATPase 0.0024 0.0124 0.0292
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0038 0.0223 0.3558
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.003 0.0168 0.1189
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0207 0.9317
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0085 0.3686
Chlamydia trachomatis metal transport ATPase 0.0012 0.0036 0.5
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0036 0.0207 0.049
Trichomonas vaginalis cation-transporting ATPase, putative 0.0024 0.0124 0.5551
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0084 0.0559 0.1321

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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