Detailed information for compound 2070339

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 347.475 | Formula: C18H25N3O2S
  • H donors: 0 H acceptors: 2 LogP: 2.41 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cnc(o1)CN(C1CCN(C1)CCc1cccs1)C(=O)C
  • InChi: 1S/C18H25N3O2S/c1-3-16-11-19-18(23-16)13-21(14(2)22)15-6-8-20(12-15)9-7-17-5-4-10-24-17/h4-5,10-11,15H,3,6-9,12-13H2,1-2H3
  • InChiKey: UPLZAUWEKIGPCH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0138 0.1577 0.1556
Brugia malayi Cytochrome P450 family protein 0.0027 0.0233 0.0391
Onchocerca volvulus 0.0037 0.0351 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Loa Loa (eye worm) hypothetical protein 0.0074 0.0806 0.1498
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Onchocerca volvulus 0.0138 0.1577 0.4618
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Brugia malayi hypothetical protein 0.0147 0.1686 0.3198
Onchocerca volvulus 0.0084 0.0926 0.2674
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0074 0.0806 0.1498
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.1577 0.2988
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Brugia malayi hypothetical protein 0.0064 0.0676 0.1248
Schistosoma mansoni cpg binding protein 0.0037 0.0349 0.0324
Brugia malayi Cation transporter family protein 0.0138 0.1577 0.2988
Brugia malayi follicle stimulating hormone receptor 0.0283 0.3328 0.6372
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0438 0.5205 0.5
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0351 0.0326
Echinococcus granulosus nervana 2 0.0052 0.0532 0.0508
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0793 0.1474
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0233 0.0391
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0676 0.1248
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0052 0.0532 0.0508
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0793 0.1474
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Echinococcus multilocularis geminin 0.0175 0.2028 0.2008
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0138 0.1577 0.1556
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0084 0.0926 0.0903
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Schistosoma mansoni hypothetical protein 0.0175 0.2028 0.2008
Loa Loa (eye worm) hypothetical protein 0.0383 0.4546 0.8725
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.1577 0.2988
Echinococcus multilocularis nervana 2 0.0084 0.0926 0.0903
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0138 0.1577 0.1556
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0064 0.0676 0.1248
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0138 0.1577 0.1556
Onchocerca volvulus Putative nachr subunit 0.0138 0.1577 0.4618
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0049 0.0036
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0051 0.0026
Schistosoma mansoni cpg binding protein 0.0035 0.0325 0.03
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0351 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0812 0.0789
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0138 0.1577 0.1556
Echinococcus granulosus nAChR subunit 0.0074 0.0806 0.0782
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0233 0.0182
Schistosoma mansoni nAChR subunit 0.0138 0.1577 0.1556
Schistosoma mansoni acetylcholine receptor-related 0.0064 0.0676 0.0653
Echinococcus multilocularis nervana 2 0.0052 0.0532 0.0508
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0209
Schistosoma mansoni nAChR subunit 0.0138 0.1577 0.1556
Schistosoma mansoni nAChR subunit 0.0138 0.1577 0.1556
Loa Loa (eye worm) ACC-1 protein 0.0138 0.1577 0.2988
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0138 0.1577 0.1556
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0438 0.5205 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0064 0.0676 0.1248
Schistosoma mansoni nAChR subunit 0.0138 0.1577 0.1556
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0138 0.1577 0.1556
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0138 0.1577 0.1556
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0074 0.0806 0.1498
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0717 0.1138
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0793 0.077
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.3328 0.6372
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0438 0.5205 0.5193
Echinococcus granulosus nervana 2 0.0084 0.0926 0.0903
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Brugia malayi Cation transporter family protein 0.0138 0.1577 0.2988
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Echinococcus granulosus glycine receptor subunit alpha 1 0.0138 0.1577 0.1556
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0325 0.0569
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.001 0.003 0.0058
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0233 0.0391
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.014 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Schistosoma mansoni acetylcholine receptor subunit beta 0.0064 0.0676 0.0653
Brugia malayi CXXC zinc finger family protein 0.0035 0.0325 0.0569
Loa Loa (eye worm) hypothetical protein 0.0084 0.0926 0.173
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0074 0.0806 0.0782
Loa Loa (eye worm) ACC-1 protein 0.0138 0.1577 0.2988
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0064 0.0676 0.1248
Onchocerca volvulus 0.0064 0.0676 0.1928
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0138 0.1577 0.2988
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0138 0.1577 0.2988
Loa Loa (eye worm) hypothetical protein 0.0037 0.0351 0.0619
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0138 0.1577 0.1556
Echinococcus granulosus geminin 0.0175 0.2028 0.2008
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.001 0.003 0.0058
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0793 0.4452
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0793 0.1474
Onchocerca volvulus 0.0074 0.0806 0.2315
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.014 0.0116
Echinococcus multilocularis glycine receptor subunit beta 0.0138 0.1577 0.1556
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0138 0.1577 0.1556
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0438 0.5205 1
Echinococcus multilocularis nervana 2 0.0084 0.0926 0.0903
Schistosoma mansoni transmemberane protein 0.0084 0.0926 0.0903
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.1577 0.2988
Schistosoma mansoni ap endonuclease 0.0019 0.014 0.0116
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0138 0.1577 0.1556
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0138 0.1577 0.2988
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.014 0.0213
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0438 0.5205 1
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0438 0.5205 1
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0438 0.5205 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0806 0.1498
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0286 0.3367 0.637
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.014 0.0643
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0138 0.1577 0.2988
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0138 0.1577 0.2988
Schistosoma mansoni nAChR subunit 0.0138 0.1577 0.1556
Echinococcus granulosus glycine receptor subunit alpha 1 0.0138 0.1577 0.1556
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0138 0.1577 0.1556
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0438 0.5205 0.5193
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0138 0.1577 0.2988
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0074 0.0806 0.1498
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0138 0.1577 0.1556
Brugia malayi Cytochrome P450 family protein 0.0027 0.0233 0.0391
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0138 0.1577 0.2988
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0793 0.1289
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0438 0.5205 1
Onchocerca volvulus 0.0064 0.0676 0.1928
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0233 0.0391
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Schistosoma mansoni cpg binding protein 0.0037 0.0349 0.0324
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Brugia malayi excitatory GABA receptor EXP-1A 0.0138 0.1577 0.2988
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0052 0.0532 0.0508
Brugia malayi Pre-SET motif family protein 0.0037 0.0351 0.0619
Brugia malayi hypothetical protein 0.0064 0.0676 0.1248
Loa Loa (eye worm) hypothetical protein 0.0074 0.0806 0.1498
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0793 0.077
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0084 0.0926 0.0903
Loa Loa (eye worm) hypothetical protein 0.0074 0.0806 0.1498
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0233 0.0182
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0793 0.077
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0051 0.0026
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Onchocerca volvulus 0.0052 0.0532 0.1499
Plasmodium vivax SET domain protein, putative 0.0037 0.0351 0.0415
Echinococcus granulosus glycine receptor subunit beta 0.0138 0.1577 0.1556
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Loa Loa (eye worm) hypothetical protein 0.0074 0.0806 0.1498
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0064 0.0676 0.1248
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0351 0.0326
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0138 0.1577 0.2988
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0438 0.5205 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2959 0.5658
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.014 0.027
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0138 0.1577 0.1556
Onchocerca volvulus 0.0138 0.1577 0.4618
Schistosoma mansoni nAChR subunit 0.0138 0.1577 0.1556
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0052 0.0532 0.0508
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0138 0.1577 0.2988
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0138 0.1577 0.1556
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.0676 0.0653
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0351 0.0326
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.014 0.027
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Loa Loa (eye worm) hypothetical protein 0.0074 0.0806 0.1498
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0084 0.0926 0.0903
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.1577 0.2988
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0084 0.0926 0.0903
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0051 0.004
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0793 0.1289
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0084 0.0926 0.0903
Echinococcus multilocularis nAChR subunit 0.0138 0.1577 0.1556
Echinococcus granulosus glycine receptor subunit alpha 1 0.0138 0.1577 0.1556
Onchocerca volvulus 0.0138 0.1577 0.4618
Loa Loa (eye worm) acetylcholine receptor protein 0.0064 0.0676 0.1248
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0052 0.0532 0.0508
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0438 0.5205 0.5193
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0074 0.0806 0.0782
Echinococcus granulosus nervana 2 0.0052 0.0532 0.0508
Brugia malayi Cation transporter family protein 0.0138 0.1577 0.2988
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.014 0.5
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0084 0.0926 0.0903
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Brugia malayi Pre-SET motif family protein 0.0252 0.2959 0.5658
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0138 0.1577 0.1556
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0074 0.0806 0.1498
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.1577 0.2988
Schistosoma mansoni neurotransmitter gated ion channel 0.0074 0.0806 0.0782
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0138 0.1577 0.1556
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0233 0.0391
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0145 0.1661 0.3002
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0064 0.0676 0.0653
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0138 0.1577 0.1556
Brugia malayi hypothetical protein 0.0064 0.0676 0.1248
Schistosoma mansoni nAChR subunit 0.0138 0.1577 0.1556
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0138 0.1577 0.2988
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Brugia malayi hypothetical protein 0.0064 0.0676 0.1248
Echinococcus granulosus glycine receptor subunit beta 0.0138 0.1577 0.1556
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0138 0.1577 0.2988
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0138 0.1577 0.2988
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0351 0.0326
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0438 0.5205 1
Echinococcus multilocularis glycine receptor subunit beta 0.0138 0.1577 0.1556
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0138 0.1577 0.1556
Echinococcus multilocularis cpg binding protein 0.0037 0.0349 0.0324
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0064 0.0676 0.1248
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0141 0.161 0.2902
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0325 0.0301
Schistosoma mansoni nAChR subunit 0.0064 0.0676 0.0653
Onchocerca volvulus 0.0074 0.0806 0.2315
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0676 0.1248
Schistosoma mansoni hypothetical protein 0.0175 0.2028 0.2008
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0438 0.5205 1
Onchocerca volvulus 0.0035 0.0325 0.088
Onchocerca volvulus 0.0138 0.1577 0.4618
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0064 0.0676 0.0653
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0138 0.1577 0.1556
Echinococcus granulosus nAChR subunit 0.0138 0.1577 0.1556
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0064 0.0676 0.0653
Schistosoma mansoni ap endonuclease 0.0019 0.014 0.0116
Loa Loa (eye worm) hypothetical protein 0.0074 0.0806 0.1498
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0138 0.1577 0.2988
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.014 0.0213
Schistosoma mansoni nAChR subunit 0.0064 0.0676 0.0653
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.0676 0.0653
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0351 0.0415
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0793 0.077
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0138 0.1577 0.1556
Echinococcus multilocularis nAChR subunit 0.0074 0.0806 0.0782
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0438 0.5205 1
Brugia malayi glucose-6-phosphate dehydrogenase 0.0438 0.5205 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0286 0.3367 0.6447
Loa Loa (eye worm) LGC-31 protein 0.0138 0.1577 0.2988
Loa Loa (eye worm) hypothetical protein 0.0064 0.0676 0.1248
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Loa Loa (eye worm) GABA receptor subunit 0.0074 0.0806 0.1498
Entamoeba histolytica hypothetical protein 0.0074 0.0806 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0676 0.1248
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0351 0.0326
Brugia malayi hypothetical protein 0.0064 0.0676 0.1248
Loa Loa (eye worm) hypothetical protein 0.0074 0.0806 0.1498
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0064 0.0676 0.0653
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0138 0.1577 0.1556
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0438 0.5205 1
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3379 0.6492
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0064 0.0676 0.0653
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0438 0.5205 1
Echinococcus multilocularis nervana 2 0.0052 0.0532 0.0508
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.1577 0.2988
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0138 0.1577 0.2988
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0233 0.0182
Onchocerca volvulus 0.0138 0.1577 0.4618
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0138 0.1577 0.2988
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0351 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.014 0.0213
Echinococcus granulosus cpg binding protein 0.0037 0.0349 0.0324
Leishmania major cytochrome p450-like protein 0.0027 0.0233 0.0182
Loa Loa (eye worm) hypothetical protein 0.0084 0.0926 0.173
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.014 0.0116
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0152 0.1744 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.0058
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0138 0.1577 0.2988
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0138 0.1577 0.1556
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0438 0.5205 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Onchocerca volvulus 0.0138 0.1577 0.4618
Echinococcus granulosus nervana 2 0.0084 0.0926 0.0903
Onchocerca volvulus 0.0064 0.0676 0.1928
Onchocerca volvulus 0.0287 0.3379 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0138 0.1577 0.1556
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0084 0.0926 0.0903
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0084 0.0926 0.0903
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988
Loa Loa (eye worm) hypothetical protein 0.0074 0.0806 0.1498
Loa Loa (eye worm) hypothetical protein 0.0138 0.1577 0.2988

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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