Detailed information for compound 2070382

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 336.413 | Formula: C14H20N6O2S
  • H donors: 1 H acceptors: 4 LogP: 0.54 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1nnc(s1)CN1CCOC(C1)CNc1cccnn1
  • InChi: 1S/C14H20N6O2S/c1-2-21-14-19-18-13(23-14)10-20-6-7-22-11(9-20)8-15-12-4-3-5-16-17-12/h3-5,11H,2,6-10H2,1H3,(H,15,17)
  • InChiKey: GJHMQVMFKOHUEU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.1145 0.1602
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.1145 0.1602
Brugia malayi ecdysone receptor 0.001 0.0303 0.0348
Entamoeba histolytica hypothetical protein 0.0015 0.0664 1
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.1145 0.1602
Echinococcus multilocularis netrin receptor unc 5 0.0008 0.0113 0.0113
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.1145 0.1602
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0007 0.0069 0.0102
Schistosoma mansoni nephrin 0.0006 0.0003 0.0006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.1145 0.1145
Schistosoma mansoni nuclear hormone receptor 0.0022 0.1145 0.2274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.1145 0.1688
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0026 0.1429 0.1429
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0303 0.0303
Mycobacterium ulcerans aldehyde dehydrogenase 0.0026 0.1429 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.1145 0.1688
Brugia malayi nuclear hormone receptor 0.0022 0.1145 0.1602
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.1145 0.1145
Echinococcus multilocularis roundabout 2 0.0008 0.012 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1524 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0007 0.0069 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0007 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1524 0.5
Onchocerca volvulus 0.0073 0.4886 0.9813
Onchocerca volvulus Tyrosine kinase homolog 0.0075 0.4978 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.1145 0.1688
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0394 0.0781
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0394 0.0483
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0303 0.0348
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0303 0.0303
Echinococcus granulosus twitchin 0.0006 0.0003 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0303 0.0303
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0015 0.0664 0.0664
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0007 0.0069 0.5
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0031 0.1829 0.1829
Echinococcus multilocularis cysteine protease 0.0007 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0394 0.0394
Brugia malayi nuclear receptor NHR-67 0.001 0.0303 0.0348
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.1145 0.2274
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0036 0.2148 0.2148
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.1145 0.1602
Entamoeba histolytica hypothetical protein 0.0015 0.0664 1
Brugia malayi hypoxia-induced factor 1 0.0064 0.4207 0.616
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0303 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1524 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.1145 0.1145
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0025 0.1353 0.8824
Echinococcus granulosus roundabout 2 0.0008 0.012 0.012
Brugia malayi follicle stimulating hormone receptor 0.0099 0.6787 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.1145 0.1145
Loa Loa (eye worm) hypothetical protein 0.001 0.0303 0.0447
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.1145 0.1688
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1524 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0303 0.0348
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0015 0.0664 0.0664
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0303 0.0447
Echinococcus multilocularis cathepsin L cysteine protease 0.0007 0.0069 0.0069
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0054 0.3444 0.3444
Loa Loa (eye worm) hypothetical protein 0.0022 0.1145 0.1688
Onchocerca volvulus Netrin receptor homolog 0.0007 0.0088 0.0038
Leishmania major cathepsin L-like protease 0.0027 0.1524 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0303 0.0447
Loa Loa (eye worm) hypothetical protein 0.0012 0.0394 0.058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0007 0.0069 0.0069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0026 0.1429 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.1145 0.1145
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.1145 0.1145
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.1145 0.1602
Plasmodium falciparum cysteine proteinase falcipain 3 0.0007 0.0069 0.5
Leishmania major cathepsin L-like protease 0.0027 0.1524 1
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.1145 0.1145
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.1145 0.1602
Schistosoma mansoni cathepsin F (C01 family) 0.0007 0.0069 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.1145 0.1602
Plasmodium vivax vivapain-2 0.0007 0.0069 0.5
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0303 0.0303
Brugia malayi hypothetical protein 0.0012 0.0394 0.0483
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.1145 0.2274
Loa Loa (eye worm) hypothetical protein 0.0021 0.1081 0.1593
Echinococcus granulosus cathepsin l1 0.0007 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.0015 0.0664 1
Brugia malayi Nuclear hormone receptor E75 0.001 0.0303 0.0348
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.1145 0.1145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1524 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0394 0.058
Schistosoma mansoni nuclear hormone receptor 0.001 0.0303 0.0602
Brugia malayi hypothetical protein 0.0069 0.4598 0.6742
Loa Loa (eye worm) TK/KIN16 protein kinase 0.008 0.5363 0.7902
Echinococcus multilocularis jun protein 0.0036 0.2148 0.2148
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0303 0.0303
Brugia malayi Nuclear hormone receptor E75 0.001 0.0303 0.0348
Schistosoma mansoni coup transcription factor 0.0022 0.1145 0.2274
Loa Loa (eye worm) ctsf protein 0.0007 0.0069 0.0102
Schistosoma mansoni cellular tumor antigen P53 0.0021 0.1081 0.2146
Echinococcus granulosus single minded 2 0.0015 0.0665 0.0665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1524 0.5
Echinococcus granulosus neuroglian 0.0006 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0303 0.0447
Schistosoma mansoni hypothetical protein 0.0054 0.3444 0.6837
Schistosoma mansoni aldehyde dehydrogenase 0.0026 0.1429 0.2837
Brugia malayi steroid hormone receptor 0.0022 0.1145 0.1602
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Brugia malayi hypothetical protein 0.0012 0.0394 0.0483
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.1145 0.2274
Schistosoma mansoni nuclear hormone receptor 0.001 0.0303 0.0602
Echinococcus granulosus nuclear factor of activated T cells 5 0.0031 0.1829 0.1829
Schistosoma mansoni cell adhesion molecule 0.0007 0.0029 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.1145 0.1602
Loa Loa (eye worm) hypothetical protein 0.0012 0.0394 0.058
Echinococcus granulosus FTZ F1 alpha 0.0022 0.1145 0.1145
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0042
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0026 0.1429 0.9347
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0303 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0303 0.0447
Echinococcus granulosus cathepsin l cysteine peptidase 0.0007 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Schistosoma mansoni zinc finger protein 0.001 0.0303 0.0602
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0303 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1524 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0303 0.0447
Onchocerca volvulus 0.0015 0.0665 0.1213
Loa Loa (eye worm) hypothetical protein 0.0022 0.1145 0.1688
Echinococcus multilocularis neuroglian 0.0006 0.0003 0.0003
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.1145 0.1145
Loa Loa (eye worm) DR-78 0.001 0.0303 0.0447
Schistosoma mansoni hypothetical protein 0.0015 0.0664 0.1318
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1524 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.1145 0.2192
Loa Loa (eye worm) hypothetical protein 0.0008 0.012 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1524 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0394 0.0483
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.1145 0.1145
Brugia malayi nuclear receptor NHR-88 0.0022 0.1145 0.1602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0303 0.0602
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.1145 0.1145
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0007 0.0069 0.5
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0007 0.0029 0.0029
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.1145 0.1145
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.1145 0.2274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1524 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.5363 0.788
Brugia malayi nuclear receptor RXR 0.001 0.0303 0.0348
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.1145 0.1145
Echinococcus multilocularis cysteine protease 0.0007 0.0069 0.0069
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.1524 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.1145 0.1145
Schistosoma mansoni aldehyde dehydrogenase 0.0026 0.1429 0.2837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0303 0.0447
Schistosoma mansoni hypothetical protein 0.0029 0.1662 0.3299
Loa Loa (eye worm) hypothetical protein 0.0007 0.0069 0.0102
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0026 0.1429 0.5
Schistosoma mansoni nuclear receptor 0.001 0.0303 0.0602
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.1145 0.2274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1524 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0303 0.0303
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.1145 0.1145
Loa Loa (eye worm) cysteine protease 0.0007 0.0069 0.0102
Loa Loa (eye worm) hypothetical protein 0.0012 0.0394 0.058
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.1145 0.2274
Brugia malayi nuclear receptor NHR-88 0.001 0.0303 0.0348
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0303 0.0303
Schistosoma mansoni thyroid hormone receptor 0.0075 0.5038 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.1145 0.1688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Toxoplasma gondii aldehyde dehydrogenase 0.0026 0.1429 1
Schistosoma mansoni thyroid hormone receptor 0.0075 0.5038 1
Brugia malayi bZIP transcription factor family protein 0.0036 0.2148 0.3095
Loa Loa (eye worm) hypothetical protein 0.001 0.0303 0.0447
Loa Loa (eye worm) hypothetical protein 0.0012 0.0394 0.058
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0026 0.1429 0.1429
Loa Loa (eye worm) hypothetical protein 0.001 0.0303 0.0447
Brugia malayi bHLH-PAS transcription factor 0.0015 0.0665 0.0887
Schistosoma mansoni cathepsin F (C01 family) 0.0007 0.0069 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0303 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.1145 0.1602
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0054 0.3444 0.3444
Brugia malayi hypothetical protein 0.0015 0.0664 0.0885
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0303 0.0348
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.1145 0.1688
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.1145 0.1602
Brugia malayi ecdysteroid receptor 0.0022 0.1145 0.1602
Onchocerca volvulus 0.0021 0.1081 0.2061
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1524 1
Echinococcus granulosus jun protein 0.0036 0.2148 0.2148
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0303 0.0303
Brugia malayi conserved hypotetical protein 0.001 0.0303 0.0348
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0007 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.001 0.0303 0.0447
Onchocerca volvulus 0.0022 0.1145 0.2192
Schistosoma mansoni aryl hydrocarbon receptor 0.0021 0.1056 0.2096
Schistosoma mansoni transcription factor LCR-F1 0.0015 0.0664 0.1318
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0007 0.0069 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.1145 0.2192
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0007 0.0069 0.0102
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0303 0.0303
Echinococcus multilocularis tumor protein p63 0.0144 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0007 0.0069 0.0069
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0036 0.2148 0.2148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Loa Loa (eye worm) fibroinase 0.0007 0.0069 0.0102
Loa Loa (eye worm) hypothetical protein 0.0008 0.012 0.0177
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0303 0.0447
Loa Loa (eye worm) hypothetical protein 0.001 0.0303 0.0447
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Schistosoma mansoni jun-related protein 0.0029 0.1662 0.3299
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.1145 0.1602
Loa Loa (eye worm) hypothetical protein 0.001 0.0303 0.0447
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1524 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.1145 0.1602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Onchocerca volvulus 0.001 0.0303 0.0477
Entamoeba histolytica hypothetical protein 0.0015 0.0664 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.1145 0.1688
Loa Loa (eye worm) hypothetical protein 0.0022 0.1145 0.1688
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1524 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.1145 0.1602
Leishmania major cathepsin L-like protease 0.0027 0.1524 1
Plasmodium vivax vivapain-2 0.0007 0.0069 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.1145 0.2192
Echinococcus granulosus netrin receptor unc 5 0.0008 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0022 0.1145 0.1688
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0007 0.0069 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Brugia malayi PAS domain containing protein 0.0021 0.1056 0.1469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.1145 0.1688
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.1145 0.2274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.1145 0.1688
Onchocerca volvulus 0.0028 0.1591 0.3099
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.1145 0.2274
Schistosoma mansoni single-minded 0.0021 0.1056 0.2096
Brugia malayi hypothetical protein 0.001 0.0303 0.0348
Loa Loa (eye worm) hypothetical protein 0.001 0.0303 0.0447
Onchocerca volvulus 0.001 0.0303 0.0477
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0022 0.1145 0.1688
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0303 0.0447
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0303 0.0477
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.1145 0.2274
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0099 0.6787 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0021 0.1102 0.7098
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0303 0.0477
Loa Loa (eye worm) hypothetical protein 0.0035 0.2077 0.3061
Brugia malayi Immunoglobulin I-set domain containing protein 0.0008 0.0113 0.0066
Brugia malayi nuclear receptor RXR 0.0012 0.0394 0.0483
Brugia malayi nuclear hormone receptor 0.001 0.0303 0.0348
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.1145 0.1688
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0069 0.4598 0.6775
Brugia malayi hypothetical protein 0.0028 0.1591 0.2265
Loa Loa (eye worm) hypoxia-induced factor 1 0.0064 0.4207 0.6199
Brugia malayi tailless protein 0.001 0.0303 0.0348
Brugia malayi hypothetical protein 0.001 0.0303 0.0348
Echinococcus multilocularis transfer RNA-Lys 0.0015 0.0665 0.0665
Schistosoma mansoni netrin receptor unc5 0.0008 0.0113 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.1145 0.1688
Echinococcus multilocularis thyroid hormone receptor alpha 0.0075 0.5038 0.5038
Schistosoma mansoni nuclear receptor 0.001 0.0303 0.0602
Mycobacterium ulcerans aldehyde dehydrogenase 0.0026 0.1429 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.1145 0.1145
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.1145 0.1602
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.1145 0.1602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0069 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0394 0.058
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0394 0.0781

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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