Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.6296 | 0.5169 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0134 | 0.2998 | 0.1922 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0134 | 0.2998 | 0.2998 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0134 | 0.2998 | 0.0868 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0134 | 0.2998 | 0.0868 |
Schistosoma mansoni | adenosine deaminase-related | 0.0348 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0348 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.6296 | 0.5169 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0134 | 0.2998 | 0.0868 |
Schistosoma mansoni | AMP deaminase | 0.0113 | 0.2333 | 0.1154 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0134 | 0.2998 | 0.0868 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0134 | 0.2998 | 0.0868 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0134 | 0.2998 | 0.2998 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0348 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.6296 | 0.5169 |
Brugia malayi | Adenosylhomocysteinase | 0.0134 | 0.2998 | 0.0868 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0134 | 0.2998 | 0.0868 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0348 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0348 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0134 | 0.2998 | 0.0868 |
Echinococcus multilocularis | adenosine deaminase | 0.0348 | 1 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0134 | 0.2998 | 0.0868 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0134 | 0.2998 | 0.0868 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0348 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0348 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0348 | 1 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0134 | 0.2998 | 1 |
Treponema pallidum | adenosine deaminase | 0.0348 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0134 | 0.2998 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0348 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0348 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0348 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0348 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0348 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0134 | 0.2998 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.6296 | 0.5169 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -7.7 | Inhibition of [3H]-glycine binding to N-methyl-D-aspartate glutamate receptor in synaptic membranes of rat cerebral cortex | ChEMBL. | 10479281 |
Log Ki (binding) | = 7.7 | Inhibition of [3H]-glycine binding to N-methyl-D-aspartate glutamate receptor in synaptic membranes of rat cerebral cortex | ChEMBL. | 10479281 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.