Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Brugia malayi | notch-like transmembrane receptor | 0.0099 | 0.073 | 0.0863 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.073 | 0.073 |
Echinococcus granulosus | fibropellin Ia | 0.0099 | 0.073 | 0.0703 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0099 | 0.073 | 0.073 |
Onchocerca volvulus | 0.0099 | 0.073 | 0.1094 | |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.328 | 0.5006 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0099 | 0.073 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0099 | 0.073 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0099 | 0.073 | 0.073 |
Onchocerca volvulus | Peroxidasin homolog | 0.0551 | 0.6434 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0551 | 0.6434 | 1 |
Schistosoma mansoni | notch | 0.0099 | 0.073 | 0.073 |
Loa Loa (eye worm) | Notch2 | 0.0099 | 0.073 | 0.1114 |
Onchocerca volvulus | Peroxidase homolog | 0.0551 | 0.6434 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0152 | 0.1404 | 0.2143 |
Brugia malayi | EGF-like domain containing protein | 0.0099 | 0.073 | 0.0863 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0099 | 0.073 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Echinococcus granulosus | peroxidasin | 0.0551 | 0.6434 | 0.6424 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0099 | 0.073 | 0.0863 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Schistosoma mansoni | single-minded | 0.0059 | 0.0222 | 0.0222 |
Echinococcus granulosus | protein jagged 1 | 0.0099 | 0.073 | 0.0703 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0099 | 0.073 | 0.0703 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0182 | 0.1776 | 0.271 |
Onchocerca volvulus | 0.0551 | 0.6434 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.073 | 0.073 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.073 | 0.073 |
Onchocerca volvulus | 0.0551 | 0.6434 | 1 | |
Echinococcus granulosus | protein jagged 1 | 0.0099 | 0.073 | 0.0703 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.073 | 0.073 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0551 | 0.6434 | 0.982 |
Brugia malayi | Peroxidasin | 0.0551 | 0.6434 | 0.761 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.024 | 0.0284 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Brugia malayi | Cadherin domain containing protein | 0.0099 | 0.073 | 0.0863 |
Echinococcus granulosus | protein jagged 2 | 0.0099 | 0.073 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Schistosoma mansoni | slit | 0.0099 | 0.073 | 0.073 |
Echinococcus granulosus | delta-like protein 1 | 0.0099 | 0.073 | 0.0703 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0099 | 0.073 | 0.0703 |
Onchocerca volvulus | 0.0099 | 0.073 | 0.1094 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0099 | 0.073 | 0.0863 |
Brugia malayi | Animal haem peroxidase family protein | 0.0551 | 0.6434 | 0.761 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Schistosoma mansoni | notch | 0.0099 | 0.073 | 0.073 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1968 | 0.3004 |
Schistosoma mansoni | notch | 0.0099 | 0.073 | 0.073 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Echinococcus multilocularis | protein jagged 1 | 0.0099 | 0.073 | 0.0703 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0551 | 0.6434 | 0.982 |
Echinococcus granulosus | neural cadherin | 0.0099 | 0.073 | 0.0703 |
Onchocerca volvulus | 0.0099 | 0.073 | 0.1094 | |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.0259 | 0.2753 | 0.2753 |
Schistosoma mansoni | notch | 0.0099 | 0.073 | 0.073 |
Echinococcus granulosus | protein jagged 2 | 0.0099 | 0.073 | 0.0703 |
Brugia malayi | Animal haem peroxidase family protein | 0.0551 | 0.6434 | 0.761 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Schistosoma mansoni | cell polarity protein | 0.0099 | 0.073 | 0.073 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0059 | 0.0222 | 0.0222 |
Schistosoma mansoni | septate junction protein | 0.0099 | 0.073 | 0.073 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.073 | 0.073 |
Brugia malayi | Delta serrate ligand family protein | 0.0099 | 0.073 | 0.0863 |
Brugia malayi | EGF-like domain containing protein | 0.0099 | 0.073 | 0.0863 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0099 | 0.073 | 0.1094 |
Brugia malayi | Muscle positioning protein 4 | 0.0099 | 0.073 | 0.0863 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0551 | 0.6434 | 0.982 |
Brugia malayi | Cytochrome P450 family protein | 0.0152 | 0.1404 | 0.166 |
Brugia malayi | EGF-like domain containing protein | 0.0099 | 0.073 | 0.0863 |
Brugia malayi | hypothetical protein | 0.0551 | 0.6434 | 0.761 |
Brugia malayi | Animal haem peroxidase family protein | 0.0551 | 0.6434 | 0.761 |
Loa Loa (eye worm) | notch protein | 0.0099 | 0.073 | 0.1114 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1378 | 0.2102 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Schistosoma mansoni | notch | 0.0099 | 0.073 | 0.073 |
Echinococcus granulosus | notch | 0.0099 | 0.073 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Echinococcus multilocularis | peroxidasin | 0.0551 | 0.6434 | 0.6424 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.073 | 0.073 |
Brugia malayi | EGF-like domain containing protein | 0.0099 | 0.073 | 0.0863 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Schistosoma mansoni | peroxidasin | 0.0551 | 0.6434 | 0.6434 |
Echinococcus multilocularis | protein jagged 2 | 0.0099 | 0.073 | 0.0703 |
Onchocerca volvulus | 0.0551 | 0.6434 | 1 | |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0711 | 0.8455 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.024 | 0.0367 |
Onchocerca volvulus | Slit protein homolog | 0.0099 | 0.073 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Brugia malayi | Animal haem peroxidase family protein | 0.0551 | 0.6434 | 0.761 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0551 | 0.6434 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0099 | 0.073 | 0.0703 |
Onchocerca volvulus | 0.0099 | 0.073 | 0.1094 | |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Brugia malayi | EGF-like domain containing protein | 0.0099 | 0.073 | 0.0863 |
Brugia malayi | hypothetical protein | 0.0197 | 0.1968 | 0.2328 |
Echinococcus multilocularis | neural cadherin | 0.0099 | 0.073 | 0.0703 |
Onchocerca volvulus | Putative cubilin | 0.0099 | 0.073 | 0.1094 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0099 | 0.073 | 0.0703 |
Brugia malayi | PAS domain containing protein | 0.0059 | 0.0222 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Brugia malayi | Animal haem peroxidase family protein | 0.0551 | 0.6434 | 0.761 |
Onchocerca volvulus | Dual oxidase homolog | 0.0551 | 0.6434 | 1 |
Giardia lamblia | High cysteine protein | 0.0099 | 0.073 | 0.5 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0099 | 0.073 | 0.1094 |
Echinococcus multilocularis | slit 2 protein | 0.0099 | 0.073 | 0.0703 |
Mycobacterium ulcerans | putative regulatory protein | 0.0043 | 0.0029 | 0.5 |
Echinococcus granulosus | slit 2 protein | 0.0099 | 0.073 | 0.0703 |
Onchocerca volvulus | Peroxidase homolog | 0.0551 | 0.6434 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.0043 | 0.0029 | 0.0035 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0551 | 0.6434 | 0.982 |
Brugia malayi | hypoxia-induced factor 1 | 0.0182 | 0.1776 | 0.21 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0099 | 0.073 | 0.0703 |
Brugia malayi | EGF-like domain containing protein | 0.0099 | 0.073 | 0.0863 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0099 | 0.073 | 0.0863 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0099 | 0.073 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Loa Loa (eye worm) | hypothetical protein | 0.056 | 0.6552 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Onchocerca volvulus | 0.0099 | 0.073 | 0.1094 | |
Schistosoma mansoni | notch | 0.0099 | 0.073 | 0.073 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0099 | 0.073 | 0.0703 |
Echinococcus multilocularis | fibropellin Ia | 0.0099 | 0.073 | 0.0703 |
Schistosoma mansoni | peroxidasin | 0.0551 | 0.6434 | 0.6434 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0099 | 0.073 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0551 | 0.6434 | 0.982 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.024 | 0.0284 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.073 | 0.073 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0099 | 0.073 | 0.0863 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Brugia malayi | EGF-like domain containing protein | 0.0099 | 0.073 | 0.0863 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Brugia malayi | Cadherin domain containing protein | 0.0099 | 0.073 | 0.0863 |
Echinococcus multilocularis | notch | 0.0099 | 0.073 | 0.0703 |
Brugia malayi | Blistered cuticle protein 3 | 0.0551 | 0.6434 | 0.761 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.6434 | 0.982 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.073 | 0.1114 |
Echinococcus multilocularis | protein jagged 1 | 0.0099 | 0.073 | 0.0703 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0099 | 0.073 | 0.0863 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.024 | 0.0367 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.