Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0126 | 0.4557 | 0.9212 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.3527 | 0.713 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0608 | 0.0577 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.0608 | 0.0577 |
Brugia malayi | nuclear receptor RXR | 0.0032 | 0.0608 | 0.0577 |
Onchocerca volvulus | 0.006 | 0.1792 | 0.1766 | |
Echinococcus granulosus | geminin | 0.0102 | 0.3527 | 0.4006 |
Brugia malayi | nuclear receptor NHR-88 | 0.0028 | 0.0466 | 0.0435 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.006 | 0.1792 | 0.1766 |
Schistosoma mansoni | nuclear hormone receptor | 0.006 | 0.1792 | 0.3623 |
Echinococcus multilocularis | FTZ F1 alpha | 0.006 | 0.1792 | 0.2017 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.4947 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 1 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0028 | 0.0466 | 0.0435 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.006 | 0.1792 | 0.3623 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.006 | 0.1792 | 0.1766 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0608 | 0.0577 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.006 | 0.1792 | 0.2017 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1792 | 0.1766 |
Echinococcus multilocularis | tumor protein p63 | 0.0227 | 0.8757 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.006 | 0.1792 | 0.1766 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.006 | 0.1792 | 0.1766 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.006 | 0.1792 | 0.1766 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0028 | 0.0466 | 0.0435 |
Echinococcus multilocularis | geminin | 0.0102 | 0.3527 | 0.4006 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.006 | 0.1792 | 0.1766 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0032 | 0.0608 | 0.066 |
Onchocerca volvulus | 0.0028 | 0.0466 | 0.0435 | |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0028 | 0.0466 | 0.0435 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.006 | 0.1792 | 0.1766 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0028 | 0.0466 | 0.0435 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.1009 | 0.112 |
Brugia malayi | Cytochrome P450 family protein | 0.0021 | 0.0157 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Schistosoma mansoni | coup transcription factor | 0.006 | 0.1792 | 0.3623 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.006 | 0.1792 | 0.1766 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.006 | 0.1792 | 0.3623 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1792 | 0.1766 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.006 | 0.1792 | 0.1766 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.006 | 0.1792 | 0.3623 |
Loa Loa (eye worm) | runx1 | 0.0032 | 0.0626 | 0.0595 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0092 | 0.3129 | 0.3549 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.006 | 0.1792 | 0.1766 |
Schistosoma mansoni | nuclear hormone receptor | 0.0028 | 0.0466 | 0.0942 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.006 | 0.1792 | 0.1766 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.006 | 0.1792 | 0.1766 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1792 | 0.1766 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.006 | 0.1792 | 0.1766 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0018 | 0.0039 | 0.0078 |
Brugia malayi | nuclear hormone receptor | 0.0028 | 0.0466 | 0.0435 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0028 | 0.0466 | 0.0497 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0028 | 0.0466 | 0.0435 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.006 | 0.1792 | 0.1766 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0046 | 0.1181 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0126 | 0.4557 | 0.5186 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.006 | 0.1792 | 0.2017 |
Schistosoma mansoni | nuclear receptor | 0.0028 | 0.0466 | 0.0942 |
Brugia malayi | nuclear receptor NHR-67 | 0.0028 | 0.0466 | 0.0435 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0038 | 0.0879 | 0.097 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.006 | 0.1792 | 0.1766 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.006 | 0.1792 | 0.1766 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0028 | 0.0466 | 0.0497 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0032 | 0.0608 | 0.1229 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0076 | 0.2436 | 0.2755 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0038 | 0.0879 | 0.0849 |
Echinococcus granulosus | Ankyrin | 0.0018 | 0.0039 | 0.0007 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1009 | 0.098 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0033 | 0.0668 | 0.1351 |
Brugia malayi | nuclear hormone receptor | 0.006 | 0.1792 | 0.1766 |
Brugia malayi | Cytochrome P450 family protein | 0.0021 | 0.0157 | 0.0125 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0032 | 0.0065 |
Echinococcus granulosus | tumor protein p63 | 0.0227 | 0.8757 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0164 | 0.6139 | 0.6127 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0164 | 0.6139 | 0.6127 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.4947 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.006 | 0.1792 | 0.3623 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0028 | 0.0466 | 0.0497 |
Brugia malayi | Death domain containing protein | 0.0018 | 0.0032 | 0.000000043691 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.006 | 0.1792 | 0.3623 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.006 | 0.1792 | 0.1766 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0018 | 0.0032 | 0.0065 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0038 | 0.0879 | 0.097 |
Brugia malayi | nuclear receptor RXR | 0.0028 | 0.0466 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0039 | 0.0006 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.006 | 0.1792 | 0.2017 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Brugia malayi | ecdysone receptor | 0.0028 | 0.0466 | 0.0435 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.006 | 0.1792 | 0.1766 |
Onchocerca volvulus | 0.0033 | 0.0668 | 0.0638 | |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0076 | 0.2436 | 0.2755 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0608 | 0.0577 |
Loa Loa (eye worm) | steroid hormone receptor | 0.006 | 0.1792 | 0.1766 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0608 | 0.0577 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.2436 | 0.4924 |
Brugia malayi | Uncoordinated protein 44 | 0.0018 | 0.0032 | 0.000000043691 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.006 | 0.1792 | 0.3623 |
Brugia malayi | ecdysteroid receptor | 0.006 | 0.1792 | 0.1766 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Brugia malayi | nuclear receptor NHR-88 | 0.006 | 0.1792 | 0.1766 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0028 | 0.0466 | 0.0497 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.006 | 0.1792 | 0.2017 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0038 | 0.0879 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.006 | 0.1792 | 0.1766 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1009 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0.0032 | 0.000000043691 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0038 | 0.0879 | 0.1776 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.006 | 0.1792 | 0.1766 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.006 | 0.1792 | 0.2017 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1009 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.006 | 0.1792 | 0.2017 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.006 | 0.1792 | 0.2017 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.0608 | 0.0577 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0038 | 0.0879 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0028 | 0.0466 | 0.0435 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0028 | 0.0466 | 0.0942 |
Schistosoma mansoni | nuclear receptor | 0.0028 | 0.0466 | 0.0942 |
Schistosoma mansoni | nuclear hormone receptor | 0.0028 | 0.0466 | 0.0942 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.006 | 0.1792 | 0.3623 |
Trypanosoma brucei | cytochrome P450, putative | 0.0021 | 0.0157 | 0.1787 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.006 | 0.1792 | 0.2017 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0028 | 0.0466 | 0.0435 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0028 | 0.0466 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1792 | 0.1766 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0028 | 0.0466 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1792 | 0.1766 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0028 | 0.0466 | 0.0942 |
Schistosoma mansoni | lozenge | 0.0032 | 0.0626 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1792 | 0.1766 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.1009 | 0.204 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0018 | 0.0032 | 0.000000049914 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0032 | 0.0608 | 0.0577 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.006 | 0.1792 | 0.1766 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.006 | 0.1792 | 0.1766 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.006 | 0.1792 | 0.2017 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0028 | 0.0466 | 0.0497 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0028 | 0.0466 | 0.0497 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0032 | 0.0608 | 0.066 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.1462 | 0.1435 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0021 | 0.0157 | 0.0125 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0577 | 0.1167 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.006 | 0.1792 | 0.2017 |
Loa Loa (eye worm) | DR-78 | 0.0028 | 0.0466 | 0.0435 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0021 | 0.0157 | 0.0125 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.3527 | 0.713 |
Echinococcus multilocularis | Ankyrin | 0.0018 | 0.0039 | 0.0007 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0028 | 0.0466 | 0.0435 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0038 | 0.0879 | 0.0849 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0028 | 0.0466 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1792 | 0.1766 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.1462 | 0.1435 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0608 | 0.0577 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.006 | 0.1792 | 0.3623 |
Echinococcus granulosus | FTZ F1 alpha | 0.006 | 0.1792 | 0.2017 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0028 | 0.0466 | 0.0435 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0018 | 0.0032 | 0.000000049914 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1009 | 0.204 |
Brugia malayi | steroid hormone receptor | 0.006 | 0.1792 | 0.1766 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1792 | 0.1766 |
Schistosoma mansoni | netrin receptor unc5 | 0.0018 | 0.0032 | 0.0065 |
Brugia malayi | conserved hypotetical protein | 0.0028 | 0.0466 | 0.0435 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0021 | 0.0157 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0022 | 0.0206 | 0.0199 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0022 | 0.0206 | 0.0199 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0028 | 0.0466 | 0.0497 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.006 | 0.1792 | 0.1766 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0032 | 0.0608 | 0.1229 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0608 | 0.0577 |
Schistosoma mansoni | zinc finger protein | 0.0028 | 0.0466 | 0.0942 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0136 | 0.4947 | 0.5633 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0028 | 0.0466 | 0.0435 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0038 | 0.0879 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0028 | 0.0466 | 0.0497 |
Echinococcus multilocularis | Protein lozenge | 0.0032 | 0.0626 | 0.068 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1009 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0668 | 0.0638 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1009 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.006 | 0.1792 | 0.1766 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.1009 | 0.112 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0028 | 0.0466 | 0.0497 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0038 | 0.0879 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0028 | 0.0466 | 0.0942 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.006 | 0.1792 | 0.1766 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0466 | 0.0435 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0095 | 0.3231 | 0.3666 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.006 | 0.1792 | 0.2017 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0092 | 0.3129 | 0.3549 |
Brugia malayi | tailless protein | 0.0028 | 0.0466 | 0.0435 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.006 | 0.1792 | 0.2017 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.006 | 0.1792 | 0.2017 |
Onchocerca volvulus | 0.0028 | 0.0466 | 0.0435 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.006 | 0.1792 | 0.2017 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0608 | 0.0577 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0021 | 0.0157 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.006 | 0.1792 | 0.1766 |
Onchocerca volvulus | 0.0257 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.