Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, gamma | Starlite/ChEMBL | References |
Mus musculus | retinoid X receptor alpha | Starlite/ChEMBL | References |
Mus musculus | retinoid X receptor gamma | Starlite/ChEMBL | References |
Mus musculus | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Mus musculus | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Mus musculus | retinoid X receptor beta | Starlite/ChEMBL | References |
Mus musculus | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor gamma | 340 aa | 338 aa | 24.6 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, gamma | 340 aa | 338 aa | 24.6 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor alpha | 439 aa | 352 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.0818 | 0.2358 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0818 | 0.2358 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0977 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0873 | 0.4999 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0922 | 0.7359 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | nM | Transcriptional activation of Retinoic acid receptor RAR beta;NA=not active | ChEMBL. | 8784454 |
EC50 (binding) | nM | Transcriptional activation of Retinoic acid receptor RAR alpha;NA=not active | ChEMBL. | 8784454 |
EC50 (binding) | nM | Transcriptional activation of Retinoic acid receptor RAR gamma;NA=not active | ChEMBL. | 8784454 |
EC50 (binding) | 0 nM | Transcriptional activation of Retinoic acid receptor RAR alpha;NA=not active | ChEMBL. | 8784454 |
EC50 (binding) | 0 nM | Transcriptional activation of Retinoic acid receptor RAR beta;NA=not active | ChEMBL. | 8784454 |
EC50 (binding) | 0 nM | Transcriptional activation of Retinoic acid receptor RAR gamma;NA=not active | ChEMBL. | 8784454 |
EC50 (binding) | = 2600 nM | Transcriptional activation of Retinoid X receptor RXR beta | ChEMBL. | 8784454 |
EC50 (binding) | = 2600 nM | Transcriptional activation of Retinoid X receptor RXR gamma | ChEMBL. | 8784454 |
EC50 (binding) | = 2600 nM | Transcriptional activation of Retinoid X receptor RXR beta | ChEMBL. | 8784454 |
EC50 (binding) | = 2600 nM | Transcriptional activation of Retinoid X receptor RXR gamma | ChEMBL. | 8784454 |
EC50 (binding) | = 2800 nM | Transcriptional activation of Retinoid X receptor RXR alpha | ChEMBL. | 8784454 |
EC50 (binding) | = 2800 nM | Transcriptional activation of Retinoid X receptor RXR alpha | ChEMBL. | 8784454 |
Kd (binding) | = 2518 nM | Dissociation constant for binding to Retinoid X receptor alpha | ChEMBL. | 8784454 |
Kd (binding) | = 2518 nM | Dissociation constant for binding to Retinoid X receptor alpha | ChEMBL. | 8784454 |
Kd (binding) | = 3993 nM | Dissociation constant for binding to Retinoid X receptor gamma | ChEMBL. | 8784454 |
Kd (binding) | = 3993 nM | Dissociation constant for binding to Retinoid X receptor gamma | ChEMBL. | 8784454 |
Kd (binding) | = 4122 nM | Dissociation constant for binding to Retinoid X receptor beta | ChEMBL. | 8784454 |
Kd (binding) | = 4122 nM | Dissociation constant for binding to Retinoid X receptor beta | ChEMBL. | 8784454 |
Kd (binding) | = 10000 nM | Dissociation constant for binding to Retinoic acid receptor alpha | ChEMBL. | 8784454 |
Kd (binding) | = 10000 nM | Dissociation constant for binding to Retinoic acid receptor beta | ChEMBL. | 8784454 |
Kd (binding) | = 10000 nM | Dissociation constant for binding to Retinoic acid receptor gamma | ChEMBL. | 8784454 |
Kd (binding) | = 10000 nM | Dissociation constant for binding to Retinoic acid receptor alpha | ChEMBL. | 8784454 |
Kd (binding) | = 10000 nM | Dissociation constant for binding to Retinoic acid receptor beta | ChEMBL. | 8784454 |
Kd (binding) | = 10000 nM | Dissociation constant for binding to Retinoic acid receptor gamma | ChEMBL. | 8784454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.