Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | patched 1 | 0.0514 | 0.3622 | 0.3622 |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 0.3622 | 0.3622 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0514 | 0.3622 | 0.3622 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0514 | 0.3622 | 0.3622 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0514 | 0.3622 | 0.3622 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0238 | 0.1223 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0335 | 0.2064 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0335 | 0.2064 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0238 | 0.1223 | 0.1223 |
Mycobacterium ulcerans | thymidylate synthase | 0.0238 | 0.1223 | 0.1223 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0097 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0238 | 0.1223 | 0.1223 |
Echinococcus multilocularis | protein dispatched 1 | 0.0514 | 0.3622 | 0.3622 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1248 | 1 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0514 | 0.3622 | 0.3622 |
Echinococcus granulosus | thymidylate synthase | 0.0238 | 0.1223 | 0.1223 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0514 | 0.3622 | 0.3622 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0586 | 0.4245 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0335 | 0.2064 | 0.1951 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0335 | 0.2064 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0193 | 0.0838 | 0.0707 |
Brugia malayi | CHE-14 protein | 0.0514 | 0.3622 | 0.3622 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0238 | 0.1223 | 1 |
Onchocerca volvulus | 0.0238 | 0.1223 | 0.5 | |
Echinococcus multilocularis | protein patched | 0.0514 | 0.3622 | 0.3622 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1248 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0113 | 0.014 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.1248 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1248 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0238 | 0.1223 | 0.1223 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1248 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1248 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1248 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1248 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0514 | 0.3622 | 0.3622 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0514 | 0.3622 | 0.8483 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0586 | 0.4245 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0335 | 0.2064 | 0.1339 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0514 | 0.3622 | 0.3622 |
Echinococcus multilocularis | thymidylate synthase | 0.0238 | 0.1223 | 0.1223 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0113 | 0.014 | 0.1148 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0193 | 0.0838 | 0.0707 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0586 | 0.4245 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1248 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0335 | 0.2064 | 0.1339 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0586 | 0.4245 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.