Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Niemann Pick C1 protein | 0.0506 | 0.3614 | 0.3614 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0506 | 0.3614 | 0.3614 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0506 | 0.3614 | 0.3614 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0238 | 0.1243 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0335 | 0.2098 | 0.5 |
Schistosoma mansoni | patched 1 | 0.0506 | 0.3614 | 0.3614 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.3614 | 0.3614 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.123 | 1 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0506 | 0.3614 | 0.3614 |
Mycobacterium ulcerans | thymidylate synthase | 0.0238 | 0.1243 | 0.1243 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0335 | 0.2098 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0238 | 0.1243 | 0.1243 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0097 | 0 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0506 | 0.3614 | 0.3614 |
Loa Loa (eye worm) | thymidylate synthase | 0.0238 | 0.1243 | 0.1243 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0193 | 0.0851 | 0.0719 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0506 | 0.3614 | 0.3614 |
Echinococcus granulosus | thymidylate synthase | 0.0238 | 0.1243 | 0.1243 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0577 | 0.4237 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0335 | 0.2098 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0335 | 0.2098 | 0.1984 |
Brugia malayi | CHE-14 protein | 0.0506 | 0.3614 | 0.3614 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.123 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0238 | 0.1243 | 1 |
Onchocerca volvulus | 0.0238 | 0.1243 | 0.5 | |
Echinococcus multilocularis | protein patched | 0.0506 | 0.3614 | 0.3614 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.123 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.123 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0238 | 0.1243 | 0.1243 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.123 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.123 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.123 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0113 | 0.0143 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.123 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0335 | 0.2098 | 0.1363 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0506 | 0.3614 | 0.3614 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0506 | 0.3614 | 0.8477 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0506 | 0.3614 | 0.3614 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0577 | 0.4237 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.123 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0335 | 0.2098 | 0.1363 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0577 | 0.4237 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0238 | 0.1243 | 0.1243 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0113 | 0.0143 | 0.1148 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0577 | 0.4237 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0193 | 0.0851 | 0.0719 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.