Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0796 | 1 | 1 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0201 | 0.2021 | 0.193 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0201 | 0.2021 | 0.0444 |
Echinococcus multilocularis | thymidylate synthase | 0.0123 | 0.0977 | 0.0977 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0328 | 0.3721 | 0.3721 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0796 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0123 | 0.0977 | 0.0977 |
Echinococcus multilocularis | protein dispatched 1 | 0.0328 | 0.3721 | 0.3721 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0173 | 0.165 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0328 | 0.3721 | 0.8548 |
Brugia malayi | CHE-14 protein | 0.0328 | 0.3721 | 0.3721 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0796 | 1 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0328 | 0.3721 | 0.3721 |
Loa Loa (eye worm) | thymidylate synthase | 0.0123 | 0.0977 | 0.0977 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0201 | 0.2021 | 0.193 |
Schistosoma mansoni | patched 1 | 0.0328 | 0.3721 | 0.3721 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0374 | 0.4334 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0123 | 0.0977 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0374 | 0.4334 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0173 | 0.165 | 0.1555 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0328 | 0.3721 | 0.3721 |
Leishmania major | squalene monooxygenase-like protein | 0.0201 | 0.2021 | 0.0444 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0328 | 0.3721 | 0.3721 |
Chlamydia trachomatis | dihydrofolate reductase | 0.005 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0123 | 0.0977 | 0.0977 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0123 | 0.0977 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0374 | 0.4334 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0123 | 0.0977 | 0.0977 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0173 | 0.165 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0796 | 1 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0328 | 0.3721 | 0.3721 |
Onchocerca volvulus | 0.0123 | 0.0977 | 0.5 | |
Mycobacterium tuberculosis | Hypothetical protein | 0.0059 | 0.0112 | 0.1148 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0374 | 0.4334 | 1 |
Brugia malayi | hypothetical protein | 0.0059 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.3721 | 0.3721 |
Echinococcus multilocularis | protein patched | 0.0328 | 0.3721 | 0.3721 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0796 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0796 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0328 | 0.3721 | 0.3721 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0796 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0796 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0123 | 0.0977 | 0.0977 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0328 | 0.3721 | 0.3721 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0796 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0173 | 0.165 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.