Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0314 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0123 | 0 | 0.5 |
Echinococcus multilocularis | protein patched | 0.0129 | 0.0314 | 0.0314 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0314 | 0.0314 |
Echinococcus multilocularis | protein dispatched 1 | 0.0129 | 0.0314 | 0.0314 |
Brugia malayi | CHE-14 protein | 0.0129 | 0.0314 | 0.0314 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0129 | 0.0314 | 0.0314 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0129 | 0.0314 | 0.0314 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0147 | 0.126 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0314 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0314 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0314 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0314 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0314 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0129 | 0.0314 | 0.0314 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0129 | 0.0314 | 0.0314 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0147 | 0.126 | 0.5 |
Onchocerca volvulus | 0.0123 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0123 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0174 | 0.2636 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0147 | 0.126 | 1 |
Schistosoma mansoni | patched 1 | 0.0129 | 0.0314 | 0.0314 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0147 | 0.126 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0129 | 0.0314 | 0.0314 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0174 | 0.2636 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0129 | 0.0314 | 0.0314 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0314 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0174 | 0.2636 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0129 | 0.0314 | 0.0314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.