Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0975 | 0.0957 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0013 | 0.0929 | 0.0911 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.2507 | 0.2492 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0013 | 0.0929 | 0.2132 |
Schistosoma mansoni | nuclear hormone receptor | 0.0013 | 0.0929 | 0.2132 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0013 | 0.0929 | 0.0911 |
Onchocerca volvulus | 0.0006 | 0.0252 | 0.1004 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.2507 | 0.2492 |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.0008 | 0.0429 | 0.041 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0013 | 0.0929 | 0.0911 |
Echinococcus multilocularis | musashi | 0.0029 | 0.2507 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0009 | 0.0541 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0009 | 0.0541 | 0.1222 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.2507 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0013 | 0.0929 | 0.2132 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0013 | 0.0929 | 0.2132 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0013 | 0.0929 | 0.0911 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0006 | 0.0252 | 0.0232 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0047 | 0.4284 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0013 | 0.0929 | 0.3655 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0009 | 0.0541 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0013 | 0.0929 | 0.3655 |
Schistosoma mansoni | thyroid hormone receptor | 0.0013 | 0.0929 | 0.2132 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0006 | 0.0252 | 0.0232 |
Schistosoma mansoni | hypothetical protein | 0.0005 | 0.011 | 0.021 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0006 | 0.0252 | 0.0543 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0013 | 0.0929 | 0.3655 |
Onchocerca volvulus | 0.0006 | 0.0252 | 0.1004 | |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0006 | 0.0252 | 0.0931 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0929 | 0.0911 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0006 | 0.0252 | 0.0543 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0013 | 0.0929 | 0.3706 |
Brugia malayi | hypothetical protein | 0.0007 | 0.0324 | 0.0305 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.2507 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Trichomonas vaginalis | protein disulfide isomerase, putative | 0.0004 | 0.002 | 0.0009 |
Toxoplasma gondii | kringle domain-containing protein | 0.0005 | 0.011 | 0.1715 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0006 | 0.0252 | 0.0232 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0006 | 0.0252 | 0.0931 |
Brugia malayi | nuclear receptor NHR-88 | 0.0013 | 0.0929 | 0.0911 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0006 | 0.0252 | 0.0931 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0013 | 0.0929 | 0.3655 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.1027 | 0.4049 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0013 | 0.0929 | 0.2132 |
Toxoplasma gondii | exonuclease III APE | 0.0009 | 0.0541 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0006 | 0.0252 | 0.0232 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0013 | 0.0929 | 0.0911 |
Echinococcus granulosus | lamin | 0.0029 | 0.2507 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1027 | 0.1009 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0006 | 0.0252 | 0.0232 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0013 | 0.0929 | 0.0911 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0013 | 0.0929 | 0.0911 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0013 | 0.0929 | 0.0911 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0013 | 0.0929 | 0.2132 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0013 | 0.0929 | 0.0911 |
Brugia malayi | ecdysteroid receptor | 0.0013 | 0.0929 | 0.0911 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0013 | 0.0929 | 0.3655 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0929 | 0.0911 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0006 | 0.0252 | 0.0931 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.2507 | 1 |
Trichomonas vaginalis | protein disulfide isomerase, putative | 0.0004 | 0.002 | 0.0009 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0013 | 0.0929 | 0.0911 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0006 | 0.0252 | 0.0931 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0013 | 0.0929 | 0.3706 |
Brugia malayi | nuclear receptor NHR-67 | 0.0006 | 0.0252 | 0.0232 |
Schistosoma mansoni | lamin | 0.0029 | 0.2507 | 0.5833 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 1 | 1 |
Onchocerca volvulus | 0.0029 | 0.2507 | 1 | |
Schistosoma mansoni | lamin | 0.0029 | 0.2507 | 0.5833 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0006 | 0.0252 | 0.0232 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0006 | 0.0252 | 0.0931 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0009 | 0.0541 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0013 | 0.0929 | 0.0911 |
Brugia malayi | steroid hormone receptor | 0.0013 | 0.0929 | 0.0911 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0006 | 0.0252 | 0.0931 |
Echinococcus multilocularis | anti dorsalizing morphogenetic protein 1a | 0.0008 | 0.0429 | 0.1645 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0324 | 0.0305 |
Brugia malayi | nuclear hormone receptor | 0.0006 | 0.0252 | 0.0232 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0009 | 0.0541 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2455 | 0.244 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0005 | 0.011 | 0.1715 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0013 | 0.0929 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0006 | 0.0252 | 0.0232 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0005 | 0.011 | 0.1715 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0009 | 0.0541 | 0.2095 |
Onchocerca volvulus | 0.0013 | 0.0929 | 0.3706 | |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0099 | 0.0079 |
Schistosoma mansoni | nuclear receptor | 0.0006 | 0.0252 | 0.0543 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0007 | 0.0324 | 0.1223 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.1179 | 0.1161 |
Onchocerca volvulus | 0.0005 | 0.011 | 0.0437 | |
Brugia malayi | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0975 | 0.0957 |
Brugia malayi | Protein kinase domain containing protein | 0.0005 | 0.011 | 0.009 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0009 | 0.0541 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0009 | 0.0541 | 0.2095 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2507 | 0.2492 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0013 | 0.0929 | 0.3655 |
Onchocerca volvulus | 0.0029 | 0.2507 | 1 | |
Brugia malayi | nuclear hormone receptor | 0.0013 | 0.0929 | 0.0911 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0009 | 0.0541 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0007 | 0.0324 | 0.0305 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0006 | 0.0252 | 0.1004 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0013 | 0.0929 | 0.3655 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0013 | 0.0929 | 0.0911 |
Echinococcus granulosus | FTZ F1 alpha | 0.0013 | 0.0929 | 0.3655 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0013 | 0.0929 | 0.3655 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0013 | 0.0929 | 0.3706 |
Brugia malayi | nuclear receptor NHR-88 | 0.0006 | 0.0252 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1076 | 0.1058 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0324 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0929 | 0.0911 |
Brugia malayi | nuclear receptor RXR | 0.0006 | 0.0252 | 0.0232 |
Schistosoma mansoni | zinc finger protein | 0.0006 | 0.0252 | 0.0543 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0006 | 0.0252 | 0.0232 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0013 | 0.0929 | 0.3655 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0013 | 0.0929 | 0.3655 |
Leishmania major | hypothetical protein, conserved | 0.0005 | 0.011 | 0.1715 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0009 | 0.0541 | 1 |
Echinococcus granulosus | anti dorsalizing morphogenetic protein 1a | 0.0008 | 0.0429 | 0.1645 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0013 | 0.0929 | 0.0911 |
Giardia lamblia | Hypothetical protein | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0013 | 0.0929 | 0.0911 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0013 | 0.0929 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.011 | 0.009 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0009 | 0.0541 | 1 |
Brugia malayi | tailless protein | 0.0006 | 0.0252 | 0.0232 |
Loa Loa (eye worm) | bone morphogenic protein 6 | 0.0008 | 0.0429 | 0.041 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.1179 | 0.1161 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0006 | 0.0252 | 0.0931 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0013 | 0.0929 | 0.3655 |
Schistosoma mansoni | nuclear hormone receptor | 0.0006 | 0.0252 | 0.0543 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0013 | 0.0929 | 0.2132 |
Loa Loa (eye worm) | DR-78 | 0.0006 | 0.0252 | 0.0232 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.1027 | 0.4049 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0007 | 0.0324 | 0.0713 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0005 | 0.011 | 0.1715 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Echinococcus multilocularis | lamin | 0.0029 | 0.2507 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0013 | 0.0929 | 0.3655 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0007 | 0.0324 | 0.1223 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0324 | 0.0305 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0009 | 0.0541 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0013 | 0.0929 | 0.3655 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0006 | 0.0252 | 0.0931 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0324 | 0.0305 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0013 | 0.0929 | 0.2132 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0013 | 0.0929 | 0.0911 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0013 | 0.0929 | 0.2132 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0929 | 0.0911 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.1076 | 0.1058 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0009 | 0.0541 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0005 | 0.011 | 0.009 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0013 | 0.0929 | 0.3655 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0013 | 0.0929 | 0.0911 |
Brugia malayi | Kringle domain containing protein | 0.0005 | 0.011 | 0.009 |
Schistosoma mansoni | coup transcription factor | 0.0013 | 0.0929 | 0.2132 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0324 | 0.0305 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0013 | 0.0929 | 0.3655 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0013 | 0.0929 | 0.2132 |
Schistosoma mansoni | ap endonuclease | 0.0009 | 0.0541 | 0.1222 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0929 | 0.0911 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0007 | 0.0324 | 0.0713 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0007 | 0.0324 | 0.0305 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0009 | 0.0541 | 0.5 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Trichomonas vaginalis | protein disulfide isomerase, putative | 0.0004 | 0.002 | 0.0009 |
Brugia malayi | hypothetical protein | 0.0007 | 0.0324 | 0.0305 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0009 | 0.0541 | 0.0522 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.2507 | 0.2492 |
Schistosoma mansoni | nuclear receptor | 0.0006 | 0.0252 | 0.0543 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0929 | 0.0911 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0006 | 0.0252 | 0.0543 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0005 | 0.011 | 0.0359 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0006 | 0.0252 | 0.0232 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0006 | 0.0252 | 0.0931 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0006 | 0.0252 | 0.0931 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0013 | 0.0929 | 0.3655 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0005 | 0.011 | 0.0359 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0009 | 0.0541 | 0.0522 |
Brugia malayi | ecdysone receptor | 0.0006 | 0.0252 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0929 | 0.0911 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0013 | 0.0929 | 0.0911 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0009 | 0.0541 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0013 | 0.0929 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0929 | 0.0911 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0009 | 0.0541 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0009 | 0.0541 | 0.0522 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0006 | 0.0252 | 0.1004 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Brugia malayi | Fibroblast growth factor family protein | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0013 | 0.0929 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0252 | 0.0232 |
Brugia malayi | nuclear receptor RXR | 0.0007 | 0.0324 | 0.0305 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0013 | 0.0929 | 0.0911 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0013 | 0.0929 | 0.2132 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0006 | 0.0252 | 0.0931 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0007 | 0.0324 | 0.0305 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0013 | 0.0929 | 0.3655 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.2507 | 0.5833 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0013 | 0.0929 | 0.0911 |
Brugia malayi | conserved hypotetical protein | 0.0006 | 0.0252 | 0.0232 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.2507 | 0.2492 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0013 | 0.0929 | 0.0911 |
Schistosoma mansoni | nuclear hormone receptor | 0.0006 | 0.0252 | 0.0543 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.