Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0202 | 0.3271 | 0.2004 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0202 | 0.3271 | 0.2004 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0202 | 0.3271 | 0.2004 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0491 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.2817 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.023 | 0.3928 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2817 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0202 | 0.3271 | 0.8327 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0491 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.023 | 0.3928 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0491 | 1 | 1 |
Onchocerca volvulus | 0.013 | 0.1585 | 0.5 | |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0491 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2817 | 0.2817 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0202 | 0.3271 | 0.2004 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0202 | 0.3271 | 0.2004 |
Brugia malayi | thymidylate synthase | 0.013 | 0.1585 | 0.1585 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0491 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0202 | 0.3271 | 0.2004 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.1585 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.023 | 0.3928 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.1585 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.3271 | 0.2004 |
Schistosoma mansoni | patched 1 | 0.0202 | 0.3271 | 0.2004 |
Echinococcus multilocularis | protein dispatched 1 | 0.0202 | 0.3271 | 0.2004 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2817 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0202 | 0.3271 | 0.2004 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.023 | 0.3928 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0202 | 0.3271 | 0.2004 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0491 | 1 | 1 |
Brugia malayi | CHE-14 protein | 0.0202 | 0.3271 | 0.3271 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0491 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0491 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.