Detailed information for compound 2071322

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 329.321 | Formula: C14H18F3N5O
  • H donors: 0 H acceptors: 3 LogP: 2.03 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1onc(n1)C1CCCN1Cc1nccn1CC(F)(F)F
  • InChi: 1S/C14H18F3N5O/c1-2-12-19-13(20-23-12)10-4-3-6-21(10)8-11-18-5-7-22(11)9-14(15,16)17/h5,7,10H,2-4,6,8-9H2,1H3
  • InChiKey: SUDZSQQIRHALKI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ubiquitin specific protease 41 0.0088 0.046 0.0432
Loa Loa (eye worm) hypothetical protein 0.0164 0.114 0.1141
Loa Loa (eye worm) hypothetical protein 0.0184 0.1316 0.1316
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0088 0.046 0.0432
Echinococcus granulosus sodium bile acid cotransporter 0.0042 0.0051 0.002
Echinococcus multilocularis follistatin 0.0044 0.0074 0.0043
Brugia malayi nuclear hormone receptor family member odr-7 0.0164 0.114 0.114
Entamoeba histolytica cysteine proteinase, putative 0.0077 0.0366 0.3182
Loa Loa (eye worm) hypothetical protein 0.004 0.003 0.003
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0298 0.0268
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0164 0.114 0.1141
Loa Loa (eye worm) hypothetical protein 0.0065 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0164 0.114 0.1141
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0164 0.114 0.1114
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1157 0.9994 1
Onchocerca volvulus 0.0065 0.0258 0.0827
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0348 0.2778 0.2778
Trypanosoma cruzi cysteine peptidase, putative 0.044 0.3598 0.3589
Echinococcus granulosus carbonic anhydrase II 0.1157 0.9994 1
Toxoplasma gondii cathepsin CPL 0.0115 0.0706 0.1505
Brugia malayi Cathepsin L-like precursor 0.0115 0.0706 0.0706
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0044 0.0074 0.0074
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0059 0.0207 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0226 0.0209
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0226 0.2892
Onchocerca volvulus Bile acid receptor homolog 0.0348 0.2778 1
Loa Loa (eye worm) hypothetical protein 0.0544 0.4523 0.4526
Onchocerca volvulus 0.0115 0.0706 0.246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0348 0.2778 0.278
Schistosoma mansoni retinoic acid receptor RXR 0.0348 0.2778 0.278
Loa Loa (eye worm) hypothetical protein 0.0044 0.0074 0.0074
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0164 0.114 0.1114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.044 0.3598 0.3581
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.044 0.3598 0.3581
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.003 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0348 0.2778 0.2778
Loa Loa (eye worm) hypothetical protein 0.0088 0.046 0.0461
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0044 0.0074 0.0074
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0348 0.2778 0.2758
Trypanosoma brucei protein kinase, putative 0.0062 0.0226 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0348 0.2778 0.2778
Onchocerca volvulus 0.0042 0.0051 0.0074
Brugia malayi Papain family cysteine protease containing protein 0.0115 0.0706 0.0706
Brugia malayi secreted modular calcium-binding protein 1 0.0044 0.0074 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.0706 1
Brugia malayi ecdysteroid receptor 0.0348 0.2778 0.2778
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0348 0.2778 0.2758
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0184 0.1316 0.1316
Echinococcus multilocularis cathepsin L 0.0059 0.0207 0.0178
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0348 0.2778 0.2758
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0115 0.0706 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0348 0.2778 0.2778
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0348 0.2778 0.278
Echinococcus granulosus Solute carrier organic anion transporter family 0.0065 0.0258 0.0228
Echinococcus granulosus cathepsin l1 0.0077 0.0366 0.0337
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0226 0.2892
Schistosoma mansoni thyroid hormone receptor 0.092 0.7878 0.7883
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0115 0.0706 0.0707
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0184 0.1316 0.129
Schistosoma mansoni nuclear hormone receptor 0.0164 0.114 0.1141
Brugia malayi hypothetical protein 0.0164 0.114 0.114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0207 0.0178
Schistosoma mansoni steroid hormone receptor ad4bp 0.0348 0.2778 0.278
Trypanosoma cruzi cysteine peptidase, putative 0.044 0.3598 0.3589
Echinococcus granulosus follistatin 0.0044 0.0074 0.0043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.0706 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0348 0.2778 0.278
Onchocerca volvulus Cathepsin L homolog 0.0115 0.0706 0.246
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1157 0.9994 0.9994
Leishmania major cathepsin L-like protease 0.044 0.3598 0.3581
Echinococcus multilocularis sodium bile acid cotransporter 0.0042 0.0051 0.002
Brugia malayi SPARC precursor 0.0044 0.0074 0.0074
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0149 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0226 0.0226
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0038 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0077 0.0366 0.0366
Schistosoma mansoni follistatin 0.0044 0.0074 0.0074
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0088 0.046 0.0444
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0065 0.0258 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0348 0.2778 0.2778
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0544 0.4523 0.4526
Loa Loa (eye worm) hypothetical protein 0.0038 0.0018 0.0018
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0044 0.0074 0.0096
Schistosoma mansoni hypothetical protein 0.0323 0.256 0.2561
Brugia malayi Nuclear hormone receptor-like 1 0.0994 0.8537 0.8537
Brugia malayi Nuclear hormone receptor E75 0.0164 0.114 0.114
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0348 0.2778 0.2758
Brugia malayi photoreceptor-specific nuclear receptor 0.0348 0.2778 0.2778
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0088 0.046 0.507
Loa Loa (eye worm) hypothetical protein 0.004 0.003 0.003
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0572 0.4777 0.4764
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0366 0.4967
Onchocerca volvulus 0.0115 0.0706 0.246
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0044 0.0074 0.0096
Loa Loa (eye worm) cysteine protease 0.0115 0.0706 0.0707
Brugia malayi hypothetical protein 0.0065 0.0258 0.0258
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0115 0.0706 0.1156
Onchocerca volvulus 0.0044 0.0074 0.0157
Schistosoma mansoni nuclear receptor 0.0164 0.114 0.1141
Brugia malayi Cathepsin L-like precursor 0.0115 0.0706 0.0706
Echinococcus granulosus carbonic anhydrase 0.0544 0.4523 0.451
Plasmodium vivax vivapain-1 0.0059 0.0207 0.2757
Echinococcus multilocularis cysteine protease 0.0115 0.0706 0.0679
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0065 0.0258 0.0228
Trypanosoma cruzi cysteine proteinase, putative 0.0059 0.0207 0.019
Loa Loa (eye worm) hypothetical protein 0.0065 0.0258 0.0258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.044 0.3598 0.3581
Entamoeba histolytica cysteine proteinase, putative 0.0115 0.0706 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0038 0.0018 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0207 0.0178
Echinococcus granulosus sodium bile acid cotransporter 0.0042 0.0051 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Schistosoma mansoni hypothetical protein 0.0323 0.256 0.2561
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.1933 1
Brugia malayi hypothetical protein 0.0184 0.1316 0.1316
Brugia malayi nuclear hormone receptor 0.0348 0.2778 0.2778
Loa Loa (eye worm) hypothetical protein 0.0164 0.114 0.1141
Echinococcus granulosus cathepsin L cysteine protease 0.0059 0.0207 0.0178
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0115 0.0706 0.0679
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0226 0.0196
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0298 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0018 0.0018
Toxoplasma gondii transporter, major facilitator family protein 0.0065 0.0258 0.0506
Loa Loa (eye worm) hypothetical protein 0.0065 0.0258 0.0258
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0088 0.046 0.0432
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0088 0.046 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0115 0.0706 0.0679
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0348 0.2778 0.2758
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0348 0.2778 0.278
Loa Loa (eye worm) hypothetical protein 0.0077 0.0366 0.0366
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0348 0.2778 0.278
Brugia malayi sodium-independent organic anion transporter family protein 0.0065 0.0258 0.0258
Echinococcus multilocularis carbonic anhydrase 0.0544 0.4523 0.451
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0226 0.0209
Schistosoma mansoni organic anion transporter 0.0065 0.0258 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0366 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0348 0.2778 0.2778
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0348 0.2778 0.278
Plasmodium vivax unspecified product 0.0059 0.0207 0.2757
Loa Loa (eye worm) hypothetical protein 0.0044 0.0074 0.0074
Onchocerca volvulus 0.0065 0.0258 0.0827
Brugia malayi nuclear receptor NHR-88 0.0348 0.2778 0.2778
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Trypanosoma cruzi cysteine peptidase, putative 0.044 0.3598 0.3589
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0298 0.1405
Leishmania major cathepsin L-like protease 0.0115 0.0706 0.0679
Brugia malayi ecdysone receptor 0.0164 0.114 0.114
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0544 0.4523 0.4523
Loa Loa (eye worm) DR-78 0.0164 0.114 0.1141
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0298 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Schistosoma mansoni carbonic anhydrase 0.0544 0.4523 0.4526
Loa Loa (eye worm) hypothetical protein 0.0164 0.114 0.1141
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0226 0.0196
Loa Loa (eye worm) hypothetical protein 0.0164 0.114 0.1141
Brugia malayi Cathepsin L-like precursor 0.0115 0.0706 0.0706
Leishmania major cathepsin L-like protease 0.0115 0.0706 0.0679
Loa Loa (eye worm) hypothetical protein 0.0164 0.114 0.1141
Brugia malayi Cathepsin L-like precursor 0.0038 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.0706 1
Brugia malayi hypothetical protein 0.0065 0.0258 0.0258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.044 0.3598 0.3581
Entamoeba histolytica cysteine proteinase, putative 0.0115 0.0706 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0115 0.0706 0.0679
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0226 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0348 0.2778 0.278
Loa Loa (eye worm) agrin synaptic family protein 0.0044 0.0074 0.0074
Brugia malayi Cathepsin L-like precursor 0.0077 0.0366 0.0366
Echinococcus multilocularis nuclear receptor nhr 48 0.0164 0.114 0.1114
Loa Loa (eye worm) hypothetical protein 0.0065 0.0258 0.0258
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0226 0.0196
Onchocerca volvulus 0.0065 0.0258 0.0827
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0348 0.2778 0.2758
Loa Loa (eye worm) fibroinase 0.0115 0.0706 0.0707
Schistosoma mansoni sodium-bile acid cotransporter related 0.0042 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0544 0.4523 0.4526
Brugia malayi nuclear hormone receptor family member nhr-6 0.0164 0.114 0.114
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0348 0.2778 0.2778
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0088 0.046 0.0444
Onchocerca volvulus 0.0115 0.0706 0.246
Brugia malayi nuclear receptor NHR-67 0.0164 0.114 0.114
Brugia malayi MAP kinase sur-1 0.0062 0.0226 0.0226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.044 0.3598 0.3581
Echinococcus multilocularis expressed protein 0.0044 0.0074 0.0043
Onchocerca volvulus 0.0348 0.2778 1
Brugia malayi Cathepsin L-like precursor 0.0115 0.0706 0.0706
Echinococcus granulosus nuclear receptor nhr 48 0.0164 0.114 0.1114
Loa Loa (eye worm) hypothetical protein 0.0974 0.8362 0.8367
Brugia malayi Cathepsin L-like precursor 0.0115 0.0706 0.0706
Schistosoma mansoni carbonic anhydrase-related 0.0544 0.4523 0.4526
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0184 0.1316 0.1316
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0348 0.2778 1
Loa Loa (eye worm) hypothetical protein 0.004 0.003 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.044 0.3598 0.3581
Brugia malayi Cathepsin L-like precursor 0.0115 0.0706 0.0706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0051 0.0051
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0207 0.019
Onchocerca volvulus Putative organic anion transporter 0.0065 0.0258 0.0827
Onchocerca volvulus 0.0077 0.0366 0.1222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Loa Loa (eye worm) hypothetical protein 0.0544 0.4523 0.4526
Brugia malayi nuclear hormone receptor 0.0164 0.114 0.114
Echinococcus granulosus thyroid hormone receptor alpha 0.0164 0.114 0.1114
Trypanosoma brucei carbonic anhydrase-like protein 0.1157 0.9994 1
Schistosoma mansoni thyroid hormone receptor 0.092 0.7878 0.7883
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1157 0.9994 0.9994
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0115 0.0706 0.1156
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.003 0.003
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0298 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.044 0.3598 0.3581
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0018 0.0018
Echinococcus granulosus agrin 0.0044 0.0074 0.0043
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0088 0.046 0.0461
Toxoplasma gondii hypothetical protein 0.0544 0.4523 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0059 0.0207 0.0208
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0348 0.2778 0.2778
Onchocerca volvulus Putative organic anion transporter 0.0065 0.0258 0.0827
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0226 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0348 0.2778 0.2778
Brugia malayi cathepsin L-like precursor 0.0077 0.0366 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0207 0.2619
Loa Loa (eye worm) ctsf protein 0.0115 0.0706 0.0707
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1157 0.9994 1
Onchocerca volvulus Cathepsin F homolog 0.0115 0.0706 0.246
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0044 0.0074 0.0096
Echinococcus multilocularis agrin 0.0044 0.0074 0.0043
Loa Loa (eye worm) hypothetical protein 0.0348 0.2778 0.278
Schistosoma mansoni carbonic anhydrase-related 0.0544 0.4523 0.4526
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0207 0.2619
Trypanosoma cruzi cysteine peptidase, putative 0.0115 0.0706 0.0691
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0348 0.2778 0.2758
Loa Loa (eye worm) hypothetical protein 0.0348 0.2778 0.278
Leishmania major cathepsin L-like protease 0.0115 0.0706 0.0679
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.0706 1
Echinococcus multilocularis sodium bile acid cotransporter 0.0042 0.0051 0.002
Brugia malayi orphan nuclear receptor NR2E1 0.0164 0.114 0.114
Echinococcus granulosus FTZ F1 alpha 0.0348 0.2778 0.2758
Loa Loa (eye worm) steroid hormone receptor 0.0348 0.2778 0.278
Schistosoma mansoni organic anion transporter 0.0065 0.0258 0.0258
Toxoplasma gondii protease inhibitor PI2 0.0044 0.0074 0.0096
Schistosoma mansoni nuclear hormone receptor 0.0164 0.114 0.1141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.0706 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0544 0.4523 0.4526
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0088 0.046 0.6361
Schistosoma mansoni coup transcription factor 0.0348 0.2778 0.278
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0226 0.0196
Echinococcus granulosus carbonic anhydrase 0.0544 0.4523 0.451
Loa Loa (eye worm) hypothetical protein 0.0184 0.1316 0.1316
Echinococcus multilocularis cathepsin L cysteine protease 0.0115 0.0706 0.0679
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0164 0.114 0.1141
Loa Loa (eye worm) beta-lactamase 0.004 0.003 0.003
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0402 0.3258 0.3248
Brugia malayi prostaglandin transporter 0.0065 0.0258 0.0258
Leishmania major cysteine peptidase A (CPA) 0.0115 0.0706 0.0679
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0164 0.114 0.4038
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0088 0.046 0.0432
Trypanosoma cruzi cysteine proteinase, putative 0.0059 0.0207 0.019
Loa Loa (eye worm) hypothetical protein 0.0348 0.2778 0.278
Loa Loa (eye worm) hypothetical protein 0.0184 0.1316 0.1316
Echinococcus granulosus cysteine protease 0.0059 0.0207 0.0178
Brugia malayi conserved hypotetical protein 0.0164 0.114 0.114
Loa Loa (eye worm) hypothetical protein 0.004 0.003 0.003
Schistosoma mansoni cathepsin F (C01 family) 0.0115 0.0706 0.0707
Schistosoma mansoni nuclear hormone receptor 0.0348 0.2778 0.278
Loa Loa (eye worm) hypothetical protein 0.0044 0.0074 0.0074
Onchocerca volvulus 0.0164 0.114 0.4038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0059 0.0207 0.0208
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0184 0.1316 0.1316
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0038 0.0018 0.0018
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0348 0.2778 0.278
Brugia malayi hypothetical protein 0.0164 0.114 0.114
Brugia malayi Nuclear hormone receptor-like 1 0.0994 0.8537 0.8537
Echinococcus multilocularis cysteine protease 0.0115 0.0706 0.0679
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0226 0.2892
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0226 0.0435
Brugia malayi hypothetical protein 0.0184 0.1316 0.1316
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0088 0.046 0.0432
Echinococcus granulosus Nuclear hormone receptor HR96 0.0164 0.114 0.1114
Brugia malayi nuclear receptor RXR 0.0184 0.1316 0.1316
Trypanosoma cruzi cruzipain precursor, putative 0.044 0.3598 0.3589
Entamoeba histolytica cysteine protease, putative 0.0115 0.0706 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0258 0.0258
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.0207 0.0207
Leishmania major carbonic anhydrase-like protein 0.1157 0.9994 1
Schistosoma mansoni sodium-bile acid cotransporter related 0.0042 0.0051 0.0051
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0572 0.4777 0.4764
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.044 0.3598 0.3581
Echinococcus granulosus cathepsin L cysteine proteinase 0.0115 0.0706 0.0679
Echinococcus multilocularis carbonic anhydrase II 0.1157 0.9994 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0348 0.2778 0.2778
Brugia malayi tailless protein 0.0164 0.114 0.114
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0044 0.0074 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0059 0.0207 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.044 0.3598 0.3581
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0164 0.114 0.1114
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0149 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0258 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0348 0.2778 0.278
Schistosoma mansoni cathepsin s 0.0038 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.044 0.3598 0.3581
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0348 0.2778 0.278
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0065 0.0258 0.0258
Leishmania major cathepsin L-like protease 0.0115 0.0706 0.0679
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0226 0.2892
Onchocerca volvulus 0.0115 0.0706 0.246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.044 0.3598 0.3581
Onchocerca volvulus 0.0065 0.0258 0.0827
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0544 0.4523 0.4523
Plasmodium vivax vivapain-2 0.0115 0.0706 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0164 0.114 0.1114
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0065 0.0258 0.0228
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0348 0.2778 0.278
Echinococcus granulosus cathepsin L 0.0059 0.0207 0.0178
Loa Loa (eye worm) hypothetical protein 0.0348 0.2778 0.278
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0226 0.0196
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0088 0.046 0.0432
Echinococcus granulosus geminin 0.0323 0.256 0.2539
Schistosoma mansoni cathepsin F (C01 family) 0.0077 0.0366 0.0366
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0164 0.114 0.1114
Plasmodium vivax hypothetical protein, conserved 0.004 0.003 0.0187
Brugia malayi beta-lactamase 0.004 0.003 0.003
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0115 0.0706 0.0707
Loa Loa (eye worm) hypothetical protein 0.004 0.003 0.003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0348 0.2778 0.2758
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0164 0.114 0.1114
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0544 0.4523 0.4523
Echinococcus multilocularis ecdysone induced protein 78C 0.0348 0.2778 0.2758
Trypanosoma cruzi cysteine protease, putative 0.0059 0.0207 0.019
Echinococcus multilocularis carbonic anhydrase 0.0544 0.4523 0.451
Onchocerca volvulus 0.0164 0.114 0.4038
Plasmodium vivax vivapain-2 0.0115 0.0706 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.114 0.1141
Mycobacterium leprae conserved hypothetical protein 0.004 0.003 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0115 0.0706 0.0707
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.0706 1
Brugia malayi Cathepsin L-like precursor 0.0077 0.0366 0.0366
Onchocerca volvulus 0.0115 0.0706 0.246
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0298 0.0268
Echinococcus multilocularis thyroid hormone receptor alpha 0.092 0.7878 0.7876
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0226 0.0209
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0044 0.0074 0.0074
Loa Loa (eye worm) carbonic anhydrase 3 0.1157 0.9994 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0348 0.2778 0.2778
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0164 0.114 0.114
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0115 0.0706 1
Trypanosoma cruzi MFS transporter, putative 0.0065 0.0258 0.0241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.0706 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.0706 1
Brugia malayi beta-lactamase family protein 0.004 0.003 0.003
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0088 0.046 0.0432
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0184 0.1316 0.1316
Loa Loa (eye worm) hypothetical protein 0.004 0.003 0.003
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0088 0.046 0.6361
Echinococcus multilocularis geminin 0.0323 0.256 0.2539
Loa Loa (eye worm) hypothetical protein 0.0164 0.114 0.1141
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0348 0.2778 0.2758
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0366 0.4967
Brugia malayi sodium-independent organic anion transporter family protein 0.0065 0.0258 0.0258
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0088 0.046 0.0461
Onchocerca volvulus Cathepsin L homolog 0.0115 0.0706 0.246
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.0706 1
Schistosoma mansoni hypothetical protein 0.0572 0.4777 0.478
Brugia malayi nuclear receptor RXR 0.0164 0.114 0.114
Echinococcus granulosus ubiquitin specific protease 41 0.0088 0.046 0.0432
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0044 0.0074 0.0074
Plasmodium vivax vivapain-3 0.0059 0.0207 0.2757
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.003 0.0013
Echinococcus granulosus sodium bile acid cotransporter 0.0042 0.0051 0.002
Echinococcus multilocularis carbonic anhydrase 0.0544 0.4523 0.451
Trypanosoma cruzi major cysteine proteinase, putative 0.0346 0.2759 0.2748
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0348 0.2778 0.2758
Schistosoma mansoni RAR-like nuclear receptor 0.0348 0.2778 0.278
Echinococcus granulosus cathepsin l1 0.0115 0.0706 0.0679
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0164 0.114 0.4038
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0164 0.114 0.1141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.003 0.003
Echinococcus multilocularis sodium bile acid cotransporter 0.0042 0.0051 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.046 0.6361
Mycobacterium leprae Probable lipase LipE 0.004 0.003 0.5
Brugia malayi Sodium Bile acid symporter family protein 0.0042 0.0051 0.0051
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0298 0.0298
Brugia malayi steroid hormone receptor 0.0348 0.2778 0.2778
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0348 0.2778 0.278
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0348 0.2778 0.2778
Loa Loa (eye worm) nuclear receptor NHR-67 0.0164 0.114 0.1141
Leishmania major cathepsin L-like protease 0.044 0.3598 0.3581
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0184 0.1316 0.129
Loa Loa (eye worm) nuclear hormone receptor 0.0164 0.114 0.1141
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1157 0.9994 1
Loa Loa (eye worm) hypothetical protein 0.0348 0.2778 0.278
Onchocerca volvulus 0.0115 0.0706 0.246
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0298 0.0595
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0164 0.114 0.1141
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0994 0.8537 0.8543
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0298 0.0268
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1157 0.9994 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.003 0.003
Plasmodium falciparum carbonic anhydrase 0.0544 0.4523 1
Brugia malayi nuclear receptor NHR-88 0.0164 0.114 0.114
Loa Loa (eye worm) hypothetical protein 0.0348 0.2778 0.278
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0164 0.114 0.1114
Schistosoma mansoni hypothetical protein 0.0057 0.0186 0.0186
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0044 0.0074 0.0074
Onchocerca volvulus 0.0115 0.0706 0.246
Schistosoma mansoni nuclear receptor 0.0164 0.114 0.1141
Echinococcus granulosus carbonic anhydrase 0.0544 0.4523 0.451
Brugia malayi Nuclear hormone receptor E75 0.0164 0.114 0.114
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1157 0.9994 1
Loa Loa (eye worm) hypothetical protein 0.0348 0.2778 0.278
Onchocerca volvulus 0.0065 0.0258 0.0827
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0226 0.0196
Schistosoma mansoni zinc finger protein 0.0164 0.114 0.1141
Schistosoma mansoni nuclear receptor nhr-48 0.0164 0.114 0.1141
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0348 0.2778 0.2778
Loa Loa (eye worm) hypothetical protein 0.0348 0.2778 0.278
Brugia malayi beta-lactamase family protein 0.004 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0053 0.0149 0.0149
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.003 0.003
Trypanosoma brucei RNA helicase, putative 0.0057 0.0186 0.0156
Loa Loa (eye worm) hypothetical protein 0.0164 0.114 0.1141
Echinococcus granulosus Nuclear hormone receptor HR96 0.0164 0.114 0.1114
Loa Loa (eye worm) hypothetical protein 0.0164 0.114 0.1141
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0088 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0164 0.114 0.1141
Onchocerca volvulus Protein ultraspiracle homolog 0.0348 0.2778 1
Echinococcus granulosus ecdysone induced protein 78C 0.0348 0.2778 0.2758
Brugia malayi Cathepsin L-like cysteine proteinase 0.0077 0.0366 0.0366
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0544 0.4523 0.4523
Onchocerca volvulus Putative organic anion transporter 0.0065 0.0258 0.0827
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0348 0.2778 0.2758
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0348 0.2778 0.2758
Leishmania major cathepsin L-like protease 0.044 0.3598 0.3581
Plasmodium falciparum cysteine proteinase falcipain 3 0.0115 0.0706 0.1156
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0348 0.2778 0.2758
Leishmania major cathepsin L-like protease 0.0115 0.0706 0.0679
Loa Loa (eye worm) hypothetical protein 0.0065 0.0258 0.0258
Echinococcus granulosus cathepsin l cysteine peptidase 0.0115 0.0706 0.0679
Brugia malayi Steroid receptor seven-up type 2 0.0348 0.2778 0.2778
Brugia malayi sodium-independent organic anion transporter family protein 0.0065 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0115 0.0706 0.0707
Schistosoma mansoni agrin 0.0044 0.0074 0.0074
Echinococcus multilocularis FTZ F1 alpha 0.0348 0.2778 0.2758
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0706 1
Schistosoma mansoni carbonic anhydrase-related 0.0544 0.4523 0.4526
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0348 0.2778 0.278
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0544 0.4523 0.4523

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.