Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0064 | 0.2326 | 0.2434 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0018 | 0.0076 | 0.5 |
Brugia malayi | Hint module family protein | 0.003 | 0.0664 | 0.0445 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0063 | 0.2255 | 0.2352 |
Brugia malayi | nuclear hormone receptor | 0.0064 | 0.2326 | 0.2145 |
Brugia malayi | tailless protein | 0.003 | 0.0657 | 0.0438 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0123 | 0.5236 | 0.5814 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0018 | 0.0076 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0064 | 0.2326 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.003 | 0.0657 | 0.0496 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.3181 | 0.3427 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0064 | 0.2326 | 0.2145 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0064 | 0.2326 | 0.1786 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0064 | 0.2326 | 0.2567 |
Brugia malayi | ecdysteroid receptor | 0.0064 | 0.2326 | 0.2145 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0064 | 0.2326 | 0.2145 |
Brugia malayi | steroid hormone receptor | 0.0064 | 0.2326 | 0.2145 |
Onchocerca volvulus | 0.0064 | 0.2326 | 1 | |
Schistosoma mansoni | nuclear hormone receptor | 0.0064 | 0.2326 | 0.2434 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0018 | 0.0076 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0064 | 0.2326 | 0.2434 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0064 | 0.2326 | 0.2434 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0664 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.4704 | 0.4332 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.003 | 0.0657 | 0.0496 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0064 | 0.2326 | 0.2145 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0123 | 0.5236 | 0.5888 |
Brugia malayi | nuclear receptor NHR-67 | 0.003 | 0.0657 | 0.0438 |
Schistosoma mansoni | nuclear receptor | 0.003 | 0.0657 | 0.0496 |
Schistosoma mansoni | thyroid hormone receptor | 0.0139 | 0.6043 | 0.675 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0022 | 0.023 | 0.0176 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.022 | 1 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0064 | 0.2326 | 0.2434 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0064 | 0.2326 | 0.2434 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0139 | 0.6043 | 0.675 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0064 | 0.2326 | 0.2434 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2326 | 0.1786 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0064 | 0.2326 | 0.2145 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0196 | 0.8841 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0064 | 0.2326 | 0.2434 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.003 | 0.0657 | 0.0496 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2326 | 0.1786 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2326 | 0.1786 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2326 | 0.1786 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2326 | 0.1786 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0017 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0064 | 0.2326 | 0.2145 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.003 | 0.0657 | 0.0496 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0064 | 0.2326 | 0.2567 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0064 | 0.2326 | 0.2567 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0064 | 0.2326 | 0.2145 |
Entamoeba histolytica | hypothetical protein | 0.0022 | 0.023 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.0836 | 0.062 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0075 | 0.2885 | 0.3083 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0064 | 0.2326 | 1 |
Brugia malayi | Hint module family protein | 0.003 | 0.0664 | 0.0445 |
Schistosoma mansoni | nuclear receptor | 0.003 | 0.0657 | 0.0496 |
Entamoeba histolytica | hypothetical protein | 0.0022 | 0.023 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0.0657 | 0.0496 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0064 | 0.2326 | 0.1786 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0075 | 0.2885 | 0.3205 |
Brugia malayi | ecdysone receptor | 0.003 | 0.0657 | 0.0438 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0063 | 0.2255 | 0.2073 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0018 | 0.0076 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0064 | 0.2326 | 0.2145 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0064 | 0.2326 | 0.2145 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0064 | 0.2326 | 0.2145 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0836 | 0.0191 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0064 | 0.2326 | 0.1786 |
Brugia malayi | Nuclear hormone receptor E75 | 0.003 | 0.0657 | 0.0438 |
Schistosoma mansoni | thyroid hormone receptor | 0.0139 | 0.6043 | 0.675 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.0836 | 0.062 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0064 | 0.2326 | 0.2145 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.2197 | 0.2284 |
Schistosoma mansoni | nuclear hormone receptor | 0.003 | 0.0657 | 0.0496 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.003 | 0.0657 | 0.0664 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0034 | 0.0836 | 0.0704 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.2885 | 0.3083 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0196 | 0.8841 | 0.8814 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0196 | 0.8841 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0196 | 0.8841 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0064 | 0.2326 | 0.2434 |
Echinococcus granulosus | FTZ F1 alpha | 0.0064 | 0.2326 | 0.2567 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.003 | 0.0657 | 0.0438 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0064 | 0.2326 | 0.2567 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.003 | 0.0657 | 0.0438 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0017 | 0 | 0.5 |
Brugia malayi | conserved hypotetical protein | 0.003 | 0.0657 | 0.0438 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0064 | 0.2326 | 0.2567 |
Brugia malayi | nuclear receptor RXR | 0.003 | 0.0657 | 0.0438 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2326 | 0.1786 |
Schistosoma mansoni | coup transcription factor | 0.0064 | 0.2326 | 0.2434 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0064 | 0.2326 | 0.1786 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.003 | 0.0657 | 0.0496 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0044 | 0.1342 | 0.1445 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0064 | 0.2326 | 0.2434 |
Echinococcus granulosus | Desert hedgehog protein | 0.0112 | 0.4677 | 0.525 |
Schistosoma mansoni | nuclear hormone receptor | 0.003 | 0.0657 | 0.0496 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0064 | 0.2326 | 0.1786 |
Brugia malayi | nuclear receptor NHR-88 | 0.003 | 0.0657 | 0.0438 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.003 | 0.0657 | 0.0496 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0018 | 0.0076 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.0063 | 0.2255 | 0.171 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.003 | 0.0657 | 0.0664 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0064 | 0.2326 | 0.2145 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0064 | 0.2326 | 0.2434 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0064 | 0.2326 | 0.2145 |
Schistosoma mansoni | zinc finger protein | 0.003 | 0.0657 | 0.0496 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0836 | 0.0191 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0836 | 0.062 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0064 | 0.2326 | 0.2434 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0064 | 0.2326 | 0.2434 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0064 | 0.2326 | 0.2145 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0064 | 0.2326 | 0.2145 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0836 | 0.062 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2326 | 0.1786 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0064 | 0.2326 | 0.2434 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0034 | 0.0836 | 0.0704 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.003 | 0.0657 | 0.0664 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0034 | 0.0836 | 0.0191 |
Leishmania major | C-8 sterol isomerase-like protein | 0.022 | 1 | 0.5 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0034 | 0.0836 | 0.0704 |
Entamoeba histolytica | hypothetical protein | 0.0022 | 0.023 | 1 |
Brugia malayi | nuclear hormone receptor | 0.003 | 0.0657 | 0.0438 |
Brugia malayi | nuclear receptor RXR | 0.0034 | 0.0836 | 0.062 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0836 | 0.0191 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0044 | 0.1342 | 0.1291 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0836 | 0.0191 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0064 | 0.2326 | 0.2434 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0061 | 0.2169 | 0.2388 |
Brugia malayi | Nuclear hormone receptor E75 | 0.003 | 0.0657 | 0.0438 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0089 | 0.3568 | 0.3877 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0064 | 0.2326 | 0.2145 |
Echinococcus multilocularis | hedgehog | 0.0112 | 0.4677 | 0.5165 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0064 | 0.2326 | 0.2145 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.022 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0064 | 0.2326 | 0.2145 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0064 | 0.2326 | 0.1786 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.003 | 0.0657 | 0.0664 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0064 | 0.2326 | 0.2567 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0664 | 0.0007 |
Brugia malayi | hypothetical protein | 0.003 | 0.0657 | 0.0438 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0064 | 0.2326 | 0.2434 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0064 | 0.2326 | 0.2567 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.003 | 0.0657 | 0.0664 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0063 | 0.2255 | 0.2352 |
Brugia malayi | hypothetical protein | 0.003 | 0.0657 | 0.0438 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.003 | 0.0657 | 0.0496 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0034 | 0.0836 | 0.0868 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0836 | 0.0191 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0064 | 0.2326 | 0.2434 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2326 | 0.1786 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.003 | 0.0657 | 0.0438 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0064 | 0.2326 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0022 | 0.023 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0064 | 0.2326 | 0.1786 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0.0657 | 0.0664 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0196 | 0.8841 | 0.876 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.003 | 0.0657 | 0.0438 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0064 | 0.2326 | 0.1786 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.