Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0095 | 0.0116 | 0.0201 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0095 | 0.0116 | 0.0116 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 0.0302 | 0.0522 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0095 | 0.0116 | 0.0201 |
Trichomonas vaginalis | AGC family protein kinase | 0.0095 | 0.0116 | 1 |
Schistosoma mansoni | rac gtpase activating protein | 0.0114 | 0.0302 | 0.0522 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0114 | 0.0302 | 0.0522 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0114 | 0.0302 | 0.0522 |
Brugia malayi | C1-like domain containing protein | 0.0116 | 0.0323 | 0.0365 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0095 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0116 | 0.0323 | 0.0323 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.0116 | 0.0201 |
Brugia malayi | RhoGEF domain containing protein | 0.0114 | 0.0302 | 0.0342 |
Brugia malayi | Protein kinase domain containing protein | 0.0095 | 0.0116 | 0.0132 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0114 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0302 | 0.0302 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0114 | 0.0302 | 0.0522 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.0302 | 0.0522 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.0116 | 0.0201 |
Echinococcus granulosus | myotubularin protein 13 | 0.0114 | 0.0302 | 0.0522 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0114 | 0.0302 | 0.0522 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0114 | 0.0302 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0302 | 0.0302 |
Schistosoma mansoni | serine/threonine kinase | 0.0095 | 0.0116 | 0.0201 |
Brugia malayi | RhoGAP domain containing protein | 0.0114 | 0.0302 | 0.0342 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0456 | 0.3722 | 0.3722 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0302 | 0.0302 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0664 | 0.5794 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0095 | 0.0116 | 0.0116 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0128 | 0.0442 | 0.0764 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0116 | 0.0116 |
Echinococcus granulosus | protein kinase C gamma type | 0.055 | 0.4654 | 0.8033 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0302 | 0.0302 |
Onchocerca volvulus | 0.0128 | 0.0442 | 1 | |
Schistosoma mansoni | unc-13 (munc13) | 0.0128 | 0.0442 | 0.0764 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0114 | 0.0302 | 1 |
Loa Loa (eye worm) | Ras association domain family 1 isoform A | 0.0114 | 0.0302 | 0.0302 |
Trichomonas vaginalis | AGC family protein kinase | 0.0095 | 0.0116 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0095 | 0.0116 | 0.0132 |
Schistosoma mansoni | atypical protein kinase C | 0.0209 | 0.1256 | 0.2168 |
Brugia malayi | RhoGAP domain containing protein | 0.0114 | 0.0302 | 0.0342 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0095 | 0.0116 | 0.0201 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.044 | 0.3561 | 0.6146 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0114 | 0.0302 | 0.0522 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0116 | 0.0323 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0302 | 0.0302 |
Toxoplasma gondii | diacylglycerol kinase, putative | 0.0114 | 0.0302 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.055 | 0.4654 | 0.8033 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0302 | 0.0302 |
Echinococcus multilocularis | protein kinase c iota type | 0.0209 | 0.1256 | 0.2168 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 0.47 | 0.47 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0302 | 0.0302 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0664 | 0.5794 | 1 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0114 | 0.0302 | 0.0522 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0114 | 0.0302 | 0.0302 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0114 | 0.0302 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0302 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0095 | 0.0116 | 0.0201 |
Brugia malayi | protein kinase C II. | 0.0223 | 0.1396 | 0.1577 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0223 | 0.1396 | 0.2409 |
Schistosoma mansoni | vav2 | 0.0114 | 0.0302 | 0.0522 |
Echinococcus granulosus | Diacylglycerol kinase theta | 0.0114 | 0.0302 | 0.0522 |
Echinococcus granulosus | unc 13 munc13 | 0.0128 | 0.0442 | 0.0764 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0095 | 0.0116 | 0.0116 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0116 | 0.0323 | 0.0558 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0095 | 0.0116 | 0.0201 |
Echinococcus granulosus | NDR protein kinase | 0.0095 | 0.0116 | 0.0201 |
Echinococcus granulosus | protein kinase c iota type | 0.0209 | 0.1256 | 0.2168 |
Trichomonas vaginalis | AGC family protein kinase | 0.0095 | 0.0116 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0095 | 0.0116 | 1 |
Echinococcus multilocularis | N chimaerin | 0.0114 | 0.0302 | 0.0522 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0095 | 0.0116 | 0.0116 |
Trichomonas vaginalis | AGC family protein kinase | 0.0095 | 0.0116 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0095 | 0.0116 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0095 | 0.0116 | 1 |
Brugia malayi | RasGEF domain containing protein | 0.0969 | 0.885 | 1 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0116 | 0.0323 | 0.0365 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0223 | 0.1396 | 0.1396 |
Brugia malayi | diacylglycerol kinase | 0.0114 | 0.0302 | 0.0342 |
Brugia malayi | diacylglycerol kinase | 0.0114 | 0.0302 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0442 | 0.0442 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0095 | 0.0116 | 0.0201 |
Trichomonas vaginalis | AGC family protein kinase | 0.0095 | 0.0116 | 1 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0116 | 0.0323 | 0.0558 |
Trichomonas vaginalis | AGC family protein kinase | 0.0095 | 0.0116 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0095 | 0.0116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0302 | 0.0302 |
Brugia malayi | Pleckstrin Homology Domain | 0.0114 | 0.0302 | 0.0342 |
Echinococcus multilocularis | protein kinase c eta type | 0.0114 | 0.0302 | 0.0522 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0095 | 0.0116 | 0.0201 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0223 | 0.1396 | 0.2409 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0664 | 0.5794 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0116 | 0.0323 | 0.0365 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.044 | 0.3561 | 0.6146 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0116 | 0.0323 | 0.0558 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0116 | 0.0323 | 0.0323 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.0116 | 0.0201 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0114 | 0.0302 | 0.0522 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0114 | 0.0302 | 0.0522 |
Schistosoma mansoni | protein kinase C mu | 0.0114 | 0.0302 | 0.0522 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0114 | 0.0302 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0302 | 0.0302 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.0116 | 0.0201 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0095 | 0.0116 | 0.0116 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0095 | 0.0116 | 0.5 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0095 | 0.0116 | 0.0116 |
Schistosoma mansoni | unc-13 (munc13) | 0.0128 | 0.0442 | 0.0764 |
Brugia malayi | protein kinase C3,putative | 0.0116 | 0.0323 | 0.0365 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0223 | 0.1396 | 0.2409 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0095 | 0.0116 | 0.0201 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0095 | 0.0116 | 0.0132 |
Loa Loa (eye worm) | raf kinase | 0.0114 | 0.0302 | 0.0302 |
Echinococcus granulosus | protein kinase c eta type | 0.0114 | 0.0302 | 0.0522 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0664 | 0.5794 | 1 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0095 | 0.0116 | 0.0201 |
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0114 | 0.0302 | 0.0522 |
Schistosoma mansoni | protein kinase C | 0.0128 | 0.0442 | 0.0764 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0128 | 0.0442 | 0.0764 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0128 | 0.0442 | 0.0764 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.044 | 0.3561 | 0.6146 |
Brugia malayi | Hr1 repeat family protein | 0.0095 | 0.0116 | 0.0132 |
Echinococcus granulosus | N chimaerin | 0.0114 | 0.0302 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.3561 | 0.3561 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0302 | 0.0302 |
Echinococcus multilocularis | Diacylglycerol kinase theta | 0.0114 | 0.0302 | 0.0522 |
Brugia malayi | Ras association domain family 1 isoform A | 0.0114 | 0.0302 | 0.0342 |
Brugia malayi | Variant SH3 domain containing protein | 0.0114 | 0.0302 | 0.0342 |
Brugia malayi | Protein kinase c protein 2 | 0.057 | 0.4861 | 0.5493 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0095 | 0.0116 | 0.0201 |
Brugia malayi | Protein kinase domain containing protein | 0.0095 | 0.0116 | 0.0132 |
Trichomonas vaginalis | AGC family protein kinase | 0.0095 | 0.0116 | 1 |
Schistosoma mansoni | protein kinase C mu | 0.0116 | 0.0323 | 0.0558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.