Detailed information for compound 2071464

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 330.385 | Formula: C16H22N6O2
  • H donors: 2 H acceptors: 4 LogP: 0.37 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccnc1)CNC1CCCN(C1)Cc1noc(n1)C
  • InChi: 1S/C16H22N6O2/c1-12-19-15(21-24-12)11-22-7-3-5-14(10-22)18-9-16(23)20-13-4-2-6-17-8-13/h2,4,6,8,14,18H,3,5,7,9-11H2,1H3,(H,20,23)
  • InChiKey: IYSPDOLZXRJVCS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis segment polarity protein dishevelled 0.0012 0.0012 0.0002
Brugia malayi CXXC zinc finger family protein 0.0028 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0047
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0058 0.0076
Echinococcus multilocularis alpha(13)fucosyltransferase 0.0075 0.0549 0.086
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0012 0.001 0.001
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0021 0.0082 0.0641
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0065 0.0462 0.5757
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0417 0.0407
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0034 0.0034
Echinococcus granulosus mothers against decapentaplegic 5 0.002 0.0076 0.0105
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0027 0.0137 0.1379
Echinococcus granulosus segment polarity protein dishevelled 0.0012 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.0075 0.0549 0.0549
Schistosoma mansoni uridine phosphorylase 0.0102 0.0778 0.0768
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0494 0.4117 1
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0102 0.0778 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0532 0.0532
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0363 0.458
Mycobacterium ulcerans glutaminase 0.1183 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0489 0.0479
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0268 0.219 1
Brugia malayi MH1 domain containing protein 0.002 0.0076 0.0076
Schistosoma mansoni alpha(13)fucosyltransferase 0.003 0.0161 0.0151
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0058 0.0319
Toxoplasma gondii PHD-finger domain-containing protein 0.0018 0.0058 0.06
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0063 0.0084
Brugia malayi Pre-SET motif family protein 0.0125 0.097 0.097
Schistosoma mansoni cpg binding protein 0.003 0.0158 0.0147
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0065 0.0462 0.043
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0102 0.0778 0.0778
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0075 0.0549 0.1309
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0102 0.0778 1
Brugia malayi Fucosyl transferase family protein 0.0177 0.142 0.142
Schistosoma mansoni hypothetical protein 0.0054 0.0368 0.0358
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0065 0.0462 0.0722
Brugia malayi DIX domain containing protein 0.0012 0.0012 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0063 0.0053
Echinococcus granulosus purine nucleoside phosphorylase 0.0494 0.4117 0.656
Echinococcus granulosus purine nucleoside phosphorylase 0.0494 0.4117 0.656
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0018 0.0063 0.0053
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0042 0.0114
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0027 0.0137 0.1379
Echinococcus granulosus Transcription initiation factor TFIID subunit 0.0045 0.0294 0.0452
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0039 0.0236 0.0236
Echinococcus granulosus PHD finger protein rhinoceros 0.0018 0.0058 0.0076
Schistosoma mansoni dep domain containing protein 0.0012 0.0012 0.0001
Onchocerca volvulus 0.0028 0.0144 0.0322
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0012 0.0012 0.0012
Loa Loa (eye worm) DIX domain-containing protein 0.0012 0.0012 0.0012
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0252 0.2055 0.4977
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0074 0.0537 0.0537
Echinococcus granulosus alpha13fucosyltransferase 0.0075 0.0549 0.086
Schistosoma mansoni Smad4 0.002 0.0076 0.0066
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0058 0.0322
Echinococcus granulosus Pleckstrin G protein interacting region 0.0012 0.0012 0.0002
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0042 0.0114
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0102 0.0778 1
Loa Loa (eye worm) uridine phosphorylase 0.0102 0.0778 0.0778
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0494 0.4117 1
Loa Loa (eye worm) Smad1 0.002 0.0076 0.0076
Brugia malayi Ets-domain containing protein 0.0073 0.0532 0.0532
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0042 0.0114
Schistosoma mansoni glutaminase 0.1183 1 1
Schistosoma mansoni alpha 13/4 fucosyltransferase Lewis 1 0.0102 0.0777 0.0768
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0102 0.0778 1
Echinococcus granulosus methylthioadenosine phosphorylase 0.0102 0.0778 0.1226
Schistosoma mansoni alpha(13)fucosyltransferase 0.003 0.0161 0.0151
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0054 0.0368 0.0571
Toxoplasma gondii Purine nucleoside phosphorylase 0.0102 0.0778 1
Brugia malayi hypothetical protein 0.0054 0.0368 0.0368
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0102 0.0778 0.0746
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0054 0.0368 0.0571
Echinococcus multilocularis Transcription initiation factor TFIID subunit 0.0045 0.0294 0.0452
Entamoeba histolytica hypothetical protein 0.0054 0.0368 0.1547
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0042 0.0042
Echinococcus granulosus glycoprotein 3 alpha L fucosyltransferase 0.0075 0.0549 0.086
Echinococcus granulosus purine nucleoside phosphorylase 0.0494 0.4117 0.656
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0042 0.0114
Echinococcus granulosus purine nucleoside phosphorylase 0.0494 0.4117 0.656
Brugia malayi Telomerase reverse transcriptase 0.0055 0.0374 0.0374
Brugia malayi Fli-1 protein 0.0223 0.1805 0.1805
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0058 0.0058
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0102 0.0778 0.0746
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0494 0.4117 0.4097
Echinococcus multilocularis purine nucleoside phosphorylase 0.0494 0.4117 0.656
Echinococcus multilocularis regulator of G protein signaling 7 0.0012 0.0012 0.0002
Leishmania major telomerase reverse transcriptase, putative 0.0021 0.0082 0.0641
Toxoplasma gondii PHD-finger domain-containing protein 0.0018 0.0058 0.06
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0102 0.0778 0.1822
Plasmodium falciparum purine nucleoside phosphorylase 0.0102 0.0778 1
Brugia malayi jmjC domain containing protein 0.0018 0.0058 0.0058
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0058 0.0076
Loa Loa (eye worm) hypothetical protein 0.0252 0.2055 0.2055
Schistosoma mansoni ap endonuclease 0.0015 0.0034 0.0024
Brugia malayi Ets-domain containing protein 0.0073 0.0532 0.0532
Echinococcus granulosus uridine phosphorylase 1 0.0102 0.0778 0.1226
Loa Loa (eye worm) hypothetical protein 0.0063 0.0441 0.0441
Entamoeba histolytica hypothetical protein 0.0102 0.0778 0.345
Leishmania major methylthioadenosine phosphorylase, putative 0.0102 0.0778 1
Trichomonas vaginalis glutaminase, putative 0.1183 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0778 0.0746
Schistosoma mansoni TGF-beta signal transducer Smad2 0.002 0.0076 0.0066
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0042 0.0021
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0065 0.0462 0.043
Brugia malayi hypothetical protein 0.0012 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0778 0.0746
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0072 0.0098
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0034 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0058 0.0058
Loa Loa (eye worm) MH1 domain-containing protein 0.002 0.0076 0.0076
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0027 0.0137 0.1379
Trypanosoma brucei telomerase reverse transcriptase 0.0021 0.0082 0.0641
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.001
Toxoplasma gondii exonuclease III APE 0.0015 0.0034 0.029
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0012 0.0012 0.0002
Mycobacterium tuberculosis Hypothetical protein 0.0102 0.0778 0.1822
Schistosoma mansoni uridine phosphorylase 0.0102 0.0778 0.0768
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0012 0.0012 0.0001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0125 0.097 0.097
Trypanosoma brucei uridine phosphorylase 0.0102 0.0778 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0268 0.219 0.2164
Loa Loa (eye worm) MH2 domain-containing protein 0.0292 0.2401 0.2401
Brugia malayi jmjC domain containing protein 0.0018 0.0058 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0268 0.219 0.2164
Brugia malayi PHD-finger family protein 0.0018 0.0058 0.0058
Schistosoma mansoni purine nucleoside phosphorylase 0.0494 0.4117 0.4111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0063 0.0053
Echinococcus multilocularis glycoprotein 3 alpha L fucosyltransferase 0.0075 0.0549 0.086
Schistosoma mansoni dishevelled 0.0012 0.0012 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0058 0.0058
Brugia malayi Bromodomain containing protein 0.0018 0.0058 0.0058
Schistosoma mansoni alpha(13)fucosyltransferase 0.0177 0.142 0.1411
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0102 0.0778 0.0746
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0391 0.3245 0.5167
Echinococcus granulosus purine nucleoside phosphorylase 0.0494 0.4117 0.656
Leishmania major eukaryotic translation initiation factor-like 0.0065 0.0462 0.5757
Echinococcus multilocularis alpha(13)fucosyltransferase 0.0075 0.0549 0.086
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0065 0.0462 0.5757
Brugia malayi MH1 domain containing protein 0.002 0.0076 0.0076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0074 0.0537 0.0841
Brugia malayi alpha1,3-fucosyltransferase homologue 0.0177 0.142 0.142
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.002 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0268 0.219 0.2164
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0065 0.0462 0.1986
Brugia malayi translation initiation factor 4E 0.0065 0.0462 0.0462
Leishmania major glycosyl transferase, putative 0.003 0.0161 0.1709
Echinococcus multilocularis glycoprotein 3 alpha L fucosyltransferase 0.0075 0.0549 0.086
Brugia malayi glutaminase DH11.1 0.1183 1 1
Schistosoma mansoni ap endonuclease 0.0015 0.0034 0.0024
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0151 0.1195 0.1186
Echinococcus granulosus glycoprotein 3 alpha L fucosyltransferase 0.0075 0.0549 0.086
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0058 0.0076
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0102 0.0778 0.1822
Brugia malayi jmjC domain containing protein 0.0018 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0391 0.3245 0.3245
Schistosoma mansoni z-protein (S1r protein) 0.0012 0.0012 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0268 0.219 0.2164
Loa Loa (eye worm) transcription factor SMAD2 0.0292 0.2401 0.2401
Giardia lamblia UPL-1 0.0102 0.0778 0.1822
Loa Loa (eye worm) fucosyl transferase 0.0177 0.142 0.142
Mycobacterium tuberculosis Conserved hypothetical protein 0.0102 0.0778 0.1822
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0537 0.0527
Echinococcus multilocularis purine nucleoside phosphorylase 0.0494 0.4117 0.656
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0137 0.1379
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0137 0.1379
Echinococcus multilocularis purine nucleoside phosphorylase 0.0494 0.4117 0.656
Brugia malayi MTAP 0.0102 0.0778 0.0778
Onchocerca volvulus 0.0142 0.1116 0.2691
Treponema pallidum uridine phosphorylase (udp) 0.0102 0.0778 0.345
Echinococcus granulosus purine nucleoside phosphorylase 0.0494 0.4117 0.656
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0102 0.0778 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0537 0.0527
Schistosoma mansoni hypothetical protein 0.0026 0.0132 0.0121
Echinococcus granulosus glycoprotein 3 alpha L fucosyltransferase 0.0075 0.0549 0.086
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0042 0.0401
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Loa Loa (eye worm) translation initiation factor 4E 0.0065 0.0462 0.0462
Toxoplasma gondii phosphorylase family protein 0.0102 0.0778 1
Plasmodium vivax SET domain protein, putative 0.0018 0.0063 0.0391
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0102 0.0778 0.1226
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0034 0.0034
Brugia malayi uridine phosphorylase family protein 0.0102 0.0778 0.0778
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0102 0.0778 0.345
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0039 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0045 0.0294 0.0294
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0065 0.0462 0.0452
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0074 0.0537 0.0841
Entamoeba histolytica DNA repair and recombination protein, putative 0.0027 0.0137 0.0476
Schistosoma mansoni hypothetical protein 0.0281 0.2306 0.2298
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0219 0.0219
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0018 0.0058 0.0047
Brugia malayi Calcitonin receptor-like protein seb-1 0.0039 0.0236 0.0236
Schistosoma mansoni regulator of G protein signaling 0.0012 0.0012 0.0001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.0789 0.1244
Echinococcus multilocularis purine nucleoside phosphorylase 0.0391 0.3245 0.5167
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0018 0.0063 0.0084
Brugia malayi N-terminal motif family protein 0.0252 0.2055 0.2055
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0102 0.0778 0.0746
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0074 0.0537 0.0841
Trichomonas vaginalis set domain proteins, putative 0.0142 0.1116 0.1086
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0058 0.0076
Echinococcus granulosus phd:f box containing protein 0.0018 0.0058 0.0076
Echinococcus granulosus regulator of G protein signaling 7 0.0012 0.0012 0.0002
Echinococcus multilocularis cpg binding protein 0.003 0.0158 0.0235
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0042 0.0114
Brugia malayi jmjC domain containing protein 0.0068 0.0489 0.0489
Brugia malayi regulator of G-protein signaling egl-10 0.0012 0.0012 0.0012
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0072 0.0098
Schistosoma mansoni cpg binding protein 0.003 0.0158 0.0147
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0034 0.0034
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.0132 0.0132
Schistosoma mansoni cpg binding protein 0.0028 0.0144 0.0134
Plasmodium vivax JmjC domain containing protein 0.0018 0.0058 0.0322
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0058 0.0058
Schistosoma mansoni alpha(13)fucosyltransferase 0.003 0.0161 0.0151
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0102 0.0778 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0042 0.0042
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0102 0.0778 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0051
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0058 0.0048
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0494 0.4117 0.4117
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0268 0.219 0.2164
Schistosoma mansoni alpha(13)fucosyltransferase 0.0177 0.142 0.1411
Treponema pallidum fructose-bisphosphate aldolase 0.0268 0.219 1
Echinococcus granulosus dnaJ subfamily B 0.0398 0.3297 0.5251
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0042 0.0051
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0102 0.0778 0.345
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0051
Schistosoma mansoni alpha(13)fucosyltransferase 0.0177 0.142 0.1411
Brugia malayi jmjC domain containing protein 0.0018 0.0058 0.0058
Schistosoma mansoni smad 0.002 0.0076 0.0066
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0027 0.0137 0.0202
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0058 0.0076
Schistosoma mansoni smad1 5 8 and 0.002 0.0076 0.0066
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0065 0.0462 0.588
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0151 0.1195 0.1195
Echinococcus multilocularis lysine specific demethylase 5A 0.0067 0.0476 0.0744
Echinococcus granulosus purine nucleoside phosphorylase 0.0494 0.4117 0.656
Loa Loa (eye worm) PHD-finger family protein 0.0018 0.0058 0.0058
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0034 0.0038
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0102 0.0778 0.0746
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0012 0.0012 0.0012
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0131 0.1022 0.0991
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0151 0.1195 0.1893
Toxoplasma gondii RNA-directed DNA polymerase 0.0021 0.0082 0.0913
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0017 0.0052 0.0067
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0687 0.0677
Brugia malayi jmjC domain containing protein 0.0104 0.0789 0.0789
Brugia malayi Smad1 0.002 0.0076 0.0076
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0137 0.1379
Schistosoma mansoni ets-related 0.0223 0.1805 0.1797
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0065 0.0462 0.5757
Schistosoma mansoni alpha(13)fucosyltransferase 0.003 0.0161 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0074 0.0537 0.0841
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.0489 0.0765
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0058 0.0603
Treponema pallidum pfs protein (pfs) 0.0102 0.0778 0.345
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0494 0.4117 0.4097
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0018 0.0063 0.067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0268 0.219 0.2164
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0532 0.0833
Loa Loa (eye worm) hypothetical protein 0.0043 0.0269 0.0269
Schistosoma mansoni alpha(13)fucosyltransferase 0.003 0.0161 0.0151
Echinococcus granulosus peregrin 0.0018 0.0058 0.0076
Echinococcus multilocularis smad 0.002 0.0076 0.0105
Loa Loa (eye worm) latrophilin receptor protein 2 0.0012 0.001 0.001
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0058 0.0048
Schistosoma mansoni purine nucleoside phosphorylase 0.0494 0.4117 0.4111
Entamoeba histolytica hypothetical protein 0.0054 0.0368 0.1547
Onchocerca volvulus Alhambra homolog 0.0018 0.0058 0.0112
Schistosoma mansoni methylthioadenosine phosphorylase 0.0102 0.0778 0.0768
Echinococcus multilocularis glycoprotein 3 alpha L fucosyltransferase 0.0075 0.0549 0.086
Schistosoma mansoni hypothetical protein 0.0281 0.2306 0.2298
Leishmania major eukaryotic translation initiation factor-like protein 0.0065 0.0462 0.5757
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0537 0.0527
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.0789 0.1244
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0042 0.0401
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0161 0.1709
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0065 0.0462 0.043
Echinococcus granulosus smad 0.002 0.0076 0.0105
Echinococcus granulosus Smad4 0.002 0.0076 0.0105
Echinococcus multilocularis purine nucleoside phosphorylase 0.0391 0.3245 0.5167
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0058 0.0048
Echinococcus granulosus purine nucleoside phosphorylase 0.0494 0.4117 0.656
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0058 0.0076
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0102 0.0778 0.1822
Onchocerca volvulus 0.0018 0.0063 0.0125
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0137 0.1379
Toxoplasma gondii phosphorylase family protein 0.0102 0.0778 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0058 0.0322
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0065 0.0462 0.043
Entamoeba histolytica hypothetical protein 0.0054 0.0368 0.1547
Brugia malayi MH2 domain containing protein 0.002 0.0076 0.0076
Loa Loa (eye worm) glutaminase 0.1183 1 1
Leishmania major nucleoside phosphorylase-like protein 0.0102 0.0778 1
Echinococcus granulosus cpg binding protein 0.003 0.0158 0.0235
Echinococcus multilocularis PHD finger protein rhinoceros 0.0018 0.0058 0.0076
Loa Loa (eye worm) hypothetical protein 0.0026 0.0132 0.0132
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0058 0.0322
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0063 0.0084
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0268 0.219 0.2164
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0102 0.0778 0.0746
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0058 0.0603
Plasmodium falciparum phd finger protein, putative 0.0018 0.0058 0.0319
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0161 0.1709
Echinococcus multilocularis peregrin 0.0018 0.0058 0.0076
Loa Loa (eye worm) hypothetical protein 0.0039 0.0236 0.0236
Plasmodium vivax telomerase reverse transcriptase, putative 0.0021 0.0082 0.0641
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0102 0.0778 0.0746
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0012 0.0012 0.0012
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0021 0.0082 0.0641
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0268 0.219 1
Onchocerca volvulus Alpha 1,3 fucosyltransferase homolog 0.0075 0.0549 0.1308
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0051
Echinococcus multilocularis purine nucleoside phosphorylase 0.0494 0.4117 0.656
Schistosoma mansoni smad1 5 8 and 0.002 0.0076 0.0066
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0102 0.0778 0.345
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0494 0.4117 1
Plasmodium falciparum telomerase reverse transcriptase 0.0021 0.0082 0.0641
Schistosoma mansoni alpha(13)fucosyltransferase 0.0177 0.142 0.1411
Echinococcus granulosus glycoprotein 3 alpha L fucosyltransferase 0.0075 0.0549 0.086
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0131 0.1022 0.242
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0042 0.0114
Schistosoma mansoni alpha(13)fucosyltransferase 0.003 0.0161 0.0151
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0042 0.0032
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0102 0.0778 0.0746
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0489 0.0479
Schistosoma mansoni methylthioadenosine phosphorylase 0.0102 0.0778 0.0768
Loa Loa (eye worm) fli-1 protein 0.0223 0.1805 0.1805
Echinococcus multilocularis regulator of G protein signaling 7 0.0012 0.0012 0.0002
Echinococcus multilocularis jumonji domain containing protein 0.0025 0.0117 0.0171
Schistosoma mansoni methylthioadenosine phosphorylase 0.0102 0.0778 0.0768
Schistosoma mansoni dishevelled 0.0012 0.0012 0.0001
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0065 0.0462 0.1986
Loa Loa (eye worm) MH2 domain-containing protein 0.002 0.0076 0.0076
Brugia malayi hypothetical protein 0.0012 0.0012 0.0012
Schistosoma mansoni alpha(13)fucosyltransferase 0.003 0.0161 0.0151
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0268 0.219 0.2164
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0102 0.0778 0.345
Echinococcus granulosus regulator of G protein signaling 7 0.0012 0.0012 0.0002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0074 0.0537 0.0537
Echinococcus multilocularis TGF beta signal transducer SmadC 0.002 0.0076 0.0105
Leishmania major hypothetical protein, conserved 0.0018 0.0058 0.0322
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0042 0.0042
Echinococcus multilocularis segment polarity protein dishevelled 0.0012 0.0012 0.0002
Echinococcus granulosus TGF beta signal transducer SmadC 0.002 0.0076 0.0105
Echinococcus multilocularis geminin 0.0281 0.2306 0.3668
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0137 0.0476
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0065 0.0462 0.5757
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0042 0.0114
Echinococcus granulosus microtubule associated protein 2 0.0746 0.627 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0063 0.0053
Echinococcus multilocularis glycoprotein 3 alpha L fucosyltransferase 0.0075 0.0549 0.086
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0151 0.1195 0.1893
Loa Loa (eye worm) PDE1B protein 0.0151 0.1195 0.1195
Schistosoma mansoni gabp alpha 0.0073 0.0532 0.0522
Schistosoma mansoni hypothetical protein 0.0398 0.3297 0.329
Brugia malayi Pre-SET motif family protein 0.0018 0.0063 0.0063
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0494 0.4117 1
Giardia lamblia PHD finger protein 15 0.0018 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0177 0.142 0.142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0058 0.0058
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0065 0.0462 0.0722
Echinococcus multilocularis microtubule associated protein 2 0.0746 0.627 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0102 0.0778 0.345
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0144 0.0144
Echinococcus multilocularis purine nucleoside phosphorylase 0.0494 0.4117 0.656
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0058 0.0076
Schistosoma mansoni hypothetical protein 0.005 0.0335 0.0325
Brugia malayi Latrophilin receptor protein 2 0.0012 0.001 0.001
Schistosoma mansoni alpha(13)fucosyltransferase 0.0177 0.142 0.1411
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0102 0.0778 0.345
Echinococcus multilocularis Smad4 0.002 0.0076 0.0105
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0058 0.0048
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0532 0.0833
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0131 0.1022 0.0731
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0034 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0489 0.0489
Giardia lamblia Fructose-bisphosphate aldolase 0.0268 0.219 0.5282
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0042 0.0051
Schistosoma mansoni smad1 5 8 and 0.002 0.0076 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0063
Giardia lamblia Rrm3p helicase 0.0027 0.0137 0.0251
Schistosoma mansoni alpha(13)fucosyltransferase 0.003 0.0161 0.0151
Echinococcus multilocularis purine nucleoside phosphorylase 0.0494 0.4117 0.656
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.3297 0.5251
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0102 0.0778 0.0746
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0102 0.0778 0.345
Echinococcus granulosus segment polarity protein dishevelled 0.0012 0.0012 0.0002
Echinococcus granulosus geminin 0.0281 0.2306 0.3668
Brugia malayi MH2 domain containing protein 0.002 0.0076 0.0076
Entamoeba histolytica hypothetical protein 0.0054 0.0368 0.1547
Brugia malayi MH2 domain containing protein 0.0292 0.2401 0.2401
Echinococcus multilocularis uridine phosphorylase 1 0.0102 0.0778 0.1226
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0058 0.0322
Schistosoma mansoni hypothetical protein 0.0027 0.0137 0.0126
Schistosoma mansoni transcription factor LCR-F1 0.0054 0.0368 0.0358
Chlamydia trachomatis AMP nucleosidase 0.0102 0.0778 0.5
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0058 0.0048
Echinococcus granulosus jumonji domain containing protein 0.0025 0.0117 0.0171
Schistosoma mansoni microtubule-associated protein tau 0.0746 0.627 0.6266
Echinococcus multilocularis glycoprotein 3 alpha L fucosyltransferase 0.0075 0.0549 0.086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0058 0.0058
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0027 0.0137 0.0202
Giardia lamblia Telomerase catalytic subunit 0.0021 0.0082 0.0117
Echinococcus multilocularis mothers against decapentaplegic 5 0.002 0.0076 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0137 0.0103

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.