Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0146 | 0.2803 | 0.2803 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0421 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0421 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0421 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0107 | 0.179 | 0.179 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0387 | 0.9108 | 0.9108 |
Brugia malayi | Thioredoxin reductase | 0.0421 | 1 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0387 | 0.9108 | 0.9108 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0146 | 0.2803 | 0.2803 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0146 | 0.2803 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0146 | 0.2803 | 0.2803 |
Plasmodium falciparum | thioredoxin reductase | 0.0421 | 1 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0146 | 0.2803 | 0.2803 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0146 | 0.2803 | 1 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0039 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0146 | 0.2803 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma brucei | trypanothione reductase | 0.0421 | 1 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Treponema pallidum | NADH oxidase | 0.0146 | 0.2803 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0146 | 0.2803 | 0.2803 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0146 | 0.2803 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0146 | 0.2803 | 0.2803 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0107 | 0.179 | 0.179 |
Leishmania major | trypanothione reductase | 0.0421 | 1 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0146 | 0.2803 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0146 | 0.2803 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0421 | 1 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0146 | 0.2803 | 0.2803 |
Plasmodium vivax | glutathione reductase, putative | 0.0421 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0146 | 0.2803 | 0.2803 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0039 | 0 | 0.5 |
Onchocerca volvulus | 0.0039 | 0 | 0.5 | |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0146 | 0.2803 | 0.2803 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0421 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0146 | 0.2803 | 0.2803 |
Entamoeba histolytica | pyridine nucleotide-disulfide oxidoreductase family protein | 0.0039 | 0 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0039 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0146 | 0.2803 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0146 | 0.2803 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0421 | 1 | 1 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0039 | 0 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0146 | 0.2803 | 0.2803 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.0039 | 0 | 0.5 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Plasmodium falciparum | glutathione reductase | 0.0421 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0146 | 0.2803 | 0.2803 |
Entamoeba histolytica | disulphide oxidoreductase, putative | 0.0039 | 0 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0146 | 0.2803 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0146 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0421 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0421 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0146 | 0.2803 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0146 | 0.2803 | 0.2803 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0146 | 0.2803 | 0.2803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.