Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | No references |
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | No references |
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 0 | 0.5 |
Onchocerca volvulus | 0.0182 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0409 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0409 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0409 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0409 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0409 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0409 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0409 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0409 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0409 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0409 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -7.5 | In vitro inhibitory activity against human erythrocyte acetylcholinesterase | ChEMBL. | 15317459 |
IC50 (binding) | = 1.3 nM | Inhibition of (BChE) Butyrylcholinesterase of horse serum | ChEMBL. | No reference |
IC50 (binding) | = 1.3 nM | Inhibition of (BChE) Butyrylcholinesterase of horse serum | ChEMBL. | No reference |
IC50 (binding) | = 11.67 nM | Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assay | ChEMBL. | No reference |
IC50 (binding) | = 11.67 nM | Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assay | ChEMBL. | No reference |
IC50 (binding) | = 31.5 nM | Inhibition of acetylcholinesterase (AChE) of human red blood cell (type XIII) by modified radiometric AChE assay | ChEMBL. | No reference |
IC50 (binding) | = 31.5 nM | Inhibition of acetylcholinesterase (AChE) of human red blood cell (type XIII) by modified radiometric AChE assay | ChEMBL. | No reference |
IC50 (binding) | = 240 nM | Inhibition of AChE | ChEMBL. | 20053484 |
IC50 (binding) | = 0.041 uM | In vitro inhibition of Butyrylcholinesterase from human plasma. | ChEMBL. | 9357518 |
IC50 (binding) | = 0.041 uM | In vitro inhibition of Butyrylcholinesterase from human plasma. | ChEMBL. | 9357518 |
IC50 (functional) | = 0.2 uM | Inhibition of neuronal uptake of 5 - Hydroxytryptamine in rat brain homogenate | ChEMBL. | 9357518 |
IC50 (functional) | = 0.2 uM | Inhibition of neuronal uptake of 5 - Hydroxytryptamine in rat brain homogenate | ChEMBL. | 9357518 |
IC50 (binding) | = 0.24 uM | In vitro inhibition of acetylcholinesterase, isolated from rat brain. | ChEMBL. | 9357518 |
IC50 (binding) | = 0.24 uM | In vitro inhibition of acetylcholinesterase, isolated from rat brain. | ChEMBL. | 9357518 |
IC50 (functional) | = 6.1 uM | Inhibition of neuronal uptake of Noradrenaline in rat brain homogenate | ChEMBL. | 9357518 |
IC50 (functional) | = 6.1 uM | Inhibition of neuronal uptake of Noradrenaline in rat brain homogenate | ChEMBL. | 9357518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.