Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Neisseria gonorrhoeae | Dihydrofolate reductase | Starlite/ChEMBL | References |
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Plasmodium berghei | bifunctional dihydrofolate reductase-thymidylate synthase, putative | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.034 | 0.9927 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0278 | 0.7026 | 0.7078 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.034 | 0.9927 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.034 | 0.9927 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.034 | 0.9927 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0278 | 0.7026 | 0.7078 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0278 | 0.7026 | 0.7078 |
Brugia malayi | dihydrofolate reductase family protein | 0.034 | 0.9927 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.034 | 0.9927 | 1 |
Brugia malayi | P38 map kinase family protein 2 | 0.0278 | 0.7026 | 0.7078 |
Echinococcus granulosus | dihydrofolate reductase | 0.034 | 0.9927 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0278 | 0.7026 | 0.7078 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0341 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0278 | 0.7026 | 0.7078 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.034 | 0.9927 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0341 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0278 | 0.7026 | 0.7078 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0278 | 0.7026 | 0.7078 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0341 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.034 | 0.9927 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.034 | 0.9927 | 1 |
Onchocerca volvulus | 0.013 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 200000000 M | Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli | ChEMBL. | 3100802 |
I50 (binding) | = 350000000 M | Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium berghei | ChEMBL. | 3100802 |
I50 (binding) | = 3560000000 M | Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea | ChEMBL. | 3100802 |
I50 (binding) | = 520000000000 M | Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver | ChEMBL. | 3100802 |
IC50 (binding) | = 0.00000002 M | Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli | ChEMBL. | 3100802 |
IC50 (binding) | = 0.000000035 M | Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium berghei | ChEMBL. | 3100802 |
IC50 (binding) | = 0.000000356 M | Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea | ChEMBL. | 3100802 |
IC50 (binding) | = 0.000052 M | Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver | ChEMBL. | 3100802 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.